LOCUS       NM_001305229            5596 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus synapse defective Rho GTPase homolog 2 (Syde2),
            mRNA.
ACCESSION   NM_001305229 XM_003749414
VERSION     NM_001305229.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5596)
  AUTHORS   Lo,H.F., Tsai,C.Y., Chen,C.P., Wang,L.J., Lee,Y.S., Chen,C.Y.,
            Liang,C.T., Cheong,M.L. and Chen,H.
  TITLE     Association of dysfunctional synapse defective 1 (SYDE1) with
            restricted fetal growth - SYDE1 regulates placental cell migration
            and invasion
  JOURNAL   J Pathol 241 (3), 324-336 (2017)
   PUBMED   27917469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 11, 2021 this sequence version replaced NM_001305229.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.12414.1,
                                           SRR26360172.1891497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1311              JAXUCZ010000002.1  237558274-237559584
            1312-1980           JAXUCZ010000002.1  237568395-237569063
            1981-3071           JAXUCZ010000002.1  237571181-237572271
            3072-3198           JAXUCZ010000002.1  237574380-237574506
            3199-3380           JAXUCZ010000002.1  237582847-237583028
            3381-3612           JAXUCZ010000002.1  237584809-237585040
            3613-5596           JAXUCZ010000002.1  237589307-237591290
FEATURES             Location/Qualifiers
     source          1..5596
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..5596
                     /gene="Syde2"
                     /gene_synonym="RGD1564206; Syde2-ps1"
                     /note="synapse defective Rho GTPase homolog 2"
                     /db_xref="GeneID:308021"
                     /db_xref="RGD:1564206"
     exon            1..1311
                     /gene="Syde2"
                     /gene_synonym="RGD1564206; Syde2-ps1"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..4109
                     /gene="Syde2"
                     /gene_synonym="RGD1564206; Syde2-ps1"
                     /note="synapse defective 1, Rho GTPase, homolog 2"
                     /codon_start=1
                     /product="rho GTPase-activating protein SYDE2"
                     /protein_id="NP_001292158.2"
                     /db_xref="GeneID:308021"
                     /db_xref="RGD:1564206"
                     /translation="MERRAWGTWARSEQLGARVPWSRGAQEAAALGRALTCASPGTEG
                     SGDDGEDEGADYYENLPAGCAPEGAEALRASPSQAAGSSPGMEGGRQETGRLQTQLRE
                     AYYLLIQAMHDLPPDSGTRRGGPAGAQAQGQQPPLPRGAAVRRACSPRGGDRPPQQVS
                     PPRSSPTESRVGRPPSPRMQLSSCRSLESLRVSPQPPLFQRWASDSWIRCGAHRDREE
                     PQPRGGGMDGWSRGSHRAATSAALLPPFCQDPSRSSGRPFKDPAGTSVISCSQEDHPE
                     ELPLLKPPAVTVKKLQKWMYKGRLLSLGMKGRAHGTAPKVPGAQATSPNLGSWKVHEN
                     HVLSVTADQRITLTDLFENVCGSPLKKRDPGGGRGNTELSGHQALNNITVSKKRNWLY
                     QSPLRSPSLDRHYSSLSPVSPPRHRLPQPFCKPHREPCMHAVCNAAGSPSSRNGSSAF
                     SEDDADDEGEIWYNPIPEDDSLGIAHVLSLEEANAAALKLPAVRVSMLSARDLAKAET
                     RSEDLLCPTQHRGDVQTSQSNGINSVDSIHSTDIVQPCRQRLGHRTQESLTAEDSPGL
                     KSAFTGPGILVSTNRTELRALEPPSPSPSPVKKGSSITWSLPDKIKSPRTVRKLSMKM
                     KRLPEFSRKRGARGALHYTNSPDRTPPLSKWYYGEGPQSVLLPSGNPASNVISRYHLD
                     TTVSSQHSYQKKPLGSSRYPCKGGYLSDGDSPELRTRSSKHGSEHRLGKGREAVPSGC
                     SKNEIDVGAFRHYSFSDQPKCSQYISGLMSVHFYGAEGLKPPRIDSKDVFCAIQVDSV
                     NKARTALLTCRTTFLDLDHTFNIEIENAQHLKLVVFSWEPTPRRNRVCCHGTVVLPAL
                     FRVTRTHQLAVKLEPRGLIYVKVTLMEQWENSLHGLDKNRESVMFGVDIQKVVEKENA
                     GLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFEKDSKTVGLCEDQYPD
                     INVITGVLKDYLRELPSPLITKQLYQAVLDAMVKSPLKMSSNGCENESSDSRFTVDLL
                     NCLPDVEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLNQRQETSTHNNRVF
                     SDSEELASALDFKKHIEVLHYLLQLWPVQCLTVKEPRDSLCLEQSSSLNYLRRKKERP
                     CVLNLSGSDSSGVLRPRQARLDSPLSNRYAGDWSSCGESYSSSTTENFKDLDYDDVPL
                     EDGDGRDYGKMDRVDGVTEPRVPVSGGCTFQTYLTVQTIESTVDQKANLRDLQESIDT
                     LIGNLERELSKNKLNMSV"
     exon            1312..1980
                     /gene="Syde2"
                     /gene_synonym="RGD1564206; Syde2-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..3071
                     /gene="Syde2"
                     /gene_synonym="RGD1564206; Syde2-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3198
                     /gene="Syde2"
                     /gene_synonym="RGD1564206; Syde2-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3380
                     /gene="Syde2"
                     /gene_synonym="RGD1564206; Syde2-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..3612
                     /gene="Syde2"
                     /gene_synonym="RGD1564206; Syde2-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..5596
                     /gene="Syde2"
                     /gene_synonym="RGD1564206; Syde2-ps1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttatgcc aagtatgtga ggagctggcg aggaccggcc gcggtcatgg agagccgccg
       61 cctccgcccg cgcgggactc ggagcccgcc ccgcgcccag ggcgagccgg gctgctgagg
      121 cggcgcgcat ggcggagccc ctgcggagga cgctcggcta gctccgagag cggcgcggtc
      181 ccggggtgct cgggctgcac gcggacgccg tggcggcctc gctctccgag ggacgctcgc
      241 cgctccgaga gctcgtggtc cccggcatgg agcggcgggc gtgggggacc tgggcgcgct
      301 ccgagcagct aggcgcgcgg gtcccatggt ctcgcggggc tcaggaggcc gccgctctgg
      361 gccgcgcgct tacttgcgct tccccaggca cggagggcag tggcgacgac ggggaggacg
      421 agggcgccga ctactacgag aacctgcccg cgggctgcgc gcccgagggg gcggaggcgc
      481 tgcgggcctc gccttcgcaa gcggcgggct cctccccggg gatggagggc ggccgccagg
      541 agacaggcag gctgcagacc cagttgcgag aggcctatta tctgctgatc caggccatgc
      601 acgacctgcc ccctgactcg ggcacgcggc ggggcggacc cgcgggagcc caggctcagg
      661 gccagcagcc gcctctcccc cgcggcgcag ccgtgcgccg agcctgcagc ccccgaggcg
      721 gcgaccgccc tccgcagcag gtgtccccgc cccggtcgtc tccgacggag tctagagtgg
      781 gacggcctcc cagtcctcgg atgcagctgt ccagttgcag aagtctcgag agcctccgcg
      841 tgagcccgca gccgcctctg ttccagcggt gggcgagcga cagctggatc aggtgcggcg
      901 cgcacaggga cagggaggag ccccagccac gtggaggtgg gatggacggc tggagccggg
      961 gcagccacag ggctgctacg tccgctgctc tcctgcctcc cttctgccag gaccccagcc
     1021 ggtcctcggg acgtcccttt aaggatcctg cggggacctc tgtgatatcc tgcagccaag
     1081 aggaccatcc cgaggagctt cccctcctca agccacctgc ggtgactgtc aagaaactgc
     1141 agaagtggat gtataaagga cgactgttgt ccctggggat gaagggtcgc gctcatggga
     1201 cagcacccaa agttcccgga gctcaggcaa cctctccaaa tttgggcagt tggaaagtgc
     1261 atgaaaacca cgtcctctcg gtgacagcgg accaaagaat cacactgaca gacttattcg
     1321 agaatgtctg tgggtctcca ctgaagaaac gagaccctgg aggtggaagg ggtaacaccg
     1381 agcttagtgg tcaccaggcc ctgaacaaca tcactgtttc aaagaaacgc aattggctgt
     1441 atcagagccc tctgaggtct cccagtctgg acagacatta ttcctccctc tcccccgtgt
     1501 ctccgcccag gcatcggctc ccgcagcctt tctgtaaacc ccacagagaa ccctgcatgc
     1561 acgcggtgtg taacgccgcc ggttctccgt catccagaaa cggctcttca gccttcagtg
     1621 aggacgacgc cgatgacgaa ggagaaatat ggtataaccc catccccgag gacgacagcc
     1681 tgggcatagc acacgtcttg agtctggagg aggcaaacgc cgctgccctg aagctccctg
     1741 ccgtccgtgt gagcatgttg tctgctagag acctggcgaa ggcagagact cgtagtgaag
     1801 acttgctgtg tcctacccaa caccgaggtg acgtccagac ctcacagtca aatggaatta
     1861 attctgtcga ttccattcat tctacagaca ttgtgcagcc atgcagacag agattaggac
     1921 acaggacaca ggagagcctg acggcagagg acagccccgg gttgaaatct gcttttacag
     1981 gtcccgggat cttagtctct acaaatagga ctgaactgag agctctggag ccaccttctc
     2041 caagccccag ccccgtgaag aaaggcagct ccattacctg gtctttacca gacaaaataa
     2101 aatctccacg cactgtgagg aaactctcta tgaaaatgaa aaggttgcct gagttcagcc
     2161 ggaagcgggg tgccagggga gccttgcact acaccaacag tccagacagg acccctcctt
     2221 tgtctaagtg gtactatgga gaaggtcctc agagtgtact tctgccttcc gggaacccag
     2281 ccagcaacgt aataagccgg taccaccttg ataccactgt gtcctctcaa cacagctacc
     2341 agaagaaacc cctcgggagc tccaggtatc cctgtaaggg tgggtacctc agcgacggag
     2401 actcacccga acttagaact agatctagca agcatggatc cgagcacaga cttgggaaag
     2461 ggagagaagc cgttccaagc ggttgtagca aaaatgaaat agacgttggt gcctttagac
     2521 attacagctt ctcggatcaa cccaagtgct cccagtacat atccggactc atgagcgtgc
     2581 acttttatgg agcagagggt ttaaaaccgc cccggataga ctccaaagat gtcttttgtg
     2641 ccattcaggt tgactcggta aacaaagcca ggacagctct gctcacctgt cgaacgacgt
     2701 tcttggacct ggaccacact ttcaacatag agatcgaaaa tgcacagcat ttgaaactgg
     2761 tggtgttcag ctgggagccc actcccagga ggaaccgtgt gtgctgtcac ggcacggtcg
     2821 tcctgccagc tttgttcagg gtgacaagaa cacatcagct ggctgtcaag ctggaaccca
     2881 gagggctcat ttacgtcaag gtaaccttga tggaacagtg ggagaattct ctccacggcc
     2941 tggataagaa ccgagaatca gtgatgtttg gagttgacat ccaaaaagtt gtagaaaaag
     3001 aaaacgcagg cttgatggtg ccgctgctga tacagaaatg tatcatggag attgaaaaga
     3061 ggggctgtca ggttgtaggc ctgtatcgat tgtgtggttc agcagctgtg aagaaagagc
     3121 ttcgagaggc ttttgagaag gacagcaaaa ctgtcggtct gtgtgaagac cagtacccag
     3181 atataaatgt aataacaggt gttctgaagg actacctgag agaactccct tctcccctaa
     3241 taacgaagca gctgtaccag gccgtgttag acgccatggt gaagagtcct ttgaaaatgt
     3301 cgtcgaatgg ctgtgagaac gagtccagtg actccaggtt tactgtcgac ctactgaact
     3361 gcctgccaga tgttgagaag gcaaccctaa agatgttgtt agatcatctg aaactggtgg
     3421 cttcttacca cgaagtgaac aagatgacct gccagaattt ggccgtgtgc tttggaccag
     3481 tgttgcttaa tcagaggcaa gagacgtcga cgcacaacaa cagagtcttc tccgactctg
     3541 aagagcttgc gagtgctttg gactttaaga agcacatcga agttcttcac tacttgctcc
     3601 aactctggcc agtgcagtgt ctaaccgtca aggaacccag agacagtttg tgcctggagc
     3661 agtcgtcttc tctgaattac ttgaggcgaa agaaagagcg accgtgtgtg ttgaatctga
     3721 gcggttcaga ttcatcaggg gtgctgaggc caaggcaggc ccgactggat agcccactca
     3781 gtaaccgcta cgcaggggac tggagcagct gtggggagag ctactcttca agtacaacag
     3841 aaaatttcaa ggatttggat tatgatgacg ttcccttaga agatggagac ggtagagact
     3901 atggcaaaat ggatagagtg gacggcgtga ctgagccacg agtccccgtg tcaggagggt
     3961 gcacgtttca gacgtacttg acggtgcaga ccatcgagtc cacagtggat cagaaagcta
     4021 acctcagaga tctgcaagag agcattgaca ctttgattgg caatctggaa cgtgagctca
     4081 gcaaaaacaa gctgaatatg agtgtttgag gcggaggggt tgtttgattt gtgatgatgt
     4141 ttccatgtca agccttcttc cttacacaca cacacacaca cacacacaca cacacacaca
     4201 cacacacaga cacacacaca cacacacaca cagtgttgga accttaagtt aattcctaat
     4261 aagttcatgt aattcagttg taatcactat tcattgatat gtttatttac ttatgaacgg
     4321 aactgttccg ggcataaagg tgatccagac tttgggggct atttcagtag accttggcag
     4381 ctgcatggag gagacatgca gacgtctgta agggtcaagt tcgttattcc caggcaaggc
     4441 tttggtggga gctgttctgt aggtggacac agatgttctc tgctgaggac actgcaactg
     4501 gacaggccga ttcgcagtca gagtccttgt gcaatgtcat ttggtcatgt ttcatttgca
     4561 atatgaatgc tgctataaga aaaaagtttt tataaacgta aaattataca ggtgttaatg
     4621 cattctgtat taacgttcag taattattta agcttataaa aattattttt atgaatttga
     4681 gaatatatgt atatttataa cttcattatg aatctgagaa tatgtatata tttataactt
     4741 cattatgagt ccgagaatat gtatatattt ataacttcat tatgcatgta ggttttagaa
     4801 tgggggaagg ggttgactgt agcattccac atattttaaa aacaaggcca aaatgactag
     4861 ctttagaatc tctttcaggg aaggaatgtt taagtgaaaa ggacaagtca cacagacacc
     4921 acttgaatga aaacactcta gaactgttgg aggaggggca gcgacagcct ttctgttctt
     4981 gctttataga cactgtatcc ctgtggaaag ttagatttta tgttgacatc cttcagctgc
     5041 agaagggatc cggtgacttc agaagacttc acccgttccg tgcctctctg tgtcctggga
     5101 cactctcagt atttatttat agtggcatac ttaagacgtt gacttcacta gttgtccttg
     5161 tttctaaaga agatgtcttg ccgggatgcc acgtgtcaca gatgtttaaa acttttatac
     5221 ttacagaatg tgtaatttta gaagtataac ggaaacttga gttaccaagt gtgacagcca
     5281 taaggaagcc cgtttcttac tgcttttcta aatattcagg tacttagtgt aaccacttct
     5341 atgcagtgcc tataacatcc aggtaatttg aaagcccgtt ggtatgaaga aaaataacta
     5401 tttttatgag actttcattt ttttttaaaa cgttgtgtaa caaataccag agacgatgaa
     5461 gtcggtgtac atcacgagta aacagagtat ttttaaatgt tttgtagagg aagttattcg
     5521 tgccttttgt ttgctatgtc gtgtataata cataaatgta aatgctttat taaaatatta
     5581 ctaccatgtc acgcta
//
