LOCUS       NM_130735               4771 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus synaptonemal complex protein 2 (Sycp2), mRNA.
ACCESSION   NM_130735 XM_346680
VERSION     NM_130735.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4771)
  AUTHORS   Zhou,J., Stein,P., Leu,N.A., Chmatal,L., Xue,J., Ma,J., Huang,X.,
            Lampson,M.A., Schultz,R.M. and Wang,P.J.
  TITLE     Accelerated reproductive aging in females lacking a novel
            centromere protein SYCP2L
  JOURNAL   Hum Mol Genet 24 (22), 6505-6514 (2015)
   PUBMED   26362258
REFERENCE   2  (bases 1 to 4771)
  AUTHORS   Llano,E., Herran,Y., Garcia-Tunon,I., Gutierrez-Caballero,C., de
            Alava,E., Barbero,J.L., Schimenti,J., de Rooij,D.G.,
            Sanchez-Martin,M. and Pendas,A.M.
  TITLE     Meiotic cohesin complexes are essential for the formation of the
            axial element in mice
  JOURNAL   J Cell Biol 197 (7), 877-885 (2012)
   PUBMED   22711701
REFERENCE   3  (bases 1 to 4771)
  AUTHORS   La Salle,S., Palmer,K., O'Brien,M., Schimenti,J.C., Eppig,J. and
            Handel,M.A.
  TITLE     Spata22, a novel vertebrate-specific gene, is required for meiotic
            progress in mouse germ cells
  JOURNAL   Biol Reprod 86 (2), 45 (2012)
   PUBMED   22011390
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4771)
  AUTHORS   Berkowitz,K.M., Sowash,A.R., Koenig,L.R., Urcuyo,D., Khan,F.,
            Yang,F., Wang,P.J., Jongens,T.A. and Kaestner,K.H.
  TITLE     Disruption of CHTF18 causes defective meiotic recombination in male
            mice
  JOURNAL   PLoS Genet 8 (11), e1002996 (2012)
   PUBMED   23133398
REFERENCE   5  (bases 1 to 4771)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   6  (bases 1 to 4771)
  AUTHORS   Shakib,K., Norman,J.T., Fine,L.G., Brown,L.R. and
            Godovac-Zimmermann,J.
  TITLE     Proteomics profiling of nuclear proteins for kidney fibroblasts
            suggests hypoxia, meiosis, and cancer may meet in the nucleus
  JOURNAL   Proteomics 5 (11), 2819-2838 (2005)
   PUBMED   15942958
REFERENCE   7  (bases 1 to 4771)
  AUTHORS   Eijpe,M., Heyting,C., Gross,B. and Jessberger,R.
  TITLE     Association of mammalian SMC1 and SMC3 proteins with meiotic
            chromosomes and synaptonemal complexes
  JOURNAL   J Cell Sci 113 (Pt 4), 673-682 (2000)
   PUBMED   10652260
REFERENCE   8  (bases 1 to 4771)
  AUTHORS   Schalk,J.A., Offenberg,H.H., Peters,E., Groot,N.P., Hoovers,J.M.
            and Heyting,C.
  TITLE     Isolation and characterization of the human SCP2 cDNA and
            chromosomal localization of the gene
  JOURNAL   Mamm Genome 10 (6), 642-644 (1999)
   PUBMED   10341103
REFERENCE   9  (bases 1 to 4771)
  AUTHORS   Schalk,J.A., Dietrich,A.J., Vink,A.C., Offenberg,H.H., van
            Aalderen,M. and Heyting,C.
  TITLE     Localization of SCP2 and SCP3 protein molecules within synaptonemal
            complexes of the rat
  JOURNAL   Chromosoma 107 (8), 540-548 (1998)
   PUBMED   9933407
REFERENCE   10 (bases 1 to 4771)
  AUTHORS   Offenberg,H.H., Schalk,J.A., Meuwissen,R.L., van Aalderen,M.,
            Kester,H.A., Dietrich,A.J. and Heyting,C.
  TITLE     SCP2: a major protein component of the axial elements of
            synaptonemal complexes of the rat
  JOURNAL   Nucleic Acids Res 26 (11), 2572-2579 (1998)
   PUBMED   9592139
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y08981.1.
            
            On Jan 12, 2005 this sequence version replaced XM_346680.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y08981.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132264,
                                           SAMD00132266 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4771
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..4771
                     /gene="Sycp2"
                     /note="synaptonemal complex protein 2"
                     /db_xref="GeneID:83820"
                     /db_xref="RGD:69429"
     exon            1..118
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..177
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..4671
                     /gene="Sycp2"
                     /function="DNA binding protein"
                     /note="SCP-2; rnSCP2; synaptonemal complex lateral element
                     protein"
                     /codon_start=1
                     /product="synaptonemal complex protein 2"
                     /protein_id="NP_570091.1"
                     /db_xref="GeneID:83820"
                     /db_xref="RGD:69429"
                     /translation="MPVRPDPQQLEKCIDDALRKNDFKPLVTLLQIDICEDVKIKCSK
                     QFLRKLDDLICRELHKKDIQTISNILISIGRCSKNIFILGQTGLQTMIKQGLVQKMVS
                     WFENSKEIILSQRQSKDEAVMNMIEDLFDLLMVVYDVNDEGKNQVLESFIPHICALVI
                     DSRVNFCIQQEALKKMNLMLDRIPQDANKILCNQEILTLMSNMGERILDVGDYELQVG
                     IVEALCRMTTEKRRQELAYEWFSMDFIANAFKKIKDCEFETDCRIFLNLVNGMLGDRR
                     RVFTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDDDDHQWEAVTVP
                     EEKVDMYNIEVRESKKLLTLTLKNIVKISKKEGKELLLYFDAALEITNVTKKLFGGNK
                     YKEFTRKQDISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSNLQKKLTNP
                     LEPDNSSSQRDRKNSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSR
                     APLQAIHSAEKAVSKTSESGVDYAVSLKSRQSDGRNRGNNRANHNKTATVQNKGHEHH
                     ESPDQTFNEIEETLSDAYAVEKVDKPVLPGVLDISKNKAHSRWACWTPVTTIKLCNNQ
                     RSCALPGDTFTQDTGVNKKCTKQKSVSDDDSEETQRVKYSKDVIKCNKSEEAEVCERN
                     IQEQNHPKYSQKKNTANAKKNDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNT
                     TICDKSPSRKSMRSHTKSRKELMSEVTSCELDEIPVRENSKGKRFTGTAESLINLINK
                     RYNSSDDMISTRKLKEPRDGSGFSKKPELQFNKVQRKSYRKLKTVVNVTSECPLNDVY
                     NFSLNGADEPVIKLGIQEFQATTREASMDNSIKLVDVRNRDERDLSLKTKDERILSHE
                     RKTLFSDTETECGWDDSKTDISWLRKPKSKRLMDYSRNKNTKKCKSIKSRSSTEKGQP
                     RSTVVLSKNIAKNDYEVIVDGRTRLPRRATKTKKNYKDLSTSGSESESEKEISYLFKD
                     KLPTKEETVHSSAQTKKLPKKQQKVFNTEALKGQPSEEQKNSSTLRNGREDSLYLSSA
                     SVSGSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAASPEFLNRSNRVVGHGKS
                     PRISETSAVCVRKSCSPASGLPFSPRHTTKNNSVMNIKNTNSVINNQRTQHCNSYSDV
                     SSNSSEKLYMEPESPDSCENHVQSKREENHAASPFSLSSEKIEKIWFDMPNDNTHVSG
                     PSQRGSKRRMYLEEDELSNPSEAEVQEAEEREHLVSKKLCQREHFDQHTSETSLSTPE
                     FSVPKDWQQELQGAGMFYDNINSDYKRKTDTQHKIMDDFTTKTLKLTQQHLLAMACQA
                     RGHRDENIDKFQVTLLDELEKVEKDSQTLRDLEKEFVDIEEKIVHKMRAFHQSERERF
                     RALKTSLDKSLLVYNSVYEENVLTSEMCLMKANMKMLQDKLLKEMHEEELLNIRRGLE
                     SLFKDHEGNNA"
     exon            178..321
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..450
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..555
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..580
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..666
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..752
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..787
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..930
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..983
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1029
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1125
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1186
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1335
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1410
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1557
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1657
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1806
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1873
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1931
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2062
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2481
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2609
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2646
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2708
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2766
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2822
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2880
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3043
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3081
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3258
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3457
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3663
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3846
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3847..3937
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..4093
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..4203
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4204..4298
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4299..4398
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4399..4457
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..4539
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4540..4596
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4597..4752
                     /gene="Sycp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgttggctcc caggagactg aggaggcgcc ataacactcg acggcccttg ccggcggagg
       61 tggtcgccag gtcccgggtg tcctggctgc aggtggcgca ggtctacggg agaccgtggt
      121 gtctgtcctc tcctattctt aaatgaagtc aaaatgccag tgagaccaga cccccaacag
      181 ttagaaaagt gtattgatga tgctttgaga aaaaacgact tcaagccttt ggtgacactt
      241 ttacaaattg atatttgtga agatgtgaag attaaatgca gcaaacaatt cctccgcaag
      301 ttggatgact taatatgcag ggaacttcat aaaaaggata tccaaactat ttcaaacatc
      361 ttgatatcta ttggaagatg tagcaagaat atctttatat tgggacaaac tggacttcaa
      421 accatgataa aacaaggatt agtccaaaag atggtttcct ggtttgaaaa ttccaaggag
      481 attattctga gtcagcgaca atcaaaagat gaagctgtta tgaatatgat agaagactta
      541 tttgatcttt tgatggtcgt atatgacgtc aatgatgaag gtaaaaacca agtattggaa
      601 agtttcatac ctcacatctg tgccctggtt attgattcaa gagtgaattt ttgcattcag
      661 caagaggctt taaaaaaaat gaatttgatg cttgacagaa tacctcaaga tgccaacaaa
      721 atactttgta atcaagaaat attaactctc atgagtaata tgggagaaag gattttagat
      781 gtaggagatt atgaattaca ggtaggcatt gtggaagctt tgtgtagaat gactaccgaa
      841 aaacggaggc aggagctggc atatgaatgg ttttcaatgg actttattgc taatgcattt
      901 aagaaaatta aagactgtga atttgaaaca gattgcagaa tatttctcaa cttggtaaac
      961 ggcatgctgg gtgacagaag aagggtcttt acatttcctt gcttgtcagc atttcttggt
     1021 aaatatgagc tgcagatacc atcagatgaa aaacttgagg aattctggat tgattttaat
     1081 ctcgggagcc acactctgtc attctacatt gctggagatg atgatgatca ccaatgggaa
     1141 gctgtcactg tgcctgaaga aaaagttgat atgtacaaca ttgaagtgag agaatcaaag
     1201 aagctactga ctctaacttt gaaaaatata gtaaaaatta gtaaaaaaga aggaaaagag
     1261 ttacttttgt attttgatgc agcattagaa atcaccaatg tgactaaaaa actttttggt
     1321 ggaaataagt ataaggaatt taccagaaaa caagatattt cagttgccaa aacatccatt
     1381 catgtacttt ttgatgcaag tggatcacag attctagtac cagaaagtca accatctcca
     1441 gtcaaagaaa acctcattca tctaaaagag aaatctaacc tccaaaagaa acttacaaac
     1501 cctctagaac cagacaacag cagcagccag cgcgacagga aaaacagcca ggatgagatc
     1561 actacaccta gcagaaagaa aatgtctgaa gcatcaatga ttgttcccga tacagacaga
     1621 tacactgtgc gaagtccaat actcttaatc aacacatcaa ccccgcgaag aagtagggca
     1681 ccactgcaag caatacattc tgctgagaag gctgtttcta aaacatcaga aagtggagtg
     1741 gattatgctg tgtcactcaa atctagacaa tctgatggaa gaaatagagg gaacaataga
     1801 gccaatcata acaaaactgc tacagtacaa aacaaaggac atgagcacca tgaatcccca
     1861 gaccaaactt tcaatgaaat tgaggaaact ctctctgatg catatgcagt ggaaaaagta
     1921 gacaagcctg tattacctgg tgttttagac atctcgaaaa ataaagcaca ttccagatgg
     1981 gcatgttgga cacctgtaac aactatcaaa ctctgcaata accagagatc ctgtgcttta
     2041 ccaggagata cttttaccca agatactggt gtcaacaaaa aatgcactaa acaaaaatca
     2101 gtatctgatg atgattctga agaaacacaa agggtaaaat atagtaaaga tgtcatcaag
     2161 tgtaacaagt cagaagaagc agaagtttgt gaaagaaaca ttcaagaaca aaatcatcct
     2221 aaatattcac aaaagaaaaa tactgcaaat gcaaagaaga atgattggca tattgaatct
     2281 gaaacaactt ataaatcagt actcctaaat aagacaactg aagaatcact catctataag
     2341 aagacgtgtg tattgtcaaa agatgtgaat actactatct gtgataaaag cccttctaga
     2401 aaaagcatga ggagccatac aaagtcaagg aaagaactga tgtctgaagt tacttcatgt
     2461 gagctagatg aaataccagt gagagaaaat tcaaaaggga aaagatttac tggtacagca
     2521 gaatccttga taaacctaat taataagagg tataactcaa gtgatgacat gatatcaaca
     2581 agaaaactga aggagcctcg ggatggcagt gggttttcaa agaaacctga actgcagttc
     2641 aataaggttc agagaaagag ttacagaaaa ctgaagactg ttgttaatgt tacttctgaa
     2701 tgtccactga atgatgtata taatttcagc ttgaatggag ccgatgagcc tgttataaaa
     2761 cttggaatcc aagaatttca agctacaact agagaagcta gtatggataa ttcaataaaa
     2821 ttggtagatg taaggaaccg tgatgaacgt gacctttctc tcaaaacaaa agatgaaaga
     2881 atattaagtc atgagaggaa aactctcttc agtgacactg aaacagaatg tggttgggat
     2941 gacagcaaga ctgacattag ctggctaagg aaaccaaaat caaaaagact aatggattat
     3001 agtagaaata aaaacacaaa aaaatgtaaa agtataaaat caaggtcatc cacggaaaag
     3061 ggacagccaa gatccacagt ggtactcagt aaaaacattg cgaaaaatga ttatgaagta
     3121 attgtagatg ggagaaccag acttccacga agagcaacaa aaacaaaaaa aaattacaaa
     3181 gatctctcaa cttcaggatc agaatcagag agtgaaaaag aaatttcata tttgtttaaa
     3241 gataaactac caacaaagga ggagactgtc cattccagcg cccaaacaaa gaaactgccc
     3301 aagaaacaac agaaagtctt caatacagaa gcgctgaaag gacagccttc agaagaacag
     3361 aaaaattcat ctacgctaag aaatgggaga gaagacagtc tgtacttgtc ttctgcatct
     3421 gtgtctggga gctcgtcatc tgtggaagtg atgagatgta cagagaaaat aacagaaagg
     3481 gattttactc aggattatga ctacatcaca aagtctcttt caccatatcc aaaagctgca
     3541 tcacctgaat tcttaaacag aagcaataga gtggtaggtc atggaaaatc accaagaatt
     3601 agtgagacca gtgcagtatg tgtgagaaag agttgctcac ctgcttcagg actgcccttt
     3661 tcgcccagac acacaaccaa gaataattct gttatgaata taaaaaatac aaattcagtg
     3721 ataaataatc aaagaaccca acattgtaac agctattcag atgtaagcag taacagttca
     3781 gagaaacttt atatggaacc cgaatctccg gatagctgtg aaaaccatgt gcaaagcaag
     3841 agagaggaaa atcatgcagc ctctccattt tcattgtcta gtgaaaaaat agagaaaata
     3901 tggtttgaca tgcccaatga caatactcat gtatcaggtc ccagtcaacg tggtagcaaa
     3961 agacggatgt acctagaaga agatgagcta agtaatccca gtgaagcaga agtgcaagag
     4021 gcagaagaaa gggaacattt ggtttccaaa aaactatgtc aaagggaaca tttcgatcag
     4081 catacctctg aaacttcatt atcaacacca gagttttctg ttcctaagga ctggcaacag
     4141 gagttacaag gtgctgggat gttttatgat aacatcaact cagattataa aaggaaaact
     4201 gacacacaac ataaaatcat ggatgatttt actacaaaga cattgaaact gactcaacaa
     4261 catctgttgg caatggcctg tcaagctcgg ggacacaggg atgaaaatat tgacaaattc
     4321 caagtcactc tcctagatga gctggaaaaa gttgaaaaag actcacagac tttacgagac
     4381 ttggagaaag agtttgtgga catcgaagaa aagatagttc acaagatgag ggcatttcac
     4441 caaagtgagc gagaaaggtt tcgtgctttg aaaacttcat tggataaaag tttgcttgtc
     4501 tataattctg tttatgaaga gaatgttctt acatctgaga tgtgtttgat gaaagcaaac
     4561 atgaaaatgc tacaagacaa gctactgaag gagatgcatg aagaggaact tctcaacata
     4621 cgcagaggac tggagtcatt attcaaggat catgaaggaa acaatgcatg aaatctggct
     4681 gctgtcaaca cactttatct gattagtttt tgtgtatgaa tgaaaaaata ataaagtagc
     4741 cttgcaaata tgaaaaaaaa aaaaaaaaaa a
//
