LOCUS       NM_012810               3529 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus synaptonemal complex protein 1 (Sycp1), mRNA.
ACCESSION   NM_012810
VERSION     NM_012810.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3529)
  AUTHORS   Dunce,J.M., Dunne,O.M., Ratcliff,M., Millan,C., Madgwick,S.,
            Uson,I. and Davies,O.R.
  TITLE     Structural basis of meiotic chromosome synapsis through SYCP1
            self-assembly
  JOURNAL   Nat Struct Mol Biol 25 (7), 557-569 (2018)
   PUBMED   29915389
REFERENCE   2  (bases 1 to 3529)
  AUTHORS   Barau,J., Teissandier,A., Zamudio,N., Roy,S., Nalesso,V.,
            Herault,Y., Guillou,F. and Bourc'his,D.
  TITLE     The DNA methyltransferase DNMT3C protects male germ cells from
            transposon activity
  JOURNAL   Science 354 (6314), 909-912 (2016)
   PUBMED   27856912
REFERENCE   3  (bases 1 to 3529)
  AUTHORS   Finsterbusch,F., Ravindranathan,R., Dereli,I., Stanzione,M.,
            Trankner,D. and Toth,A.
  TITLE     Alignment of Homologous Chromosomes and Effective Repair of
            Programmed DNA Double-Strand Breaks during Mouse Meiosis Require
            the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein
  JOURNAL   PLoS Genet 12 (10), e1006393 (2016)
   PUBMED   27760146
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3529)
  AUTHORS   Inoue,H., Ogonuki,N., Hirose,M., Hatanaka,Y., Matoba,S., Chuma,S.,
            Kobayashi,K., Wakana,S., Noguchi,J., Inoue,K., Tanemura,K. and
            Ogura,A.
  TITLE     Mouse D1Pas1, a DEAD-box RNA helicase, is required for the
            completion of first meiotic prophase in male germ cells
  JOURNAL   Biochem Biophys Res Commun 478 (2), 592-598 (2016)
   PUBMED   27473657
REFERENCE   5  (bases 1 to 3529)
  AUTHORS   Sun,X., Brieno-Enriquez,M.A., Cornelius,A., Modzelewski,A.J.,
            Maley,T.T., Campbell-Peterson,K.M., Holloway,J.K. and Cohen,P.E.
  TITLE     FancJ (Brip1) loss-of-function allele results in spermatogonial
            cell depletion during embryogenesis and altered processing of
            crossover sites during meiotic prophase I in mice
  JOURNAL   Chromosoma 125 (2), 237-252 (2016)
   PUBMED   26490168
REFERENCE   6  (bases 1 to 3529)
  AUTHORS   Tay,J., Hodgman,R., Sarkissian,M. and Richter,J.D.
  TITLE     Regulated CPEB phosphorylation during meiotic progression suggests
            a mechanism for temporal control of maternal mRNA translation
  JOURNAL   Genes Dev 17 (12), 1457-1462 (2003)
   PUBMED   12815066
REFERENCE   7  (bases 1 to 3529)
  AUTHORS   Parra,M.T., Viera,A., Gomez,R., Page,J., Carmena,M., Earnshaw,W.C.,
            Rufas,J.S. and Suja,J.A.
  TITLE     Dynamic relocalization of the chromosomal passenger complex
            proteins inner centromere protein (INCENP) and aurora-B kinase
            during male mouse meiosis
  JOURNAL   J Cell Sci 116 (Pt 6), 961-974 (2003)
   PUBMED   12584241
REFERENCE   8  (bases 1 to 3529)
  AUTHORS   Di Carlo,A.D., Travia,G. and De Felici,M.
  TITLE     The meiotic specific synaptonemal complex protein SCP3 is expressed
            by female and male primordial germ cells of the mouse embryo
  JOURNAL   Int J Dev Biol 44 (2), 241-244 (2000)
   PUBMED   10794082
REFERENCE   9  (bases 1 to 3529)
  AUTHORS   Schmekel,K., Meuwissen,R.L., Dietrich,A.J., Vink,A.C., van
            Marle,J., van Veen,H. and Heyting,C.
  TITLE     Organization of SCP1 protein molecules within synaptonemal
            complexes of the rat
  JOURNAL   Exp Cell Res 226 (1), 20-30 (1996)
   PUBMED   8660935
REFERENCE   10 (bases 1 to 3529)
  AUTHORS   Meuwissen,R.L., Offenberg,H.H., Dietrich,A.J., Riesewijk,A., van
            Iersel,M. and Heyting,C.
  TITLE     A coiled-coil related protein specific for synapsed regions of
            meiotic prophase chromosomes
  JOURNAL   EMBO J 11 (13), 5091-5100 (1992)
   PUBMED   1464329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000077.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_012810.3.
            
            On Feb 26, 2021 this sequence version replaced NM_012810.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760384
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JACYVU010000077.1  5984966-5985055     c
            91-203              JACYVU010000077.1  5984569-5984681     c
            204-288             JACYVU010000077.1  5982568-5982652     c
            289-332             JACYVU010000077.1  5982367-5982410     c
            333-389             JACYVU010000077.1  5981985-5982041     c
            390-554             JACYVU010000077.1  5980672-5980836     c
            555-622             JACYVU010000077.1  5979623-5979690     c
            623-696             JACYVU010000077.1  5977725-5977798     c
            697-755             JACYVU010000077.1  5974213-5974271     c
            756-825             JACYVU010000077.1  5971754-5971823     c
            826-899             JACYVU010000077.1  5971030-5971103     c
            900-1008            JACYVU010000077.1  5964389-5964497     c
            1009-1103           JACYVU010000077.1  5950013-5950107     c
            1104-1288           JACYVU010000077.1  5949400-5949584     c
            1289-1356           JACYVU010000077.1  5947248-5947315     c
            1357-1418           JACYVU010000077.1  5937992-5938053     c
            1419-1523           JACYVU010000077.1  5926417-5926521     c
            1524-1627           JACYVU010000077.1  5925399-5925502     c
            1628-1745           JACYVU010000077.1  5923623-5923740     c
            1746-1816           JACYVU010000077.1  5921328-5921398     c
            1817-1898           JACYVU010000077.1  5898514-5898595     c
            1899-1961           JACYVU010000077.1  5894743-5894805     c
            1962-2024           JACYVU010000077.1  5887546-5887608     c
            2025-2087           JACYVU010000077.1  5886394-5886456     c
            2088-2204           JACYVU010000077.1  5874751-5874867     c
            2205-2315           JACYVU010000077.1  5874070-5874180     c
            2316-2408           JACYVU010000077.1  5872669-5872761     c
            2409-2483           JACYVU010000077.1  5871252-5871326     c
            2484-2540           JACYVU010000077.1  5845725-5845781     c
            2541-2720           JACYVU010000077.1  5840797-5840976     c
            2721-2864           JACYVU010000077.1  5827271-5827414     c
            2865-2951           JACYVU010000077.1  5825725-5825811     c
            2952-3529           JACYVU010000077.1  5825056-5825633     c
FEATURES             Location/Qualifiers
     source          1..3529
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3529
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /note="synaptonemal complex protein 1"
                     /db_xref="GeneID:25276"
                     /db_xref="RGD:3794"
     exon            1..90
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..203
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..288
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..3089
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /note="SCP-1; A coiled-coil related protein specific for
                     synapsed regions of meiotic prophase chromosomes"
                     /codon_start=1
                     /product="synaptonemal complex protein 1"
                     /protein_id="NP_036942.2"
                     /db_xref="GeneID:25276"
                     /db_xref="RGD:3794"
                     /translation="MSSLSKNRENIDTDPAFQKLSILPMLEQVANSGSCHYQEGVNDS
                     DFENSEPMSRLYSKLYKEAEKIKKWKVSIESELKQKENKLQENRKIIEAQRKAIQELQ
                     FENEKVSLKLEEEIQENKDLIKENNATRHWCNLLKETCARSAEKTSKYEYEREETRQV
                     YVDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYQKEVNNKENQV
                     SLLLIQSTEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELNEKKDHLTSELED
                     IKMSMQRSMSTQKTLEEDLQIATKTIYQLTEEKEAQMEELNKAKTTHSLVVTELKATT
                     CTLEELLRTEQQRLENNEDQLKLITMELQKKSSELEEMTKFKNNKEVELEELKTILAE
                     DQKLLDEKKQVEKLAEELQGKEQELTFLLQTREKEIHDLEVQVTVTKTSEEHYLKQVE
                     EMKTELEKEKLKNIELTANCDMLLLENKKLVQEASDMVLELKKHQEDIINCKKQEERM
                     LKQIETLEEKEMNLRDELESVRKEFIQQGDEVKCKLDKSEENARSIEYEVLKKEKQMK
                     ILENKCNNLKKQIENKSKNIEELHQENKALKKKSSAENKQLNAYEIKVNKLELELAST
                     KQKFEEMINNYQKEIEIKKISEEKLLGEVEKAKATVDEAVKLQKEIDLRCQHKIAEMV
                     ALMEKHKHQYDKIVEERDSELGLYKNREQEQSSAKVALETELSNIRNELVSLKKQLEV
                     EKEEKEKLKMEQENTAILTDKKDKKIQASLLESPEATSWKFDSKTTPSQNISRLSSSM
                     DSGKSKDNRDSLRASAKSILSTTVTKEYTVKTPTKKSIYQRENKYLPTGGSNKKRKTV
                     FEFDVNSDSSETTDLLSLVSEEDISNRIYNNNTPDSHLLVKTPKQTPLSLSTPASFTK
                     FGSLKKMREDRWATIAKIDRKRRLKEAEKLFT"
     exon            289..332
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..389
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..554
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..622
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..696
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..755
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..825
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..899
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1008
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1103
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1288
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1356
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1418
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1523
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1627
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1745
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1816
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1898
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1961
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2024
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2087
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2204
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2315
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2408
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2483
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2540
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2720
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2864
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2951
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3529
                     /gene="Sycp1"
                     /gene_synonym="SCP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgggcttct aggaggttct gaggcagaag ctctcagttc cattcgatgt cttcataaag
       61 aagcgctcgc gggcacggag cctgccatcg gcgccatgga gaagcagaag cccttcacgt
      121 tgttcgtccc accgagactg agcagcagtc aagtgtcggc tgtgaaacct cagacggcgg
      181 gaggagactc caactacttc aagactgtca acaaatgcac agaaggtgat tttggtgttc
      241 cattgacaat gtccagtcta tcaaaaaatc gggaaaacat tgatacagat cccgcttttc
      301 aaaaacttag cattttgccc atgcttgaac aggttgcaaa ttctggcagt tgccactatc
      361 aggaaggagt aaatgactct gattttgaga attcagagcc aatgagcaga ctgtactcaa
      421 agctgtataa agaggctgaa aagataaaaa agtggaaagt gagcatagag tctgaactga
      481 agcagaaaga aaataagttg caagaaaaca gaaagataat tgaagcccag cgaaaagcca
      541 ttcaggaact tcagtttgaa aatgaaaaag taagcttgaa attagaagaa gaaattcaag
      601 aaaataaaga tttaatcaag gagaataatg ctacaagaca ttggtgtaat ttactcaagg
      661 aaacctgtgc tagatctgca gaaaagacaa gtaaatatga atatgagcga gaagaaacca
      721 gacaagttta tgtggatcta aataataaca ttgagaaaat gatactagct tttgaggaac
      781 ttcgtgtgca agctgagaat gccaggctgg aaatgcactt taagttaaag gaagatcatg
      841 aaaaaatcca acatcttgaa gaagaatatc agaaggaagt aaacaacaag gaaaaccagg
      901 tatcactact attgatccaa agtactgaga aagaaaataa aatgaaagat ttaacatttc
      961 tgctagagga atccagagat aaagctaatc aattagagga aaaaacaaaa ttacaagatg
     1021 aaaacttaaa agaattaaat gaaaagaagg atcatttaac atcagaactt gaagatatta
     1081 aaatgtccat gcaaagaagt atgagcactc agaagacttt agaggaagat ttacagatag
     1141 caacaaaaac gatttatcag ctcactgaag aaaaagaagc tcaaatggaa gaactcaaca
     1201 aagctaaaac tactcactca cttgtggtga ctgaacttaa agccactaca tgtaccttgg
     1261 aggaattact gagaacagaa cagcaaagat tggaaaataa tgaggatcaa ctgaaactga
     1321 ttactatgga gctccagaag aaatcaagtg aactagaaga gatgactaaa tttaaaaata
     1381 acaaagaagt ggaacttgaa gaattaaaaa ccatattggc agaagaccaa aaacttttag
     1441 atgaaaagaa acaagttgag aagcttgctg aagaattaca agggaaagaa caagaactaa
     1501 ctttcctttt gcaaaccaga gagaaagaaa tccatgattt ggaagtacaa gtaactgtca
     1561 ctaaaacaag tgaagaacat tatttaaaac aggttgaaga aatgaaaact gagcttgaaa
     1621 aagagaaact taagaatatt gaattaactg caaactgtga catgcttttg cttgagaaca
     1681 aaaaattggt acaagaagca agtgatatgg tcctagaact caagaaacat caagaagata
     1741 tcattaattg caaaaagcaa gaagaaagga tgttgaaaca aatagaaact ttggaagaaa
     1801 aagaaatgaa tttaagggat gaactggaat cagtaagaaa agagttcata cagcaaggag
     1861 atgaagttaa atgtaaattg gacaagagtg aagaaaatgc tcgaagcatt gaatatgaag
     1921 ttttaaagaa agaaaagcag atgaagatat tagaaaataa gtgtaataat ttaaagaaac
     1981 aaatcgaaaa taaaagcaag aatattgaag agcttcacca ggagaataaa gccttgaaaa
     2041 aaaaaagttc agcagaaaac aaacaactga atgcatatga gataaaggtc aataaattag
     2101 agttggaatt agcaagtacc aagcaaaaat ttgaagaaat gattaacaac taccagaaag
     2161 aaattgagat aaaaaagatt tcagaagaaa agcttttggg agaggttgag aaagccaaag
     2221 caacagttga tgaagccgta aagttacaga aagaaattga tttacgatgc caacataaaa
     2281 tagctgagat ggtagcactt atggaaaaac ataagcacca atatgataag attgttgaag
     2341 aaagagactc agaattagga ctttataaaa acagagaaca ggaacagtct tcagcaaagg
     2401 ttgctttgga gactgaatta tctaatatca gaaacgaact tgtatccctt aagaagcaac
     2461 ttgaagtaga aaaagaagaa aaagagaaat taaaaatgga acaagaaaac acagctattc
     2521 tcacagataa aaaagacaag aaaatacagg catctttgct ggaatcacct gaagccacta
     2581 gttggaaatt tgattctaaa acaactccct cacaaaatat atctcggctt tcctcatcaa
     2641 tggatagtgg caaatccaaa gataacagag atagtctgcg ggcatctgcc aaaagcattt
     2701 tatctacaac agttacaaag gaatatacag tgaagacacc aactaaaaag agcatatatc
     2761 aaagagaaaa caagtattta cctactggag gaagtaataa aaagagaaaa actgtctttg
     2821 aatttgatgt taattcagat agttcagaaa ctactgatct tttgagcttg gtttcagagg
     2881 aagatatatc aaacaggatt tataataata atacaccaga ttctcatcta ttagtcaaaa
     2941 ctcccaaaca gactccttta tctttatcaa ctcctgcatc ttttacgaag tttggaagtc
     3001 tgaaaaaaat gagagaagac cgttgggcaa cgattgctaa aattgatagg aaaagaagac
     3061 taaaggaagc agaaaagtta tttacttaat ttcagaaaat caatgttggt tatagagact
     3121 aatagttaac tttattattt cccagagagc caaactttac tgaggaattc agactttaaa
     3181 attaattaca taaataattt gtttgttatg tttgtggtct aaatataaag taactatatt
     3241 tgaatttttt tattgtattc agatacttag attttgttgc ttttacttgc aatggatatt
     3301 gaaattcaaa ggtttttttt tttttttttt ttttttttgt cttctcctcc ctacccccaa
     3361 gagctgagga ccaaacccag tgctttgtgc ttgctaggca agcgctctac cactgagctt
     3421 aatccctaac cctgaagttc aaatttttta ttttgagctt ttgaccatta gaaatgcatt
     3481 atcgagactt ataatttatt ctttattatt aaaatatttt ggatgcaaa
//
