LOCUS       NM_012662                599 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus seminal vesicle secretory protein 4 (Svs4), mRNA.
ACCESSION   NM_012662
VERSION     NM_012662.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 599)
  AUTHORS   Prevete,N., Rossi,F.W., Triggiani,M., Marone,G., de Paulis,A.,
            Metafora,V., De Maria,S., Carteni,M., Ragone,R., Ravagnan,G. and
            Metafora,S.
  TITLE     Antiapoptotic seminal vesicle protein IV induces histamine release
            from human FcepsilonRI+ cells
  JOURNAL   Int Arch Allergy Immunol 151 (4), 318-330 (2010)
   PUBMED   19851073
  REMARK    GeneRIF: induces histamine release from human FcepsilonRI+ cells
REFERENCE   2  (bases 1 to 599)
  AUTHORS   Metafora,V., Stiuso,P., Ferranti,P., Giannattasio,A., Dicitore,A.,
            Ravagnan,G., De Maria,S., Pontoni,G., Carteni,M. and Metafora,S.
  TITLE     In vitro stimulatory effect of anti-apoptotic seminal vesicle
            protein 4 on purified peroxidase enzymes
  JOURNAL   FEBS J 275 (15), 3870-3883 (2008)
   PUBMED   18616464
  REMARK    GeneRIF: native seminal vesicle protein 4 was shown by
            spectrophotometric and electrospray-MS analysis to interact with
            NADPH, an electron donor substrate of the selenium-dependent
            glutathione peroxidase/glutathione reductase redox system
REFERENCE   3  (bases 1 to 599)
  AUTHORS   Fuggetta,M.P., Lanzilli,G., Cottarelli,A., Ravagnan,G., Carteni,M.,
            De Maria,S., Metafora,B.M., Metafora,V. and Metafora,S.
  TITLE     Anti-apoptotic seminal vesicle protein IV inhibits cell-mediated
            immunity
  JOURNAL   J Reprod Immunol 78 (2), 85-93 (2008)
   PUBMED   18243331
  REMARK    GeneRIF: findings indicate that seminal vesicle protein IV has a
            marked in vitro inhibitory effect on natural killer cell,
            lymphokine-activated killer cell and cytotoxic T lymphocyte
            cytotoxicity
REFERENCE   4  (bases 1 to 599)
  AUTHORS   Vilasi,S. and Ragone,R.
  TITLE     Abundance of intrinsic disorder in SV-IV, a multifunctional
            androgen-dependent protein secreted from rat seminal vesicle
  JOURNAL   FEBS J 275 (4), 763-774 (2008)
   PUBMED   18215165
  REMARK    GeneRIF: Data strongly suggest that SV-IV needs large plasticity to
            efficiently interact with the different targets that characterize
            its multifaceted biological function, and should therefore be
            better classified as an intrinsically disordered protein.
REFERENCE   5  (bases 1 to 599)
  AUTHORS   Morelli,F., Peluso,G., Petillo,O., Giannattasio,A., Filosa,S.,
            Motta,C.M., Tammaro,S., Zatterale,A., Calzone,R., Budillon,A.,
            Carteni,M., de Maria,S., Costanza,M.R., Nigro,A., Petrazzuolo,M.,
            Buommino,E., Rizzo,M., Capasso,G., Baiano,S., Moscatiello,F.,
            Ravagnan,G., Fuggetta,M.P., Tajana,G., Stiuso,P., Metafora,B.M.,
            Metafora,V. and Metafora,S.
  TITLE     The immunomodulatory protein SV-IV protects serum-deprived cells
            against apoptosis but not against G0/G1 arrest: possible
            implications for the survival of implanting embryo
  JOURNAL   J Cell Physiol 212 (3), 610-625 (2007)
   PUBMED   17458892
  REMARK    GeneRIF: Seminal vesicle protein 4 act as a cell survival factor,
            preventing apoptosis but not cell cycle arrest. May be involved in
            survival of implanting embryos.
REFERENCE   6  (bases 1 to 599)
  AUTHORS   McDonald,C.J., Eliopoulos,E. and Higgins,S.J.
  TITLE     Divergent protein coding regions in otherwise closely related
            androgen-regulated mRNAs
  JOURNAL   EMBO J 3 (11), 2517-2521 (1984)
   PUBMED   6548962
REFERENCE   7  (bases 1 to 599)
  AUTHORS   Harris,S.E., Mansson,P.E., Tully,D.B. and Burkhart,B.
  TITLE     Seminal vesicle secretion IV gene: allelic difference due to a
            series of 20-base-pair direct tandem repeats within an intron
  JOURNAL   Proc Natl Acad Sci U S A 80 (21), 6460-6464 (1983)
   PUBMED   6579532
REFERENCE   8  (bases 1 to 599)
  AUTHORS   Kandala,J.C., Kistler,M.K., Lawther,R.P. and Kistler,W.S.
  TITLE     Characterization of a genomic clone for rat seminal vesicle
            secretory protein IV
  JOURNAL   Nucleic Acids Res 11 (10), 3169-3186 (1983)
   PUBMED   6304626
REFERENCE   9  (bases 1 to 599)
  AUTHORS   Mansson,P.E., Sugino,A. and Harris,S.E.
  TITLE     Use of a cloned double stranded cDNA coding for a major androgen
            dependent protein in rat seminal vesicle secretion: the effect of
            testosterone in gene expression
  JOURNAL   Nucleic Acids Res 9 (4), 935-946 (1981)
   PUBMED   6164983
REFERENCE   10 (bases 1 to 599)
  AUTHORS   Pan,Y.C., Silverberg,A.B., Harris,S.E. and Li,S.S.
  TITLE     Complete amino acid sequence of a major secretory protein from rat
            seminal vesicle
  JOURNAL   Int J Pept Protein Res 16 (2), 143-146 (1980)
   PUBMED   7007263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 2, 2014 this sequence version replaced NM_012662.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X01114.1, BF417050.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000003.1  173369752-173369878 c
            128-426             JAXUCZ010000003.1  173368993-173369291 c
            427-599             JAXUCZ010000003.1  173367643-173367815 c
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..599
                     /gene="Svs4"
                     /gene_synonym="ADP; RNSVSP4U; Svp4; SVS IV; SVSIV1"
                     /note="seminal vesicle secretory protein 4"
                     /db_xref="GeneID:24802"
                     /db_xref="RGD:3791"
     exon            1..127
                     /gene="Svs4"
                     /gene_synonym="ADP; RNSVSP4U; Svp4; SVS IV; SVSIV1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..387
                     /gene="Svs4"
                     /gene_synonym="ADP; RNSVSP4U; Svp4; SVS IV; SVSIV1"
                     /note="seminal vesicle protein 4; SVS protein S; Seminal
                     vesicle protein-4; seminal vesicle protein 2;
                     androgen-dependent protein; seminal vesicle secretory
                     protein IV"
                     /codon_start=1
                     /product="seminal vesicle secretory protein 4 precursor"
                     /protein_id="NP_036794.1"
                     /db_xref="GeneID:24802"
                     /db_xref="RGD:3791"
                     /translation="MKSTSLFLCSLLLLLVTGAIGRKTKEKYSQSEEVVSESFASGPS
                     SGSSDELVRDKPYGPKVSGGSFGEEASEEISSRRSKHISRSSGGSNMEGESSYAKKKR
                     SRFAQDVLN"
     exon            128..426
                     /gene="Svs4"
                     /gene_synonym="ADP; RNSVSP4U; Svp4; SVS IV; SVSIV1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..599
                     /gene="Svs4"
                     /gene_synonym="ADP; RNSVSP4U; Svp4; SVS IV; SVSIV1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atataaacta agaactcagc tcagccttca gtcaagagct tttctggcaa gatgaagtct
       61 accagcttgt tcctctgttc tctgctcctc cttctagtga caggagccat tgggagaaaa
      121 actaaggaaa aatactcaca gtcggaagaa gttgtcagtg agagctttgc ctcgggccct
      181 tcctcgggtt cttctgatga attagtgaga gacaagccat atggccccaa agtctcgggc
      241 ggctcctttg gtgaggaagc ttctgaggag ataagtagca gaaggagcaa gcacatctct
      301 aggagttccg gtggctccaa catggaaggt gagagctcgt atgccaagaa aaagaggagc
      361 cggtttgccc aagacgtact caactgatag tgcatcgggc agctgaacat ctggaccaat
      421 atgccggagc cacattgcct ggatgaagcc tgtgatgtct tcagcatgca gctcccatgt
      481 ggtctcagag gcagtccctg gatggcattt ccttctcatg cttgtttgtc ttgaggttct
      541 taaacctaac attcaggaac tttctgtcca ataaagagat aacaatctgc atcattaac
//
