LOCUS       NM_001271084            1180 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus small VCP interacting protein (Svip), mRNA.
ACCESSION   NM_001271084 XM_001080929 XM_574455
VERSION     NM_001271084.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1180)
  AUTHORS   Jia,D., Wang,Y.Y., Wang,P., Huang,Y., Liang,D.Y., Wang,D.,
            Cheng,C., Zhang,C., Guo,L., Liang,P., Wang,Y., Jia,Y. and Li,C.
  TITLE     SVIP alleviates CCl4-induced liver fibrosis via activating
            autophagy and protecting hepatocytes
  JOURNAL   Cell Death Dis 10 (2), 71 (2019)
   PUBMED   30683843
  REMARK    GeneRIF: SVIP is closely associated with the level of autophagy
            during the development of CCl4-induced hepatic fibrosis. SVIP can
            induce autophagy and suspend hepatic fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1180)
  AUTHORS   Tiwari,S., Siddiqi,S., Zhelyabovska,O. and Siddiqi,S.A.
  TITLE     Silencing of Small Valosin-containing Protein-interacting Protein
            (SVIP) Reduces Very Low Density Lipoprotein (VLDL) Secretion from
            Rat Hepatocytes by Disrupting Its Endoplasmic Reticulum
            (ER)-to-Golgi Trafficking
  JOURNAL   J Biol Chem 291 (24), 12514-12526 (2016)
   PUBMED   27129256
  REMARK    GeneRIF: Data sugggest that small valosin-containing
            protein-interacting protein (SVIP) acts as a regulator of VLDL
            transport vesicle (VTV) formation by interacting with its cargo and
            coat proteins.
REFERENCE   3  (bases 1 to 1180)
  AUTHORS   Zhong,Y., Shen,H., Wang,Y., Yang,Y., Yang,P. and Fang,S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   4  (bases 1 to 1180)
  AUTHORS   Wu,J., Peng,D., Voehler,M., Sanders,C.R. and Li,J.
  TITLE     Structure and expression of a novel compact myelin protein - small
            VCP-interacting protein (SVIP)
  JOURNAL   Biochem Biophys Res Commun 440 (1), 173-178 (2013)
   PUBMED   24055875
  REMARK    GeneRIF: SVIP and valosin containing protein were seen to be
            co-localized in neuronal cell bodies.
REFERENCE   5  (bases 1 to 1180)
  AUTHORS   Wang,Y., Ballar,P., Zhong,Y., Zhang,X., Liu,C., Zhang,Y.J.,
            Monteiro,M.J., Li,J. and Fang,S.
  TITLE     SVIP induces localization of p97/VCP to the plasma and lysosomal
            membranes and regulates autophagy
  JOURNAL   PLoS One 6 (8), e24478 (2011)
   PUBMED   21909394
REFERENCE   6  (bases 1 to 1180)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   7  (bases 1 to 1180)
  AUTHORS   Ballar,P., Zhong,Y., Nagahama,M., Tagaya,M., Shen,Y. and Fang,S.
  TITLE     Identification of SVIP as an endogenous inhibitor of endoplasmic
            reticulum-associated degradation
  JOURNAL   J Biol Chem 282 (47), 33908-33914 (2007)
   PUBMED   17872946
REFERENCE   8  (bases 1 to 1180)
  AUTHORS   Wang,Q., Li,L. and Ye,Y.
  TITLE     Regulation of retrotranslocation by p97-associated deubiquitinating
            enzyme ataxin-3
  JOURNAL   J Cell Biol 174 (7), 963-971 (2006)
   PUBMED   17000876
REFERENCE   9  (bases 1 to 1180)
  AUTHORS   Nagahama,M., Suzuki,M., Hamada,Y., Hatsuzawa,K., Tani,K.,
            Yamamoto,A. and Tagaya,M.
  TITLE     SVIP is a novel VCP/p97-interacting protein whose expression causes
            cell vacuolation
  JOURNAL   Mol Biol Cell 14 (1), 262-273 (2003)
   PUBMED   12529442
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 1, 2012 this sequence version replaced
            XM_001080929.2, XM_574455.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB607646.1, SRR26360172.1831049.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000001.1  110728567-110728741 c
            176-226             JAXUCZ010000001.1  110726822-110726872 c
            227-337             JAXUCZ010000001.1  110726315-110726425 c
            338-1180            JAXUCZ010000001.1  110723051-110723893 c
FEATURES             Location/Qualifiers
     source          1..1180
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1180
                     /gene="Svip"
                     /gene_synonym="RGD1565432"
                     /note="small VCP interacting protein"
                     /db_xref="GeneID:499157"
                     /db_xref="RGD:1565432"
     exon            1..175
                     /gene="Svip"
                     /gene_synonym="RGD1565432"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..352
                     /gene="Svip"
                     /gene_synonym="RGD1565432"
                     /codon_start=1
                     /product="small VCP/p97-interacting protein"
                     /protein_id="NP_001258013.1"
                     /db_xref="GeneID:499157"
                     /db_xref="RGD:1565432"
                     /translation="MGLCFPCPAESAPPSPSPEEKRAKLAEAAERRQKEAASRGILDI
                     QSVEAKKKKKEQLEKQMETSGPPAGGLRWTVS"
     exon            176..226
                     /gene="Svip"
                     /gene_synonym="RGD1565432"
                     /inference="alignment:Splign:2.1.0"
     exon            227..337
                     /gene="Svip"
                     /gene_synonym="RGD1565432"
                     /inference="alignment:Splign:2.1.0"
     exon            338..1180
                     /gene="Svip"
                     /gene_synonym="RGD1565432"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctccgctc ggggccgagc tttgcagcag gtcaggtggg ggcggggctt gctgctgggc
       61 ggggcctgct gcagccccca gccaggattc gggttcccgg cccagggtgc ctgcgtcccc
      121 catggggctg tgcttcccgt gtcccgcgga gtccgcaccg ccatccccga gcccggaaga
      181 gaaaagagca aagctggcag aggcagcaga aagaaggcaa aaggaggcgg catctcgggg
      241 aattttggat atccagtcgg tggaggcaaa gaaaaagaag aaagaacaat tagaaaagca
      301 gatggaaaca tcagggccac cagcaggggg acttagatgg acagtgtcat gaagcatatt
      361 ctacctgggg gagaatcctg ccaccaactc cagcatctgc cgtcgatggg tttcagctga
      421 tgcctcctct ttacaaagag tcagactgta tcattagtgc cctttagtgt gatcctaaaa
      481 ctaaatatac taaatataca aagatattgg taatattttt atttccaaac ttactaaata
      541 gcccactttt cattctattc aactttgcct acatctattt tctctttcgt aggaagtaac
      601 tttgcagttt ttgtagttaa aatatggatc caaaaggtat acatgcatgg cgtgtcgtgg
      661 tcctacgtat atccccagtg ttgagtatgc tcccatacct ctgctttata ggtagccctg
      721 ctccctagag tcatgtggta cagcctgcgg tctctctctc actagacagg aagacttcag
      781 ctcccagact tagtgccttt aagctgattg atcatcaggg aaaatcctga agatgcattt
      841 gaaggacttc aggcaaagga agttttattt ttataaccca ctaagaaatg aatattcgta
      901 ggcaaatgtt gactgtctgc taatttattt tctgtaccta aggcatatca cattaaacat
      961 gtcaggagga cgtcagctca gtgacctgct gatgtgtcct actagacgca tgaaagtctg
     1021 tgtagtgaag ggatgaggcc aaccgtgaat gaggttggag atgatgaggg atactttatc
     1081 tctccaaatt tcccaagcat ttttattctt ctgtatttat ttagaatcat tgtaagatct
     1141 atacagacat ggtgttacca ataaaagtat gaaagagaaa
//
