LOCUS       NM_001419684           11252 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus sushi, von Willebrand factor type A, EGF and
            pentraxin domain containing 1 (Svep1), mRNA.
ACCESSION   NM_001419684 XM_039111039
VERSION     NM_001419684.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11252)
  AUTHORS   Samuelov,L., Li,Q., Bochner,R., Najor,N.A., Albrecht,L.,
            Malchin,N., Goldsmith,T., Grafi-Cohen,M., Vodo,D., Fainberg,G.,
            Meilik,B., Goldberg,I., Warshauer,E., Rogers,T., Edie,S.,
            Ishida-Yamamoto,A., Burzenski,L., Erez,N., Murray,S.A.,
            Irvine,A.D., Shultz,L., Green,K.J., Uitto,J., Sprecher,E. and
            Sarig,O.
  TITLE     SVEP1 plays a crucial role in epidermal differentiation
  JOURNAL   Exp Dermatol 26 (5), 423-430 (2017)
   PUBMED   27892606
REFERENCE   2  (bases 1 to 11252)
  AUTHORS   Karpanen,T., Padberg,Y., van de Pavert,S.A., Dierkes,C.,
            Morooka,N., Peterson-Maduro,J., van de Hoek,G., Adrian,M.,
            Mochizuki,N., Sekiguchi,K., Kiefer,F., Schulte,D. and
            Schulte-Merker,S.
  TITLE     An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic
            Vessel Formation
  JOURNAL   Circ Res 120 (8), 1263-1275 (2017)
   PUBMED   28179432
REFERENCE   3  (bases 1 to 11252)
  AUTHORS   Morooka,N., Futaki,S., Sato-Nishiuchi,R., Nishino,M., Totani,Y.,
            Shimono,C., Nakano,I., Nakajima,H., Mochizuki,N. and Sekiguchi,K.
  TITLE     Polydom Is an Extracellular Matrix Protein Involved in Lymphatic
            Vessel Remodeling
  JOURNAL   Circ Res 120 (8), 1276-1288 (2017)
   PUBMED   28179430
REFERENCE   4  (bases 1 to 11252)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 11252)
  AUTHORS   Shefer,G. and Benayahu,D.
  TITLE     SVEP1 is a novel marker of activated pre-determined skeletal muscle
            satellite cells
  JOURNAL   Stem Cell Rev Rep 6 (1), 42-49 (2010)
   PUBMED   20052625
  REMARK    GeneRIF: SVEP1 is expressed in activated skeletal muscle satellite
            cells prior to their determination to the myogenic lineage.
REFERENCE   6  (bases 1 to 11252)
  AUTHORS   Shur,I., Zemer-Tov,E., Socher,R. and Benayahu,D.
  TITLE     SVEP1 expression is regulated in estrogen-dependent manner
  JOURNAL   J Cell Physiol 210 (3), 732-739 (2007)
   PUBMED   17139625
REFERENCE   7  (bases 1 to 11252)
  AUTHORS   Wang,L., Zheng,A., Yi,L., Xu,C., Ding,M. and Deng,H.
  TITLE     Identification of potential nuclear reprogramming and
            differentiation factors by a novel selection method for cloning
            chromatin-binding proteins
  JOURNAL   Biochem Biophys Res Commun 325 (1), 302-307 (2004)
   PUBMED   15522233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 13, 2023 this sequence version replaced XM_039111039.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-725               JAXUCZ010000005.1  77782568-77783292   c
            726-981             JAXUCZ010000005.1  77760980-77761235   c
            982-1158            JAXUCZ010000005.1  77757321-77757497   c
            1159-1317           JAXUCZ010000005.1  77718528-77718686   c
            1318-1497           JAXUCZ010000005.1  77717257-77717436   c
            1498-1677           JAXUCZ010000005.1  77710609-77710788   c
            1678-1872           JAXUCZ010000005.1  77705213-77705407   c
            1873-1991           JAXUCZ010000005.1  77703123-77703241   c
            1992-2121           JAXUCZ010000005.1  77698081-77698210   c
            2122-2229           JAXUCZ010000005.1  77691513-77691620   c
            2230-2361           JAXUCZ010000005.1  77690697-77690828   c
            2362-2556           JAXUCZ010000005.1  77689394-77689588   c
            2557-2678           JAXUCZ010000005.1  77688052-77688173   c
            2679-2787           JAXUCZ010000005.1  77685642-77685750   c
            2788-2952           JAXUCZ010000005.1  77684053-77684217   c
            2953-3186           JAXUCZ010000005.1  77683244-77683477   c
            3187-3348           JAXUCZ010000005.1  77680630-77680791   c
            3349-3510           JAXUCZ010000005.1  77678541-77678702   c
            3511-3672           JAXUCZ010000005.1  77675063-77675224   c
            3673-3764           JAXUCZ010000005.1  77674448-77674539   c
            3765-3861           JAXUCZ010000005.1  77673225-77673321   c
            3862-3975           JAXUCZ010000005.1  77672368-77672481   c
            3976-4089           JAXUCZ010000005.1  77668645-77668758   c
            4090-4291           JAXUCZ010000005.1  77667846-77668047   c
            4292-4449           JAXUCZ010000005.1  77664612-77664769   c
            4450-4651           JAXUCZ010000005.1  77662482-77662683   c
            4652-4827           JAXUCZ010000005.1  77660314-77660489   c
            4828-4952           JAXUCZ010000005.1  77657087-77657211   c
            4953-5076           JAXUCZ010000005.1  77655826-77655949   c
            5077-5247           JAXUCZ010000005.1  77654620-77654790   c
            5248-5421           JAXUCZ010000005.1  77653545-77653718   c
            5422-5541           JAXUCZ010000005.1  77652994-77653113   c
            5542-5718           JAXUCZ010000005.1  77650701-77650877   c
            5719-5803           JAXUCZ010000005.1  77650400-77650484   c
            5804-5995           JAXUCZ010000005.1  77649622-77649813   c
            5996-6163           JAXUCZ010000005.1  77648191-77648358   c
            6164-6836           JAXUCZ010000005.1  77637536-77638208   c
            6837-9622           JAXUCZ010000005.1  77633267-77636052   c
            9623-9848           JAXUCZ010000005.1  77631361-77631586   c
            9849-10004          JAXUCZ010000005.1  77630139-77630294   c
            10005-10068         JAXUCZ010000005.1  77623507-77623570   c
            10069-10242         JAXUCZ010000005.1  77620251-77620424   c
            10243-10419         JAXUCZ010000005.1  77618941-77619117   c
            10420-10590         JAXUCZ010000005.1  77613926-77614096   c
            10591-10686         JAXUCZ010000005.1  77612960-77613055   c
            10687-10782         JAXUCZ010000005.1  77611065-77611160   c
            10783-10876         JAXUCZ010000005.1  77607764-77607857   c
            10877-11252         JAXUCZ010000005.1  77606523-77606898   c
FEATURES             Location/Qualifiers
     source          1..11252
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..11252
                     /gene="Svep1"
                     /note="sushi, von Willebrand factor type A, EGF and
                     pentraxin domain containing 1"
                     /db_xref="GeneID:685899"
                     /db_xref="RGD:1588987"
     exon            1..725
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..10898
                     /gene="Svep1"
                     /note="Sushi, von Willebrand factor type A, EGF and
                     pentraxin domain-containing protein 1"
                     /codon_start=1
                     /product="sushi, von Willebrand factor type A, EGF and
                     pentraxin domain-containing protein 1 precursor"
                     /protein_id="NP_001406613.1"
                     /db_xref="GeneID:685899"
                     /db_xref="RGD:1588987"
                     /translation="MWTRLAFCCWALALVSGWTNFQPMAPSLNFSFRLFPEASPGALG
                     RLAVPPRSGEEEAVGSKVERLGRTFRSRVRRLRELSDRLELVFLVDESSSVGQTNFLN
                     ELKFVRKLLSDFPVVSTATRVAIVTFSSKNNVVARVDYISTSRAHQHKCALLSREIPA
                     ITYRGGGTYTMGAFQQAAQILRHSRENSTKVIFLITDGYSNGGDPRPIAASLRDFGVE
                     IFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQEDMA
                     HCSYLCEAGRDCCDRMASCKCGTHTGQFECICEKGYYGKGLQYECTACPPGTYKPEAS
                     PGGISTCIPCPDENHTSPPGSTAPEDCVCREGYQRSGQTCEVVHCPALKPPENGFFIQ
                     NTCKNHFNAACGVRCRPGFDLVGSSIHLCQPNGLWSGTESFCRVRTCPHLRQPKHGHI
                     SCSTVEMSYNTVCLVTCNEGYRLEGHAKLTCQGNAQWDGTEPRCVERHCATFQKPKGV
                     IISPPSCGKQPAKPGMICQLGCRQGYILSGIREVRCATSGKWSARVQTAVCKDVEAPQ
                     ISCPNDIKAKTEGQQDSANVTWQVPTAKDNSGEKVSVHVHPAFSPPYLFPIGEVAITY
                     TATDSSGNQASCTFYIKVIDVEPPVIDWCRSPPPIQVVEKEHPASWDEPQFSDNSGAE
                     LVITSSHTQGDLFPHGETVVWYTATDPSGNNRTCDIHIVIKGSPCEVPFTPVNGDFIC
                     AQDSAGVNCSLTCREGYDFTEGSTEKYYCAFEDGIWRPPYSTEWPDCAIKRFANHGFK
                     SFEMLYKTTRCDDMDLFKKFSAAFETTLGKMVPSFCSDADDIDCRLEDLTKKYCIEYN
                     YNYENGFAIGPGGWGAGNRLDYSYDHFLDVVQETPADVGKTRSSRIKRTVPLSDPQIQ
                     LIFNITASVPLPEERNDTVELENQQRLIRTLETITNRLKSTLNKGPMYSFQLASETVV
                     ADSNSLETEKAFLFCRPGSVLRGRMCVNCPLGTSYSLEHSTCESCLMGSYQDEEGQLE
                     CKLCPPRTHTEYLHSRSISECKAQCKQGTYSSSGLETCESCPLGTYQPDFGSRSCLPC
                     PETTTTVKRGAVDISACGVPCPVGEFSRSGLTPCYPCPRDYYQPNAGKSFCLACPFYG
                     TTTITGATSITDCSSFSSTFSAAEESIVPLAAPGPTQNKYEVSSQVFHECFLNPCHNS
                     GTCQQLGRGYVCLCPPGYTGLKCETDIDECSSLPCLNGGICRDKVGGFTCECSSGYTG
                     QICEENINECSSSPCLNKGTCTDGLASYRCTCVSGYVGVHCETDVNECQSSPCLNNAV
                     CKDQVGGFSCKCPPGFLGTRCEKNVDECLSQPCQNGATCKDGANSFRCQCPAGFTGPH
                     CELNINECQSNPCRNQATCVDELNSYSCKCRPGFSGRRCETEQPSGFNLDFEVSGIYG
                     YVLLDGVLPTLHAITCAFWMKSSDVINYGTPISYALEGNKDNTFLLTDYNGWVLYVNG
                     KEKITNCPSVNDGIWHHIAITWTSTGGAWRVYIDGELSDSGTGLSVGKAIPGGGALVL
                     GQEQDKKGEGFNPAESFVGSISQLNLWDYVLSPQQVKSLASSCPEELSRGNVLAWPDF
                     VSGITGKVKVDSSSIFCSDCPSLEGSVPHLRPASGDRKPGSKVSLFCDPGFQMVGNPV
                     QYCLNQGQWSQPLPHCERIRCGLPPTLENGFYSAEDLHAGSTVTYQCTSGYYLLGDSR
                     MFCTDNGSWNGISPSCLDVDECAVGSDCSEHASCLNTNGSYICSCKPPYTGDGKNCAE
                     PVKCKAPENPENGHSLGKIYSVGAEVTFSCEEGHQLVGVRKITCLESGEWDHLRPSCE
                     AISCGAPPVPENGGVDGSAFTYGSKVRYRCDKGYTLAGDEESACLASGSWSHSSPVCE
                     LVKCSQPENINNGKYILSGLTYLSIASYSCEDGYSLQGPSLIECTASGSWDRAPPSCQ
                     LVSCGEPPMVKDALTTGSNFTFGNMVTYTCKEGYTLAGPDTIICQANGKWNSSNHQCL
                     AVSCDEPPNVDHASPETAHRLFGDTAFYYCADGYSLADNSQLICNAQGNWVPPEGQAV
                     PRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECLRGGQWS
                     PSPLSVQCIPVRCGEPPSITNGYPSGTNYSFGAVVAYSCHKGFYIKGEKKSTCEATGQ
                     WSRPLPTCHPVSCNEPPKVENGFLEHTTGRTFESEARFQCNPGYKAVGSPVFVCQANR
                     HWHSDAPLSCTPLNCGKPPPIQNGFLRGESFEVGSKVQFVCNEGYELVGDNSWTCQKS
                     GKWSKKPSPKCVPTKCAEPPLLENQLVLKELTSEVGVMTISCKEGHALQGPSVLKCLP
                     SGQWNGSFPVCKLVLCQSPPLIPFGVPASSGALHFGSTVKYLCVDGFFLRGNPIILCQ
                     VDGTWSSPLPECVPVECPQPEEILNGIIHVQGLAYLSTTLYTCKPGFELVGNTTTLCG
                     ENGQWLGGKPMCRPIECPEPKEILNGQFSSVSFQYGQTITYSCDRGFRLEGPKSLTCL
                     ETGNWDMDAPSCNAIHCSDPQPIENGFVEGADYRYGAMIIYSCFPGFQVVGHAMQTCE
                     ETGWSSSSPTCVPIDCGLPPHIDFGDCTRVSDGQGYFVQEDDMMEVPYLTPHPQHLEA
                     TAKASEITEESLVPHASQFLYGTTVSYRCEPGYELLGIPVLVCQEDGTWNGTAPSCIS
                     IECDLPVAPENGFLHFTQTTMGSAAQYSCKPGHVLEGSHLRLCLQNKQWSGTVPRCEV
                     ISCSEPNPLGNGSIKGNDYSYLGVLHYECDSGYVLNGTEKRTCQENKQWDGHEPVCLP
                     VDCGSPPVPTNGQVTGEEYTFQKEIAYSCGEGFILEGARSRVCLTNGSWSGTTPSCVP
                     VRCPAPPQVANGVTDGLDYGFKKEVTFHCLEGYVLQGTPKLTCQSNGTWDAEVPICKP
                     ATCGPPADLPQGFPNGFSFFHGGHIQYQCFTGYKLHGNPSRRCLPDGSWSGSTPSCLP
                     CTCSTPIIQQGTVNATDLGCGKTVQIECFKGFKLLGLPEITCDANGQWSDFPLCEHAD
                     CGPLPTVPNGIVIKGSPSEDNVVTYSCRPGYIIQGSSDLICTEKGIWSEPYPTCEPVS
                     CGPPPTVANAVATGEAHTYESKVKLRCLEGYVVDTDTDTFTCQQDGRWFPERINCSPK
                     TCPVPSNRTRIRVHGDDFQVNRQVSVSCTEGFTYDGADRSTCQPDGTWEPPLSEESCI
                     PVVCGQPESPEHGFVVGSEYSFGSTVVYQCDPGYELEGNRERVCQENRQWSGRVAVCR
                     ESRCEAPAEFPNGKAVLENTTSGPSLLFSCHRGYTLEGPPEAHCTANGTWSHLAPLCK
                     PNPCPVPFVIPENALLSEREFYVNQNVSIKCREGFLLKGNGIITCNPDETWTQTNARC
                     EKISCGPPTHVENAIARGVHYQYGDMVTFSCYSGYMLEGSLRSVCLENGTWTPPPICR
                     AVCRFPCQNGGVCQRPNACSCPDGWMGRLCEEPICILPCLNGGRCVAPYRCDCPAGWT
                     GSRCHTATCQSPCLNGGKCVRPNRCHCLSSWTGHDCSRKRRSGL"
     exon            726..981
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1158
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1317
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1497
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1677
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1872
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1991
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2121
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2229
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2361
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2556
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2678
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2787
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2952
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3186
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3348
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3510
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3672
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3764
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3861
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..3975
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            3976..4089
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..4291
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            4292..4449
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            4450..4651
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            4652..4827
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            4828..4952
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            4953..5076
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            5077..5247
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            5248..5421
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            5422..5541
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            5542..5718
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            5719..5803
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            5804..5995
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            5996..6163
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            6164..6836
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            6837..9622
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            9623..9848
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            9849..10004
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            10005..10068
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            10069..10242
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            10243..10419
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            10420..10590
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            10591..10686
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            10687..10782
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            10783..10876
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
     exon            10877..11252
                     /gene="Svep1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctccc gagtcccaga gctgccagag gagtctggat cgtgtcccca gtgtcacatg
       61 caagaacgct gaggttcgcg gctgctaccc agggtccccc tcctctcggt ccaggacccc
      121 tggcgcctct ctgcgctctc gggggactgt cgccttgcac tcccccgggc caccgctcgg
      181 tccccagcgc gatgtggacg cgtctggcct tttgttgctg ggctctggca ctggtgtccg
      241 gctggaccaa cttccagccc atggccccgt cgctcaactt cagcttccgc ctgttccccg
      301 aggcctcgcc gggggctctg ggaagactgg ccgtgcctcc ccggtccggt gaggaggagg
      361 cagtggggag caaagtggag cgtctgggcc gaacgttccg gagccgcgtg cggcgcctgc
      421 gggagctcag cgaccgcctg gagctcgtct tcctggtgga cgagtcctcc agcgtgggcc
      481 aaaccaactt cctcaacgaa ctcaaattcg tgcgcaagct gctgtccgac tttcccgtgg
      541 tgtccacggc cacgcgcgtg gctatcgtca ccttctcgtc caagaacaac gtggtggcgc
      601 gcgtggatta catttccacc agccgcgcgc accagcacaa gtgcgcgctg ctcagccgtg
      661 agattccggc catcacctac cgcggtggtg gcacctacac catgggcgcc ttccagcaag
      721 ctgcgcaaat tctccgtcac tctagagaaa actccaccaa agtcatattt ctcatcaccg
      781 atggctattc caatggcgga gaccccagac ctattgcggc atcactgagg gacttcggag
      841 tggagatctt cacgttcggg atttggcagg ggaatatccg agaactgaat gacatggctt
      901 ccaccccgaa ggaagaacac tgctatctgc tccacagttt tgaagaattt gaggctttag
      961 ctcgcagggc attgcatgaa gacctacctt ctgggagttt tatccaagag gacatggccc
     1021 actgctctta tctctgtgag gctggaaggg actgctgtga cagaatggcc agctgcaaat
     1081 gcgggacaca cacaggtcaa tttgaatgca tctgtgagaa gggctattat gggaaaggtc
     1141 tacagtacga gtgcacagct tgcccgccag ggacgtataa gccagaagct tctccaggag
     1201 gaatcagcac gtgcatccca tgtcctgatg aaaaccacac ctctccacct ggaagcacag
     1261 cccctgaaga ctgtgtgtgc cgagagggat accagagatc tggccagacc tgtgaggttg
     1321 tccactgtcc tgcactgaaa cctcctgaaa atggtttctt tatacaaaac acttgcaaaa
     1381 accacttcaa tgctgcctgt ggggtccgat gtcgccctgg atttgacctc gtgggaagca
     1441 gtatccattt gtgtcaaccc aatggtttgt ggtctgggac agaaagcttc tgcagagtga
     1501 gaacatgtcc ccatctccga cagcccaaac acggccacat cagctgctcc actgtggaaa
     1561 tgtcctacaa cactgtgtgt ttggttacct gcaatgaagg atacagatta gaaggacatg
     1621 ctaagcttac ctgtcaagga aatgcccagt gggatggcac agagccgcgg tgtgtagaac
     1681 gccactgtgc cactttccag aagcccaagg gcgtcatcat ttctccaccc agctgtggca
     1741 agcagccagc caagcctggg atgatctgtc agctgggctg ccgccagggg tacattttat
     1801 ctgggatccg agaagtgaga tgcgccacat ctggaaagtg gagtgccaga gttcagacag
     1861 ctgtgtgcaa agacgtggag gctccacaaa tcagctgtcc aaatgacatc aaggcaaaga
     1921 ctgagggaca gcaggactct gctaatgtca cttggcaagt cccaacggct aaagacaact
     1981 ctggtgaaaa ggtgtcagtc catgtccatc cagcctttag cccaccttac ctcttcccaa
     2041 ttggagaagt ggccatcacc tacacggcaa ccgactcatc cggtaaccaa gccagctgca
     2101 ctttctacat taaggttatt gacgtcgagc ctcctgtcat agactggtgc cgatctccac
     2161 ctccaatcca ggtcgtagag aaggagcacc ctgccagctg ggacgagcct cagttctcag
     2221 acaactccgg ggctgaactg gtcattacca gcagtcacac acaaggcgac ctgtttcctc
     2281 atggggaaac ggtggtgtgg tatacagcca ccgacccctc aggcaacaac agaacctgcg
     2341 acatccacat tgtcataaaa ggttctccct gtgaggttcc cttcacccct gtaaacgggg
     2401 actttatctg tgcccaggat agtgctggag ttaactgcag cctgacctgc cgggagggct
     2461 atgatttcac agaagggtcg actgagaaat actactgtgc ttttgaagat ggcatctgga
     2521 gaccaccata ttctacagaa tggccagact gtgctataaa acgttttgca aaccatggct
     2581 tcaagtcctt tgagatgcta tacaaaacca ctcgctgtga tgacatggat ctgtttaaga
     2641 agttttctgc agcttttgag actaccctgg ggaaaatggt cccatccttt tgtagcgatg
     2701 ctgatgacat tgactgcaga ctggaggacc tgaccaaaaa atactgcatc gaatataatt
     2761 acaactatga aaatggcttt gcaattggac cagggggctg gggtgcaggt aacaggctgg
     2821 attactccta cgaccacttc ctggatgttg tacaggaaac gcccgctgat gtaggcaaaa
     2881 caagatcatc acggattaaa agaactgtcc cattgtctga cccccaaatt cagctaattt
     2941 ttaacatcac agctagtgtg ccactcccag aggaaagaaa tgataccgtt gaattggaaa
     3001 atcagcagcg actcattagg acattggaaa caatcacaaa tcgcctgaaa agcaccttga
     3061 ataaagggcc catgtattct ttccagcttg cctcagaaac ggtggtggct gacagcaatt
     3121 ccctagaaac agaaaaggct tttctcttct gcagaccagg ctcggtgctg agggggcgca
     3181 tgtgtgtcaa ctgccccctg ggaacctctt actctctgga gcattccacc tgtgaaagct
     3241 gcctcatggg atcctatcaa gatgaagaag ggcagctgga gtgcaagctc tgtcccccga
     3301 ggactcacac ggaatatctc cattcaagaa gcatctcgga atgcaaagct cagtgtaagc
     3361 aaggcaccta ctcttccagt gggctggaga cctgcgagtc gtgtccgctc ggtacttatc
     3421 aaccagactt tggatcccgg agctgcctcc catgcccaga aaccaccacg actgtgaaaa
     3481 gaggagctgt ggacatctct gcttgtggag tgccctgccc agtaggagaa ttctcccgtt
     3541 ctggcttaac accctgctat ccttgtcctc gagactatta ccaacccaat gcagggaagt
     3601 ccttctgcct cgcttgtccc ttttatggaa ctacaaccat cactggggcc acgtccatca
     3661 cagactgctc gagttttagc tccactttct cagcagcaga agaaagcata gtgcccctcg
     3721 cggcccctgg acctacccaa aacaagtatg aagtcagcag tcaggtcttt cacgaatgct
     3781 tcttaaaccc ttgccacaac agtggaacct gccaacagct tgggcgtggt tatgtctgtc
     3841 tctgtccacc tggatacaca ggcttaaagt gtgagaccga tattgatgaa tgcagctcac
     3901 tgccttgcct caacggtgga atctgtagag acaaagtcgg gggattcact tgtgaatgtt
     3961 catcgggtta tacaggtcaa atatgtgaag aaaatataaa tgagtgcagc tccagcccat
     4021 gcttgaataa aggaacctgc actgacggct tggcgagcta ccgctgcacc tgcgtgagcg
     4081 gatacgtcgg tgtgcactgt gaaacagacg tcaatgaatg ccagtcgagc ccctgcttaa
     4141 acaatgccgt ttgtaaagac caagttgggg gtttctcgtg caaatgccca cctggatttt
     4201 tgggtactcg gtgtgagaaa aatgtggatg agtgtctcag ccagccatgc caaaacggag
     4261 ccacttgtaa ggatggcgcc aacagcttca ggtgccaatg tccagcaggc ttcacagggc
     4321 cacactgtga actgaacatc aatgagtgtc agtccaaccc atgcaggaac caggccacct
     4381 gcgtggatga actaaactca tacagttgta aatgtcggcc aggattttca ggccgcaggt
     4441 gtgagacaga acagccttcg ggttttaacc tggattttga agtttctggc atctacgggt
     4501 acgtccttct agatggagtg cttccaacac tccatgccat aacctgtgca ttctggatga
     4561 agtcctctga tgtcatcaac tacggaacgc ccatctccta tgcactggag ggcaacaaag
     4621 acaacacctt cctcctgact gattacaatg gctgggttct ttatgtgaat ggaaaggaaa
     4681 agatcaccaa ctgcccctct gtaaatgatg gcatttggca tcatattgca atcacatgga
     4741 caagcactgg tggagcctgg agggtctata tagacgggga gctatctgac agtggtactg
     4801 gcctctctgt tggcaaagcc atacctggtg gtggtgcatt agttcttggg caagagcaag
     4861 acaaaaaagg agagggattc aacccggctg agtcttttgt gggctccata agccagctca
     4921 acctctggga ctatgtcctg tctccacagc aggtgaagtc gctggccagc tcctgcccag
     4981 aggaactcag tcggggaaac gtgttagcat ggcctgattt cgtatcgggg atcacgggga
     5041 aggtgaaggt tgattccagc agcatcttct gctctgattg cccatcttta gaagggtccg
     5101 tgcctcacct gagacctgca tcaggagatc gaaagccagg ttccaaagtc agtctgttct
     5161 gtgacccggg cttccagatg gtcgggaatc cggtgcagta ttgtttgaac caagggcagt
     5221 ggtcacagcc actccctcac tgtgaacgca ttcgctgtgg gctgcctccc accttggaga
     5281 atggcttcta ttcagccgag gacctccatg ctggcagcac agtgacctat cagtgcacca
     5341 gtggctacta cctgttgggt gactccagaa tgttctgtac ggacaacggg agctggaacg
     5401 gcatttctcc atcctgtctc gatgttgatg agtgtgcagt cggctcggac tgtagtgagc
     5461 acgcctcctg cctgaacacc aacggatcct acatatgctc gtgcaagccc ccgtacacgg
     5521 gagatgggaa aaactgtgca gaacctgtta aatgtaaggc tccagaaaat ccagagaatg
     5581 gccactcttt gggcaagatt tatagcgtgg gtgctgaagt cacattttcc tgtgaagaag
     5641 ggcaccagct ggtgggagtg agaaaaatca cgtgtttgga gtctggcgag tgggatcacc
     5701 tcagaccatc ctgtgaagcc atttcctgtg gtgccccacc tgttcctgaa aatggcggtg
     5761 ttgacgggtc agcgttcaca tatggcagta aggtgaggta caggtgtgat aaaggctata
     5821 ccttggccgg ggatgaagag tcagcatgcc ttgctagtgg ttcgtggagt cactcctctc
     5881 ctgtgtgtga gctggtgaag tgttcccagc ctgagaacat aaataacggg aaatacatcc
     5941 taagcgggct cacctacctt tcgattgcat catattcctg tgaggacgga tacagcttac
     6001 agggcccgtc gctcattgaa tgcacagctt ccggcagctg ggacagagcg ccacctagtt
     6061 gtcaacttgt gtcctgcgga gagcctccaa tggtcaaaga tgccctcacc acagggagca
     6121 acttcacttt tgggaacatg gtcacttaca catgcaagga gggctacacc cttgccggcc
     6181 ctgacaccat catatgccag gccaacggca agtggaattc aagtaaccac cagtgcctgg
     6241 ccgtctcctg cgacgagccc cccaatgtgg accacgcctc tccagagact gcgcacaggc
     6301 tcttcgggga caccgcgttc tactactgtg cagatggtta cagcctggct gacaattccc
     6361 agctcatctg caacgcccag gggaactggg ttccccccga gggccaggct gtgccccgct
     6421 gcatagctca cttctgtgag aaacccccat ctgtttccta cagcatcttg gagtctgtga
     6481 gcaaagcaaa atttgcagct ggctcggtag taagcttcaa gtgcatggag ggtttcgtac
     6541 tgaacacctc agcgaagatt gaatgcctga gaggcggaca gtggagccct tctcccttgt
     6601 ccgtccagtg catcccagtg cggtgcggag agcctccaag catcacaaat ggctacccga
     6661 gtggaacgaa ctacagtttc ggggccgtgg tggcgtacag ctgccacaag ggattctata
     6721 tcaaagggga gaagaagagc acatgtgagg ccacgggaca gtggagtaga cccctgccca
     6781 cctgccaccc cgtatcctgt aacgaaccac ctaaggttga gaacggcttc ctggagcaca
     6841 ccactggcag gacctttgag agcgaagcaa ggttccagtg caacccaggt tacaaggcag
     6901 tcggaagccc tgtgtttgtc tgccaagcca accgacactg gcacagtgac gcccctctgt
     6961 cctgcacgcc tctcaactgt gggaaacccc ctcccattca gaatggcttc ttgagaggag
     7021 aaagctttga agtagggtcc aaggttcagt ttgtctgtaa tgagggctat gagctggttg
     7081 gtgataattc ttggacttgc cagaaatctg gcaaatggag caagaaacca agcccaaagt
     7141 gtgtccccac taagtgtgca gagcctcccc tcttagaaaa ccagctcgtg ctgaaggaat
     7201 taacttctga ggtaggcgtg atgaccattt cctgtaaaga gggccatgcc ttgcagggcc
     7261 cctctgtcct caagtgcttg ccatccgggc aatggaacgg ttcctttcct gtttgtaagc
     7321 tggtcctttg tcagtcgcct cccttgattc ccttcggcgt ccccgcgtct tcgggtgctc
     7381 ttcactttgg aagtaccgtc aagtatttgt gtgtcgatgg gtttttctta agaggcaatc
     7441 caatcatcct ctgccaagtt gacggcacct ggagttctcc gttgcccgag tgcgttccgg
     7501 tggaatgtcc ccaacctgag gagatcctca acggcatcat ccatgtgcaa gggctcgcct
     7561 atctcagcac cacgctctac acctgtaagc caggcttcga gttagtgggc aacaccacca
     7621 ccctctgtgg ggaaaatggc cagtggcttg gaggaaaacc aatgtgcaga cccattgaat
     7681 gcccagagcc caaagagatt ctaaatggcc aattctcttc cgtgagcttt cagtatggac
     7741 aaaccatcac atactcttgt gaccgaggct tccggctcga aggtcccaaa tccctgacct
     7801 gtttagagac aggtaactgg gatatggatg ccccatcttg caatgccatc cactgtagtg
     7861 acccccagcc catcgaaaat ggtttcgtag aaggcgcgga ttacagatat ggcgccatga
     7921 ttatctatag ctgtttcccc gggtttcagg tggttgggca tgccatgcag acctgcgaag
     7981 agacggggtg gtcaagctcc agcccgacgt gtgtacccat agactgcggt ctccctcctc
     8041 acatagactt tggagactgc actagagtca gcgatgggca gggatatttt gtccaagaag
     8101 acgacatgat ggaagtccca tatctgactc ctcaccctca acatttggaa gcgacagcca
     8161 aagcgtcgga aatcacagag gagtcccttg taccacatgc atcccaattt ctatatggca
     8221 cgacggtgtc ttatcgctgt gagcctggtt atgaactgct gggaatccct gtgctggtct
     8281 gccaggaaga tggcacatgg aatgggaccg caccctcttg tatttccatt gaatgtgatt
     8341 tgcccgttgc tcccgaaaat ggctttctac attttacaca gactactatg ggcagtgccg
     8401 cccaatatag ttgcaagccg gggcacgttc tagaaggctc ccacttgaga ctttgtctac
     8461 agaataagca gtggagtggc acggttccac gctgtgaagt catctcatgc agtgagccaa
     8521 acccactcgg gaatgggtcc atcaaaggaa acgactactc atacctgggt gtgttgcact
     8581 acgagtgtga ctccggctat gtgctcaatg gcactgagaa gaggacatgc caagaaaata
     8641 aacagtggga tggccatgag cctgtatgcc ttcctgtgga ttgtggctcg cccccggtcc
     8701 ccaccaatgg ccaagtgacg ggagaagagt acacattcca aaaggagatt gcatactctt
     8761 gtggtgaagg gttcatactt gaaggagcca ggagtcgtgt ctgtcttacc aatggaagtt
     8821 ggagtggtac cactcccagc tgtgtgcctg tcagatgtcc tgccccacca caggtggcaa
     8881 atggggtgac agatggccta gactatgggt tcaagaaaga agtaacattc cactgtctag
     8941 agggctatgt gttgcagggg actccgaaac tcacctgtca gtccaatggg acttgggatg
     9001 cagaagttcc catctgtaaa ccagctacct gtggtcctcc tgccgatctt ccccagggct
     9061 tccctaatgg cttttccttt tttcatgggg gccacataca gtaccaatgt tttactggtt
     9121 ataaactcca cggaaaccca tcaaggagat gccttcccga tggttcctgg agcggcagca
     9181 cgccttcctg tctaccttgc acgtgttcca cacccatcat tcaacagggg accgtcaatg
     9241 caactgattt gggctgtgga aagacggtcc agatcgagtg cttcaaaggc ttcaaactgc
     9301 ttggacttcc tgaaatcacc tgtgatgcca acggccaatg gtctgacttc ccactctgtg
     9361 agcatgctga ttgtggccct ctcccaactg tacccaacgg aatcgtcatc aagggtagcc
     9421 cttcagagga caacgtggta acttacagct gcagacctgg ctacatcata cagggtagtt
     9481 cagatctgat ttgtacagag aaggggatat ggagcgagcc ttacccaacg tgtgagcccg
     9541 tgtcctgtgg acccccaccg acggttgcca atgcagtggc aacaggagag gcacatacct
     9601 atgaaagcaa agtgaaactc aggtgtctgg aagggtatgt ggtggatacg gacacagaca
     9661 cattcacctg ccagcaagat ggtcggtggt tccctgaaag aatcaactgc agtcctaaaa
     9721 catgtcctgt gccatccaac aggacgcgca tacgtgttca cggagatgac ttccaggtga
     9781 atagacaagt ttctgtgtcg tgcacagaag ggtttaccta tgacggagca gaccggtcaa
     9841 cgtgccagcc cgatggtaca tgggagccac cgctttccga ggaatcctgc atcccggttg
     9901 tctgtgggca gcctgaaagt ccagagcatg gattcgtggt cggcagtgaa tacagcttcg
     9961 gaagcaccgt tgtttatcag tgtgaccctg gctatgaatt agaggggaac agggaacgag
    10021 tctgccagga gaacagacag tggagtggac gggtggcagt atgcagagag agcagatgtg
    10081 aggctccggc tgagtttccc aatgggaagg ctgtcttgga aaacaccaca tctggaccca
    10141 gcctgctgtt ttcctgtcac agaggctaca ccctggaagg gccccctgag gcacactgca
    10201 ctgcaaatgg aacctggagt cacctggctc ccctctgcaa accaaatcca tgccctgttc
    10261 cttttgtgat tcctgagaat gccctccttt ctgagagaga gttttacgtc aaccagaatg
    10321 tatctatcaa gtgcagagaa ggcttcctgc tcaaaggcaa cggcatcatc acgtgcaacc
    10381 ctgacgagac ttggacacag acaaacgcca gatgtgaaaa aatctcctgt ggtcctccaa
    10441 ctcatgtgga aaacgcaatt gctcgaggtg tgcattacca atatggggac atggtcacct
    10501 tctcctgtta cagtggctac atgctagaag gttccctcag gagtgtatgc ctagaaaatg
    10561 gaacatggac accacctcct atctgcagag ctgtctgccg gttcccatgt cagaatggag
    10621 gggtctgcca acgaccaaac gcttgctcct gcccagacgg ttggatggga cgactttgtg
    10681 aagagccaat atgcatactc ccctgtttga atggtgggcg ctgtgtggcc ccttatcggt
    10741 gtgactgccc cgcaggctgg actggatccc gctgtcatac agctacttgt cagtctccct
    10801 gcttaaatgg cgggaaatgc gtaagaccaa accgatgcca ttgtctctca tcctggacag
    10861 gacacgattg ctccaggaaa aggagaagcg ggctttaacc ccatacccca ccacctctcc
    10921 caaagcagga tcatctcctt ccagtagctc ctggaactca caccaagaaa gaccaacacg
    10981 gtgctggggc ttgttttgtt ttataagctt gaggttgacg ttttaatttt tgtgatctat
    11041 tttgttattt tttttgtgac gtcctttctt acatgtttgc attgtttaaa tatgcttgca
    11101 ttttctatat aaaagttata ttagacggac actgctccat cctcaccaga tgtacatact
    11161 ccactgtctg ctgggaaaac ccctggattt cgtttttatt caattactta aagatgactt
    11221 tccattaaaa tatattttgc tactaaataa gg
//
