LOCUS       NM_001038992             688 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus small vasohibin binding protein (Svbp),
            transcript variant 2, mRNA.
ACCESSION   NM_001038992
VERSION     NM_001038992.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 688)
  AUTHORS   Iqbal,Z., Tawamie,H., Ba,W., Reis,A., Halak,B.A., Sticht,H.,
            Uebe,S., Kasri,N.N., Riazuddin,S., van Bokhoven,H. and Abou
            Jamra,R.
  TITLE     Loss of function of SVBP leads to autosomal recessive intellectual
            disability, microcephaly, ataxia, and hypotonia
  JOURNAL   Genet Med 21 (8), 1790-1796 (2019)
   PUBMED   30607023
  REMARK    GeneRIF: Knocking down Svbp in rat primary hippocampal neurons led
            to a significant decrease in the number of excitatory synapses.
            SVBP is not only involved in angiogenesis, but also has vital
            functions in the central nervous system. Biallelic loss-of-function
            variants in SVBP lead to intellectual disability.
REFERENCE   2  (bases 1 to 688)
  AUTHORS   Zhou,C., Yan,L., Zhang,W.H. and Liu,Z.
  TITLE     Structural basis of tubulin detyrosination by VASH2/SVBP
            heterodimer
  JOURNAL   Nat Commun 10 (1), 3212 (2019)
   PUBMED   31324789
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 688)
  AUTHORS   Adamopoulos,A., Landskron,L., Heidebrecht,T., Tsakou,F.,
            Bleijerveld,O.B., Altelaar,M., Nieuwenhuis,J., Celie,P.H.N.,
            Brummelkamp,T.R. and Perrakis,A.
  TITLE     Crystal structure of the tubulin tyrosine carboxypeptidase complex
            VASH1-SVBP
  JOURNAL   Nat Struct Mol Biol 26 (7), 567-570 (2019)
   PUBMED   31270470
REFERENCE   4  (bases 1 to 688)
  AUTHORS   Wang,N., Bosc,C., Ryul Choi,S., Boulan,B., Peris,L., Olieric,N.,
            Bao,H., Krichen,F., Chen,L., Andrieux,A., Olieric,V., Moutin,M.J.,
            Steinmetz,M.O. and Huang,H.
  TITLE     Structural basis of tubulin detyrosination by the vasohibin-SVBP
            enzyme complex
  JOURNAL   Nat Struct Mol Biol 26 (7), 571-582 (2019)
   PUBMED   31235911
REFERENCE   5  (bases 1 to 688)
  AUTHORS   Li,F., Hu,Y., Qi,S., Luo,X. and Yu,H.
  TITLE     Structural basis of tubulin detyrosination by vasohibins
  JOURNAL   Nat Struct Mol Biol 26 (7), 583-591 (2019)
   PUBMED   31235910
REFERENCE   6  (bases 1 to 688)
  AUTHORS   Liao,S., Rajendraprasad,G., Wang,N., Eibes,S., Gao,J., Yu,H.,
            Wu,G., Tu,X., Huang,H., Barisic,M. and Xu,C.
  TITLE     Molecular basis of vasohibins-mediated detyrosination and its
            impact on spindle function and mitosis
  JOURNAL   Cell Res 29 (7), 533-547 (2019)
   PUBMED   31171830
  REMARK    Erratum:[Cell Res. 2019 Sep;29(9):778. doi:
            10.1038/s41422-019-0215-y.. PMID: 31395957]
REFERENCE   7  (bases 1 to 688)
  AUTHORS   Nieuwenhuis,J., Adamopoulos,A., Bleijerveld,O.B., Mazouzi,A.,
            Stickel,E., Celie,P., Altelaar,M., Knipscheer,P., Perrakis,A.,
            Blomen,V.A. and Brummelkamp,T.R.
  TITLE     Vasohibins encode tubulin detyrosinating activity
  JOURNAL   Science 358 (6369), 1453-1456 (2017)
   PUBMED   29146869
REFERENCE   8  (bases 1 to 688)
  AUTHORS   Aillaud,C., Bosc,C., Peris,L., Bosson,A., Heemeryck,P., Van
            Dijk,J., Le Friec,J., Boulan,B., Vossier,F., Sanman,L.E., Syed,S.,
            Amara,N., Coute,Y., Lafanechere,L., Denarier,E., Delphin,C.,
            Pelletier,L., Humbert,S., Bogyo,M., Andrieux,A., Rogowski,K. and
            Moutin,M.J.
  TITLE     Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate
            neuron differentiation
  JOURNAL   Science 358 (6369), 1448-1453 (2017)
   PUBMED   29146868
REFERENCE   9  (bases 1 to 688)
  AUTHORS   Suzuki,Y., Kobayashi,M., Miyashita,H., Ohta,H., Sonoda,H. and
            Sato,Y.
  TITLE     Isolation of a small vasohibin-binding protein (SVBP) and its role
            in vasohibin secretion
  JOURNAL   J Cell Sci 123 (Pt 18), 3094-3101 (2010)
   PUBMED   20736312
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099226.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099226.1, CV078848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..688
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..688
                     /gene="Svbp"
                     /gene_synonym="Ccdc23; RGD1311232"
                     /note="small vasohibin binding protein"
                     /db_xref="GeneID:362578"
                     /db_xref="RGD:1311232"
     exon            1..95
                     /gene="Svbp"
                     /gene_synonym="Ccdc23; RGD1311232"
                     /inference="alignment:Splign:2.1.0"
     exon            96..245
                     /gene="Svbp"
                     /gene_synonym="Ccdc23; RGD1311232"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..332
                     /gene="Svbp"
                     /gene_synonym="Ccdc23; RGD1311232"
                     /note="isoform b is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 23; coiled-coil
                     domain containing 23"
                     /codon_start=1
                     /product="small vasohibin-binding protein isoform b"
                     /protein_id="NP_001034081.1"
                     /db_xref="GeneID:362578"
                     /db_xref="RGD:1311232"
                     /translation="MDPPARKEKSKVKEPAFRVEKAKQKSAQQELKQRQRAEIYALNR
                     VMTELEQQQFDEFCKQMQPPGE"
     exon            246..661
                     /gene="Svbp"
                     /gene_synonym="Ccdc23; RGD1311232"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgggcgct gcggtcccgc ggaaggggga ggctagggta aactccgcgt gggggcttgt
       61 ctgcgacgtg gcggagttcg ggagcctgag gccgggtcag agctgatcag gaagcattcg
      121 gaagccaaac catggatcca cctgcccgga aagaaaaatc caaagttaaa gaacctgcct
      181 tcagagtgga gaaggctaaa cagaaatctg cccagcagga gctgaagcaa agacaaagag
      241 cagagatcta tgctctcaac agagtcatga cggagctgga gcagcagcag tttgatgagt
      301 tctgtaagca gatgcagccc cccggggagt gagccagcct gcatcccagt cagagggact
      361 gggcctttgt ctgtgagctc attcccactg tttcgccgct gccgccgagc tggcccattg
      421 gagccttaca gaactgatca ggacttgtgg agacctctgc actgaatttc ctataggtaa
      481 cttccacctc actggttttt actctcaaaa ctggcccagt gcttgctggg tagacttttc
      541 atctaggaca gtggattttt tcaaaaagat cttttttcta ttgtttgaga aaaatcattg
      601 tttcttgtga aactgtgttt cttccctaaa aataataaaa tacaaaaatg tttgtccttg
      661 caaaaaaaaa aaaaaaaaaa aaaaaaaa
//
