LOCUS       NM_031593               2622 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus synaptic vesicle glycoprotein 2c (Sv2c), mRNA.
ACCESSION   NM_031593
VERSION     NM_031593.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2622)
  AUTHORS   Tejero,R., Lopez-Manzaneda,M., Arumugam,S. and Tabares,L.
  TITLE     Synaptotagmin-2, and -1, linked to neurotransmission impairment and
            vulnerability in Spinal Muscular Atrophy
  JOURNAL   Hum Mol Genet 25 (21), 4703-4716 (2016)
   PUBMED   28173138
REFERENCE   2  (bases 1 to 2622)
  AUTHORS   Strotmeier,J., Mahrhold,S., Krez,N., Janzen,C., Lou,J., Marks,J.D.,
            Binz,T. and Rummel,A.
  TITLE     Identification of the synaptic vesicle glycoprotein 2 receptor
            binding site in botulinum neurotoxin A
  JOURNAL   FEBS Lett 588 (7), 1087-1093 (2014)
   PUBMED   24583011
REFERENCE   3  (bases 1 to 2622)
  AUTHORS   Boyken,J., Gronborg,M., Riedel,D., Urlaub,H., Jahn,R. and Chua,J.J.
  TITLE     Molecular profiling of synaptic vesicle docking sites reveals novel
            proteins but few differences between glutamatergic and GABAergic
            synapses
  JOURNAL   Neuron 78 (2), 285-297 (2013)
   PUBMED   23622064
REFERENCE   4  (bases 1 to 2622)
  AUTHORS   Dong,M., Yeh,F., Tepp,W.H., Dean,C., Johnson,E.A., Janz,R. and
            Chapman,E.R.
  TITLE     SV2 is the protein receptor for botulinum neurotoxin A
  JOURNAL   Science 312 (5773), 592-596 (2006)
   PUBMED   16543415
  REMARK    GeneRIF: findings show that botulinum neurotoxin (BoNT/A) enters
            neurons by binding to the synaptic vesicle protein SV2 (isoforms A,
            B, and C);SV2 acts as the protein receptor for BoNT/A
REFERENCE   5  (bases 1 to 2622)
  AUTHORS   Mahrhold,S., Rummel,A., Bigalke,H., Davletov,B. and Binz,T.
  TITLE     The synaptic vesicle protein 2C mediates the uptake of botulinum
            neurotoxin A into phrenic nerves
  JOURNAL   FEBS Lett 580 (8), 2011-2014 (2006)
   PUBMED   16545378
REFERENCE   6  (bases 1 to 2622)
  AUTHORS   Iezzi,M., Theander,S., Janz,R., Loze,C. and Wollheim,C.B.
  TITLE     SV2A and SV2C are not vesicular Ca2+ transporters but control
            glucose-evoked granule recruitment
  JOURNAL   J Cell Sci 118 (Pt 23), 5647-5660 (2005)
   PUBMED   16306227
REFERENCE   7  (bases 1 to 2622)
  AUTHORS   Schivell,A.E., Mochida,S., Kensel-Hammes,P., Custer,K.L. and
            Bajjalieh,S.M.
  TITLE     SV2A and SV2C contain a unique synaptotagmin-binding site
  JOURNAL   Mol Cell Neurosci 29 (1), 56-64 (2005)
   PUBMED   15866046
  REMARK    GeneRIF: SV2-synaptotagmin interaction act in regulated exocytosis
            and SV2A and SV2C, via their additional synaptotagmin binding site,
            function differently than SV2B.
REFERENCE   8  (bases 1 to 2622)
  AUTHORS   Wang,M.M., Janz,R., Belizaire,R., Frishman,L.J. and Sherry,D.M.
  TITLE     Differential distribution and developmental expression of synaptic
            vesicle protein 2 isoforms in the mouse retina
  JOURNAL   J Comp Neurol 460 (1), 106-122 (2003)
   PUBMED   12687700
REFERENCE   9  (bases 1 to 2622)
  AUTHORS   Janz,R. and Sudhof,T.C.
  TITLE     SV2C is a synaptic vesicle protein with an unusually restricted
            localization: anatomy of a synaptic vesicle protein family
  JOURNAL   Neuroscience 94 (4), 1279-1290 (1999)
   PUBMED   10625067
REFERENCE   10 (bases 1 to 2622)
  AUTHORS   Janz,R., Hofmann,K. and Sudhof,T.C.
  TITLE     SVOP, an evolutionarily conserved synaptic vesicle protein,
            suggests novel transport functions of synaptic vesicles
  JOURNAL   J Neurosci 18 (22), 9269-9281 (1998)
   PUBMED   9801366
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031593.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF060174.1, SRR26360194.1157422.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000002.1  29163046-29163168   c
            124-804             JAXUCZ010000002.1  29113815-29114495   c
            805-985             JAXUCZ010000002.1  29068030-29068210   c
            986-1137            JAXUCZ010000002.1  29055127-29055278   c
            1138-1271           JAXUCZ010000002.1  29003680-29003813   c
            1272-1361           JAXUCZ010000002.1  29003107-29003196   c
            1362-1472           JAXUCZ010000002.1  29000784-29000894   c
            1473-1561           JAXUCZ010000002.1  28999899-28999987   c
            1562-1726           JAXUCZ010000002.1  28996029-28996193   c
            1727-1860           JAXUCZ010000002.1  28992235-28992368   c
            1861-2064           JAXUCZ010000002.1  28990782-28990985   c
            2065-2224           JAXUCZ010000002.1  28990167-28990326   c
            2225-2622           JAXUCZ010000002.1  28967631-28968028   c
FEATURES             Location/Qualifiers
     source          1..2622
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..2622
                     /gene="Sv2c"
                     /note="synaptic vesicle glycoprotein 2c"
                     /db_xref="GeneID:29643"
                     /db_xref="RGD:619718"
     exon            1..123
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            124..804
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..2408
                     /gene="Sv2c"
                     /note="synaptic vesicle protein 2C"
                     /codon_start=1
                     /product="synaptic vesicle glycoprotein 2C"
                     /protein_id="NP_113781.1"
                     /db_xref="GeneID:29643"
                     /db_xref="RGD:619718"
                     /translation="MEDSYKDRTSLMKGAKDIAKEVKKQTVKKVNQAVDRAQDEYTQR
                     SYSRFQDEDDDDDYYPPGETYSGEANDDEGSSEATEGHDEEDEIYEGEYQGIPSTNQG
                     KDSIVSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGM
                     ALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRK
                     QSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFAEVLAREKRG
                     EHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSV
                     VALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDEL
                     IEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRENTIKLTIVWFTLSFGYYGL
                     SVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFLGVKFK
                     SVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNK
                     TGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISC
                     FFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAA
                     VLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQVLM"
     exon            805..985
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1137
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1271
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1361
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1472
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1561
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1726
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1860
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2064
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2224
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2622
                     /gene="Sv2c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgctgca ggagagagtg gcagaccgaa gcggcctcgg gctgcaaacg gaggggcgct
       61 cgcgcggcga cggctgcagg gctgacaccg ctcagggcag gggggtccca ggcggctgga
      121 acgctctatt ctgaactgtg agtggatgat gctgttgcag ccaagctgct gaacacactc
      181 cgtggactct tccctgctgt gccttgccca tcggccgaga taaaatggaa gactcctaca
      241 aggataggac ttcactgatg aagggcgcca aggacattgc caaagaggtg aagaagcaaa
      301 cagtgaagaa ggtgaaccag gcagtggacc gggcccagga tgaatacacc cagcggtcct
      361 acagccgatt ccaggatgaa gatgatgatg atgactacta cccacctgga gaaacctaca
      421 gtggggaggc caatgatgat gaaggctcaa gtgaagccac tgagggtcac gatgaagaag
      481 acgagatcta tgaaggggaa taccagggca tccccagcac gaaccaaggg aaggacagca
      541 tagtgtctgt aggacaaccc aaaggagatg agtacaagga ccgcagagag ctggagtcag
      601 agaggagggc tgatgaggag gagctcgccc agcagtatga gctgataatc caagagtgtg
      661 gccatggccg tttccagtgg gcccttttct tcgtcctggg catggctctc atggcagacg
      721 gcgtggaggt gtttgtggtg ggctttgtgt tacccagtgc agagacagac ctatgcatac
      781 cgaattcagg atctggatgg ctaggcagca tagtgtacct cgggatgatg gtgggggcgt
      841 tcttctgggg aggactggca gacaaagtgg gaaggaagca gtctcttctg atttgcatgt
      901 ccgtcaacgg attctttgcc ttcctttctt catttgtcca aggttacggc ttctttctcc
      961 tctgtcgttt gctttcagga ttcgggattg gaggcgccat tcccactgtg ttctcctact
     1021 ttgctgaagt cctggcccgg gagaagcgcg gtgagcacct cagttggctc tgcatgttct
     1081 ggatgattgg cggtatctat gcttcagcca tggcctgggc catcatcccc cactatgggt
     1141 ggagcttcag catgggctca gcctaccagt tccacagctg gcgcgtcttc gtcatcgtct
     1201 gtgccctccc gtgcgtctcc tcggtggtgg ccctcacctt catgcccgaa agccctcggt
     1261 tcttgctgga ggtaggaaaa catgatgaag cctggatgat tctgaagcta attcatgata
     1321 ccaacatgag agcccggggc cagccagaga aggtcttcac ggtaaataaa atcaagactc
     1381 ccaagcaaat agatgagctg attgagattg agagtgacac aggaacctgg taccggaggt
     1441 gttttgttcg gatccgcaca gaactgtacg gaatttggtt gacttttatg agatgcttca
     1501 actacccggt cagggaaaac accataaagc ttacgattgt ttggttcacc ctgtcctttg
     1561 ggtactatgg actgtccgtt tggttcccag atgtcattaa acacctccag tctgacgagt
     1621 acgccctgct gactcggaat gtgcagaagg ataaatatgc aaactttagc attaacttca
     1681 ccatggaaaa ccaggtccac accggaatgg aatatgacaa tggcaggttc ctcggagtca
     1741 aattcaaatc ggtaaccttc aaggattcag tgtttaagtc ctgcaccttt gacgatgtga
     1801 cctcagtcaa cacctacttc aagaactgca cgtttattga tacccttttt gagaacacag
     1861 attttgagcc ctataaattc atagacagcg agtttcaaaa ctgctcgttt cttcacaata
     1921 agacgggatg tcagattact tttgacgacg actacagtgc ctactggatt tactttgtca
     1981 actttctcgg gacattggca gtgttaccag gaaatatcgt gtctgctctc ctgatggaca
     2041 ggatcgggcg cttaacgatg ctaggtggct ccatggtgct ctcggggatc agctgcttct
     2101 tcctgtggtt tggcaccagc gaatccatga tgataggcat gctgtgcttg tacaacggac
     2161 tgaccatctc agcgtggaac tctcttgatg tagtcacggt ggaactatac cccacagacc
     2221 ggagagcaac gggctttggc ttcttgaacg cactctgtaa agcagcggcc gtcctgggaa
     2281 acttaatatt cggctccttg gtcagcatca ccaaagcaat ccctatcctg ctggcttcca
     2341 ccgtgctcgt gtgtggagga ctcgtggggc tgcgcctgcc cgacacaaga acccaggttc
     2401 tgatgtgaca aaagccattc tcttctctca ccatgggtca gccctattgc ctgactcaag
     2461 gcttcagagt ttttatgtat agaaaggtgg ccaagtatca gaactcaaac ttttgctgtg
     2521 acgtaaatgt agctgtgtat tgtccccgcc agtgtgattt gcagggtcct ccccctcccc
     2581 cgcgccttgt tatcttttcc taattgtgat gttcctgctt cc
//
