LOCUS       NM_057207               5213 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus synaptic vesicle glycoprotein 2b (Sv2b), mRNA.
ACCESSION   NM_057207
VERSION     NM_057207.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5213)
  AUTHORS   Fronczak,K.M., Li,Y., Henchir,J., Dixon,C.E. and Carlson,S.W.
  TITLE     Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in the
            Cortex and Hippocampus in a Rat Model of Traumatic Brain Injury
  JOURNAL   Mol Neurobiol 58 (11), 6006-6019 (2021)
   PUBMED   34435329
  REMARK    GeneRIF: Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in
            the Cortex and Hippocampus in a Rat Model of Traumatic Brain
            Injury.
REFERENCE   2  (bases 1 to 5213)
  AUTHORS   Tejero,R., Lopez-Manzaneda,M., Arumugam,S. and Tabares,L.
  TITLE     Synaptotagmin-2, and -1, linked to neurotransmission impairment and
            vulnerability in Spinal Muscular Atrophy
  JOURNAL   Hum Mol Genet 25 (21), 4703-4716 (2016)
   PUBMED   28173138
REFERENCE   3  (bases 1 to 5213)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   4  (bases 1 to 5213)
  AUTHORS   Boyken,J., Gronborg,M., Riedel,D., Urlaub,H., Jahn,R. and Chua,J.J.
  TITLE     Molecular profiling of synaptic vesicle docking sites reveals novel
            proteins but few differences between glutamatergic and GABAergic
            synapses
  JOURNAL   Neuron 78 (2), 285-297 (2013)
   PUBMED   23622064
REFERENCE   5  (bases 1 to 5213)
  AUTHORS   Yang,S.Y., Jeon,S.K., Kang,J.H., Yoo,H.I., Kim,Y.S., Moon,J.S.,
            Kim,M.S., Koh,J.T., Oh,W.M. and Kim,S.H.
  TITLE     Synaptic vesicle protein 2b is expressed temporospatially in
            (pre)odontoblasts in developing molars
  JOURNAL   Eur J Oral Sci 120 (6), 505-512 (2012)
   PUBMED   23167466
  REMARK    GeneRIF: For the first time, synaptic vesicle protein (SV) 2b, an
            important transmembrane transporter of Ca2+-stimulated vesicle
            exocytosis, was identified as a differentially expressed molecule
            localized in fully differentiated odontoblasts and
            pre-odontoblasts.
REFERENCE   6  (bases 1 to 5213)
  AUTHORS   Pyle,R.A., Schivell,A.E., Hidaka,H. and Bajjalieh,S.M.
  TITLE     Phosphorylation of synaptic vesicle protein 2 modulates binding to
            synaptotagmin
  JOURNAL   J Biol Chem 275 (22), 17195-17200 (2000)
   PUBMED   10747945
REFERENCE   7  (bases 1 to 5213)
  AUTHORS   Janz,R. and Sudhof,T.C.
  TITLE     SV2C is a synaptic vesicle protein with an unusually restricted
            localization: anatomy of a synaptic vesicle protein family
  JOURNAL   Neuroscience 94 (4), 1279-1290 (1999)
   PUBMED   10625067
REFERENCE   8  (bases 1 to 5213)
  AUTHORS   Janz,R., Hofmann,K. and Sudhof,T.C.
  TITLE     SVOP, an evolutionarily conserved synaptic vesicle protein,
            suggests novel transport functions of synaptic vesicles
  JOURNAL   J Neurosci 18 (22), 9269-9281 (1998)
   PUBMED   9801366
REFERENCE   9  (bases 1 to 5213)
  AUTHORS   Hayashi,M., Yamamoto,A., Yatsushiro,S., Yamada,H., Futai,M.,
            Yamaguchi,A. and Moriyama,Y.
  TITLE     Synaptic vesicle protein SV2B, but not SV2A, is predominantly
            expressed and associated with microvesicles in rat pinealocytes
  JOURNAL   J Neurochem 71 (1), 356-365 (1998)
   PUBMED   9648885
REFERENCE   10 (bases 1 to 5213)
  AUTHORS   Bajjalieh,S.M., Peterson,K., Linial,M. and Scheller,R.H.
  TITLE     Brain contains two forms of synaptic vesicle protein 2
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2150-2154 (1993)
   PUBMED   7681585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L10362.1, CB609053.1, CO402345.1, DV721065.1, BG671769.1,
            BF285601.1 and AI716529.1.
            
            On Apr 19, 2007 this sequence version replaced NM_057207.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L10362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2961              L10362.1           1-2961
            2962-3126           CB609053.1         399-563
            3127-3659           L10362.1           3128-3660
            3660-4043           CO402345.1         256-639
            4044-4365           DV721065.1         257-578
            4366-4727           BG671769.1         300-661
            4728-4801           BF285601.1         250-323
            4802-5213           AI716529.1         1-412               c
FEATURES             Location/Qualifiers
     source          1..5213
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..5213
                     /gene="Sv2b"
                     /note="synaptic vesicle glycoprotein 2b"
                     /db_xref="GeneID:117556"
                     /db_xref="RGD:619716"
     exon            1..59
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            60..890
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..2491
                     /gene="Sv2b"
                     /note="synaptic vesicle protein 2B"
                     /codon_start=1
                     /product="synaptic vesicle glycoprotein 2B"
                     /protein_id="NP_476555.1"
                     /db_xref="GeneID:117556"
                     /db_xref="RGD:619716"
                     /translation="MDDYRYRDNYEGYAPNDGYYRGNEQNPEEDAQSDVTEGHDEEDE
                     IYEGEYQGIPHPDDVKSKQTKMAPSRADGLRGQADLMAERMEDEEQLAHQYETIIDEC
                     GHGRFQWTLFFVLVLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGLIVYLGMMA
                     GAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPI
                     VFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYHFHSW
                     RVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKV
                     FTVSHIKTPKQMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLI
                     LAVVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQ
                     HGKLVNDKFIKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHK
                     FIDCRFINSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRL
                     KMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRA
                     TAFGILNGLCKLGAILGNTIFASFVGITKVVPILLAAASLVGGGLVALRLPETREQVL
                     M"
     exon            891..1071
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1223
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1357
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1447
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1558
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1647
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1812
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1946
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2147
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2307
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..5199
                     /gene="Sv2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctacccag atcaacggtg ctctaccgct gaatcgctcg ctgcggattt tccacccagg
       61 ccacaacctt cagtagaagg acaaacatca cagccagtga gctgccaagc agtgctccga
      121 ccgaccttgt caaagagagc agctggtccc agttttagtc agcacctctc agcataagtg
      181 tctgggtcac agaaggagaa caggtcaaca tttccaaaga catttaacac accagcacaa
      241 aaggctactt aggttgtctt tgtatgaatt tggttgacta gagaagtaaa ttaaaaaggt
      301 gctttgattg aagaagtcac atggacataa tcaccatttc aacaatatat tagatgatgg
      361 ttattggaac agcccaaaca tttaccacag agcaagagat atagcttgag tggctactag
      421 actattccag aatcaaggaa tggatgacta caggtatcgg gacaactatg agggctatgc
      481 ccctaatgat ggctactacc ggggcaatga gcagaacccg gaagaagatg cacagagcga
      541 tgttacagaa ggccacgatg aagaggatga gatctatgag ggcgagtacc aaggcatccc
      601 tcatccagat gatgtcaagt ctaagcagac taagatggca ccgtccagag cagatggcct
      661 tcggggccag gcagacctga tggctgagag aatggaagat gaggagcagc tcgctcacca
      721 gtacgagacc atcattgatg agtgtggcca tgggcgcttc cagtggaccc tctttttcgt
      781 cttggtcttg gccttgatgg ctgacggagt ggaagtgttt gtggtgagct ttgctctgcc
      841 aagtgcagag aaagatatgt gtctgtcaag ttccaagaaa ggaatgctcg ggctgattgt
      901 ctacctagga atgatggcag gagccttcat cctggggggc ctggctgata aactgggaag
      961 gaagaaggtc ctcagcatgt ccttggctat caatgcttcc tttgcctccc tctcctcctt
     1021 cgtgcaggga tatggagctt tcctcttctg cagactcatc tcaggcatag gtattggggg
     1081 ctccctgcca attgtttttg cctacttttc tgagttctta tcacgggaga aacgcggtga
     1141 gcatctcagc tggctgggta tcttctggat gactgggggc atctacgcat ctgccatggc
     1201 ctggagcatc attccacact atggctgggg cttcagcatg ggaaccaatt atcacttcca
     1261 cagctggaga gtgtttgtca tcgtctgtgc tctgcctgcc actgtgtcca tggtggccct
     1321 gaagttcatg ccagaaagcc ccaggttcct gctggagatg ggcaagcatg atgaagcctg
     1381 gatgattctc aagcaagtcc atgacaccaa catgagagct aaggggaccc ctgagaaggt
     1441 gttcacggtt tcccacatca aaactcccaa gcaaatggat gaattcattg agatccagag
     1501 ttcaacaggg acttggtacc agcgctggtt ggtcaggttc atgaccattt tcaaacaggt
     1561 gtgggataac gccttgtact gtgtgatggg accctacaga atgaacaccc tgattctggc
     1621 tgtggtctgg ttcaccatgg ccttaagtta ctatggcctg acagtgtggt tccccgacat
     1681 gatccggtat ttccaggatg aagaatataa gtctaaaatg aaggtgtttt ttggtgagca
     1741 cgtgcatggc gccacaatca acttcaccat ggaaaaccag atccaccaac atgggaagct
     1801 tgtgaacgat aagttcataa agatgtactt taagcatgtc ctctttgagg acacattctt
     1861 tgacaaatgc tattttgaag atgtgacatc cacagatact tatttcaaga actgcaccat
     1921 tgaatcgact accttctaca acacagacct ctacaaacac aagttcattg actgtcggtt
     1981 tatcaattcc acctttctgg agcagaagga gggctgccac atggactttg aagaggacaa
     2041 tgattttctg atttacctcg tcagcttcct cggcagcctg tctgtcttgc ctgggaacat
     2101 aatttctgcc ctgctcatgg acagaatcgg aagacttaag atgattggtg gctccatgct
     2161 catctctgca gtctgctgct tcttcctgtt ttttggcaac agcgagtctg cgatgatcgg
     2221 ctggcaatgc ctgttctgtg ggaccagcat tgcagcctgg aatgctctgg atgtgatcac
     2281 agtagagctg tatcccacca accagagggc cactgccttc ggcatcctca atggactgtg
     2341 caaacttggt gccatcctgg gaaacactat ctttgcttct tttgttggga tcaccaaagt
     2401 ggtccccatc cttctggctg ctgcttctct ggttggaggt ggcttggttg cccttcgact
     2461 gccagagact cgagagcagg tcctgatgtg aacagcaccg tggggagagg aagatgggaa
     2521 gatctttttt caggacactt cagcacagcc acacctcctg cctctcactg tccacaggac
     2581 accacggaca gcacagaagg agaaatggac tgtgtgatcc ctagtttagg acccacttca
     2641 gttgttaata cgtttttaac tcaggtcatt ggctaggggt gcccagagtc aaccttagga
     2701 tcccagagct gtgcgcttag cttcaggtct ctcgatccaa ggcaggggga ggacactcca
     2761 gtaaatccat atagtaagca agaaattgct tgcatttcag actgacattg aggacaagaa
     2821 acacttaatc tcctctatgt agcttctggg agcccagtga cctagcagat tgcctcagtt
     2881 gggagtggga tcaatacata aatatcagat tcacagaaca gactatatat ttgcatttga
     2941 aagtatcacc tatcatattt tccttttgaa aattggcacg gtagtattga agatactctg
     3001 atatagaaaa acccaatatt gaagcaaaat gtatatagac tgacttttca tctcaagcgt
     3061 cctgaacttt gcacaaagaa gaggtgacac gtcaagagtg atatttatta tggttttgct
     3121 ctactcagag acacttgagg ttggttatta tgtaaactat gtttgtatat agcagttttg
     3181 aggttttatt cccacaaatg gtagctgcta agattgccag cattttagcc gaatttgggg
     3241 agaactcgcc attcaaggtc ccaggaaact ggtgcaaatg gatgatgttt aagcatgatg
     3301 tcagtgcagc catcttgcct gctgtcagga ggatgtactt ggcaagccac atgctatttc
     3361 ctttacctgg gaatttttct tcaacttggt agggcagtta cttttctctc caatgctgat
     3421 cgcttgtgaa actcaggtcc atgggtcgtt tgatgctgtt tacccaggaa gaacaggaag
     3481 aaaggtttat ttttattttt attttttaat ggctgcttgc attttccttt taaagaaaaa
     3541 caaaacaaaa caacacaggt aactggccaa ggatgggaaa atgaaatcac agttcttcaa
     3601 agtgtgagtc cttactgttt gatttcaaag gaaaacacaa tgcactttta ttacagcatt
     3661 taggacctat acgaaattta tgctctatgt gctggctctg gggttttgaa atgggccatt
     3721 agcatgcacg ttaggaaata aaaggcacga gatacattcc tgtcttcagt gctccaagga
     3781 agcttttcct gagatccaga atggactgtg aatgtggaaa tggaaggact cagggcatac
     3841 cattctggca ggtgtcagcc atttacctgt agtttggagg ccatggtggg gtagcagctt
     3901 ttgttcatta gaaccctctg ggatggtaga gacagggagc caggggttcc tgccacctga
     3961 gctgcacttg cctgggccag gggaacatct gaccataaga actagtttgc tcacgctatt
     4021 cgcagtacac acaagagttg caaagtgcta acctttgcct attagaaacc ctcccaaatc
     4081 caagccaaac taatggctac attgagtgtt ttctcagttt tgtggaaata gttagatgcc
     4141 aggacagttc aagccatttc cccctaatcc tctagaatat aagtcagagt gaaatttttg
     4201 agaccttccc atcttcaagt ctggctaacg catttactct gcttctctgg ttcccacctc
     4261 tttatctata acacattact ttctgtacag ggaaggaaga tgcatcaggt ctgatgtgat
     4321 acccccattc ccccaaatat aaatatatat aaatatacag aatgtattca tgtttctctc
     4381 ggtgttttat aggaattaac tgataatgct ctgttgataa tgagaaactt tctgtaacat
     4441 agctgtaaca tcctttccca ttttcctgtg atatggaatg cactggctag ggtcctgaga
     4501 gaatcgtgta agtctgtggt tatagatccc ccatgacagt attctttaat gggataatag
     4561 acctcagtgt gcagttacca ctcaagaagt gtacaagaga gttagaatcc acacttacag
     4621 ccagatatat cttgtaaact taaaatctgg ttaatttttt aagcatagga gtgggtggct
     4681 gcagtccttt taggctaact gtacttggtt tctgagctct gtcttctaca ttacatttat
     4741 ggctccttaa actgattgcc taaccaacca agggcaattc ccatccatcc atcacatggg
     4801 ttgtgggaag gatgcagcca tggtgtgcag cttccttcat gaaggattat ctggccatgg
     4861 tacctgactg cttcataact tgctgtcact ctgggtgaga taatgtgtct ttaaaaacag
     4921 tccctgtggc aggtcactgg gatataatgt acaacattct tagccatcat ttcttttctt
     4981 tttttttctt ttttttgttt tgccctgaga gactcccagt ggtttctact gagggctaaa
     5041 gggacgagct gttccctcat tgagcaagac cgttcgctgt tcatgatgtg ttttatgatg
     5101 gcttctttgg gagttgcttc ttcaacagtc tcaactgtgc tgtgggatct cctgatgctg
     5161 acttttgacc tttcgtttta ttaaaactaa ttagtgaaaa aaaaaaaaaa aaa
//
