LOCUS       NM_057210               4264 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus synaptic vesicle glycoprotein 2a (Sv2a), mRNA.
ACCESSION   NM_057210 XM_006232952
VERSION     NM_057210.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4264)
  AUTHORS   Li,C., Wang,Z., Ren,M., Ren,S., Wu,G. and Wang,L.
  TITLE     Synaptic vesicle protein 2A mitigates parthanatos via
            apoptosis-inducing factor in a rat model of pharmacoresistant
            epilepsy
  JOURNAL   CNS Neurosci Ther 30 (5), e14778 (2024)
   PUBMED   38801174
  REMARK    GeneRIF: Synaptic vesicle protein 2A mitigates parthanatos via
            apoptosis-inducing factor in a rat model of pharmacoresistant
            epilepsy.
REFERENCE   2  (bases 1 to 4264)
  AUTHORS   Fronczak,K.M., Li,Y., Henchir,J., Dixon,C.E. and Carlson,S.W.
  TITLE     Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in the
            Cortex and Hippocampus in a Rat Model of Traumatic Brain Injury
  JOURNAL   Mol Neurobiol 58 (11), 6006-6019 (2021)
   PUBMED   34435329
  REMARK    GeneRIF: Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in
            the Cortex and Hippocampus in a Rat Model of Traumatic Brain
            Injury.
REFERENCE   3  (bases 1 to 4264)
  AUTHORS   Thomsen,M.B., Jacobsen,J., Lillethorup,T.P., Schacht,A.C.,
            Simonsen,M., Romero-Ramos,M., Brooks,D.J. and Landau,A.M.
  TITLE     In vivo imaging of synaptic SV2A protein density in healthy and
            striatal-lesioned rats with [11C]UCB-J PET
  JOURNAL   J Cereb Blood Flow Metab 41 (4), 819-830 (2021)
   PUBMED   32538280
  REMARK    GeneRIF: In vivo imaging of synaptic SV2A protein density in
            healthy and striatal-lesioned rats with [11C]UCB-J PET.
REFERENCE   4  (bases 1 to 4264)
  AUTHORS   Ge,Y.X., Lin,Y.Y., Bi,Q.Q. and Chen,Y.J.
  TITLE     Brivaracetam Prevents the Over-expression of Synaptic Vesicle
            Protein 2A and Rescues the Deficits of Hippocampal Long-term
            Potentiation In Vivo in Chronic Temporal Lobe Epilepsy Rats
  JOURNAL   Curr Neurovasc Res 17 (4), 354-360 (2020)
   PUBMED   32407277
  REMARK    GeneRIF: Brivaracetam Prevents the Over-expression of Synaptic
            Vesicle Protein 2A and Rescues the Deficits of Hippocampal
            Long-term Potentiation In Vivo in Chronic Temporal Lobe Epilepsy
            Rats.
REFERENCE   5  (bases 1 to 4264)
  AUTHORS   Vanoye-Carlo,A. and Gomez-Lira,G.
  TITLE     Differential expression of SV2A in hippocampal glutamatergic and
            GABAergic terminals during postnatal development
  JOURNAL   Brain Res 1715, 73-83 (2019)
   PUBMED   30905653
  REMARK    GeneRIF: Differential expression of SV2A in hippocampal
            glutamatergic and GABAergic terminals during postnatal development.
REFERENCE   6  (bases 1 to 4264)
  AUTHORS   Haucke,V. and De Camilli,P.
  TITLE     AP-2 recruitment to synaptotagmin stimulated by tyrosine-based
            endocytic motifs
  JOURNAL   Science 285 (5431), 1268-1271 (1999)
   PUBMED   10455054
REFERENCE   7  (bases 1 to 4264)
  AUTHORS   Schivell,A.E., Batchelor,R.H. and Bajjalieh,S.M.
  TITLE     Isoform-specific, calcium-regulated interaction of the synaptic
            vesicle proteins SV2 and synaptotagmin
  JOURNAL   J Biol Chem 271 (44), 27770-27775 (1996)
   PUBMED   8910372
REFERENCE   8  (bases 1 to 4264)
  AUTHORS   Gingrich,J.A., Andersen,P.H., Tiberi,M., el Mestikawy,S.,
            Jorgensen,P.N., Fremeau,R.T. Jr. and Caron,M.G.
  TITLE     Identification, characterization, and molecular cloning of a novel
            transporter-like protein localized to the central nervous system
  JOURNAL   FEBS Lett 312 (2-3), 115-122 (1992)
   PUBMED   1426240
REFERENCE   9  (bases 1 to 4264)
  AUTHORS   Feany,M.B., Lee,S., Edwards,R.H. and Buckley,K.M.
  TITLE     The synaptic vesicle protein SV2 is a novel type of transmembrane
            transporter
  JOURNAL   Cell 70 (5), 861-867 (1992)
   PUBMED   1355409
REFERENCE   10 (bases 1 to 4264)
  AUTHORS   Bajjalieh,S.M., Peterson,K., Shinghal,R. and Scheller,R.H.
  TITLE     SV2, a brain synaptic vesicle protein homologous to bacterial
            transporters
  JOURNAL   Science 257 (5074), 1271-1273 (1992)
   PUBMED   1519064
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Mar 2, 2021 this sequence version replaced
            XM_006232952.4, NM_057210.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L05435.1, SRR26360194.355670.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000002.1  186430363-186430486
            125-1079            JAXUCZ010000002.1  186433893-186434847
            1080-1260           JAXUCZ010000002.1  186436320-186436500
            1261-1412           JAXUCZ010000002.1  186437436-186437587
            1413-1546           JAXUCZ010000002.1  186437668-186437801
            1547-1636           JAXUCZ010000002.1  186438361-186438450
            1637-1747           JAXUCZ010000002.1  186438665-186438775
            1748-1836           JAXUCZ010000002.1  186438936-186439024
            1837-2001           JAXUCZ010000002.1  186439566-186439730
            2002-2135           JAXUCZ010000002.1  186440031-186440164
            2136-2342           JAXUCZ010000002.1  186443099-186443305
            2343-2502           JAXUCZ010000002.1  186443850-186444009
            2503-4264           JAXUCZ010000002.1  186444400-186446161
FEATURES             Location/Qualifiers
     source          1..4264
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4264
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /note="synaptic vesicle glycoprotein 2a"
                     /db_xref="GeneID:117559"
                     /db_xref="RGD:619715"
     exon            1..124
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..1079
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..2686
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /note="synaptic vesicle protein 2; synaptic vesicle
                     protein 2A; synaptic vesicle transmembrane transporter
                     (SV2) RNA"
                     /codon_start=1
                     /product="synaptic vesicle glycoprotein 2A"
                     /protein_id="NP_476558.2"
                     /db_xref="GeneID:117559"
                     /db_xref="RGD:619715"
                     /translation="MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRR
                     SYSRFEEEEDDDDFPAPADGYYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIP
                     RAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKDREELAQQYETILRECG
                     HGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVG
                     AFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIV
                     FSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWR
                     VFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVF
                     SVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMM
                     MGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRG
                     GQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKF
                     VNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGR
                     LRMLAGSSVLSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKR
                     TTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQV
                     LQ"
     exon            1080..1260
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1412
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1546
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1636
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1747
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1836
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2001
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2135
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2342
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2502
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..4264
                     /gene="Sv2a"
                     /gene_synonym="Sv2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggcaggt ctgcagtgcc gcttcccctg gtaccgggag gagcagtcgt cgctgccgcc
       61 tcagccctgt ggctggaccc cctccctcac ccggggactc cctgacccgg ggaaccaagc
      121 tcaggtctcc agagcctccc agaagaaaaa taggcagccc tccctgaaat atcttggctc
      181 ctcagtttat cctttccaac ctggctcccc cttcccagtt cccctcccta ctccctgtct
      241 ccctccccaa ctcaccctac tgaactgggt gcagagcaaa gcccttttcg cccttttccc
      301 catctggact tctctggcca gttcctctta gtccgatccc aaagacactg gaacacattt
      361 ctaaagggtc ttcttgatcc ctccaattca ttgagcaaag ggctgaaaaa gaagcagaga
      421 gtaaggtaga gccagtgact cgcccccaag ccccatcatg gaagaaggct ttcgagaccg
      481 agcagcgttc atccgtgggg ccaaagacat tgccaaggaa gttaagaagc acgcggccaa
      541 gaaggtggtg aagggtctcg acagagtcca ggatgaatat tcccgaaggt cctactcccg
      601 ctttgaggag gaggaggatg atgatgactt ccctgcccct gctgacggct attaccgcgg
      661 agaaggggcc caggatgagg aggaaggtgg cgcttccagt gatgccactg agggccacga
      721 tgaggatgat gagatctacg agggagaata tcagggcatc ccccgggcag agtctggggg
      781 caaaggcgaa cggatggcag atggggcacc cctggctgga gtgagagggg gcttaagtga
      841 tggggagggt ccccctgggg gtcgcgggga ggcgcagcgg cgtaaagatc gggaagaatt
      901 ggctcagcag tatgagacca tcctccggga gtgcggccat ggtcgcttcc agtggacact
      961 ctacttcgtg ctgggtctgg cgctgatggc cgatggtgta gaggtctttg tggtgggctt
     1021 tgtgctgccc agtgctgaga aagatatgtg cctgtcggac tccaacaaag gcatgctagg
     1081 cctcattgtg tacctgggca tgatggtggg ggccttcctc tggggaggcc tggctgatcg
     1141 gctgggtcgg agacagtgtc tgctcatctc gctctcagtc aacagcgtct tcgctttctt
     1201 ctcatccttc gtccagggtt atggcacctt ccttttctgc cgcctccttt ctggggttgg
     1261 gattggtggt tccatcccca ttgtcttctc ctatttttcg gagtttctgg cccaggagaa
     1321 acgtggggag catttgagct ggctctgtat gttctggatg attggtggcg tgtatgcagc
     1381 tgcaatggcc tgggccatca tcccccacta tgggtggagt ttccagatgg gctctgctta
     1441 ccagttccac agctggaggg tctttgtcct cgtctgtgcc tttccctctg tgtttgccat
     1501 cggggctctg actacgcagc cggagagtcc ccgcttcttc ttagagaatg ggaagcacga
     1561 tgaggcctgg atggtgctga agcaggttca tgacaccaac atgcgagcca agggccatcc
     1621 tgagcgagtc ttctcagtaa cccacattaa aacgattcat caggaggatg aattgattga
     1681 gatccagtca gacacaggaa cctggtacca gcgctgggga gtgcgggctt tgagcctggg
     1741 gggtcaggtt tgggggaact tcctctcctg cttcagtcca gagtaccggc gcatcactct
     1801 gatgatgatg ggggtatggt tcaccatgtc cttcagctac tacggtttga ctgtctggtt
     1861 tcccgacatg atccgccatc tccaggctgt ggactatgca gcccgaacca aagtgttccc
     1921 aggggagcgc gtggagcacg tgacatttaa cttcacactg gagaatcaga tccaccgagg
     1981 gggacagtac ttcaatgaca agttcatcgg gctgcgtctg aagtcagtgt cctttgagga
     2041 ttccctgttt gaggaatgtt actttgaaga tgtcacatcc agcaacacat tcttccgcaa
     2101 ctgcacattc atcaacaccg tgttctacaa cacggacctg tttgagtaca agttcgtgaa
     2161 cagccgcctg gtgaacagca cattcctgca caataaggaa ggttgcccac tagatgtgac
     2221 agggacgggc gaaggtgcct acatggtgta ctttgtcagc ttcttgggga cactggctgt
     2281 gctccctgga aatattgtgt ctgctctgct catggacaag attggcaggc tcagaatgct
     2341 tgctggttcc agtgtgttgt cctgtgtttc ctgcttcttc ctgtcttttg ggaacagtga
     2401 gtcagccatg atcgctctgc tctgcctttt tgggggagtc agtattgcat cctggaacgc
     2461 gctggacgtg ctgactgttg aactctaccc ttccgacaag aggacgacgg ccttcggctt
     2521 cctgaatgcc ctgtgtaagc tggcagctgt actgggcatc agcatcttca cgtcctttgt
     2581 gggaatcacc aaggccgctc ccatcctctt cgcctcagct gcgcttgccc ttggtagctc
     2641 tctggctctg aagctgcctg agacccgggg acaggtgctg cagtgaggga tgggggagtg
     2701 tctcaggggc tttagggatg gcaggcacac tgtgaccaat aatttctttt atccctaccc
     2761 tgccctgctg tcctggtcct actccgtgtt tggtgtctta gctgtgtgcc tgtgtgcatg
     2821 tgtgtgaccc tgacgggcag gggctacggg gagggtccct ttgtcccatg tttgggagga
     2881 gggactcccc acctgctgcc accctcaact ttgcacaagg agaaggctga gctgcatcct
     2941 tctctccctc agtgttagca ggggtgggga cgactgtttc tctgctccag gtgttccaga
     3001 atttctgcct ttcccatcat tccctccgcc taggccctgg tgaaccacag gtatggagtt
     3061 atagtggggg ctgaggcttg gaccaaaaga acttcttgag tgggagcctc ccaaggatgc
     3121 tggggagtag caataaacct tagcctccgt tttcacctca attcaggcta caagtgtgaa
     3181 gcctggattt tatggaatta gttttctgat tcttatttat atgtaagttc tgaggcagct
     3241 tagctggact gtgtgtggat gtatacatac actcatatgt gtgtgtgtgt gcgcgcgtgc
     3301 gtgtgcgtgt gtgtatgtgt gccatggggt aggggtacca ctatactgtt caattataag
     3361 ccaagagtag tagtttcagt gagcacacac acaacactgt ttttctatcg taactcccag
     3421 aatcttgtac ctgtgttggg gctgcaggca gaagtccttg gtcaggctgg ggtgagccct
     3481 gcaatcttgg gggacctgag ggcacctgac aaggactttc tccttcctct agagaggttc
     3541 tacccactag ccacagccct cccatctgac ctgtccacac aggcagtgta tcagaggaaa
     3601 gaaagggaaa ataaccaggc acacatggtc aaaccagcag gtctgaaagc acaagaagct
     3661 ggggcagggg caggaagcag gggtccatcc cctaaccctt ctcaaaaagg ctgggtcgtg
     3721 agggacccct aatgcaggga cctgaagcct cagtttcccc atcttgccct tccacagaac
     3781 agcctctgta ggtagagctg ccccccgtcc taccctactc ttgtggctgc tttctttggt
     3841 actcttccca ctcccaccgt agctgtgacg tgttgtagtt tttagctgtt tgtaaaatgt
     3901 taaaaaaaaa aaaaagttaa aaggaagtta aactaaaaaa aaaaaaaatc caaattcacc
     3961 ctccttatgc tgtgtctggt gccctcaacc ctaaggccat tccgattttg taacactgaa
     4021 ccaggtggtg actgtttaat cgtgtctgtg ctcaaaggac tgccttctcc tccagtgccc
     4081 agtgtgtgtg tgccccttcc ctcatcattc cgttgctgga cgtggccctc tcccttacgt
     4141 ccccagggga gacacagcca cttgtttgtc tcccggggag ccctgaacct gactccattg
     4201 atgtgaaaaa atgaaatgaa aaatactgct gaaaaataaa gggtctgaac ccttaaaact
     4261 caaa
//
