LOCUS       NM_001106956            3135 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SUV39H1 histone lysine methyltransferase
            (Suv39h1), transcript variant 1, mRNA.
ACCESSION   NM_001106956 XM_001063363 XM_217594
VERSION     NM_001106956.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3135)
  AUTHORS   Yang,G., Weng,X., Zhao,Y., Zhang,X., Hu,Y., Dai,X., Liang,P.,
            Wang,P., Ma,L., Sun,X., Hou,L., Xu,H., Fang,M., Li,Y., Jenuwein,T.,
            Xu,Y. and Sun,A.
  TITLE     The histone H3K9 methyltransferase SUV39H links SIRT1 repression to
            myocardial infarction
  JOURNAL   Nat Commun 8, 14941 (2017)
   PUBMED   28361889
  REMARK    GeneRIF: SUV39H augments intracellular reactive oxygen species
            levels in a SIRT1-dependent manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3135)
  AUTHORS   Zhang,J., Liang,L., Miao,X., Wu,S., Cao,J., Tao,B., Mao,Q., Mo,K.,
            Xiong,M., Lutz,B.M., Bekker,A. and Tao,Y.X.
  TITLE     Contribution of the Suppressor of Variegation 3-9 Homolog 1 in
            Dorsal Root Ganglia and Spinal Cord Dorsal Horn to Nerve
            Injury-induced Nociceptive Hypersensitivity
  JOURNAL   Anesthesiology 125 (4), 765-778 (2016)
   PUBMED   27483126
  REMARK    GeneRIF: SUV39H1 plays a critical role in chromosome dynamics and
            development, neurite outgrowth, and ethanol-induced neuroadaptation
            through gene-specific silencing.
REFERENCE   3  (bases 1 to 3135)
  AUTHORS   Yang,B., Yang,J., Bai,J., Pu,P., Liu,J., Wang,F. and Ruan,B.
  TITLE     Suv39h1 protects from myocardial ischemia-reperfusion injury in
            diabetic rats
  JOURNAL   Cell Physiol Biochem 33 (4), 1176-1185 (2014)
   PUBMED   24752040
  REMARK    GeneRIF: Overexpression of Suv39h1 results in the de-activation of
            proinflammatory pathways and reduced apoptosis and myocardial
            injury.
REFERENCE   4  (bases 1 to 3135)
  AUTHORS   He,Y., Korboukh,I., Jin,J. and Huang,J.
  TITLE     Targeting protein lysine methylation and demethylation in cancers
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 44 (1), 70-79 (2012)
   PUBMED   22194015
  REMARK    Review article
REFERENCE   5  (bases 1 to 3135)
  AUTHORS   Bosch-Presegue,L., Raurell-Vila,H., Marazuela-Duque,A.,
            Kane-Goldsmith,N., Valle,A., Oliver,J., Serrano,L. and Vaquero,A.
  TITLE     Stabilization of Suv39H1 by SirT1 is part of oxidative stress
            response and ensures genome protection
  JOURNAL   Mol Cell 42 (2), 210-223 (2011)
   PUBMED   21504832
  REMARK    GeneRIF: SirT1 preserves heterochromatin structure: it modulates
            Suv39h1 protein levels in stress conditions by preventing
            MDM2-mediated polyubiquitination at K87.
REFERENCE   6  (bases 1 to 3135)
  AUTHORS   Davison,J.M., Mellott,T.J., Kovacheva,V.P. and Blusztajn,J.K.
  TITLE     Gestational choline supply regulates methylation of histone H3,
            expression of histone methyltransferases G9a (Kmt1c) and Suv39h1
            (Kmt1a), and DNA methylation of their genes in rat fetal liver and
            brain
  JOURNAL   J Biol Chem 284 (4), 1982-1989 (2009)
   PUBMED   19001366
  REMARK    GeneRIF: mRNA and protein expression of histone methyltransferases
            G9a and Suv39h1 were directly related to the availability of
            choline
REFERENCE   7  (bases 1 to 3135)
  AUTHORS   Renthal,W., Carle,T.L., Maze,I., Covington,H.E. 3rd, Truong,H.T.,
            Alibhai,I., Kumar,A., Montgomery,R.L., Olson,E.N. and Nestler,E.J.
  TITLE     Delta FosB mediates epigenetic desensitization of the c-fos gene
            after chronic amphetamine exposure
  JOURNAL   J Neurosci 28 (29), 7344-7349 (2008)
   PUBMED   18632938
REFERENCE   8  (bases 1 to 3135)
  AUTHORS   Pogribny,I.P., Ross,S.A., Tryndyak,V.P., Pogribna,M., Poirier,L.A.
            and Karpinets,T.V.
  TITLE     Histone H3 lysine 9 and H4 lysine 20 trimethylation and the
            expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in
            hepatocarcinogenesis induced by methyl deficiency in rats
  JOURNAL   Carcinogenesis 27 (6), 1180-1186 (2006)
   PUBMED   16497704
  REMARK    GeneRIF: Suv4-20h2 and Suv-39h1 histone methyltransferases are
            expressed and Histone H3 lysine 9 and H4 lysine 20 are
            trimethylated in hepatocarcinogenesis induced by methyl deficiency
            in rats [Suv4-20h2 and Suv-39h1]
REFERENCE   9  (bases 1 to 3135)
  AUTHORS   Liu,D.X., Nath,N., Chellappan,S.P. and Greene,L.A.
  TITLE     Regulation of neuron survival and death by p130 and associated
            chromatin modifiers
  JOURNAL   Genes Dev 19 (6), 719-732 (2005)
   PUBMED   15769944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 25, 2022 this sequence version replaced NM_001106956.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.60585.1,
                                           SRR26643292.64989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               JAXUCZ010000021.1  17093176-17093668
            494-639             JAXUCZ010000021.1  17095341-17095486
            640-1302            JAXUCZ010000021.1  17096653-17097315
            1303-1449           JAXUCZ010000021.1  17103294-17103440
            1450-1579           JAXUCZ010000021.1  17103526-17103655
            1580-3135           JAXUCZ010000021.1  17104387-17105942
FEATURES             Location/Qualifiers
     source          1..3135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..3135
                     /gene="Suv39h1"
                     /gene_synonym="RGD1565028; Suv39h1l1"
                     /note="SUV39H1 histone lysine methyltransferase"
                     /db_xref="GeneID:302553"
                     /db_xref="RGD:1565028"
     exon            1..493
                     /gene="Suv39h1"
                     /gene_synonym="RGD1565028; Suv39h1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..1713
                     /gene="Suv39h1"
                     /gene_synonym="RGD1565028; Suv39h1l1"
                     /EC_number="2.1.1.354"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone-lysine N-methyltransferase SUV39H1; suppressor of
                     variegation 3-9 homolog 1-like 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SUV39H1
                     isoform 1"
                     /protein_id="NP_001100426.1"
                     /db_xref="GeneID:302553"
                     /db_xref="RGD:1565028"
                     /translation="MGEPATLGCSVCCKSSWNQLQDLCRLAKLSCPALGVSKKNLYDF
                     EVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCVRILKQFHKDLERELVRRH
                     RRSKPPRHLDPNLANYLVQKAKQRRALQRWEQELNAKRSHLGRITVENEVDLDGPPRS
                     FVYINEYRVGEGITLNQVAVGCECQDCLLAPTGGCCPGASLHKFAYNDQGQVRLKAGQ
                     PIYECNSRCCCGYDCPNRVVQKGIRYNLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVG
                     EIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVY
                     NVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGS
                     PKKRVRIECKCGTTACRKYLF"
     exon            494..639
                     /gene="Suv39h1"
                     /gene_synonym="RGD1565028; Suv39h1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..1302
                     /gene="Suv39h1"
                     /gene_synonym="RGD1565028; Suv39h1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1449
                     /gene="Suv39h1"
                     /gene_synonym="RGD1565028; Suv39h1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1579
                     /gene="Suv39h1"
                     /gene_synonym="RGD1565028; Suv39h1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..3135
                     /gene="Suv39h1"
                     /gene_synonym="RGD1565028; Suv39h1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc gaggcctttt aggcccgaat gtcgttagct gtggagaaag atggcggaaa
       61 atttaaaagg tgaagctgtg gtggtagaga cgcaagctac tggcccggcc gagtagaatg
      121 gagggaaggt gtccagggtt ccgagccggg cgtccggagc cacggaacct ggagctagaa
      181 ggccggcgcg gaaaacgtgg ggcccgagag cgcgggccgg gcgcgcgggc agggcggggc
      241 tgaggggagg gggcgcgtgc ttcggccgcg gggggcgcgg ggctgcgcag actgcgcgcg
      301 gggtttctcg gccgcgcgcg gctggccggc gcgcctacgc gcgtgagaga gtcctgaaga
      361 gaaggttgcg gccacgcgcg ggaaaagcgg ctctcagtga ccgttaccct ttcggtttcc
      421 acgggagacg ccggaagggg aggaagaagt ggaacggacc cccttctcaa aatgggggaa
      481 ccggcgactc taggttgcag tgtgtgctgt aaatcttcct ggaatcagct gcaggatctg
      541 tgccgactag ccaagctttc ttgtcctgcc cttggtgttt ctaagaagaa tctgtatgac
      601 tttgaagttg aatacctgtg tgattataag aagatccgtg agcaggagta ttacctggtt
      661 aaatggcgtg ggtatcctga ctcagagaac acctgggagc cacggcagaa tctcaaatgt
      721 gtgcgcattc ttaagcagtt ccacaaggac ttagaaagag agcttgtccg gcgacaccgc
      781 cggtcaaagc cacccaggca tctggaccca aacttagcca attacctggt gcagaaggcc
      841 aagcagaggc gggcactgca gcgttgggaa caagagctca atgccaagcg cagccatctg
      901 gggcggatca ctgtggagaa tgaggtagac ctggatggcc ctccaaggtc ctttgtctat
      961 atcaatgagt atcgagttgg tgagggcatc accctcaacc aggtagctgt tggctgtgag
     1021 tgccaggact gtctgttggc acccactgga ggctgttgcc ctggagcatc cctgcacaag
     1081 tttgcctaca atgaccaagg ccaggtgcga ctgaaagctg ggcagcccat ctacgagtgc
     1141 aactctcgct gttgctgtgg ctatgactgc ccaaaccgtg tagtccagaa aggcatccgc
     1201 tacaacctct gcatcttccg cactgatgat ggccgaggct ggggtgtccg cacgctggaa
     1261 aagatccgca aaaatagctt tgttatggag tatgtgggag agattattac ctcagaggag
     1321 gcagagcgga ggggccagat ctacgaccgc cagggcgcca cctacctctt tgacctggac
     1381 tacgtggagg acgtatatac cgtggatgcc gcctattatg gcaacatctc tcactttgtc
     1441 aaccatagtt gtgatcccaa cctgcaggtg tacaacgtat tcatagacaa ccttgatgag
     1501 cgactacccc gcatcgcatt ctttgccaca agaaccatct gggcgggcga ggagctcacc
     1561 tttgattaca acatgcaagt ggaccccgtg gacatggaga gtacccgaat ggactccaac
     1621 tttggcctgg cagggctccc cggctccccc aagaaacggg tccgtattga atgcaaatgt
     1681 gggacaacag cttgccgaaa atacctcttc tagccctgag aagtctgagg ccagactaac
     1741 tgaaggggcc tgaagccacc ttcctcttct ctactgctac cctcttgtca agaatgacca
     1801 tcaatcagag ccttgtctgc ctccacttgt cctcacctgc cccaacctgc tccagggtca
     1861 gggctgttgt gaggactaac tcccggtacc ctttccctgt tcctttcccc tatccaggcc
     1921 catcaggcat tgcacttaaa actcccagcc ccattttcag aagcatattt ttcacatcag
     1981 gattccctag atttggaatt catgtcaatg gaggtccaaa gactgaaaag actgagcaac
     2041 tcagccccaa agcagatttt tttctctgca gctctatgta gttagttcag gctggcgttg
     2101 gacctttaat cctcctgtct cagctttcct catgatgaaa ttataggtgt aaacccagct
     2161 aattgtatct gctaattttc taattgtatc tgcttcagct ctgagcccga gtgacctgtt
     2221 gcaggcctct tcactgctct atgaggaagc aacccctagg cagacagaca tcagagctga
     2281 gataccagcc caacatcaaa ctggatcagc aaccacgggg cctttgtact catgaaagaa
     2341 aaggcaatct ccagaaaggc tgattctgct cattgtgctt ttaatgctgg ctaatactaa
     2401 ccttaagacg catagggttg caaagagagt tgcaggtctg aaaagtagtt gcccaaatcc
     2461 catcagaatg ggaatgaagt aaatacctct ttgaaagccc ctcagaaggg ttagaactaa
     2521 gttttaccat caggaagtag agtgctgggc ttactggaaa cccagccatg gcatttgatg
     2581 gccactagaa ttagaagctg gaaccaagat ctaggtattc tgtagaaagc acttaaaaag
     2641 acaataacgt gcatcgatta gaaggtgatg tgatgccagg cacttggtag agcacctggt
     2701 ccatatggat tgtctcaggg aagccttgaa aaccacagag gtggagccca ggaaaaagcc
     2761 catgtgacag aaggcaatgt ctaggcctaa aatacttgtc agctccaagt attcacctgg
     2821 gtccacttgt ctcaaagtta actgcctaga gttgtacaaa aggcaaagat tctgatggct
     2881 gccttgtccc ctgcttcccc acctccagga agcttttcct gagttcctat acccagagta
     2941 cccctttgtg aaactctgta ccctgctacc agatgccagg tctgtgtgtg tattttgtat
     3001 atatgtgtcc tgcccacact ccccaggctg accttcaggc atggactgaa tctggttttc
     3061 tgtgtaccct cctcagccct ctctagcctg gagtgcacac caataaactt tgttgttgaa
     3121 ttaataagct ggaga
//
