LOCUS       NM_001012462            2415 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Suv3 like RNA helicase (Supv3l1), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001012462 XM_215393
VERSION     NM_001012462.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2415)
  AUTHORS   Pietras,Z., Wojcik,M.A., Borowski,L.S., Szewczyk,M., Kulinski,T.M.,
            Cysewski,D., Stepien,P.P., Dziembowski,A. and Szczesny,R.J.
  TITLE     Dedicated surveillance mechanism controls G-quadruplex forming
            non-coding RNAs in human mitochondria
  JOURNAL   Nat Commun 9 (1), 2558 (2018)
   PUBMED   29967381
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2415)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2415)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2415)
  AUTHORS   Szczesny,R.J., Borowski,L.S., Brzezniak,L.K., Dmochowska,A.,
            Gewartowski,K., Bartnik,E. and Stepien,P.P.
  TITLE     Human mitochondrial RNA turnover caught in flagranti: involvement
            of hSuv3p helicase in RNA surveillance
  JOURNAL   Nucleic Acids Res 38 (1), 279-298 (2010)
   PUBMED   19864255
REFERENCE   5  (bases 1 to 2415)
  AUTHORS   Wang,D.D., Shu,Z., Lieser,S.A., Chen,P.L. and Lee,W.H.
  TITLE     Human mitochondrial SUV3 and polynucleotide phosphorylase form a
            330-kDa heteropentamer to cooperatively degrade double-stranded RNA
            with a 3'-to-5' directionality
  JOURNAL   J Biol Chem 284 (31), 20812-20821 (2009)
   PUBMED   19509288
REFERENCE   6  (bases 1 to 2415)
  AUTHORS   Khidr,L., Wu,G., Davila,A., Procaccio,V., Wallace,D. and Lee,W.H.
  TITLE     Role of SUV3 helicase in maintaining mitochondrial homeostasis in
            human cells
  JOURNAL   J Biol Chem 283 (40), 27064-27073 (2008)
   PUBMED   18678873
REFERENCE   7  (bases 1 to 2415)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   8  (bases 1 to 2415)
  AUTHORS   Pereira,M., Mason,P., Szczesny,R.J., Maddukuri,L., Dziwura,S.,
            Jedrzejczak,R., Paul,E., Wojcik,A., Dybczynska,L., Tudek,B.,
            Bartnik,E., Klysik,J., Bohr,V.A. and Stepien,P.P.
  TITLE     Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss
            of the SUV3 gene results in mouse embryonic lethality
  JOURNAL   Mech Ageing Dev 128 (11-12), 609-617 (2007)
   PUBMED   17961633
REFERENCE   9  (bases 1 to 2415)
  AUTHORS   Szczesny,R.J., Obriot,H., Paczkowska,A., Jedrzejczak,R.,
            Dmochowska,A., Bartnik,E., Formstecher,P., Polakowska,R. and
            Stepien,P.P.
  TITLE     Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by
            a caspase- and AIF-dependent pathway
  JOURNAL   Biol Cell 99 (6), 323-332 (2007)
   PUBMED   17352692
REFERENCE   10 (bases 1 to 2415)
  AUTHORS   Minczuk,M., Piwowarski,J., Papworth,M.A., Awiszus,K.,
            Schalinski,S., Dziembowski,A., Dmochowska,A., Bartnik,E.,
            Tokatlidis,K., Stepien,P.P. and Borowski,P.
  TITLE     Localisation of the human hSuv3p helicase in the mitochondrial
            matrix and its preferential unwinding of dsDNA
  JOURNAL   Nucleic Acids Res 30 (23), 5074-5086 (2002)
   PUBMED   12466530
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089883.1.
            
            On Apr 20, 2005 this sequence version replaced XM_215393.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089883.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2415
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..2415
                     /gene="Supv3l1"
                     /note="Suv3 like RNA helicase"
                     /db_xref="GeneID:294385"
                     /db_xref="RGD:1305565"
     exon            1..286
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2346
                     /gene="Supv3l1"
                     /EC_number="3.6.4.13"
                     /note="ATP-dependent RNA helicase SUPV3L1, mitochondrial;
                     SUV3-like helicase; SUV3-like protein 1; suppressor of
                     var1 3-like protein 1"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase SUPV3L1,
                     mitochondrial precursor"
                     /protein_id="NP_001012480.1"
                     /db_xref="GeneID:294385"
                     /db_xref="RGD:1305565"
                     /translation="MSLPRCALLWARLPAGRGAGPRAAPCSALRALVGSFPGASGRVP
                     CLAASSSASGGSKAPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKILDKFYK
                     RQEIQKLSADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIVLNDICFSAAHVDDLFP
                     FFLRHAKQIFPVLECKDDLRQISDLRRPPNWYPEARAIQRKIIFHSGPTNSGKTYHAI
                     QRYLSATSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERLTVEPEGKQATHVSCTV
                     EMCNVATPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGESAAIDLVTELLY
                     TTGEEVEVQKYERLTPISVLDRALESLDNLRPGDCIVCFSKNDIYSVSRQIEIRGLES
                     AVIYGSLPPGTKLAQARKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSINE
                     KGEKELEPITTSQALQIAGRAGRFSSHFKEGEVTTMHRDDLALLKEILNRPVDPIQAA
                     GLHPTAEQIEMFAYHLPETTLSNLIDIFVDFAQVDGQYFVCNMDDFKFSAELIQHIPL
                     SLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKD
                     LMDLEAVHDVFDLYLWLSYRFIDMFPDSSFVRSLQKELDVIIQEGVHNITKLIKISES
                     HKLLNLEPSGSQSRLPGASKSPARRTRGTKTGNKAAEPPSPSDKELPLASRLVQQGLL
                     TADMLKQLQKEWLTQRPEQGKEKVGTRRKKKDPNSD"
     exon            287..364
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..472
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..587
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..756
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..868
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..946
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1038
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1219
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1313
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1533
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1614
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1791
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1940
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2389
                     /gene="Supv3l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagccgcgg cctcaatgtc cttgcctaga tgtgccctgc tgtgggctcg gctcccggcg
       61 gggcgcgggg ctgggccccg ggcggctcct tgctccgctc ttcgcgctct cgtggggtcg
      121 ttccccgggg cttcaggacg cgttccctgc ctggccgcct cctcctctgc ctctggtggc
      181 tccaaagccc cgaacacgtc cttgttcgtg ccgctgacag tgaagcctca gggtcccagc
      241 gccgatggcg acgtaggcgc cgagcttact cggcctctgg acaagaatga agtaaagaag
      301 atcttagaca agttctataa gcggcaagaa attcagaagc tgagtgctga ctatggactt
      361 gatgctcgtc tcttccacca agctttcata agcttcagaa attacatcat gcagtctcat
      421 tccctggacg tggacatcca cattgtcttg aatgacatct gcttcagtgc agctcatgtg
      481 gacgatttgt ttccgttttt cttgagacat gccaaacaga tatttcctgt attggaatgc
      541 aaggatgacc tacgtcaaat cagtgacctg aggagaccgc ccaactggta cccagaagcc
      601 agagccatac agcggaagat aatattccac tcaggtccca ccaacagtgg gaagacctac
      661 cacgcaatcc agagatactt gtcagcgacc tccggcgtgt actgcggccc tctgaagctg
      721 ctggcgcatg agatctttga gaagagcaat gccgctggtg tgccgtgtga cttggtgaca
      781 ggtgaagagc ggctgacggt tgaacctgag gggaaacaag ccacccatgt ctcttgtact
      841 gtggagatgt gcaacgttgc aactccttat gaagtggctg tgatcgatga aatccagatg
      901 attcgggacc cagccagagg atgggcttgg accagagctc tgctaggact ctgtgctgag
      961 gaagtccacc tgtgcggaga atctgctgcc attgacctgg tcactgagct cctgtacacc
     1021 actggggagg aggtggaggt tcagaagtac gagaggctta cccccatttc tgtgctggac
     1081 cgtgcactgg agtctttaga caaccttcgg cctggggact gcattgtctg ctttagcaag
     1141 aatgacattt attctgtgag ccgacagatt gaaattcggg gcctggaatc cgcagtgata
     1201 tacggcagcc tgccgcctgg aaccaaactt gctcaagcaa gaaagtttaa tgaccccaat
     1261 gatccgtgca aaatcctcgt agctacagat gcgattggca tgggacttaa tttgagcata
     1321 aggagaatta ttttttactc ccttataaag cccagcatca atgaaaaggg agagaaggag
     1381 ctggagccca tcaccacctc ccaagccctg cagatcgcgg gcagagccgg cagattcagc
     1441 tcacacttta aagaggggga ggtgaccaca atgcaccgag acgacttggc tttattgaag
     1501 gagattttga atagacctgt ggatcctata caggccgctg gacttcaccc aactgctgag
     1561 cagatcgaga tgtttgccta ccacctcccc gagacaacgc tgtccaatct cattgatatt
     1621 tttgtagact ttgcacaagt cgatgggcag tactttgtct gcaacatgga tgattttaag
     1681 ttctctgcag agctgatcca gcatattcca ctcagtctcc gggtgaggta tgtgttctgc
     1741 acagccccca tcaataagaa acagcctttc gtctgctcgt cgctcttaca gtttgccagg
     1801 cagtacagca ggaatgagcc cctgaccttt gcctggctac gccggtacat caagtggcct
     1861 ctgcttccac ctaagaacat taaagacctc atggatcttg aagctgtcca tgatgtcttt
     1921 gatctttacc tgtggctaag ctaccgattt attgatatgt ttccagactc cagctttgtt
     1981 cggagtctcc agaaagaact ggatgtcatt atccaagaag gtgtgcacaa tatcaccaaa
     2041 ctgattaaaa tctctgagtc acacaagctc ttgaatctgg agccatcagg gagccagtca
     2101 cgtttgccag gagcctccaa gagcccagct agaaggacac gtggcactaa aacagggaat
     2161 aaggcggcag agccacccag ccccagtgac aaggagctgc cccttgcctc taggctggtg
     2221 cagcaaggac tcctcactgc agacatgctg aagcagcttc agaaggagtg gctgacacaa
     2281 cggccagaac aaggcaaaga gaaagtgggg acacggagaa agaagaagga ccccaactct
     2341 gattagtctt tttttaattt tgcaaataaa aatcaatttt aaatccttaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaa
//
