LOCUS       NM_001105828            1107 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus SPT4 homolog, DSIF elongation factor subunit
            (Supt4h1), mRNA.
ACCESSION   NM_001105828 XM_001081172 XM_213415
VERSION     NM_001105828.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1107)
  AUTHORS   Kwak,H. and Lis,J.T.
  TITLE     Control of transcriptional elongation
  JOURNAL   Annu Rev Genet 47, 483-508 (2013)
   PUBMED   24050178
  REMARK    Review article
REFERENCE   2  (bases 1 to 1107)
  AUTHORS   Schneider,D.A.
  TITLE     RNA polymerase I activity is regulated at multiple steps in the
            transcription cycle: recent insights into factors that influence
            transcription elongation
  JOURNAL   Gene 493 (2), 176-184 (2012)
   PUBMED   21893173
  REMARK    Review article
REFERENCE   3  (bases 1 to 1107)
  AUTHORS   Flynn,R.A., Almada,A.E., Zamudio,J.R. and Sharp,P.A.
  TITLE     Antisense RNA polymerase II divergent transcripts are P-TEFb
            dependent and substrates for the RNA exosome
  JOURNAL   Proc Natl Acad Sci U S A 108 (26), 10460-10465 (2011)
   PUBMED   21670248
REFERENCE   4  (bases 1 to 1107)
  AUTHORS   Wada,T., Takagi,T., Yamaguchi,Y., Watanabe,D. and Handa,H.
  TITLE     Evidence that P-TEFb alleviates the negative effect of DSIF on RNA
            polymerase II-dependent transcription in vitro
  JOURNAL   EMBO J 17 (24), 7395-7403 (1998)
   PUBMED   9857195
REFERENCE   5  (bases 1 to 1107)
  AUTHORS   Wada,T., Takagi,T., Yamaguchi,Y., Ferdous,A., Imai,T., Hirose,S.,
            Sugimoto,S., Yano,K., Hartzog,G.A., Winston,F., Buratowski,S. and
            Handa,H.
  TITLE     DSIF, a novel transcription elongation factor that regulates RNA
            polymerase II processivity, is composed of human Spt4 and Spt5
            homologs
  JOURNAL   Genes Dev 12 (3), 343-356 (1998)
   PUBMED   9450929
REFERENCE   6  (bases 1 to 1107)
  AUTHORS   Hartzog,G.A., Basrai,M.A., Ricupero-Hovasse,S.L., Hieter,P. and
            Winston,F.
  TITLE     Identification and analysis of a functional human homolog of the
            SPT4 gene of Saccharomyces cerevisiae
  JOURNAL   Mol Cell Biol 16 (6), 2848-2856 (1996)
   PUBMED   8649394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 30, 2021 this sequence version replaced NM_001105828.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228457.1, BC168730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000010.1  73036574-73036718
            146-252             JAXUCZ010000010.1  73037206-73037312
            253-308             JAXUCZ010000010.1  73041391-73041446
            309-362             JAXUCZ010000010.1  73041849-73041902
            363-1107            JAXUCZ010000010.1  73042077-73042821
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1107
                     /gene="Supt4h1"
                     /gene_synonym="Supt4h2"
                     /note="SPT4 homolog, DSIF elongation factor subunit"
                     /db_xref="GeneID:287608"
                     /db_xref="RGD:1306372"
     exon            1..145
                     /gene="Supt4h1"
                     /gene_synonym="Supt4h2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..430
                     /gene="Supt4h1"
                     /gene_synonym="Supt4h2"
                     /note="suppressor of Ty 4 homolog 2; suppressor of Ty 4
                     homolog 1"
                     /codon_start=1
                     /product="transcription elongation factor SPT4"
                     /protein_id="NP_001099298.2"
                     /db_xref="GeneID:287608"
                     /db_xref="RGD:1306372"
                     /translation="MALETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCDAYLQMKG
                     NREMVYDCTSSSFDGIIAMMSPEDSWVSKWQRVSNFKPGVYAVSVTGRLPQGIVRELK
                     SRGVAYKSRDTAIKT"
     exon            146..252
                     /gene="Supt4h1"
                     /gene_synonym="Supt4h2"
                     /inference="alignment:Splign:2.1.0"
     exon            253..308
                     /gene="Supt4h1"
                     /gene_synonym="Supt4h2"
                     /inference="alignment:Splign:2.1.0"
     exon            309..362
                     /gene="Supt4h1"
                     /gene_synonym="Supt4h2"
                     /inference="alignment:Splign:2.1.0"
     exon            363..1107
                     /gene="Supt4h1"
                     /gene_synonym="Supt4h2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcgaccg gcattctggg taataatctg tttacttcct gtggccgtgg aacccgtatt
       61 atcgtatacg gcgagaatgg ccctggagac ggtgccaaag gacctgcggc atctgcgagc
      121 ttgtttgctg tgctcgttag tcaagactat agaccagttt gaatatgatg ggtgtgacaa
      181 ttgcgatgca tacctacaaa tgaagggcaa cagagagatg gtgtacgact gcaccagctc
      241 ttcatttgat ggaatcatcg cgatgatgag tccagaggac agctgggtct ccaagtggca
      301 gcgcgtcagt aactttaagc caggtgtata tgctgtgtca gtcactggtc gtctgcccca
      361 aggaattgtg cgggagctga aaagtcgagg agtggcctac aaatcgagag acacagcaat
      421 aaagacctag ctagatgcag gccatagcgt cttgttctct acttctgtcc ttgttttctt
      481 gtggaactaa aaggtgggac ccaaagactc cttgccctcc agctcaggat cagcagaccc
      541 cgtgaaggca gcacatccgg ccttaagtca cctccctttc tctgaccact ggtgaagtgg
      601 gagtgtctga gtggattctc agaggctgta tcaggagagt aagatgctga tttcccacct
      661 ctgttcaggg ttttgccttt gtccatgggc aggactttgg ttcaaatgcc aataaaacaa
      721 acctttggag tacttaaaca aaacttaaag agtactaagg cctgtgcctt tgtacctttt
      781 cctctcagga tgaagcctca cttccctgct gaccggaagt ccaatatcct gtcctctctc
      841 cctggtgtac cctcctttga aggaatcaag gctgcttggt gcctttttcc ttgaccctct
      901 ttcacttccc tctcttcctt tgtctctttt ctttgctcct gttgtacctt tgccaggtga
      961 tctgggtttt tgtgtttcca tggaaaacag gccctccttt ggctaagaag ggagccatgg
     1021 gtaatgccac attggccaag atgtctttct ttcttttctt ttttttttaa taataaaaca
     1081 tttaccatat attctcacta aatcaca
//
