LOCUS       NM_031127               2150 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus sulfite oxidase (Suox), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_031127
VERSION     NM_031127.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2150)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2150)
  AUTHORS   Kucukatay,V., Bor-Kucukatay,M., Atsak,P. and Agar,A.
  TITLE     Effect of ingested sulfite on hippocampus antioxidant enzyme
            activities in sulfite oxidase competent and deficient rats
  JOURNAL   Int J Neurosci 117 (7), 971-983 (2007)
   PUBMED   17613108
  REMARK    GeneRIF: Results suggest that hippocampus antioxidant enzymes
            (defense mechanism against the oxidative challenge) are
            up-regulated by ingested sulfites in sulfite oxidase competent
            rats.
REFERENCE   3  (bases 1 to 2150)
  AUTHORS   Meneses-Lorente,G., Guest,P.C., Lawrence,J., Muniappa,N.,
            Knowles,M.R., Skynner,H.A., Salim,K., Cristea,I.,
            Mortishire-Smith,R., Gaskell,S.J. and Watt,A.
  TITLE     A proteomic investigation of drug-induced steatosis in rat liver
  JOURNAL   Chem Res Toxicol 17 (5), 605-612 (2004)
   PUBMED   15144217
REFERENCE   4  (bases 1 to 2150)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 2150)
  AUTHORS   Woo,W.H., Yang,H., Wong,K.P. and Halliwell,B.
  TITLE     Sulphite oxidase gene expression in human brain and in other human
            and rat tissues
  JOURNAL   Biochem Biophys Res Commun 305 (3), 619-623 (2003)
   PUBMED   12763039
  REMARK    GeneRIF: Sulfite oxidase gene expression in brain and in other
            tissues.
REFERENCE   6  (bases 1 to 2150)
  AUTHORS   Barber,M.J. and Neame,P.J.
  TITLE     A conserved cysteine in molybdenum oxotransferases
  JOURNAL   J Biol Chem 265 (34), 20912-20915 (1990)
   PUBMED   2249998
REFERENCE   7  (bases 1 to 2150)
  AUTHORS   Amy,N.K.
  TITLE     Effect of dietary protein and methionine on sulfite oxidase
            activity in rats
  JOURNAL   J Nutr 118 (8), 941-944 (1988)
   PUBMED   3404287
REFERENCE   8  (bases 1 to 2150)
  AUTHORS   Crawford,N.M., Smith,M., Bellissimo,D. and Davis,R.W.
  TITLE     Sequence and nitrate regulation of the Arabidopsis thaliana mRNA
            encoding nitrate reductase, a metalloflavoprotein with three
            functional domains
  JOURNAL   Proc Natl Acad Sci U S A 85 (14), 5006-5010 (1988)
   PUBMED   3393528
REFERENCE   9  (bases 1 to 2150)
  AUTHORS   Ono,H. and Ito,A.
  TITLE     Transport of the precursor for sulfite oxidase into intermembrane
            space of liver mitochondria: characterization of import and
            processing activities
  JOURNAL   J Biochem 95 (2), 345-352 (1984)
   PUBMED   6715303
REFERENCE   10 (bases 1 to 2150)
  AUTHORS   Ono,H. and Ito,A.
  TITLE     Evidence for participation of the inner membrane in the import of
            sulfite oxidase into the intermembrane space of liver mitochondria
  JOURNAL   Biochem Biophys Res Commun 107 (1), 258-264 (1982)
   PUBMED   6181785
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031127.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061991.1, SRR26360190.1408619.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000007.1  1690169-1690235     c
            68-245              JAXUCZ010000007.1  1689750-1689927     c
            246-2150            JAXUCZ010000007.1  1687666-1689570     c
FEATURES             Location/Qualifiers
     source          1..2150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2150
                     /gene="Suox"
                     /note="sulfite oxidase"
                     /db_xref="GeneID:81805"
                     /db_xref="RGD:619994"
     exon            1..67
                     /gene="Suox"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1655
                     /gene="Suox"
                     /EC_number="1.8.3.1"
                     /note="sulfite oxidase, mitochondrial"
                     /codon_start=1
                     /product="sulfite oxidase, mitochondrial precursor"
                     /protein_id="NP_112389.3"
                     /db_xref="GeneID:81805"
                     /db_xref="RGD:619994"
                     /translation="MLPRLYRSVAVGLPRAIRAKSTPLRLCIQACSSSDSLKPQHPSL
                     TFSDDNSRTRGWKVMGTLIGLGAVLAYHDHRCRASQESPRIYSKEDVRSHNNLQTGVW
                     VTLGSEVFDVTKFVDLHPGGQSKLMLAAGGPLEPFWALYAVHNQPHVRELLAEYKIGE
                     LNPEDRMSPPLEASDPYSNDPMRHPALRINSQRPFNAEPPPELLTESYITPNPIFFTR
                     NHLPVPNLDPDTYRLHVVGAPGGQSLSLSLDDLHKFPKHEVTVTLQCAGNRRSEMNKV
                     KEVKGLEWRTGAISTARWAGARLCDVLAQAGHRLRETEAHVCFEGLDSDPTGTAYGAS
                     IPLARAMDPQAEVLLAYEMNGQPLPRDHGFPVRVVVPGVVGARHVKWLGRVSVESEES
                     YSHWQRRDYKGFSPSVDWDTVDFDLAPSIQELPIQSAITQPQDGTTVESGEVIIKGYA
                     WSGGGRAVIRVDVSMDGGLTWQEAELEGEEQHPRKAWAWRIWQLKAHVPAEQKELNII
                     CKAVDDSYNVQPDTVAPIWNLRGVLSNAWHRVHVQVVP"
     exon            68..245
                     /gene="Suox"
                     /inference="alignment:Splign:2.1.0"
     exon            246..2150
                     /gene="Suox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaggtctgc cacaatgctg cctcggctat acagatctgt ggctgtgggg cttccgcggg
       61 ccatcagagc caagtcaacc cccttgagac tctgcattca agcatgttcc tcaagtgact
      121 cacttaagcc gcagcatccc agcctcacct tttctgatga taactcaagg actcggggat
      181 ggaaagtcat ggggaccctg ataggccttg gtgccgtgct ggcctatcat gaccatcggt
      241 gtagggcttc tcaggagtca ccacggatat actctaaaga ggatgtgcgt tctcacaaca
      301 accttcaaac tggagtctgg gtaactctag gctctgaggt ctttgatgtc acaaaatttg
      361 tggacctgca tccaggagga caatcaaaac tgatgctagc tgctggaggt cccctagaac
      421 ccttctgggc cctctatgct gttcacaacc agccccatgt acgtgagtta ctggctgagt
      481 ataagattgg ggagctgaac cccgaagata gaatgtcccc tcccttggag gcctctgacc
      541 cttattccaa tgaccctatg cgtcatccag ccctgaggat taatagccag cgccccttta
      601 atgcagagcc tcctcctgaa ctgcttacag aaagctacat cacaccaaac cctattttct
      661 ttacccggaa ccatctgcct gtacctaacc tggacccaga cacctatcgc ttgcatgtag
      721 taggggcacc tggaggtcag tcgctctctc tctccttgga tgatttgcat aagttcccca
      781 aacatgaggt cactgtcact ctgcagtgtg ctggtaaccg gcgctcggag atgaataagg
      841 tcaaggaagt gaaaggtctg gagtggagaa caggggccat cagcacggca cgctgggccg
      901 gggcacggct ctgtgatgtc ttagcccagg ctggtcaccg actccgtgaa accgaggccc
      961 atgtctgttt tgaaggactg gattcagacc ccactggaac tgcctatggg gcatccatcc
     1021 ctctggctcg ggccatggat ccccaagccg aggtcctcct ggcttatgag atgaatggtc
     1081 agcctctgcc tcgtgaccat ggcttccccg taagggtggt ggttcctggt gtggtaggtg
     1141 ctcgccatgt caagtggttg ggcagagtga gtgtggagtc agaggaaagt tatagtcact
     1201 ggcagaggcg ggattacaaa ggcttttctc catctgtgga ctgggacact gtagactttg
     1261 atctagcccc atcaattcag gaactaccca tccagtcagc tatcacacag cctcaagatg
     1321 ggacgactgt agaatcagga gaggtgatta tcaagggcta tgcatggagt ggtggtggta
     1381 gggctgtgat tcgagtggat gtgtctatgg atggtggact gacctggcag gaagctgagc
     1441 tggagggaga ggaacagcat cccaggaagg cctgggcttg gcgaatatgg cagttgaaag
     1501 ctcacgtgcc agctgagcag aaggaattga acatcatttg taaagcggta gatgacagtt
     1561 acaacgtgca gccagacact gtggccccaa tctggaacct tcgaggcgtg ctcagcaatg
     1621 cctggcaccg tgtccacgtt caggtggttc catgaaagca tggaacagca gtttgtaccc
     1681 aaaggacccc tacacctctt taccaaccca gccttaatcc tcggtgccat agataaacgt
     1741 ttccttcctc tactgagggg agaaagcagc tctcaagaca tcactttctt accctaccat
     1801 acctttactt ctcatgcctc ccctcaggcc ttgttttgca ttgcttagat tcttcagata
     1861 tgtgtgtgat gtatggaatg tgtaaaaact gtacgttatt tctttttctt cttcatcatc
     1921 ttgttttttt tcccttcaag acagggtttc tctgtgtagc cctggctgtc ctggaactca
     1981 ctttgtagac caaactgcct gccttagtct ccagaatcgg gggattaaag gcatgtgccg
     2041 ccactgcccg tctacaactt tcaatcgcct ctgggatgca aggagatttc cctcttagag
     2101 tgcttttaaa acgattccaa taaagtgtct gtttaagact atgactggaa
//
