LOCUS       NP_001007148             757 aa            linear   ROD 24-JUN-2024
DEFINITION  SUN domain-containing protein 1 [Rattus norvegicus].
ACCESSION   NP_001007148 XP_341042
VERSION     NP_001007148.1
DBSOURCE    REFSEQ: accession NM_001007147.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 757)
  AUTHORS   Sharma,V.P., Williams,J., Leung,E., Sanders,J., Eddy,R.,
            Castracane,J., Oktay,M.H., Entenberg,D. and Condeelis,J.S.
  TITLE     SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility
            of Breast Carcinoma Cells in Fibrillar ECM Microenvironment
  JOURNAL   Cells 10 (6), 1549 (2021)
   PUBMED   34205257
  REMARK    GeneRIF: SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast
            Motility of Breast Carcinoma Cells in Fibrillar ECM
            Microenvironment.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 757)
  AUTHORS   Ishiguro,K., Kim,J., Shibuya,H., Hernandez-Hernandez,A., Suzuki,A.,
            Fukagawa,T., Shioi,G., Kiyonari,H., Li,X.C., Schimenti,J., Hoog,C.
            and Watanabe,Y.
  TITLE     Meiosis-specific cohesin mediates homolog recognition in mouse
            spermatocytes
  JOURNAL   Genes Dev 28 (6), 594-607 (2014)
   PUBMED   24589552
REFERENCE   3  (residues 1 to 757)
  AUTHORS   Link,J., Leubner,M., Schmitt,J., Gob,E., Benavente,R., Jeang,K.T.,
            Xu,R. and Alsheimer,M.
  TITLE     Analysis of meiosis in SUN1 deficient mice reveals a distinct role
            of SUN2 in mammalian meiotic LINC complex formation and function
  JOURNAL   PLoS Genet 10 (2), e1004099 (2014)
   PUBMED   24586178
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 757)
  AUTHORS   Horn,H.F., Kim,D.I., Wright,G.D., Wong,E.S., Stewart,C.L., Burke,B.
            and Roux,K.J.
  TITLE     A mammalian KASH domain protein coupling meiotic chromosomes to the
            cytoskeleton
  JOURNAL   J Cell Biol 202 (7), 1023-1039 (2013)
   PUBMED   24062341
REFERENCE   5  (residues 1 to 757)
  AUTHORS   Davidson,E.H., Sultan,S.M., Butala,P., Knobel,D. and Warren,S.M.
  TITLE     Lacunocanalicular fluid flow transduces mechanical tension stress
            during distraction osteogenesis
  JOURNAL   J Craniofac Surg 24 (5), 1558-1564 (2013)
   PUBMED   24036726
REFERENCE   6  (residues 1 to 757)
  AUTHORS   Zhang,X., Lei,K., Yuan,X., Wu,X., Zhuang,Y., Xu,T., Xu,R. and
            Han,M.
  TITLE     SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the
            nucleus during neurogenesis and neuronal migration in mice
  JOURNAL   Neuron 64 (2), 173-187 (2009)
   PUBMED   19874786
REFERENCE   7  (residues 1 to 757)
  AUTHORS   Stewart-Hutchinson,P.J., Hale,C.M., Wirtz,D. and Hodzic,D.
  TITLE     Structural requirements for the assembly of LINC complexes and
            their function in cellular mechanical stiffness
  JOURNAL   Exp Cell Res 314 (8), 1892-1905 (2008)
   PUBMED   18396275
REFERENCE   8  (residues 1 to 757)
  AUTHORS   Crisp,M., Liu,Q., Roux,K., Rattner,J.B., Shanahan,C., Burke,B.,
            Stahl,P.D. and Hodzic,D.
  TITLE     Coupling of the nucleus and cytoplasm: role of the LINC complex
  JOURNAL   J Cell Biol 172 (1), 41-53 (2006)
   PUBMED   16380439
REFERENCE   9  (residues 1 to 757)
  AUTHORS   Padmakumar,V.C., Libotte,T., Lu,W., Zaim,H., Abraham,S.,
            Noegel,A.A., Gotzmann,J., Foisner,R. and Karakesisoglou,I.
  TITLE     The inner nuclear membrane protein Sun1 mediates the anchorage of
            Nesprin-2 to the nuclear envelope
  JOURNAL   J Cell Sci 118 (Pt 15), 3419-3430 (2005)
   PUBMED   16079285
REFERENCE   10 (residues 1 to 757)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085844.1.
            
            On Nov 22, 2004 this sequence version replaced XP_341042.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     Protein         1..757
                     /product="SUN domain-containing protein 1"
                     /calculated_mol_wt=84658
     Region          64..259
                     /region_name="MRP"
                     /note="Mitochondrial RNA binding protein MRP; pfam09387"
                     /db_xref="CDD:430576"
     Region          349..>512
                     /region_name="CALCOCO1"
                     /note="Calcium binding and coiled-coil domain (CALCOCO1)
                     like; pfam07888"
                     /db_xref="CDD:462303"
     Region          397..450
                     /region_name="SUN1_cc1"
                     /note="coiled-coil domain 1 of SUN domain-containing
                     protein 1 and similar proteins; cd21439"
                     /db_xref="CDD:410605"
     Site            order(399..400,403,406..407,410..411,413..414,417..418,
                     420..421,424..425,427..428,431,434..435,438,441..442,
                     445..446,448..450)
                     /site_type="other"
                     /note="putative trimer interface [polypeptide binding]"
                     /db_xref="CDD:410605"
     Region          621..755
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     CDS             1..757
                     /gene="Sun1"
                     /gene_synonym="Unc84a"
                     /coded_by="NM_001007147.1:68..2341"
                     /db_xref="GeneID:360773"
                     /db_xref="RGD:1359142"
ORIGIN      
        1 mdfsrlhtyt ppqcvpentg ytyalsssys sdaldfeteh rlepvfdspr msrrslrlit
       61 ttaayssgdg qtvdthists ratpakgret rtvkqrsask pafsinhlsg kglssstshd
      121 sscslrsatv lrhpvldesl ireqtkvdhf wgldddgdlk ggnkaatqgn gelaaevass
      181 ngytcrdcrm lsartdalta hsavhgptsr vysrdrtlrp rkaasgtfww lgsgwyqfvt
      241 liswlnvfll trclrnickv fvlllpllll lgagfslwgq gnffsllpml nwtamqpaqr
      301 vdnpkdmhrp gplspspplk vdpmasqwpq esdmgqkias lsaqchnhde rlaeltvllq
      361 klqirvdqvd dgreglslwv kdmvgqhlqe igsieppdak tdfltlhhdh evrlssledv
      421 lrklteksea iqkeleetkl ragsrdeeqp lldrvqhlel elnllksqls dwqhlrssce
      481 qadariqetv qlmfsedqpg gslewllqkl ssrfvskdel qvllhdlelk llqnithhit
      541 vtgqaptsea ivsamsqagi sgiteaqahi ivnnalrlys qdktgmvdfa lesgggsils
      601 trcsetyetk tallslfgvp lwyfsqsprv viqpdiypgn cwafkgsqgy lvvrlsmkiy
      661 pttftmehip ktlsptgnis saprdfavyg leteyqeegq plgrftydqe gdslqmfhtl
      721 erpdqgfqiv elrvlsnwgh peytclyrfr vhgepiq
//
