LOCUS       NM_001024295            1569 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus small ubiquitin-like modifier 3 (Sumo3), mRNA.
ACCESSION   NM_001024295 XM_574733
VERSION     NM_001024295.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1569)
  AUTHORS   Zhou,X., Gao,C., Huang,W., Yang,M., Chen,G., Jiang,L., Gou,F.,
            Feng,H., Ai,N. and Xu,Y.
  TITLE     High glucose induces sumoylation of Smad4 via SUMO2/3 in mesangial
            cells
  JOURNAL   Biomed Res Int 2014, 782625 (2014)
   PUBMED   24971350
  REMARK    GeneRIF: These results suggest that high glucose may activate TGF-
            beta/Smad signaling through sumoylation of Samd4 by SUMO2/3 in
            mesangial cells.
REFERENCE   2  (bases 1 to 1569)
  AUTHORS   Richard,P., Feng,S. and Manley,J.L.
  TITLE     A SUMO-dependent interaction between Senataxin and the exosome,
            disrupted in the neurodegenerative disease AOA2, targets the
            exosome to sites of transcription-induced DNA damage
  JOURNAL   Genes Dev 27 (20), 2227-2232 (2013)
   PUBMED   24105744
REFERENCE   3  (bases 1 to 1569)
  AUTHORS   Wang,L., Ma,Q., Yang,W., Mackensen,G.B. and Paschen,W.
  TITLE     Moderate hypothermia induces marked increase in levels and nuclear
            accumulation of SUMO2/3-conjugated proteins in neurons
  JOURNAL   J Neurochem 123 (3), 349-359 (2012)
   PUBMED   22891650
  REMARK    GeneRIF: Exposure to moderate 30 degrees C hypothermia in rats is
            sufficient to markedly modify the pattern and subcellular
            localization of SUMO2/3 in neurons, and hypothermia triggers
            nuclear translocation of the SUMO-conjugating enzyme Ubc9.
REFERENCE   4  (bases 1 to 1569)
  AUTHORS   Cong,L., Pakala,S.B., Ohshiro,K., Li,D.Q. and Kumar,R.
  TITLE     SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor
            antigen 1 (MTA1) synergistically regulate its transcriptional
            repressor function
  JOURNAL   J Biol Chem 286 (51), 43793-43808 (2011)
   PUBMED   21965678
REFERENCE   5  (bases 1 to 1569)
  AUTHORS   Zhu,L., Doyle,T.J. and Kim,K.H.
  TITLE     Retinoic acid modulates the subcellular localization of small
            ubiquitin-related modifier-2/3 (SUMO-2/3) in the testis
  JOURNAL   J Androl 31 (4), 406-418 (2010)
   PUBMED   20075418
  REMARK    GeneRIF: disruption of the retinoic acid receptor alpha gene in the
            testis resulted in alteration of SUMO-2/3 subcellular localization
REFERENCE   6  (bases 1 to 1569)
  AUTHORS   Yang,W., Sheng,H., Warner,D.S. and Paschen,W.
  TITLE     Transient focal cerebral ischemia induces a dramatic activation of
            small ubiquitin-like modifier conjugation
  JOURNAL   J Cereb Blood Flow Metab 28 (5), 892-896 (2008)
   PUBMED   18167501
  REMARK    GeneRIF: Considering the marked effect of SUMO conjugation on the
            function of target proteins, it is very likely that the
            postischemic activation of sumoylation has a significant effect on
            the fate of neurons exposed to transient ischemia.
REFERENCE   7  (bases 1 to 1569)
  AUTHORS   Jambunathan,S. and Fontes,J.D.
  TITLE     Sumoylation of the zinc finger protein ZXDC enhances the function
            of its transcriptional activation domain
  JOURNAL   Biol Chem 388 (9), 965-972 (2007)
   PUBMED   17696781
REFERENCE   8  (bases 1 to 1569)
  AUTHORS   Baba,D., Maita,N., Jee,J.G., Uchimura,Y., Saitoh,H., Sugasawa,K.,
            Hanaoka,F., Tochio,H., Hiroaki,H. and Shirakawa,M.
  TITLE     Crystal structure of SUMO-3-modified thymine-DNA glycosylase
  JOURNAL   J Mol Biol 359 (1), 137-147 (2006)
   PUBMED   16626738
REFERENCE   9  (bases 1 to 1569)
  AUTHORS   Gomez-del Arco,P., Koipally,J. and Georgopoulos,K.
  TITLE     Ikaros SUMOylation: switching out of repression
  JOURNAL   Mol Cell Biol 25 (7), 2688-2697 (2005)
   PUBMED   15767674
REFERENCE   10 (bases 1 to 1569)
  AUTHORS   Hardeland,U., Steinacher,R., Jiricny,J. and Schar,P.
  TITLE     Modification of the human thymine-DNA glycosylase by ubiquitin-like
            proteins facilitates enzymatic turnover
  JOURNAL   EMBO J 21 (6), 1456-1464 (2002)
   PUBMED   11889051
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001024295.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083728.1, SRR26643286.46699.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000020.1  11020191-11020287   c
            98-226              JAXUCZ010000020.1  11017017-11017145   c
            227-298             JAXUCZ010000020.1  11012902-11012973   c
            299-1569            JAXUCZ010000020.1  11009734-11011004   c
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1569
                     /gene="Sumo3"
                     /note="small ubiquitin-like modifier 3"
                     /db_xref="GeneID:499417"
                     /db_xref="RGD:1561022"
     exon            1..97
                     /gene="Sumo3"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..409
                     /gene="Sumo3"
                     /note="SUMO-3; SMT3 suppressor of mif two 3 homolog 3"
                     /codon_start=1
                     /product="small ubiquitin-related modifier 3"
                     /protein_id="NP_001019466.1"
                     /db_xref="GeneID:499417"
                     /db_xref="RGD:1561022"
                     /translation="MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMK
                     AYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGTASRASVPTP
                     SHFPDICY"
     exon            98..226
                     /gene="Sumo3"
                     /inference="alignment:Splign:2.1.0"
     exon            227..298
                     /gene="Sumo3"
                     /inference="alignment:Splign:2.1.0"
     exon            299..1569
                     /gene="Sumo3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcagaga gcgtgactcg cccgctccag tgccaccggt tcccgctgcg cttgccgccg
       61 ccgtcgccgc gcaaccatgt cggaagagaa gcccaaggag ggtgtgaaga cagagaacga
      121 ccacatcaac ctgaaagtgg cagggcagga tggctcagtg gtgcagttca agatcaagag
      181 gcacactccg ctgagcaagc tgatgaaggc ctactgtgag aggcagggct tgtcaatgag
      241 gcagattcga ttccggtttg atggacaacc aatcaacgaa acagacactc cagcccagct
      301 ggagatggag gatgaggaca ccattgatgt attccagcag cagacgggag gaacggcctc
      361 ccgagccagc gtccccacac ccagccattt tcctgacatt tgctattgaa tggtgaccat
      421 gcagccacac caatcacaca agagtccgca gaagccagag tcaccgaaaa gagtctcctt
      481 tcccgatgcg cttggagtga actacatcca gaatacgctg cagggcgaga gcattacata
      541 ccctggtcgt taggagggtt tggtttgggg gaaatgaggc gtggggtttt tggggtttgt
      601 tttgttttca tttgtttcct cccatttcta aaattttttc tcccccaaac ttgggtctgg
      661 atgtacagac tctcaccctg tggcctgagt ctaatcccta gaactatggt ttcctccggt
      721 gtgacttgtc ctgatcaggt agagagagct tgtggtcaca ttacccagtg ggcatacctg
      781 tgggatgtgg ggaggggcag agaagcagaa ttccacccgt ttgttgtagg cataggatat
      841 taaaatgtga aatactgtaa atttgagctt tgtcaagcat atggtgaagt taagggaaaa
      901 agaccagtgc ttcttaaaaa ctgtgaggag tcttcctact gtggcccagg ccggcatatg
      961 cccacttgct tctggcatct ggtaatggat acatcggtaa gggtggcata gtgaaaccca
     1021 ccccccaccc tttttataat gtccaagaaa gtaattgtcc cgtcccattt ggaaattgaa
     1081 catgatctca gattcttctg gtccttgcta gatatataat tatggtttct gtctaagaag
     1141 gtaatcagtt aagtatcaag tttgctgcag tgttgtgtaa gagccccgct ttcaagtgtg
     1201 gttgcaaaag caagcccagg aaaggtgacc tcattttccc ggattgtggt gtgcagtttt
     1261 ccaagtgtgt gttaacggga cgcctcggtg ggtgactgcg gttctgcatc gtggggtcag
     1321 ttaaatgtct atagttcctg cctgccatcc ttctgtaagg atccattgct gcttgatggc
     1381 catctctgcc ttttatagtc acccgacact gacctaccat ctctcgcttg cttaaagtcc
     1441 cgaggaaaat gtttctgcct gtttgctgcg tgggcctggg tggggtgtct gtcggctctg
     1501 ttgtgtttct tcaccggttt gtacctgttg tcctttacta ctgtaaacag taaatatagt
     1561 ttggtattc
//
