LOCUS       NM_133594               1090 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus small ubiquitin-like modifier 2 (Sumo2), mRNA.
ACCESSION   NM_133594 XM_212688
VERSION     NM_133594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1090)
  AUTHORS   Ding,Y., Chen,F., Yang,W., Fu,X. and Xie,Y.
  TITLE     SENP5 deteriorates traumatic brain injury via SUMO2-dependent
            suppression of E2F1 SUMOylation
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (8), 1193-1203 (2023)
   PUBMED   37403456
  REMARK    GeneRIF: SENP5 deteriorates traumatic brain injury via
            SUMO2-dependent suppression of E2F1 SUMOylation.
REFERENCE   2  (bases 1 to 1090)
  AUTHORS   Zhou,X., Gao,C., Huang,W., Yang,M., Chen,G., Jiang,L., Gou,F.,
            Feng,H., Ai,N. and Xu,Y.
  TITLE     High glucose induces sumoylation of Smad4 via SUMO2/3 in mesangial
            cells
  JOURNAL   Biomed Res Int 2014, 782625 (2014)
   PUBMED   24971350
  REMARK    GeneRIF: These results suggest that high glucose may activate TGF-
            beta/Smad signaling through sumoylation of Samd4 by SUMO2/3 in
            mesangial cells.
REFERENCE   3  (bases 1 to 1090)
  AUTHORS   Richard,P., Feng,S. and Manley,J.L.
  TITLE     A SUMO-dependent interaction between Senataxin and the exosome,
            disrupted in the neurodegenerative disease AOA2, targets the
            exosome to sites of transcription-induced DNA damage
  JOURNAL   Genes Dev 27 (20), 2227-2232 (2013)
   PUBMED   24105744
REFERENCE   4  (bases 1 to 1090)
  AUTHORS   Wang,L., Ma,Q., Yang,W., Mackensen,G.B. and Paschen,W.
  TITLE     Moderate hypothermia induces marked increase in levels and nuclear
            accumulation of SUMO2/3-conjugated proteins in neurons
  JOURNAL   J Neurochem 123 (3), 349-359 (2012)
   PUBMED   22891650
  REMARK    GeneRIF: Exposure to moderate 30 degrees C hypothermia in rats is
            sufficient to markedly modify the pattern and subcellular
            localization of SUMO2/3 in neurons; hypothermia triggers nuclear
            translocation of the SUMO-conjugating enzyme Ubc9.
REFERENCE   5  (bases 1 to 1090)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 1090)
  AUTHORS   Jambunathan,S. and Fontes,J.D.
  TITLE     Sumoylation of the zinc finger protein ZXDC enhances the function
            of its transcriptional activation domain
  JOURNAL   Biol Chem 388 (9), 965-972 (2007)
   PUBMED   17696781
REFERENCE   7  (bases 1 to 1090)
  AUTHORS   Lin,D.Y., Huang,Y.S., Jeng,J.C., Kuo,H.Y., Chang,C.C., Chao,T.T.,
            Ho,C.C., Chen,Y.C., Lin,T.P., Fang,H.I., Hung,C.C., Suen,C.S.,
            Hwang,M.J., Chang,K.S., Maul,G.G. and Shih,H.M.
  TITLE     Role of SUMO-interacting motif in Daxx SUMO modification,
            subnuclear localization, and repression of sumoylated transcription
            factors
  JOURNAL   Mol Cell 24 (3), 341-354 (2006)
   PUBMED   17081986
REFERENCE   8  (bases 1 to 1090)
  AUTHORS   Gomez-del Arco,P., Koipally,J. and Georgopoulos,K.
  TITLE     Ikaros SUMOylation: switching out of repression
  JOURNAL   Mol Cell Biol 25 (7), 2688-2697 (2005)
   PUBMED   15767674
REFERENCE   9  (bases 1 to 1090)
  AUTHORS   Farkas,R.H., Qian,J., Goldberg,J.L., Quigley,H.A. and Zack,D.J.
  TITLE     Gene expression profiling of purified rat retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2503-2513 (2004)
   PUBMED   15277470
REFERENCE   10 (bases 1 to 1090)
  AUTHORS   Mannen,H., Tsoi,S.C., Krushkal,J.S., Li,W.H. and Li,S.S.
  TITLE     The cDNA cloning and molecular evolution of reptile and pigeon
            lactate dehydrogenase isozymes
  JOURNAL   Mol Biol Evol 14 (11), 1081-1087 (1997)
   PUBMED   9364765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF976332.1 and BC078746.1.
            
            On Oct 31, 2008 this sequence version replaced NM_133594.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132296,
                              SAMD00132297 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                CF976332.1         5-70
            67-1090             BC078746.1         1-1024
FEATURES             Location/Qualifiers
     source          1..1090
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1090
                     /gene="Sumo2"
                     /gene_synonym="Smt3A; Smt3h2"
                     /note="small ubiquitin-like modifier 2"
                     /db_xref="GeneID:690244"
                     /db_xref="RGD:621761"
     exon            1..181
                     /gene="Sumo2"
                     /gene_synonym="Smt3A; Smt3h2"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..448
                     /gene="Sumo2"
                     /gene_synonym="Smt3A; Smt3h2"
                     /note="SUMO-2; sentrin-2; SMT3 homolog 2; ubiquitin-like
                     protein SMT3B; ubiquitin-like protein SMT3A; SMT3
                     suppressor of mif two 3 homolog 2"
                     /codon_start=1
                     /product="small ubiquitin-related modifier 2"
                     /protein_id="NP_598278.1"
                     /db_xref="GeneID:690244"
                     /db_xref="RGD:621761"
                     /translation="MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLM
                     KAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY"
     exon            182..313
                     /gene="Sumo2"
                     /gene_synonym="Smt3A; Smt3h2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..385
                     /gene="Sumo2"
                     /gene_synonym="Smt3A; Smt3h2"
                     /inference="alignment:Splign:2.1.0"
     exon            386..1049
                     /gene="Sumo2"
                     /gene_synonym="Smt3A; Smt3h2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcggggg gagggagcgc acgacgtgcg cgcgccctct gcctcgtcca ccgctgccgc
       61 ctccttcttc tgccgctcct ggtgctgctt gtgtgctcct tcagtgcgga cctggtgcct
      121 cttttgtgaa gcggcagctg aggagactcc ggcgctcgcc atggccgacg agaaacccaa
      181 ggaaggagtc aagactgaga acaacgatca tattaatttg aaggtggcgg gacaggatgg
      241 ttctgtggtg cagtttaaga ttaagaggca tacaccactt agtaaactaa tgaaagccta
      301 ttgtgaacgg cagggtttgt caatgaggca gatcagattc cggtttgatg ggcaaccaat
      361 caacgaaaca gacacacctg cacagttgga aatggaggat gaagatacga ttgatgtgtt
      421 ccagcagcag acaggaggcg tctactgaaa agggaacctg ctactttact ccagaatttt
      481 gttatagacc aagaatacat tctcaattag aaagccgcaa tttggtcccg ccacatcctg
      541 actactgcag tatagtttct ctcctctttc atttccctgt cctcatttct ttattgtaca
      601 taagtaactg gtgtgtgtgc acaagcatat tgctcttttt ttcttttcct tttttaaact
      661 aaatggccga tgttctgttt tggttacatc agatggagac agtctgggga cagttctggt
      721 tctgtgacaa tatccccctt ctccactagt ggcatgctca gtcagctcct atctctctat
      781 ccagtaagtt attttgctct cattgtttta acaaaagaat ccaacaacac aaaatcctcg
      841 cataccttgt tcgattggag aattttaatg tttttcattt atcattgtaa aaccaaggac
      901 aattttataa cttttttgta cgtagctgtt acatgtaggg caatctgtct ttaagtaggg
      961 ataaattact cttgaacaaa atgatcctag atagttttcc cttcaagtca agcgtcttgt
     1021 tgtttaaata aacttcttgt ttaaaatgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1081 aaaaaaaaaa
//
