LOCUS       NM_001009672            1150 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus small ubiquitin-like modifier 1 (Sumo1), mRNA.
ACCESSION   NM_001009672 XM_217413
VERSION     NM_001009672.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1150)
  AUTHORS   Wang,L., Wang,P., Xu,S., Li,Z., Duan,D.D., Ye,J., Li,J., Ding,Y.,
            Zhang,W., Lu,J. and Liu,P.
  TITLE     The cross-talk between PARylation and SUMOylation in C/EBPbeta at
            K134 site participates in pathological cardiac hypertrophy
  JOURNAL   Int J Biol Sci 18 (2), 783-799 (2022)
   PUBMED   35002525
  REMARK    GeneRIF: The cross-talk between PARylation and SUMOylation in
            C/EBPbeta at K134 site participates in pathological cardiac
            hypertrophy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1150)
  AUTHORS   Du,C.P., Wang,M., Geng,C., Hu,B., Meng,L., Xu,Y., Cheng,B.,
            Wang,N., Zhu,Q.J. and Hou,X.Y.
  TITLE     Activity-Induced SUMOylation of Neuronal Nitric Oxide Synthase Is
            Associated with Plasticity of Synaptic Transmission and
            Extracellular Signal-Regulated Kinase 1/2 Signaling
  JOURNAL   Antioxid Redox Signal 32 (1), 18-34 (2020)
   PUBMED   31642335
  REMARK    GeneRIF: Activity-Induced SUMOylation of Neuronal Nitric Oxide
            Synthase Is Associated with Plasticity of Synaptic Transmission and
            Extracellular Signal-Regulated Kinase 1/2 Signaling.
REFERENCE   3  (bases 1 to 1150)
  AUTHORS   Chen,Y.D., Liu,J.Y., Lu,Y.M., Zhu,H.T., Tang,W., Wang,Q.X. and
            Lu,H.Y.
  TITLE     Functional roles of C/EBPalpha and SUMO-modification in lung
            development
  JOURNAL   Int J Mol Med 40 (4), 1037-1046 (2017)
   PUBMED   28902364
  REMARK    GeneRIF: C/EBPalpha played a role in lung development and provided
            the insight into the mechanism underlying SUMO-modification.
REFERENCE   4  (bases 1 to 1150)
  AUTHORS   Cuomo,O., Pignataro,G., Sirabella,R., Molinaro,P., Anzilotti,S.,
            Scorziello,A., Sisalli,M.J., Di Renzo,G. and Annunziato,L.
  TITLE     Sumoylation of LYS590 of NCX3 f-Loop by SUMO1 Participates in Brain
            Neuroprotection Induced by Ischemic Preconditioning
  JOURNAL   Stroke 47 (4), 1085-1093 (2016)
   PUBMED   26979866
  REMARK    GeneRIF: SUMO1 knockdown worsened ischemic damage and reduced the
            protective effect of preconditioning. NCX3 sumoylation participates
            in SUMO1 protective role during ischemic preconditioning.
REFERENCE   5  (bases 1 to 1150)
  AUTHORS   Jiang,Y., Wang,J., Tian,H., Li,G., Zhu,H., Liu,L., Hu,R. and Dai,A.
  TITLE     Increased SUMO-1 expression in response to hypoxia: Interaction
            with HIF-1alpha in hypoxic pulmonary hypertension
  JOURNAL   Int J Mol Med 36 (1), 271-281 (2015)
   PUBMED   25976847
  REMARK    GeneRIF: SUMO1 may participate in the modulation of HIF1alpha
            through sumoylation in hypoxic pulmonary hypertension.
REFERENCE   6  (bases 1 to 1150)
  AUTHORS   Eloranta,J.J. and Hurst,H.C.
  TITLE     Transcription factor AP-2 interacts with the SUMO-conjugating
            enzyme UBC9 and is sumolated in vivo
  JOURNAL   J Biol Chem 277 (34), 30798-30804 (2002)
   PUBMED   12072434
REFERENCE   7  (bases 1 to 1150)
  AUTHORS   Hardeland,U., Steinacher,R., Jiricny,J. and Schar,P.
  TITLE     Modification of the human thymine-DNA glycosylase by ubiquitin-like
            proteins facilitates enzymatic turnover
  JOURNAL   EMBO J 21 (6), 1456-1464 (2002)
   PUBMED   11889051
REFERENCE   8  (bases 1 to 1150)
  AUTHORS   Hong,Y., Rogers,R., Matunis,M.J., Mayhew,C.N., Goodson,M.L.,
            Park-Sarge,O.K. and Sarge,K.D.
  TITLE     Regulation of heat shock transcription factor 1 by stress-induced
            SUMO-1 modification
  JOURNAL   J Biol Chem 276 (43), 40263-40267 (2001)
   PUBMED   11514557
  REMARK    Erratum:[J Biol Chem 2002 Jul 19;277(29):26708. Goodson M
            [corrected to Goodson ML]]
REFERENCE   9  (bases 1 to 1150)
  AUTHORS   Duprez,E., Saurin,A.J., Desterro,J.M., Lallemand-Breitenbach,V.,
            Howe,K., Boddy,M.N., Solomon,E., de The,H., Hay,R.T. and
            Freemont,P.S.
  TITLE     SUMO-1 modification of the acute promyelocytic leukaemia protein
            PML: implications for nuclear localisation
  JOURNAL   J Cell Sci 112 (Pt 3), 381-393 (1999)
   PUBMED   9885291
REFERENCE   10 (bases 1 to 1150)
  AUTHORS   Sternsdorf,T., Jensen,K. and Will,H.
  TITLE     Evidence for covalent modification of the nuclear dot-associated
            proteins PML and Sp100 by PIC1/SUMO-1
  JOURNAL   J Cell Biol 139 (7), 1621-1634 (1997)
   PUBMED   9412458
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088322.1.
            
            On Jan 13, 2005 this sequence version replaced XM_217413.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088322.1, FQ215643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMD00132302
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..1150
                     /gene="Sumo1"
                     /note="small ubiquitin-like modifier 1"
                     /db_xref="GeneID:301442"
                     /db_xref="RGD:1306919"
     exon            1..53
                     /gene="Sumo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..347
                     /gene="Sumo1"
                     /note="SUMO-1; ubiquitin-like 1 (sentrin); SMT3 suppressor
                     of mif two 3 homolog 1"
                     /codon_start=1
                     /product="small ubiquitin-related modifier 1"
                     /protein_id="NP_001009672.1"
                     /db_xref="GeneID:301442"
                     /db_xref="RGD:1306919"
                     /translation="MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHL
                     KKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV"
     exon            54..128
                     /gene="Sumo1"
                     /inference="alignment:Splign:2.1.0"
     exon            129..206
                     /gene="Sumo1"
                     /inference="alignment:Splign:2.1.0"
     exon            207..278
                     /gene="Sumo1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..1126
                     /gene="Sumo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctgtggt gcggagaccc ccgggtgaat ccaccgacac catgtctgac caggaggcaa
       61 aaccttcaac tgaggactta ggagataaga aagaaggaga atacattaaa ctcaaagtta
      121 ttggacagga cagcagtgag atccatttca aagtgaaaat gacaacacat ctcaagaagc
      181 tcaaagaatc gtactgtcaa agacagggag ttccaatgaa ttcactcagg tttctctttg
      241 aaggtcagag aattgctgat aatcatactc caaaagaact gggaatggag gaagaagacg
      301 tgattgaagt ttatcaggaa caaacggggg gtcactcgac ggtttagata attcttttta
      361 ttttttattt tttccttttc cctcaatcct tttttatttt taaaaatagt tcttttgtaa
      421 tgtggtgttc aaaatgaaaa ttgaatactg gcactccatc tcttagaaca tctggtaatc
      481 tgaattctag tgttcaatat tcattattgg ttgtttttgt tgtgctgatt tttggtgatc
      541 agacctcagc tcccttaaca ttgcccttct tcctttaaga gatttcatgt gtgcacacag
      601 agaggccacc ctttccagga ctgtgcattt tcagggttgt gatgataaaa ggatcgacta
      661 atgggagctt ccctgtgacc tttcaatggc cctgcagttc cggtatgtgg ttgcttcact
      721 cctggactat gattttcagt gggagatgga gatttttcag agaaccgaac tgtggaaaat
      781 gaccttttct cagcttgaag ctacttttaa aatctgaggg tctggaccaa aagaagaaca
      841 tcatgtttgt agtcaaggta acagatacag tgagagtaac agctaactcc aaaagtggct
      901 tcactggaga gaaagaaagt gtcttgagca agacagtatt gtcagaagat cccaggaaag
      961 ttctaatctt catcagcagt taataataaa gttactcata cagaagtgta cgcaacagac
     1021 actgctcctt ttgattctgt tgtacttttt ggcctgggac atgggttttc aagggacatc
     1081 atctgtacca gcttcattaa aataaacaat atttgtaaaa accgtaaaaa aaaaaaaaaa
     1141 aaaaaaaaaa
//
