LOCUS       NM_001108639            2478 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus sulfatase modifying factor 1 (Sumf1), mRNA.
ACCESSION   NM_001108639 XM_001078283 XM_342731
VERSION     NM_001108639.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2478)
  AUTHORS   Holder PG, Jones LC, Drake PM, Barfield RM, Banas S, de Hart GW,
            Baker J and Rabuka D.
  TITLE     Reconstitution of Formylglycine-generating Enzyme with Copper(II)
            for Aldehyde Tag Conversion
  JOURNAL   J Biol Chem 290 (25), 15730-15745 (2015)
   PUBMED   25931126
REFERENCE   2  (bases 1 to 2478)
  AUTHORS   Schlotawa L, Ennemann EC, Radhakrishnan K, Schmidt B, Chakrapani A,
            Christen HJ, Moser H, Steinmann B, Dierks T and Gartner J.
  TITLE     SUMF1 mutations affecting stability and activity of formylglycine
            generating enzyme predict clinical outcome in multiple sulfatase
            deficiency
  JOURNAL   Eur J Hum Genet 19 (3), 253-261 (2011)
   PUBMED   21224894
REFERENCE   3  (bases 1 to 2478)
  AUTHORS   Gande SL, Mariappan M, Schmidt B, Pringle TH, von Figura K and
            Dierks T.
  TITLE     Paralog of the formylglycine-generating enzyme--retention in the
            endoplasmic reticulum by canonical and noncanonical signals
  JOURNAL   FEBS J 275 (6), 1118-1130 (2008)
   PUBMED   18266766
REFERENCE   4  (bases 1 to 2478)
  AUTHORS   Zito E, Fraldi A, Pepe S, Annunziata I, Kobinger G, Di Natale P,
            Ballabio A and Cosma MP.
  TITLE     Sulphatase activities are regulated by the interaction of
            sulphatase-modifying factor 1 with SUMF2
  JOURNAL   EMBO Rep 6 (7), 655-660 (2005)
   PUBMED   15962010
  REMARK    Erratum:[EMBO Rep. 2016 Dec;17 (12 ):1901. PMID: 27909074]
REFERENCE   5  (bases 1 to 2478)
  AUTHORS   Dierks T, Schmidt B, Borissenko LV, Peng J, Preusser A, Mariappan M
            and von Figura K.
  TITLE     Multiple sulfatase deficiency is caused by mutations in the gene
            encoding the human C(alpha)-formylglycine generating enzyme
  JOURNAL   Cell 113 (4), 435-444 (2003)
   PUBMED   12757705
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342731.3, XM_001078283.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494,
                              SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2478
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..2478
                     /gene="Sumf1"
                     /note="sulfatase modifying factor 1"
                     /db_xref="GeneID:362409"
                     /db_xref="RGD:1309939"
     exon            1..273
                     /gene="Sumf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1128
                     /gene="Sumf1"
                     /EC_number="1.13.-.-"
                     /note="formylglycine-generating enzyme"
                     /codon_start=1
                     /product="formylglycine-generating enzyme precursor"
                     /protein_id="NP_001102109.1"
                     /db_xref="GeneID:362409"
                     /db_xref="RGD:1309939"
                     /translation="MAAPAGEPAPRCCTGLAQVFLLLVLACGAAGSDEAEAGEGAVSL
                     AGSCGCGTPQRAGAHGSSAAAQRYSREANAQGLTSGPRSLALTKMVPIPAGVFTMGTD
                     DPQIKQDGEAPARRVTVDAFYMDAYEVSNADFEKFVNSTGYLTEAEKFGDSFVFEGML
                     SEPVKAQIHQAVAAAPWWLPVKGADWRHPEGPDSTILHRSNHPVLHVSWNDAVAYCAW
                     AGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYANIWQGEFPVTNTGEDGFQGT
                     APVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSAEETLNPKGPTSGKDRVKKGGSYMC
                     HKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAN"
     exon            274..447
                     /gene="Sumf1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..522
                     /gene="Sumf1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..605
                     /gene="Sumf1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..728
                     /gene="Sumf1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..843
                     /gene="Sumf1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..957
                     /gene="Sumf1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1017
                     /gene="Sumf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..2478
                     /gene="Sumf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaacaaca tggctgcgcc cgcgggagag cctgctcccc gctgctgtac agggctggct
       61 caggtcttct tgctgctggt gctggcgtgc ggggcagcgg ggagcgatga ggccgaggcc
      121 ggggaaggtg cggtgtccct cgctggttcc tgcggctgcg gaacgcccca gagggctggg
      181 gcccatggca gctcggcggc cgcgcagcgc tactcccggg aggcgaatgc ccagggcctg
      241 acctcgggcc cacgatcgct cgctctcact aagatggtcc ccatccctgc tggagtattt
      301 acaatgggca ctgatgatcc tcagatcaag caggatggag aagcccctgc caggagagtc
      361 actgtcgatg ccttttacat ggatgcctat gaagtcagca acgctgattt tgagaagttc
      421 gtgaactcaa ctggctattt aacagaggct gagaagtttg gagactcttt tgtctttgaa
      481 ggcatgctga gtgagccagt caaggcgcaa attcaccagg cagttgcagc tgctccatgg
      541 tggttacctg tcaagggcgc tgattggaga cacccagagg gcccagactc cactattctg
      601 cacaggtcaa atcatccagt cctccatgtc tcctggaatg acgccgttgc ctactgcgca
      661 tgggcgggga agaggctgcc cacggaggca gagtgggagt acagctgcag aggaggcctg
      721 cagaacaggc ttttcccctg gggcaacaaa ctgcagccca aaggacagca ttatgccaac
      781 atttggcagg gcgagtttcc tgtgaccaac actggcgagg atggcttcca aggaactgcc
      841 cccgttgatg cctttcctcc caatggctat ggcttataca acatagtggg gaacgcatgg
      901 gagtggacct cagactggtg gaccgttcac cattctgctg aggaaacgct caacccaaaa
      961 ggccccactt ctgggaaaga ccgagtgaag aagggtggat cctacatgtg ccataagtcc
     1021 tattgctaca ggtatcgctg tgcagctcga agccagaaca caccagatag ctctgcatcc
     1081 aacctgggat tccgttgtgc agcagatcac ctgcccactg caaactgaca gaggagcttt
     1141 tccaaatcca agaagttgct cacttgcagc tggcctcccg ctggacatct gaacagatct
     1201 tatgtaaagt attcccacac ctgaggagag ttacatgtcc accccgtggc caaaggaact
     1261 gtgtcgtgtg accaaattgc tgacgtctgt cagtgcttgt gctttatcgt gtggtgcatc
     1321 gttggggatc atcaccgtgt tttactttga gagccttttg aagaggagag agctgagaac
     1381 catgaagtcc tagccagact ctgccacagg gtcaaaccct ggggttcagc accttgtctg
     1441 cctgggcctc tatcccctca tggaatgagg gatggactgg acgacatgag gcgctctcca
     1501 ccttacagat tctattcgca ctagtggagt gtattgtgat tgcatagtaa gaatttatga
     1561 cagattattt ttagctattt ttttgccatg tgtgaatctt gagtaatgct aatcatataa
     1621 ggtgagagtt ctcttacgtg ttattttcag aagagggtgg ggtttgagtc ttttatattc
     1681 atactgcact ttgttctttc aaggaaatca gtgtctttta cattgttgtg acaaatctca
     1741 ttgggacagt gaggggacac tcaaattccg agttctgagc acacaggaat gcctgtggag
     1801 tgactctact gtcctttttc ttttgacatt aagtgccttt ggctcagagg gacagtttga
     1861 agccttgttt cccatttgcc ccacaagcct tcaaagaatg tgaaatgtgt actaattagg
     1921 gaaaccctta aattctaggt acaagggttt gatgttgtgt attgtaatgc taaatctgta
     1981 tatgaaggtt taggcctgtg agtgaattct tacatttaca agcttttgtt gtgcaaacct
     2041 tgttccttaa tttagaacta ttggttaaaa aaaagaaaat tgtctacagc caattattgg
     2101 agggattagt aggtaggttt gagttacctg ggggtagaga gagagaggag agagaggaga
     2161 gcaagaggaa gaaggaaagc gctggaggag ctgccatgag ggaaatggac atgtggccag
     2221 gagaaacatc agtatctggg cacagtactg cagaggtagc caggccagca gttagaaaag
     2281 tagattaggg attaaccccc agtaatggtc aaagccacgc aaaataacca tagtctgagt
     2341 ctcatttatt tgtaagcctt gaatagacta cgttcagggt atctagtata ttataccaga
     2401 gagatgagaa attgtgttca ttttgtgata tcagatgctt tgaatcatgc actatgtcaa
     2461 ataaactaat acctctca
//
