LOCUS       NM_001039665            1221 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus sulfotransferase family 2B member 1 (Sult2b1),
            mRNA.
ACCESSION   NM_001039665 XM_214935
VERSION     NM_001039665.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1221)
  AUTHORS   Heinz,L., Kim,G.J., Marrakchi,S., Christiansen,J., Turki,H.,
            Rauschendorf,M.A., Lathrop,M., Hausser,I., Zimmer,A.D. and
            Fischer,J.
  TITLE     Mutations in SULT2B1 Cause Autosomal-Recessive Congenital
            Ichthyosis in Humans
  JOURNAL   Am J Hum Genet 100 (6), 926-939 (2017)
   PUBMED   28575648
REFERENCE   2  (bases 1 to 1221)
  AUTHORS   Probert,P.M., Palmer,J.M., Alhusainy,W., Amer,A.O., Rietjens,I.M.,
            White,S.A., Jones,D.E. and Wright,M.C.
  TITLE     Progenitor-derived hepatocyte-like (B-13/H) cells metabolise
            1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent
            mechanism
  JOURNAL   Toxicol Lett 243, 98-110 (2016)
   PUBMED   26739637
  REMARK    GeneRIF: Since 1'-hydroxyestragole exposure readily produced DNA
            injury in B-13/H cells, these data suggest that cholangiocarcinomas
            generated in rats fed estragole may be dependent, in part, on
            SULT2B1 activation of the 1'-hydroxyestragole metabolite.
REFERENCE   3  (bases 1 to 1221)
  AUTHORS   Kohjitani,A., Fuda,H., Hanyu,O. and Strott,C.A.
  TITLE     Cloning, characterization and tissue expression of rat SULT2B1a and
            SULT2B1b steroid/sterol sulfotransferase isoforms: divergence of
            the rat SULT2B1 gene structure from orthologous human and mouse
            genes
  JOURNAL   Gene 367, 66-73 (2006)
   PUBMED   16368200
REFERENCE   4  (bases 1 to 1221)
  AUTHORS   Lee,K.A., Fuda,H., Lee,Y.C., Negishi,M., Strott,C.A. and
            Pedersen,L.C.
  TITLE     Crystal structure of human cholesterol sulfotransferase (SULT2B1b)
            in the presence of pregnenolone and 3'-phosphoadenosine
            5'-phosphate. Rationale for specificity differences between
            prototypical SULT2A1 and the SULT2BG1 isoforms
  JOURNAL   J Biol Chem 278 (45), 44593-44599 (2003)
   PUBMED   12923182
REFERENCE   5  (bases 1 to 1221)
  AUTHORS   Fuda,H., Lee,Y.C., Shimizu,C., Javitt,N.B. and Strott,C.A.
  TITLE     Mutational analysis of human hydroxysteroid sulfotransferase
            SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces
            cholesterol sulfotransferase, whereas exon 1A yields pregnenolone
            sulfotransferase
  JOURNAL   J Biol Chem 277 (39), 36161-36166 (2002)
   PUBMED   12145317
REFERENCE   6  (bases 1 to 1221)
  AUTHORS   Her,C., Wood,T.C., Eichler,E.E., Mohrenweiser,H.W., Ramagli,L.S.,
            Siciliano,M.J. and Weinshilboum,R.M.
  TITLE     Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded
            by a single chromosome 19 gene
  JOURNAL   Genomics 53 (3), 284-295 (1998)
   PUBMED   9799594
REFERENCE   7  (bases 1 to 1221)
  AUTHORS   Sakakibara,Y., Yanagisawa,K., Takami,Y., Nakayama,T., Suiko,M. and
            Liu,M.C.
  TITLE     Molecular cloning, expression, and functional characterization of
            novel mouse sulfotransferases
  JOURNAL   Biochem Biophys Res Commun 247 (3), 681-686 (1998)
   PUBMED   9647753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 8, 2021 this sequence version replaced NM_001039665.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY827147.1, SRR26360176.508248.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840116 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               JAXUCZ010000001.1  105397502-105397744 c
            244-386             JAXUCZ010000001.1  105348894-105349036 c
            387-595             JAXUCZ010000001.1  105343224-105343432 c
            596-722             JAXUCZ010000001.1  105341670-105341796 c
            723-817             JAXUCZ010000001.1  105341288-105341382 c
            818-998             JAXUCZ010000001.1  105337827-105338007 c
            999-1221            JAXUCZ010000001.1  105336614-105336836 c
FEATURES             Location/Qualifiers
     source          1..1221
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1221
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1"
                     /note="sulfotransferase family 2B member 1"
                     /db_xref="GeneID:292915"
                     /db_xref="RGD:1308882"
     exon            1..243
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1204
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1"
                     /EC_number="2.8.2.2"
                     /note="sulfotransferase 2B; alcohol sulfotransferase;
                     hydroxysteroid sulfotransferase 2; sulfotransferase
                     family, cytosolic, 2B, member 1"
                     /codon_start=1
                     /product="sulfotransferase 2B1"
                     /protein_id="NP_001034754.1"
                     /db_xref="GeneID:292915"
                     /db_xref="RGD:1308882"
                     /translation="MSPWSRNTCYSSPSMRLDRSCARNTARWGHWKEGKPHGGLTGET
                     EAGSSWNGGSESQKLQGEYFRYKGIPFPVGMYTPESLSLAENTSNVRDDDIFIVTYPK
                     SGTNWMIEIICLILKDGDPSWIRSEPIWQRAPWCETTISAFSLPERPSPRLMCSHLPI
                     ELFTKAAFSSKAKVIYLGRNPRDVVVSLYYYSKIAVQLKDPGTPEQFLQNFLKGEVQF
                     GSWFDHIKGWIRMRGRENFLFITYEELQQDLRGSVQLICEFLGRPLGEEALSSVVAHS
                     AFAAMKANNMSNYTLLPASLLDHRQGAFLRKGISGDWKNHFTVAQSETFDQVYREQMH
                     GLPSFPWDRSAEDGSPDGETEPSPSPSPGLASDDPNPGSSQ"
     exon            244..386
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..595
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..722
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..817
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..998
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1221
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggggtccc accctacgcg gcggcacaca gagctgcaga cacacccgga agcgcggact
       61 gccgctctcg gcgaggatgt ctccatggtc caggaatacc tgctactcgt ccccctcaat
      121 gaggctggac cggagctgcg cgcgcaacac tgctcgctgg gggcactgga aggaggggaa
      181 gcctcacggt gggctcactg gagaaactga ggcaggatca tcgtggaatg gaggatcaga
      241 aagccagaag ctgcaaggtg aatacttcag gtacaaaggc attccctttc cagtcggcat
      301 gtatacacca gagagcctca gtctggccga gaacactagc aatgtgcggg acgacgacat
      361 cttcatcgtc acctacccca aatcaggcac caactggatg attgagatca tctgcttaat
      421 cctgaaagat ggggacccct cgtggatccg ttcggagccc atctggcaac gtgcaccctg
      481 gtgcgagacc accataagtg ccttcagcct tccagagcgg cccagtcccc gcctcatgtg
      541 ctcccacctc cctattgaac tgttcacgaa ggccgccttc agctccaagg ccaaggtgat
      601 ttacttgggc cggaaccccc gggacgtcgt ggtctccctc tattattact ctaagattgc
      661 tgtacaatta aaggaccctg gtacacctga acagttcctt cagaatttcc tcaaaggaga
      721 agtgcagttt ggctcctggt ttgaccacat caagggctgg atccggatgc ggggccgaga
      781 gaacttcctg tttatcacct acgaggagct gcagcaggac ctgcgaggct ccgtgcaact
      841 catctgtgag ttcctgggcc ggccactggg tgaagaggcc ctgagctctg tggtggccca
      901 ttcagctttt gctgccatga aggccaataa catgtccaac tacacgctgc tgccggccag
      961 cctgctagac caccgccagg gggcgttcct gcgcaaaggg atcagtggcg actggaagaa
     1021 ccacttcact gtggcgcaga gtgagacttt tgaccaggtc taccgagagc aaatgcacgg
     1081 gctgccgagc ttcccctggg acaggtccgc agaggacggc agccctgatg gcgagactga
     1141 gcccagccct agccccagcc ctggcctagc ctctgatgac cccaacccag gatcctcaca
     1201 ataaacttgt cactccagcc a
//
