LOCUS       NM_031834               1220 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus sulfotransferase family 1A member 1 (Sult1a1),
            mRNA.
ACCESSION   NM_031834
VERSION     NM_031834.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1220)
  AUTHORS   Paul,S., Gangwar,A., Patir,H., Bhargava,K. and Ahmad,Y.
  TITLE     Reverse translating SULT1A1, a potential biomarker in
            roentgenographically tested rat model of rapid HAPE induction
  JOURNAL   Life Sci 229, 132-138 (2019)
   PUBMED   31100325
  REMARK    GeneRIF: High SULT1A1 expression is associated with high altitude
            pulmonary edema.
REFERENCE   2  (bases 1 to 1220)
  AUTHORS   Sachse,B., Meinl,W., Sommer,Y., Glatt,H., Seidel,A. and Monien,B.H.
  TITLE     Bioactivation of food genotoxicants 5-hydroxymethylfurfural and
            furfuryl alcohol by sulfotransferases from human, mouse and rat: a
            comparative study
  JOURNAL   Arch Toxicol 90 (1), 137-148 (2016)
   PUBMED   25370010
  REMARK    GeneRIF: SULT1A1 is responsible for bioactivation of food
            genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol.
REFERENCE   3  (bases 1 to 1220)
  AUTHORS   Ahmad,Y., Sharma,N.K., Ahmad,M.F., Sharma,M., Garg,I.,
            Srivastava,M. and Bhargava,K.
  TITLE     The proteome of Hypobaric Induced Hypoxic Lung: Insights from
            Temporal Proteomic Profiling for Biomarker Discovery
  JOURNAL   Sci Rep 5, 10681 (2015)
   PUBMED   26022216
  REMARK    GeneRIF: Higher SULT1A1 levels were observed in rats as well as in
            humans exposed to high altitude, when compared to sea-level
            controls
            Erratum:[Sci Rep. 2022 Feb 1;12(1):1981. doi:
            10.1038/s41598-022-06169-9.. PMID: 35105916]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1220)
  AUTHORS   Zhou,T., Huang,C., Chen,Y., Xu,J., Shanbhag,P.D. and Chen,G.
  TITLE     Methamphetamine regulation of sulfotransferase 1A1 and 2A1
            expression in rat brain sections
  JOURNAL   Neurotoxicology 34, 212-218 (2013)
   PUBMED   23026138
  REMARK    GeneRIF: Results suggest that the physiological functions of
            SULT1A1 in different brain regions can be affected by
            methamphetamine.
REFERENCE   5  (bases 1 to 1220)
  AUTHORS   Kurogi,K., Davidson,G., Mohammed,Y.I., Williams,F.E., Liu,M.Y.,
            Sakakibara,Y., Suiko,M. and Liu,M.C.
  TITLE     Ethanol sulfation by the human cytosolic sulfotransferases: a
            systematic analysis
  JOURNAL   Biol Pharm Bull 35 (12), 2180-2185 (2012)
   PUBMED   23207770
REFERENCE   6  (bases 1 to 1220)
  AUTHORS   Yamazoe,Y., Ozawa,S., Nagata,K., Gong,D.W. and Kato,R.
  TITLE     Characterization and expression of hepatic sulfotransferase
            involved in the metabolism of N-substituted aryl compounds
  JOURNAL   Environ Health Perspect 102 Suppl 6 (Suppl 6), 99-103 (1994)
   PUBMED   7889867
REFERENCE   7  (bases 1 to 1220)
  AUTHORS   Yerokun,T., Etheredge,J.L., Norton,T.R., Carter,H.A., Chung,K.H.,
            Birckbichler,P.J. and Ringer,D.P.
  TITLE     Characterization of a complementary DNA for rat liver aryl
            sulfotransferase IV and use in evaluating the hepatic gene
            transcript levels of rats at various stages of
            2-acetylaminofluorene-induced hepatocarcinogenesis
  JOURNAL   Cancer Res 52 (17), 4779-4786 (1992)
   PUBMED   1511441
REFERENCE   8  (bases 1 to 1220)
  AUTHORS   Hirshey,S.J., Dooley,T.P., Reardon,I.M., Heinrikson,R.L. and
            Falany,C.N.
  TITLE     Sequence analysis, in vitro translation, and expression of the cDNA
            for rat liver minoxidil sulfotransferase
  JOURNAL   Mol Pharmacol 42 (2), 257-264 (1992)
   PUBMED   1513323
REFERENCE   9  (bases 1 to 1220)
  AUTHORS   Ozawa,S., Nagata,K., Gong,D.W., Yamazoe,Y. and Kato,R.
  TITLE     Nucleotide sequence of a full-length cDNA (PST-1) for aryl
            sulfotransferase from rat liver
  JOURNAL   Nucleic Acids Res 18 (13), 4001 (1990)
   PUBMED   2374726
REFERENCE   10 (bases 1 to 1220)
  AUTHORS   Borchardt,R.T. and Schasteen,C.S.
  TITLE     Phenol sulfotransferase. I. Purification of a rat liver enzyme by
            affinity chromatography
  JOURNAL   Biochim Biophys Acta 708 (3), 272-279 (1982)
   PUBMED   6959650
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031834.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L19998.1, EX490084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000001.1  190706047-190706112 c
            67-206              JAXUCZ010000001.1  190705195-190705334 c
            207-332             JAXUCZ010000001.1  190704984-190705109 c
            333-430             JAXUCZ010000001.1  190704805-190704902 c
            431-557             JAXUCZ010000001.1  190703940-190704066 c
            558-652             JAXUCZ010000001.1  190703756-190703850 c
            653-833             JAXUCZ010000001.1  190703082-190703262 c
            834-1220            JAXUCZ010000001.1  190702592-190702978 c
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1220
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /note="sulfotransferase family 1A member 1"
                     /db_xref="GeneID:83783"
                     /db_xref="RGD:3767"
     exon            1..66
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            67..206
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..946
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /EC_number="2.8.2.1"
                     /note="Aryl sulfotransferase cytosolic, 1A,
                     phenol-preferring, member 3; aryl sulfotransferase IV;
                     sulfokinase; tyrosine-ester sulfotransferase;
                     sulphotransferase family cytosolic 1A phenol-prefering
                     member 1; sulfotransferase family 1A, phenol-preferring,
                     member 1; sulfotransferase family, cytosolic, 1A, phenol
                     preferring; Phenol sulfotransferase 1a1; minoxidil
                     sulfotransferase; sulfotransferase family, cytosolic, 1A,
                     phenol-preferring, member 1"
                     /codon_start=1
                     /product="sulfotransferase 1A1"
                     /protein_id="NP_114022.1"
                     /db_xref="GeneID:83783"
                     /db_xref="RGD:3767"
                     /translation="MEFSRPPLVHVKGIPLIKYFAETIGPLQNFTAWPDDLLISTYPK
                     SGTTWMSEILDMIYQGGKLEKCGRAPIYARVPFLEFKCPGVPSGLETLEETPAPRLLK
                     THLPLSLLPQSLLDQKVKVIYIARNAKDVVVSYYNFYNMAKLHPDPGTWDSFLENFMD
                     GEVSYGSWYQHVKEWWELRHTHPVLYLFYEDIKENPKREIKKILEFLGRSLPEETVDS
                     IVHHTSFKKMKENCMTNYTTIPTEIMDHNVSPFMRKGTTGDWKNTFTVAQNERFDAHY
                     AKTMTDCDFKFRCEL"
     exon            207..332
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            333..430
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            431..557
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..652
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            653..833
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1220
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaacgccta cacaaagatc cctatcactg agcacccgga ggcaaggctc agaaccccag
       61 gatcagcaac atggagttct cccgtccacc gctagtgcat gtgaagggta tcccactcat
      121 caaatacttt gcagagacaa ttgggccatt gcagaacttc acagcctggc ctgatgactt
      181 gctgatcagc acatacccaa agtctggtac tacctggatg agtgagatcc tggatatgat
      241 ctatcagggt ggcaagctag agaagtgtgg ccgcgccccc atctatgccc gggtaccctt
      301 ccttgagttc aaatgtccag gggttccctc aggtcttgaa actttggaag agacaccagc
      361 cccacggctc cttaagacac atctgcccct gtccttgctc cctcagagtc tgctggatca
      421 gaaggtcaag gtgatctaca ttgcccgaaa tgcaaaggat gtggttgtct cctattataa
      481 cttctacaac atggccaagc tgcaccctga tccaggcacc tgggacagct tcttggagaa
      541 cttcatggat ggggaagtgt cctatgggtc gtggtaccag cacgtgaagg agtggtggga
      601 gctgagacac actcaccctg ttctctatct cttctatgaa gacataaagg agaaccccaa
      661 aagggagatc aagaagattc tagagttttt ggggcgctct ctacccgagg agactgtgga
      721 ttccattgtt caccacacat ctttcaagaa aatgaaagag aactgcatga ctaactacac
      781 aaccatcccc actgagatta tggaccacaa tgtttctccc ttcatgagga aaggtactac
      841 tggggactgg aaaaatacct tcactgtagc ccagaatgag cgctttgatg cccactatgc
      901 taagacaatg acagattgtg acttcaagtt tcgttgtgaa ctatgagtgg attatggcta
      961 tactgggaac caaggcaaac tgacacagcc catcatgatc tcaagtaaaa tgtgatgtgt
     1021 tcaatctact tgttgtatgc ctagaggaaa tctgagctaa gagaatagga ttggggatgt
     1081 ggctgaggca gagggtttta tcaacgcatg tcaggaaagc aatcagtccc aacacctaaa
     1141 aagaacctaa agtacaaaca tgcaaaaaat agtaagataa actatatttt acctgaaaga
     1201 ataaatgcca ctgggaaatg
//
