LOCUS       NP_114022                291 aa            linear   ROD 13-FEB-2025
DEFINITION  sulfotransferase 1A1 [Rattus norvegicus].
ACCESSION   NP_114022
VERSION     NP_114022.1
DBSOURCE    REFSEQ: accession NM_031834.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 291)
  AUTHORS   Paul,S., Gangwar,A., Patir,H., Bhargava,K. and Ahmad,Y.
  TITLE     Reverse translating SULT1A1, a potential biomarker in
            roentgenographically tested rat model of rapid HAPE induction
  JOURNAL   Life Sci 229, 132-138 (2019)
   PUBMED   31100325
  REMARK    GeneRIF: High SULT1A1 expression is associated with high altitude
            pulmonary edema.
REFERENCE   2  (residues 1 to 291)
  AUTHORS   Sachse,B., Meinl,W., Sommer,Y., Glatt,H., Seidel,A. and Monien,B.H.
  TITLE     Bioactivation of food genotoxicants 5-hydroxymethylfurfural and
            furfuryl alcohol by sulfotransferases from human, mouse and rat: a
            comparative study
  JOURNAL   Arch Toxicol 90 (1), 137-148 (2016)
   PUBMED   25370010
  REMARK    GeneRIF: SULT1A1 is responsible for bioactivation of food
            genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol.
REFERENCE   3  (residues 1 to 291)
  AUTHORS   Ahmad,Y., Sharma,N.K., Ahmad,M.F., Sharma,M., Garg,I.,
            Srivastava,M. and Bhargava,K.
  TITLE     The proteome of Hypobaric Induced Hypoxic Lung: Insights from
            Temporal Proteomic Profiling for Biomarker Discovery
  JOURNAL   Sci Rep 5, 10681 (2015)
   PUBMED   26022216
  REMARK    GeneRIF: Higher SULT1A1 levels were observed in rats as well as in
            humans exposed to high altitude, when compared to sea-level
            controls
            Erratum:[Sci Rep. 2022 Feb 1;12(1):1981. doi:
            10.1038/s41598-022-06169-9.. PMID: 35105916]
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 291)
  AUTHORS   Zhou,T., Huang,C., Chen,Y., Xu,J., Shanbhag,P.D. and Chen,G.
  TITLE     Methamphetamine regulation of sulfotransferase 1A1 and 2A1
            expression in rat brain sections
  JOURNAL   Neurotoxicology 34, 212-218 (2013)
   PUBMED   23026138
  REMARK    GeneRIF: Results suggest that the physiological functions of
            SULT1A1 in different brain regions can be affected by
            methamphetamine.
REFERENCE   5  (residues 1 to 291)
  AUTHORS   Kurogi,K., Davidson,G., Mohammed,Y.I., Williams,F.E., Liu,M.Y.,
            Sakakibara,Y., Suiko,M. and Liu,M.C.
  TITLE     Ethanol sulfation by the human cytosolic sulfotransferases: a
            systematic analysis
  JOURNAL   Biol Pharm Bull 35 (12), 2180-2185 (2012)
   PUBMED   23207770
REFERENCE   6  (residues 1 to 291)
  AUTHORS   Yamazoe,Y., Ozawa,S., Nagata,K., Gong,D.W. and Kato,R.
  TITLE     Characterization and expression of hepatic sulfotransferase
            involved in the metabolism of N-substituted aryl compounds
  JOURNAL   Environ Health Perspect 102 Suppl 6 (Suppl 6), 99-103 (1994)
   PUBMED   7889867
REFERENCE   7  (residues 1 to 291)
  AUTHORS   Yerokun,T., Etheredge,J.L., Norton,T.R., Carter,H.A., Chung,K.H.,
            Birckbichler,P.J. and Ringer,D.P.
  TITLE     Characterization of a complementary DNA for rat liver aryl
            sulfotransferase IV and use in evaluating the hepatic gene
            transcript levels of rats at various stages of
            2-acetylaminofluorene-induced hepatocarcinogenesis
  JOURNAL   Cancer Res 52 (17), 4779-4786 (1992)
   PUBMED   1511441
REFERENCE   8  (residues 1 to 291)
  AUTHORS   Hirshey,S.J., Dooley,T.P., Reardon,I.M., Heinrikson,R.L. and
            Falany,C.N.
  TITLE     Sequence analysis, in vitro translation, and expression of the cDNA
            for rat liver minoxidil sulfotransferase
  JOURNAL   Mol Pharmacol 42 (2), 257-264 (1992)
   PUBMED   1513323
REFERENCE   9  (residues 1 to 291)
  AUTHORS   Ozawa,S., Nagata,K., Gong,D.W., Yamazoe,Y. and Kato,R.
  TITLE     Nucleotide sequence of a full-length cDNA (PST-1) for aryl
            sulfotransferase from rat liver
  JOURNAL   Nucleic Acids Res 18 (13), 4001 (1990)
   PUBMED   2374726
REFERENCE   10 (residues 1 to 291)
  AUTHORS   Borchardt,R.T. and Schasteen,C.S.
  TITLE     Phenol sulfotransferase. I. Purification of a rat liver enzyme by
            affinity chromatography
  JOURNAL   Biochim Biophys Acta 708 (3), 272-279 (1982)
   PUBMED   6959650
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L19998.1, EX490084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     Protein         1..291
                     /product="sulfotransferase 1A1"
                     /EC_number="2.8.2.1"
                     /note="Aryl sulfotransferase cytosolic, 1A,
                     phenol-preferring, member 3; aryl sulfotransferase IV;
                     sulfokinase; tyrosine-ester sulfotransferase;
                     sulphotransferase family cytosolic 1A phenol-prefering
                     member 1; sulfotransferase family 1A, phenol-preferring,
                     member 1; sulfotransferase family, cytosolic, 1A, phenol
                     preferring; Phenol sulfotransferase 1a1; minoxidil
                     sulfotransferase; sulfotransferase family, cytosolic, 1A,
                     phenol-preferring, member 1"
                     /calculated_mol_wt=33775
     Region          34..284
                     /region_name="Sulfotransfer_1"
                     /note="Sulfotransferase domain; pfam00685"
                     /db_xref="CDD:425820"
     Site            134
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P17988.1)"
     CDS             1..291
                     /gene="Sult1a1"
                     /gene_synonym="ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1;
                     Sult1a3"
                     /coded_by="NM_031834.2:71..946"
                     /db_xref="GeneID:83783"
                     /db_xref="RGD:3767"
ORIGIN      
        1 mefsrpplvh vkgiplikyf aetigplqnf tawpddllis typksgttwm seildmiyqg
       61 gklekcgrap iyarvpflef kcpgvpsgle tleetpaprl lkthlplsll pqslldqkvk
      121 viyiarnakd vvvsyynfyn maklhpdpgt wdsflenfmd gevsygswyq hvkewwelrh
      181 thpvlylfye dikenpkrei kkileflgrs lpeetvdsiv hhtsfkkmke ncmtnyttip
      241 teimdhnvsp fmrkgttgdw kntftvaqne rfdahyaktm tdcdfkfrce l
//
