LOCUS       NM_001034927            4172 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sulfatase 2 (Sulf2), mRNA.
ACCESSION   NM_001034927 XM_001072989 XM_230861
VERSION     NM_001034927.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4172)
  AUTHORS   Kim,H.Y., Jeong,D.W. and Kim,H.S.
  TITLE     Sulfatase 2 mediates, partially, the expression of endothelin-1 and
            the additive effect of Ang II-induced endothelin-1 expression by
            CXCL8 in vascular smooth muscle cells from spontaneously
            hypertensive rats
  JOURNAL   Cytokine 114, 98-105 (2019)
   PUBMED   30470661
  REMARK    GeneRIF: These findings suggest that Sulf2 is an up-regulatory
            factor in the additive action of CXCL8 via the AT1 R pathway on Ang
            II-induced ET-1 expression in vascular smooth muscle cells under
            hypertension environment.
REFERENCE   2  (bases 1 to 4172)
  AUTHORS   Zaman,G., Staines,K.A., Farquharson,C., Newton,P.T., Dudhia,J.,
            Chenu,C., Pitsillides,A.A. and Dhoot,G.K.
  TITLE     Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral
            fracture healing
  JOURNAL   Histochem Cell Biol 145 (1), 67-79 (2016)
   PUBMED   26464246
  REMARK    GeneRIF: Examination of epiphyseal growth plates revealed
            differential, inverse patterns of SULF1 and SULF2 expressions, with
            the former enriched in quiescent and the latter in hypertrophic
            chondrocyte zones.
REFERENCE   3  (bases 1 to 4172)
  AUTHORS   Joy,M.T., Vrbova,G., Dhoot,G.K. and Anderson,P.N.
  TITLE     Sulf1 and Sulf2 expression in the nervous system and its role in
            limiting neurite outgrowth in vitro
  JOURNAL   Exp Neurol 263, 150-160 (2015)
   PUBMED   25448158
  REMARK    GeneRIF: It is proposed that Sulf1, Sulf2 and ErbB1 are involved in
            the inhibition of neurite outgrowth and may regulate structural
            plasticity and regeneration in the nervous system.
REFERENCE   4  (bases 1 to 4172)
  AUTHORS   Nakamura,I., Fernandez-Barrena,M.G., Ortiz-Ruiz,M.C., Almada,L.L.,
            Hu,C., Elsawa,S.F., Mills,L.D., Romecin,P.A., Gulaid,K.H.,
            Moser,C.D., Han,J.J., Vrabel,A., Hanse,E.A., Akogyeram,N.A.,
            Albrecht,J.H., Monga,S.P.S., Sanderson,S.O., Prieto,J.,
            Roberts,L.R. and Fernandez-Zapico,M.E.
  TITLE     Activation of the transcription factor GLI1 by WNT signaling
            underlies the role of SULFATASE 2 as a regulator of tissue
            regeneration
  JOURNAL   J Biol Chem 288 (29), 21389-21398 (2013)
   PUBMED   23740243
REFERENCE   5  (bases 1 to 4172)
  AUTHORS   Schumacher,V.A., Schlotzer-Schrehardt,U., Karumanchi,S.A., Shi,X.,
            Zaia,J., Jeruschke,S., Zhang,D., Pavenstadt,H., Drenckhan,A.,
            Amann,K., Ng,C., Hartwig,S., Ng,K.H., Ho,J., Kreidberg,J.A.,
            Taglienti,M., Royer-Pokora,B. and Ai,X.
  TITLE     WT1-dependent sulfatase expression maintains the normal glomerular
            filtration barrier
  JOURNAL   J Am Soc Nephrol 22 (7), 1286-1296 (2011)
   PUBMED   21719793
  REMARK    Erratum:[J Am Soc Nephrol. 2011 Dec;22(12):2332. Pavenstaedt,
            Hermann [corrected to Pavenstadt, Hermann]]
REFERENCE   6  (bases 1 to 4172)
  AUTHORS   Ai,X., Kitazawa,T., Do,A.T., Kusche-Gullberg,M., Labosky,P.A. and
            Emerson,C.P. Jr.
  TITLE     SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling
            for esophageal innervation
  JOURNAL   Development 134 (18), 3327-3338 (2007)
   PUBMED   17720696
REFERENCE   7  (bases 1 to 4172)
  AUTHORS   Holst,C.R., Bou-Reslan,H., Gore,B.B., Wong,K., Grant,D.,
            Chalasani,S., Carano,R.A., Frantz,G.D., Tessier-Lavigne,M.,
            Bolon,B., French,D.M. and Ashkenazi,A.
  TITLE     Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential
            roles in mouse neonatal survival
  JOURNAL   PLoS One 2 (6), e575 (2007)
   PUBMED   17593974
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4172)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
REFERENCE   9  (bases 1 to 4172)
  AUTHORS   Nagamine,S., Koike,S., Keino-Masu,K. and Masu,M.
  TITLE     Expression of a heparan sulfate remodeling enzyme, heparan sulfate
            6-O-endosulfatase sulfatase FP2, in the rat nervous system
  JOURNAL   Brain Res Dev Brain Res 159 (2), 135-143 (2005)
   PUBMED   16139897
REFERENCE   10 (bases 1 to 4172)
  AUTHORS   Morimoto-Tomita,M., Uchimura,K., Werb,Z., Hemmerich,S. and
            Rosen,S.D.
  TITLE     Cloning and characterization of two extracellular heparin-degrading
            endosulfatases in mice and humans
  JOURNAL   J Biol Chem 277 (51), 49175-49185 (2002)
   PUBMED   12368295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY742216.1.
            
            On or before Jul 24, 2006 this sequence version replaced
            XM_230861.4, XM_001072989.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY742216.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4172
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..4172
                     /gene="Sulf2"
                     /note="sulfatase 2"
                     /db_xref="GeneID:311642"
                     /db_xref="RGD:1305078"
     exon            1..558
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..825
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             651..3278
                     /gene="Sulf2"
                     /note="sulfatase FP2; extracellular sulfatase Sulf-2"
                     /codon_start=1
                     /product="extracellular sulfatase Sulf-2 precursor"
                     /protein_id="NP_001030099.1"
                     /db_xref="GeneID:311642"
                     /db_xref="RGD:1305078"
                     /translation="MAPPGLPLWLLSTALFSLLAGSSAFLSYPRLKGRFQRDRRNIRP
                     NIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVH
                     NHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEW
                     VGLLKNSRFYNYTLCRNGMKEKHGSDYSTDYLTDLITNDSVSFFRTSKKMYPHRPVLM
                     VISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFT
                     NMLQRKRLQTLMSVDDSMETIYDMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSMP
                     YEFDIRVPFYVRGPSVEAGSLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDS
                     ERPVNRFHLKKKLRVWRDSFLVERGKLLHKREGDKVNAQEENFLPKYQRVKDLCQRAE
                     YQTACEQLGQKWQCVEDASGALKLHKCKGPVRFGGGGDRALSNLVPKYDGQSSEACSC
                     DGGGGGGDYKLGLAGRRKLFKKKYKTSYARNRSIRSVAIEVDGEVYHVGLDNMPLPRN
                     LTKRHWPGAPEDQDDKDGGSFSGTGGLPDYSAPNPIKVTHRCYILENDTVQCDLDLYK
                     SLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHKVSYHSQHKGRLKH
                     KGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNHHW
                     QTAPLWTLGPFCACTSANNNTYWCLRTINETHNFLFCEFATGFIEYFDLSTDPYQLMN
                     AVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLRDGGSYEQYRQFQRRKWP
                     EMKRPSSKSLGQLWEGWEG"
     exon            826..1065
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1217
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1387
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1538
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1714
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1843
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1900
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2030
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2241
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2470
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2567
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2662
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2722
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2892
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3035
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3159
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3193
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3247
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..4172
                     /gene="Sulf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaagtgtg tgcgtgtgtg tttagaggcg agcgcggggc tttcagcaaa ggctgccggg
       61 tgtttgcaaa ccagggcgag cccctgtgaa agcggataaa agaaaacatt tattaacgtg
      121 tcattacgag gggcagcgcc gggccggggc tgtcgcacgc ctcagggaac acttggctcc
      181 tcgctgctgg gagggaggag gaccaaaaag cggaaagagg ctggattctc tgcgcgccag
      241 cccgggggac ctgatccatg gccctcgcga cttcgcgccg gtgtttggtg gactaagaga
      301 tgcgcccccg gtccgagtgg cacacacgcg cgcacacacg cacgcgcggt cccggctcgc
      361 cggcagctcc ctgctcagcg cacatcagcc acaactccgc gcccagggcg agcgggagcg
      421 ggtgcgggtg agtgcgcccc aggcccgcga gggtgcgcgc tcggcggcgg gagcgcggcc
      481 ggccaccggc tcggcaggca gcaggccggg agccgccggg acttcgggcc ggggcgccgg
      541 gcggctgcga aggcagagat tctgagggaa gaggggaagg aatcccatcc tcaagaagcc
      601 acctcagcct ctgcatccag gaagaagcaa cagacgggca agccacgcca atggcacccc
      661 ctggcctgcc actgtggctg ctgtccaccg ctctcttctc ccttctggct ggcagctcag
      721 ccttcctctc ctatccccgc ctgaagggtc gcttccagag ggaccgcagg aatatccggc
      781 ccaacatcat cttggtgctc acggatgacc aggacgtgga gctgggctcc atgcaggtga
      841 tgaacaagac acgacgtatc atggagcagg gcggggcaca cttcatcaac gccttcgtga
      901 ctacacctat gtgctgtccc tctcgctcct ccatcctcac cggcaagtac gtccacaatc
      961 acaacaccta caccaacaac gagaactgtt cctcgccctc ctggcaggca cagcatgaga
     1021 gccgaacctt cgccgtgtac ctcaacagca ctggctaccg gacagctttc ttcggaaaat
     1081 acctcaatga atacaacggc tcatatgtgc cgcctggctg gaaggagtgg gttggactcc
     1141 ttaagaactc gcgtttttat aactacacac tctgccggaa tgggatgaag gagaagcatg
     1201 gctctgacta ctccacggat tacctcacag atctcatcac caatgacagt gtgagcttct
     1261 tccgaacatc caagaagatg tacccacaca gacctgtgct catggtcatc agccacgcag
     1321 ctccccacgg ccctgaggac tcagcacccc agtactcacg cctcttcccc aatgcatccc
     1381 agcacatcac accgagttac aactatgcac ccaacccaga caagcactgg atcatgcgct
     1441 acacgggacc catgaagccc attcacatgg aattcaccaa catgctacag cgcaaacgcc
     1501 tgcagaccct catgtctgtg gacgactcca tggagacgat ctatgacatg ctagtggaga
     1561 cgggcgagct ggacaatacc tacatcgtgt acaccgccga ccacggctac cacattggcc
     1621 agtttggcct ggtgaagggc aagtccatgc cctatgagtt tgacatcagg gtcccgttct
     1681 atgtgcgggg ccccagcgtg gaagctggct ctctgaaccc ccacatcgtc ctcaacattg
     1741 acctggcccc caccatactg gatatcgctg gactggacat ccctgcagac atggacggga
     1801 agtccatcct caaactactg gactcagagc ggccagtgaa ccggttccac ctgaaaaaga
     1861 agctgagggt ctggcgagac tccttcctgg tggaaagagg caaactgctc cacaagaggg
     1921 agggtgacaa agtgaacgcc caggaggaga acttcctgcc caagtatcag cgtgtgaagg
     1981 acctgtgtca aagggctgag taccagacag catgcgagca gctagggcag aagtggcagt
     2041 gtgtagagga cgcttctggg gcgctgaagc tgcacaagtg taaaggcccg gtgcggttcg
     2101 ggggcggtgg tgacagagcc ctctccaacc tggtgcccaa gtacgacggc caaagcagcg
     2161 aggcctgcag ctgtgacggc ggcggcggcg gaggggacta caaactgggc ctggctggac
     2221 gccggaagct ctttaagaaa aagtacaaga ccagctatgc ccggaaccgc tccatccgct
     2281 ctgtggccat cgaggtggat ggcgaggtat accacgtagg cttggataac atgccgctgc
     2341 cccgcaacct caccaagcgt cactggccag gggcccctga agaccaggat gacaaggatg
     2401 gtggaagttt cagtggtact ggtggccttc cagattattc tgcccccaat cccattaaag
     2461 tgacccatcg gtgctacatc cttgagaatg acacagtcca gtgtgacttg gacctgtaca
     2521 agtccctgca ggcttggaaa gaccacaaat tgcacatcga ccatgagatt gaaaccctgc
     2581 agaacaaaat taagaacctt cgagaagtca ggggtcacct gaagaagaag cggccagaag
     2641 aatgtgactg tcacaaagtc agttaccaca gccaacacaa aggccgcctc aagcacaagg
     2701 gctccagcct gcaccctttc aggaagggtc tgcaggagaa agacaaggtg tggctgttgc
     2761 gggagcagaa acgcaagaag aaactgcgca agctgctgaa gcgactgcag aacaatgaca
     2821 cgtgcagcat gccgggcctc acgtgcttta ctcacgacaa ccaccactgg cagaccgcgc
     2881 cgctctggac gttgggaccc ttctgcgcct gcaccagcgc caacaataac acgtactggt
     2941 gcctgcggac catcaacgag acccacaact tcctcttctg tgaattcgca actggcttca
     3001 tagaatactt tgacctcagt acggacccct accagctgat gaacgcggtc aacacactgg
     3061 acagggacgt tctcaaccag ctgcacgtcc agctcatgga gctaaggagc tgcaaaggct
     3121 acaagcagtg taacccccgg acccgcaata tggacctggg gcttagagac ggaggaagct
     3181 atgagcaata caggcagttt cagcgtcgaa aatggccaga aatgaagaga ccctcttcca
     3241 aatcactggg acagctatgg gaaggttggg aaggctaatc ggccatggag aggaacctcc
     3301 aaaaccagag gcctcctgtg gctgcccagg cgtgcaaaaa tcacccaatt ccgaggagat
     3361 cgatgctgga actgggagac ttgacaggag gcagggtctg cacttgggac aggaaatccc
     3421 gaggagaacg ccaagacttc cagaggctca ttgttttgcc ccgctttgct tcggattgaa
     3481 cctcaccggc cgcacaagga tgcgtcctga cacctggagt ctccgctcac cctttcagag
     3541 gctcaccaag acaaaggaac taattcccat ggactttcct ccagagatgg aaattgctgg
     3601 gatttaccca tcccctcccc tgtaccccct tccccactag ggaaacaagc ttgttttaac
     3661 cttcttattc tttggagaaa gcacggatgt cccaggtgct gtcaacagcg cagtcttgac
     3721 aatggtctat agcacaaaac agtaccattc acctggctgg atgagccggc tgccccagaa
     3781 gctgccttca ctgtacatat gtgactgctc acatgtaacc aacacaggga cttgtagggg
     3841 gaatctcact aatacgaaat cccattttca agagtcgcgg tgtcaataaa cactctgtgg
     3901 ctggtgtcaa gggtaatccc ttgagctttc agacatttct gttcctgccc aggattcgtt
     3961 cctttgttat ccatatccat cccagaactg atgttttcta aggtactgaa accccaagtt
     4021 gatgtgtgtc ctgtgtttta atgacattgt atttgtaaag caattttgta gtataaaagt
     4081 accatcttcc agtgttcaca tcccccccag ccaatgacta gctcttggta tgaaaaaaaa
     4141 aatctttgaa tttttgtaaa aggctatctt gg
//
