LOCUS       NM_001024899            1757 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SUFU negative regulator of hedgehog signaling
            (Sufu), mRNA.
ACCESSION   NM_001024899 XM_342061
VERSION     NM_001024899.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Ding,X., Fan,K., Hu,J., Zang,Z., Zhang,S., Zhang,Y., Lin,Z.,
            Pei,X., Zheng,X., Zhu,F., Yang,H. and Li,S.
  TITLE     SCP2-mediated cholesterol membrane trafficking promotes the growth
            of pituitary adenomas via Hedgehog signaling activation
  JOURNAL   J Exp Clin Cancer Res 38 (1), 404 (2019)
   PUBMED   31519191
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Wei,M., Ma,R., Huang,S., Liao,Y., Ding,Y., Li,Z., Guo,Q., Tan,R.,
            Zhang,L. and Zhao,L.
  TITLE     Oroxylin A increases the sensitivity of temozolomide on glioma
            cells by hypoxia-inducible factor 1alpha/hedgehog pathway under
            hypoxia
  JOURNAL   J Cell Physiol 234 (10), 17392-17404 (2019)
   PUBMED   30790292
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Cai,D., Yu,J., Qiu,J., He,B., Chen,Z., Yan,M. and Liu,Q.
  TITLE     Dynamic changes of Sonic Hedgehog signaling pathway in gastric
            mucosa of rats with MNNG-induced gastric precancerous lesions
  JOURNAL   J Cell Physiol 234 (7), 10827-10834 (2019)
   PUBMED   30537251
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Lin,J.C., Liu,Z.G., Yu,B. and Zhang,X.R.
  TITLE     MicroRNA-874 targeting SUFU involves in osteoblast proliferation
            and differentiation in osteoporosis rats through the Hedgehog
            signaling pathway
  JOURNAL   Biochem Biophys Res Commun 506 (1), 194-203 (2018)
   PUBMED   30342851
  REMARK    GeneRIF: through targeted inhibition of SUFU and activation of
            Hedgehog signaling pathway, miR-874 could promote the proliferation
            and differentiation of osteoblasts in osteoporosis rats.
            Erratum:[Biochem Biophys Res Commun. 2022 Dec 25;636(Pt 1):213.
            doi: 10.1016/j.bbrc.2022.10.084. PMID: 36336525]
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Wang,C., Li,J., Takemaru,K.I., Jiang,X., Xu,G. and Wang,B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1757)
  AUTHORS   Taylor,M.D., Liu,L., Raffel,C., Hui,C.C., Mainprize,T.G., Zhang,X.,
            Agatep,R., Chiappa,S., Gao,L., Lowrance,A., Hao,A., Goldstein,A.M.,
            Stavrou,T., Scherer,S.W., Dura,W.T., Wainwright,B., Squire,J.A.,
            Rutka,J.T. and Hogg,D.
  TITLE     Mutations in SUFU predispose to medulloblastoma
  JOURNAL   Nat Genet 31 (3), 306-310 (2002)
   PUBMED   12068298
REFERENCE   7  (bases 1 to 1757)
  AUTHORS   Meng,X., Poon,R., Zhang,X., Cheah,A., Ding,Q., Hui,C.C. and
            Alman,B.
  TITLE     Suppressor of fused negatively regulates beta-catenin signaling
  JOURNAL   J Biol Chem 276 (43), 40113-40119 (2001)
   PUBMED   11477086
REFERENCE   8  (bases 1 to 1757)
  AUTHORS   Murone,M., Luoh,S.M., Stone,D., Li,W., Gurney,A., Armanini,M.,
            Grey,C., Rosenthal,A. and de Sauvage,F.J.
  TITLE     Gli regulation by the opposing activities of fused and suppressor
            of fused
  JOURNAL   Nat Cell Biol 2 (5), 310-312 (2000)
   PUBMED   10806483
REFERENCE   9  (bases 1 to 1757)
  AUTHORS   Stone,D.M., Murone,M., Luoh,S., Ye,W., Armanini,M.P., Gurney,A.,
            Phillips,H., Brush,J., Goddard,A., de Sauvage,F.J. and Rosenthal,A.
  TITLE     Characterization of the human suppressor of fused, a negative
            regulator of the zinc-finger transcription factor Gli
  JOURNAL   J Cell Sci 112 (Pt 23), 4437-4448 (1999)
   PUBMED   10564661
REFERENCE   10 (bases 1 to 1757)
  AUTHORS   Ding,Q., Fukami,Si., Meng,X., Nishizaki,Y., Zhang,X., Sasaki,H.,
            Dlugosz,A., Nakafuku,M. and Hui,Cc.
  TITLE     Mouse suppressor of fused is a negative regulator of sonic hedgehog
            signaling and alters the subcellular distribution of Gli1
  JOURNAL   Curr Biol 9 (19), 1119-1122 (1999)
   PUBMED   10531011
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097447.1.
            
            On Jun 17, 2005 this sequence version replaced XM_342061.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132277, SAMD00132289
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1757
                     /gene="Sufu"
                     /note="SUFU negative regulator of hedgehog signaling"
                     /db_xref="GeneID:361769"
                     /db_xref="RGD:1559462"
     exon            1..352
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1628
                     /gene="Sufu"
                     /codon_start=1
                     /product="suppressor of fused homolog"
                     /protein_id="NP_001020070.1"
                     /db_xref="GeneID:361769"
                     /db_xref="RGD:1559462"
                     /translation="MAELRPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRL
                     YPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDN
                     RVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDH
                     VSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQG
                     ILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQQERVDKGIETDGSNLSGVSAKCAW
                     DDLSRPPEDDEDSRSICLGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINSQRQN
                     GLTYDRAPSRKDSLGSDISTAVIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLH
                     GRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLED
                     LTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH"
     exon            353..487
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     exon            488..624
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     exon            625..767
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     exon            768..853
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     exon            854..926
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1083
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1195
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1330
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1469
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1538
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1733
                     /gene="Sufu"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgaaggct ccgacttggg cggacggagc ctcgtgcgca ggcgcggagt tagacctcgc
       61 cgtagccccc atcgcctcgg ggactcttca tccacagtgg gtccgctggc ccataggggc
      121 gctttccctc ctctaccctc ccgggttccc cgcgcgccct acgcgcccca atggcggagc
      181 tgaggcctag cgtcgccccc ggccccgccg cgcccccggc ctctggccct agtgcccccc
      241 cggcctttgc ttcactcttt cccccgggac tccacgccat ctacggagag tgccgccgcc
      301 tctaccctga ccagccgaac ccgctccagg ttaccgctat cgtcaagtac tggttgggtg
      361 gtccagaccc cttggattat gtaagcatgt acaggaatat ggggagtcct tctgccaaca
      421 tccctgagca ctggcactac atcagctttg gcctgagtga tctctacggt gacaacagag
      481 tccacgagtt tacaggaaca gacggaccaa gtggatttgg ctttgaattg acatttcgtc
      541 tgaagagaga aactggggag tctgccccac caacatggcc agcagagctg atgcagggcc
      601 tagcccgata tgtcttccag tcagagaata ccttctgtag tggggaccac gtgtcttggc
      661 acagcccttt ggataacagt gagtcaagaa ttcagcacat gctgctgacg gaggacccac
      721 agatgcagcc tgtgcagaca ccctttgggg tagttacttt cctccagatt gttggtgtct
      781 gcactgagga gttacactca gcccagcagt ggaatgggca gggcatcctg gagctgctgc
      841 ggacagtgcc cattgctggc ggtccctggc tgataactga catgcggagg ggagaaacca
      901 tattcgagat cgatccacac ctgcaacagg agagagttga caaaggcatc gagacagacg
      961 gttctaacct gagcggtgtc agtgccaagt gtgcctggga tgacctcagc cggcctccgg
     1021 aggacgatga ggatagccgg agcatctgcc tcggcacgca gcctcgaagg ctgtctggca
     1081 aagacacaga gcagatccgg gagaccctga ggcgaggact ggagattaac agcaaacctg
     1141 tccttccacc aatcaattct caaaggcaga atggcctcac ctacgaccga gccccgagcc
     1201 gtaaggacag cttgggcagt gacatctcca cggctgttat cccccacgag ctgatccgca
     1261 cacggcagct cgaaagcgtg catctgaaat ttaaccagga gtcgggagcc ctcatccccc
     1321 tctgcctaag gggcagactc ctgcatggcc ggcacttcac ctacaagagt atcacaggtg
     1381 acatggccat cacgtttgtg tccaccggag tggaaggcgc ctttgccact gaggaacatc
     1441 cttacgcagc tcacggaccc tggttacaaa ttctgttgac agaagagttt gtagagaaaa
     1501 tgttggagga cttagaagat ctaacttctc cagaggaatt taaacttccc aaagagtaca
     1561 gctggcctga aaagaagctc aaagtgtcca tcctccccga cgtggtgttc gacagtccgc
     1621 tgcactagcc tgagctaggc cctgcagggg ccaagaggag cccagctgct cctagtgact
     1681 tccagtgtgg cagcttgtaa aggagacacc catgaataaa agggcaaatg tgaaaaaaaa
     1741 aaaaaaaaaa aaaaaaa
//
