LOCUS       NM_001001518            1544 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus succinate receptor 1 (Sucnr1), mRNA.
ACCESSION   NM_001001518 XM_579061
VERSION     NM_001001518.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1544)
  AUTHORS   Dallons,M., Alpan,E., Schepkens,C., Tagliatti,V. and Colet,J.M.
  TITLE     GPR91 Receptor Mediates Protection against Doxorubicin-Induced
            Cardiotoxicity without Altering Its Anticancer Efficacy. An In
            Vitro Study on H9C2 Cardiomyoblasts and Breast Cancer-Derived MCF-7
            Cells
  JOURNAL   Cells 9 (10), 2177 (2020)
   PUBMED   32992522
  REMARK    GeneRIF: GPR91 Receptor Mediates Protection against
            Doxorubicin-Induced Cardiotoxicity without Altering Its Anticancer
            Efficacy. An In Vitro Study on H9C2 Cardiomyoblasts and Breast
            Cancer-Derived MCF-7 Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1544)
  AUTHORS   Haffke,M., Fehlmann,D., Rummel,G., Boivineau,J., Duckely,M.,
            Gommermann,N., Cotesta,S., Sirockin,F., Freuler,F.,
            Littlewood-Evans,A., Kaupmann,K. and Jaakola,V.P.
  TITLE     Structural basis of species-selective antagonist binding to the
            succinate receptor
  JOURNAL   Nature 574 (7779), 581-585 (2019)
   PUBMED   31645725
  REMARK    GeneRIF: high-resolution crystal structure of rat SUCNR1 in complex
            with an intracellular binding nanobody in the inactive conformation
REFERENCE   3  (bases 1 to 1544)
  AUTHORS   Li,Y., Liu,Y., Wang,C., Xia,W.R., Zheng,J.Y., Yang,J., Liu,B.,
            Liu,J.Q. and Liu,L.F.
  TITLE     Succinate induces synovial angiogenesis in rheumatoid arthritis
            through metabolic remodeling and HIF-1alpha/VEGF axis
  JOURNAL   Free Radic Biol Med 126, 1-14 (2018)
   PUBMED   30030103
  REMARK    GeneRIF: More than an intermediate, succinate functioned as a
            signaling molecule to link metabolic reprograming with
            angiogenesis. Intracellular succinate induced angiogenesis through
            HIF-1alpha induction, while extracellular succinate acted on GPR91
            activation, working together to disturb energy metabolism and
            exacerbate inflammation and angiogenesis in arthritis synovium
REFERENCE   4  (bases 1 to 1544)
  AUTHORS   Lu,Y.T., Li,L.Z., Yang,Y.L., Yin,X., Liu,Q., Zhang,L., Liu,K.,
            Liu,B., Li,J. and Qi,L.W.
  TITLE     Succinate induces aberrant mitochondrial fission in cardiomyocytes
            through GPR91 signaling
  JOURNAL   Cell Death Dis 9 (6), 672 (2018)
   PUBMED   29867110
  REMARK    GeneRIF: succinate-mediated GPR91 activation might be a potential
            therapeutic strategy for protecting cardiomyocytes from ischemic
            injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1544)
  AUTHORS   Li,J., Yang,Y.L., Li,L.Z., Zhang,L., Liu,Q., Liu,K., Li,P., Liu,B.
            and Qi,L.W.
  TITLE     Succinate accumulation impairs cardiac pyruvate dehydrogenase
            activity through GRP91-dependent and independent signaling
            pathways: Therapeutic effects of ginsenoside Rb1
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (11), 2835-2847 (2017)
   PUBMED   28736181
  REMARK    GeneRIF: Succinate accumulation impairs cardiac pyruvate
            dehydrogenase activity through GRP91-dependent and independent
            signaling pathways: Therapeutic effects of ginsenoside Rb1.
REFERENCE   6  (bases 1 to 1544)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1544)
  AUTHORS   Sapieha,P., Sirinyan,M., Hamel,D., Zaniolo,K., Joyal,J.S.,
            Cho,J.H., Honore,J.C., Kermorvant-Duchemin,E., Varma,D.R.,
            Tremblay,S., Leduc,M., Rihakova,L., Hardy,P., Klein,W.H., Mu,X.,
            Mamer,O., Lachapelle,P., Di Polo,A., Beausejour,C., Andelfinger,G.,
            Mitchell,G., Sennlaub,F. and Chemtob,S.
  TITLE     The succinate receptor GPR91 in neurons has a major role in retinal
            angiogenesis
  JOURNAL   Nat Med 14 (10), 1067-1076 (2008)
   PUBMED   18836459
  REMARK    GeneRIF: a pathway of metabolite signaling where succinate, acting
            through GPR91, governs retinal angiogenesis and show the propensity
            of RGCs to act as sensors of ischemic stress.
REFERENCE   8  (bases 1 to 1544)
  AUTHORS   Toma,I., Kang,J.J., Sipos,A., Vargas,S., Bansal,E., Hanner,F.,
            Meer,E. and Peti-Peterdi,J.
  TITLE     Succinate receptor GPR91 provides a direct link between high
            glucose levels and renin release in murine and rabbit kidney
  JOURNAL   J Clin Invest 118 (7), 2526-2534 (2008)
   PUBMED   18535668
REFERENCE   9  (bases 1 to 1544)
  AUTHORS   He,W., Miao,F.J., Lin,D.C., Schwandner,R.T., Wang,Z., Gao,J.,
            Chen,J.L., Tian,H. and Ling,L.
  TITLE     Citric acid cycle intermediates as ligands for orphan
            G-protein-coupled receptors
  JOURNAL   Nature 429 (6988), 188-193 (2004)
   PUBMED   15141213
REFERENCE   10 (bases 1 to 1544)
  AUTHORS   Wittenberger,T., Schaller,H.C. and Hellebrand,S.
  TITLE     An expressed sequence tag (EST) data mining strategy succeeding in
            the discovery of new G-protein coupled receptors
  JOURNAL   J Mol Biol 307 (3), 799-813 (2001)
   PUBMED   11273702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1 and FM097467.1.
            
            On Dec 3, 2020 this sequence version replaced NM_001001518.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM094926.1, FM097467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000002.1  146368858-146368898
            42-645              FM097467.1         1-604
            646-1544            JAXUCZ010000002.1  146379462-146380360
FEATURES             Location/Qualifiers
     source          1..1544
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..1544
                     /gene="Sucnr1"
                     /gene_synonym="Gpr91"
                     /note="succinate receptor 1"
                     /db_xref="GeneID:408199"
                     /db_xref="RGD:1303193"
     exon            1..59
                     /gene="Sucnr1"
                     /gene_synonym="Gpr91"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1010
                     /gene="Sucnr1"
                     /gene_synonym="Gpr91"
                     /note="G-protein coupled receptor 91"
                     /codon_start=1
                     /product="succinate receptor 1"
                     /protein_id="NP_001001518.1"
                     /db_xref="GeneID:408199"
                     /db_xref="RGD:1303193"
                     /translation="MAQNLSCENWLALENILKKYYLSAFYGIEFIVGMLGNFTVVFGY
                     LFCMKNWNSSNVYLFNLSISDLAFLCTLPMLIRSYATGNWTYGDVLCISNRYVLHANL
                     YTSILFLTFISIDRYLLMKFPFREHILQKKEFAILISLAVWVLVTLEVLPMLTFITST
                     PIEKGDSCVDYASSGNPKYSLIYSLCLTLLGFLIPLSVMCFFYYKMVVFLKKRSQQQA
                     TVLSLNKPLRLVVLAVVIFSVLFTPYHIMRNVRIASRLDSWPQGCSQKAIKCLYILTR
                     PLAFLNSAVNPIFYFLVGDHFRDMLFSKLRQYFKSLTSFRL"
     exon            60..1544
                     /gene="Sucnr1"
                     /gene_synonym="Gpr91"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagctgtct ccagctcctg gcagagtttt ctgtggagaa agaggccgtc agcagaatgg
       61 cacagaattt atcttgtgaa aattggctgg cattagagaa tattttgaaa aagtactacc
      121 tctctgcatt ttatgggatc gagttcattg ttggaatgct tggcaatttc accgtggtgt
      181 tcggctacct cttctgcatg aagaactgga acagtagcaa cgtctatctc ttcaaccttt
      241 ccatctctga ccttgctttc ctgtgcacgc ttcccatgct gataaggagt tacgccactg
      301 ggaactggac ctatggagat gttctctgca taagcaaccg ttatgtgctt catgccaacc
      361 tctacaccag catccttttc ctcactttca ttagcataga ccgatatctg ctcatgaagt
      421 tccctttccg agaacacatt ctacaaaaga aggaatttgc cattttaatc tccctggctg
      481 tctgggtctt agtgacctta gaagttctac ctatgctcac gtttatcact tccaccccaa
      541 tagaaaaggg cgacagctgt gtcgactatg caagttctgg aaaccctaaa tacagtctca
      601 tttacagcct gtgcctgact ttgctgggct tcctcattcc tctgtctgta atgtgcttct
      661 tctactacaa aatggtagtc ttcctaaaga agaggagcca gcagcaggca actgtgctat
      721 cgctgaacaa acctctgcgc ctggtggtcc tggcagtggt gatcttctct gtactcttta
      781 caccttacca tatcatgcgc aatgtgagga ttgcctcacg cttggatagc tggccacagg
      841 gatgttccca gaaggccatc aaatgcttat acatcctgac cagacctctg gcctttctga
      901 acagtgctgt caaccccatc ttctacttcc ttgtgggaga ccatttcaga gacatgctgt
      961 ttagtaagtt gagacaatac ttcaagtccc ttacgtcctt caggctctga cctaatgtag
     1021 gtcttcactg agccagaata agactcaact ctgcagttga gttttgacca agtagaccac
     1081 cacctctagg ctttagcgtt cccaccatcc tccaaccctg agtgctagag cacaaactgg
     1141 gcacacatga atcagaagag caaccatctg tcccgatttt aggctgtacc cagagtatgg
     1201 aaaaatgagg ccccagaaag cattgacatc ttcacataag aactgaacaa aagaaaactg
     1261 atgttgtcaa tatttggaca cttaagatcc aaggcgttgg agattttaag acatcttctt
     1321 tctatcagtg taaaaggaat acgagacagc tagttctgac actgaatgca ttttgtcatt
     1381 ggtcagcttg ataagaatgt ttctgaaata gtctctatta tttttattct tgcaatatta
     1441 accttttata tgaatggtga gtagaactca atgtacaaca ttagcaatta tattcagaaa
     1501 gtacatttct tgaaaaaatg aataactgca atgcctaaat aaat
//
