LOCUS       NM_001271541            1208 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serine/threonine/tyrosine interacting protein
            (Styx), mRNA.
ACCESSION   NM_001271541 XM_003751450 XM_003752789
VERSION     NM_001271541.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1208)
  AUTHORS   Reiterer,V., Figueras-Puig,C., Le Guerroue,F., Confalonieri,S.,
            Vecchi,M., Jalapothu,D., Kanse,S.M., Deshaies,R.J., Di Fiore,P.P.,
            Behrends,C. and Farhan,H.
  TITLE     The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits
            SCFFBXW7 function
  JOURNAL   EMBO J 36 (3), 260-273 (2017)
   PUBMED   28007894
  REMARK    Erratum:[EMBO J. 2018 Mar 15;37(6):. PMID: 29545456]
REFERENCE   2  (bases 1 to 1208)
  AUTHORS   Reiterer,V., Fey,D., Kolch,W., Kholodenko,B.N. and Farhan,H.
  TITLE     Pseudophosphatase STYX modulates cell-fate decisions and cell
            migration by spatiotemporal regulation of ERK1/2
  JOURNAL   Proc Natl Acad Sci U S A 110 (31), E2934-E2943 (2013)
   PUBMED   23847209
  REMARK    GeneRIF: results identify STYX as an important regulator of ERK1/2
            signaling critical for cell migration
REFERENCE   3  (bases 1 to 1208)
  AUTHORS   Wishart,M.J. and Dixon,J.E.
  TITLE     The archetype STYX/dead-phosphatase complexes with a spermatid
            mRNA-binding protein and is essential for normal sperm production
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2112-2117 (2002)
   PUBMED   11842224
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Oct 14, 2012 this sequence version replaced
            XM_003751450.1, XM_003752789.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments to rat ESTs BF408902.1 and
            FQ204490.1 and to mouse NM_019637.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.48123.1,
                                           SRR26643292.53417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000015.1  21045063-21045327
            266-298             JAXUCZ010000015.1  21052778-21052810
            299-352             JAXUCZ010000015.1  21054346-21054399
            353-450             JAXUCZ010000015.1  21056363-21056460
            451-511             JAXUCZ010000015.1  21061725-21061785
            512-548             JAXUCZ010000015.1  21062651-21062687
            549-588             JAXUCZ010000015.1  21063270-21063309
            589-639             JAXUCZ010000015.1  21063904-21063954
            640-712             JAXUCZ010000015.1  21066392-21066464
            713-806             JAXUCZ010000015.1  21069280-21069373
            807-1208            JAXUCZ010000015.1  21072210-21072611
FEATURES             Location/Qualifiers
     source          1..1208
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1208
                     /gene="Styx"
                     /note="serine/threonine/tyrosine interacting protein"
                     /db_xref="GeneID:100912536"
                     /db_xref="RGD:1594806"
     exon            1..265
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..880
                     /gene="Styx"
                     /note="serine/threonine/tyrosine interaction protein;
                     phosphoserine/threonine/tyrosine interaction protein"
                     /codon_start=1
                     /product="serine/threonine/tyrosine-interacting protein"
                     /protein_id="NP_001258470.1"
                     /db_xref="GeneID:100912536"
                     /db_xref="RGD:1594806"
                     /translation="MEDVKLEFPSLPQCKDDAEEWTYPMRREMQEVLPGLFLGPYSSA
                     MKSKLPILQKHGITHIICIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMT
                     KEFIDGSLQNGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCINPN
                     AGFVHQLQEYEAIYLAKLTIQMMSPLQIERSLSVHSGTTGSVKRTYEDDDDFGNMQVA
                     TAQNG"
     exon            266..298
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
     exon            299..352
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
     exon            353..450
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
     exon            451..511
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
     exon            512..548
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
     exon            549..588
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
     exon            589..639
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
     exon            640..712
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
     exon            713..806
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1208
                     /gene="Styx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcagc atggcggccc gcagcgcacc gccctgccat ccgccttcct gtcgcagccg
       61 cccggacccc gtggtccgcg agtgcttgct gtgagcccgc cgcgcgtcag cccgccatcc
      121 gcccgccctc cttcccttgt cgcctctgcc agcccggggg gggggggcgg ccgggcgcgc
      181 cgcagccacc cgccggggcc cttggaccat ggaggacgtg aaactggagt tcccctcgct
      241 cccgcagtgc aaagacgacg ccgaggagtg gacttaccct atgagacgag agatgcagga
      301 agttttgcct ggattgttct taggccccta ctcttctgct atgaaaagca agctacctat
      361 actgcagaaa catggcataa ctcatataat ttgcatacgg caaaatattg aagcaaactt
      421 tattaaacca aactttcaac aattatttag gtatctagtc ttggatattg ctgataatcc
      481 agttgaaaac ataatacgtt ttttccctat gactaaagag tttattgatg gaagcttaca
      541 aaatggagga aaagttctcg tccatgggaa tgcaggtatc tctagaagtg ccgcctttgt
      601 tattgcatac atcatggaga catttgggat gaagtacaga gatgcatttg cttatgtcca
      661 agaaaggaga ttttgtatta atcctaatgc tggatttgtc caccaacttc aggaatatga
      721 agccatctac ttagcaaaat taacaataca gatgatgtca ccactccaga tagaaaggtc
      781 tttatctgtt cattctggta ctacaggtag tgtgaagaga acatatgaag atgatgatga
      841 ctttgggaac atgcaagtgg caaccgcaca gaatggctga cctgtgagga ctgttattgc
      901 acaggatcgc tggactatga ggactgttac atgggtgtga gcttccatct agaaaggaca
      961 ggatcctagt gatgataatg tgaaatggta aacacacaaa tactttcttt tcaactatac
     1021 gttgcttcca gacatgtttc tctgcaactt gttgagcaac aagttaagat gtgggacttc
     1081 tgcagtagat ggcgctgatg gacgatgggt ttactttaaa aaaaaaaact atggttttat
     1141 tataaaccaa gaattttgga cttgcaaaga ggtattattg caataatgca cttttcatac
     1201 ttgaaatt
//
