LOCUS       NM_001191872            1329 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus syntaxin binding protein 6 (Stxbp6), mRNA.
ACCESSION   NM_001191872 XM_343057
VERSION     NM_001191872.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Kondratiuk,I., Jakhanwal,S., Jin,J., Sathyanarayanan,U.,
            Kroppen,B., Pobbati,A.V., Krisko,A., Ashery,U., Meinecke,M.,
            Jahn,R., Fasshauer,D. and Milosevic,I.
  TITLE     PI(4,5)P2-dependent regulation of exocytosis by amisyn, the
            vertebrate-specific competitor of synaptobrevin 2
  JOURNAL   Proc Natl Acad Sci U S A 117 (24), 13468-13479 (2020)
   PUBMED   32467162
  REMARK    GeneRIF: PI(4,5)P2-dependent regulation of exocytosis by amisyn,
            the vertebrate-specific competitor of synaptobrevin 2.
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1329)
  AUTHORS   Constable,J.R., Graham,M.E., Morgan,A. and Burgoyne,R.D.
  TITLE     Amisyn regulates exocytosis and fusion pore stability by both
            syntaxin-dependent and syntaxin-independent mechanisms
  JOURNAL   J Biol Chem 280 (36), 31615-31623 (2005)
   PUBMED   16033762
  REMARK    GeneRIF: Can negatively regulate exocytosis independently of
            syntaxin and can also regulate the stability of the fusion pore.
REFERENCE   4  (bases 1 to 1329)
  AUTHORS   Scales,S.J., Hesser,B.A., Masuda,E.S. and Scheller,R.H.
  TITLE     Amisyn, a novel syntaxin-binding protein that may regulate SNARE
            complex assembly
  JOURNAL   J Biol Chem 277 (31), 28271-28279 (2002)
   PUBMED   12145319
  REMARK    GeneRIF: Amisyn is a novel syntaxin-binding protein that may
            regulate SNARE complex assembly.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jul 17, 2010 this sequence version replaced XM_343057.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.23747.1,
                                           SRR26643299.27289.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840114,
                                           SAMN12840115 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               JAXUCZ010000006.1  67884085-67884338   c
            255-443             JAXUCZ010000006.1  67821906-67822094   c
            444-574             JAXUCZ010000006.1  67691509-67691639   c
            575-740             JAXUCZ010000006.1  67690534-67690699   c
            741-898             JAXUCZ010000006.1  67656328-67656485   c
            899-1329            JAXUCZ010000006.1  67650556-67650986   c
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q21"
     gene            1..1329
                     /gene="Stxbp6"
                     /gene_synonym="Amisyn"
                     /note="syntaxin binding protein 6"
                     /db_xref="GeneID:362734"
                     /db_xref="RGD:1306117"
     exon            1..254
                     /gene="Stxbp6"
                     /gene_synonym="Amisyn"
                     /inference="alignment:Splign:2.1.0"
     exon            255..443
                     /gene="Stxbp6"
                     /gene_synonym="Amisyn"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..922
                     /gene="Stxbp6"
                     /gene_synonym="Amisyn"
                     /codon_start=1
                     /product="syntaxin-binding protein 6"
                     /protein_id="NP_001178801.1"
                     /db_xref="GeneID:362734"
                     /db_xref="RGD:1306117"
                     /translation="MSAKSAISKEIFAPLDERMLGAVQVKRRTKKKIPFLATGGQGEY
                     LTYICLSVTNKKPTQASITKVKQFEGSTSFVRRSQWMLEQLRQVNGIDPNRDSAEFDL
                     LFENAFDQWVASTASEKCTFFQILHHTCQRYLTDRKPEFINCQSKIMGGNSILHSAAD
                     SVTSAVQKASQALNERGERLGRAEEKTEDMKNSAQQFAETAHKLAMKHKC"
     exon            444..574
                     /gene="Stxbp6"
                     /gene_synonym="Amisyn"
                     /inference="alignment:Splign:2.1.0"
     exon            575..740
                     /gene="Stxbp6"
                     /gene_synonym="Amisyn"
                     /inference="alignment:Splign:2.1.0"
     exon            741..898
                     /gene="Stxbp6"
                     /gene_synonym="Amisyn"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1329
                     /gene="Stxbp6"
                     /gene_synonym="Amisyn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcgcgag gctgcagctg gagctctggc gcccggagtt ggagttgcca ggagtttccc
       61 cgacccctcc ctcctcgcgc agagcagcag gagcccgcgc gggagcggcg agccgcgacc
      121 agccagcagc cgagtcgagc cagctttagt ctgcagcccc gatctccacg cggggcagcc
      181 gcgggggagc actgtcttcg gttgggacgc gtgccgcgca ctaggcaccg cccgagcacg
      241 agccaggctg cacgaaaact cactgcgtgc cctcctgggt ggctctacaa tgagtgccaa
      301 gtctgccatc agcaaggaaa tttttgcacc tcttgatgaa agaatgctgg gagctgtcca
      361 agtcaagaga aggacaaaga aaaagattcc tttcttggca actgggggtc aaggcgaata
      421 tttaacttat atctgcctgt cagtgacaaa caagaaaccc acacaggcat ctatcacgaa
      481 ggtcaaacag tttgagggct ccacatcatt cgtccgaaga tcccagtgga tgcttgagca
      541 gctccgccaa gttaatggta ttgatcctaa tcgggattct gcagagtttg atttgttgtt
      601 tgaaaatgcc tttgaccagt gggttgctag cacggcctca gaaaagtgca ccttcttcca
      661 gatcctccac cacacctgcc agaggtacct cacagacagg aagccagagt ttattaactg
      721 ccaatccaaa attatgggag gaaacagcat cctccattca gcagcggata gtgtgaccag
      781 tgcggtacag aaggcaagcc aggccttgaa tgagcgaggg gaacggttag gccgagcaga
      841 ggagaagaca gaagacatga agaacagtgc ccagcagttt gcagaaactg cacacaagct
      901 tgccatgaag cacaaatgtt gagaaactgc ctatccttgt gaacctctaa agaaagtgga
      961 ggagtttggt cagcagttat tccaagactt ccagacggct tcttcttcgg ttttgctgtt
     1021 tgttggttgg tttgtttgtt tgtttgtttt cccaacataa ggacattgaa gggtatggtt
     1081 tttcatcatg agatgttaat atgaatgaaa ggcggcggtg ttgtgtgcac acatttccct
     1141 atcttgctaa ggaatgctgc aatagcatca acttcatttt tatttttttt ccattgtgtg
     1201 tgtgtgtgag tgcgagtctg tgtgttatct gtgtgtgtgc acatgttcct tttgaaggaa
     1261 aattgttttt gtagttcaaa tataaaattc agaccaaata ataagccagg tataaattag
     1321 caaaatgta
//
