LOCUS       NM_053637               2388 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus syntaxin binding protein 3 (Stxbp3), mRNA.
ACCESSION   NM_053637
VERSION     NM_053637.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2388)
  AUTHORS   Soo Hoo,L., Banna,C.D., Radeke,C.M., Sharma,N., Albertolle,M.E.,
            Low,S.H., Weimbs,T. and Vandenberg,C.A.
  TITLE     The SNARE Protein Syntaxin 3 Confers Specificity for Polarized
            Axonal Trafficking in Neurons
  JOURNAL   PLoS One 11 (9), e0163671 (2016)
   PUBMED   27662481
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2388)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 2388)
  AUTHORS   Oh,E. and Thurmond,D.C.
  TITLE     Munc18c depletion selectively impairs the sustained phase of
            insulin release
  JOURNAL   Diabetes 58 (5), 1165-1174 (2009)
   PUBMED   19188424
  REMARK    Erratum:[Diabetes. 2010 Mar;59(3):756]
REFERENCE   4  (bases 1 to 2388)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   5  (bases 1 to 2388)
  AUTHORS   Brochetta,C., Vita,F., Tiwari,N., Scandiuzzi,L., Soranzo,M.R.,
            Guerin-Marchand,C., Zabucchi,G. and Blank,U.
  TITLE     Involvement of Munc18 isoforms in the regulation of granule
            exocytosis in neutrophils
  JOURNAL   Biochim Biophys Acta 1783 (10), 1781-1791 (2008)
   PUBMED   18588921
REFERENCE   6  (bases 1 to 2388)
  AUTHORS   Imai,A., Nashida,T. and Shimomura,H.
  TITLE     Roles of Munc18-3 in amylase release from rat parotid acinar cells
  JOURNAL   Arch Biochem Biophys 422 (2), 175-182 (2004)
   PUBMED   14759605
REFERENCE   7  (bases 1 to 2388)
  AUTHORS   Widberg,C.H., Bryant,N.J., Girotti,M., Rea,S. and James,D.E.
  TITLE     Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays
            a role in insulin-stimulated GLUT4 translocation
  JOURNAL   J Biol Chem 278 (37), 35093-35101 (2003)
   PUBMED   12832401
REFERENCE   8  (bases 1 to 2388)
  AUTHORS   Schraw,T.D., Lemons,P.P., Dean,W.L. and Whiteheart,S.W.
  TITLE     A role for Sec1/Munc18 proteins in platelet exocytosis
  JOURNAL   Biochem J 374 (Pt 1), 207-217 (2003)
   PUBMED   12773094
REFERENCE   9  (bases 1 to 2388)
  AUTHORS   Houng,A., Polgar,J. and Reed,G.L.
  TITLE     Munc18-syntaxin complexes and exocytosis in human platelets
  JOURNAL   J Biol Chem 278 (22), 19627-19633 (2003)
   PUBMED   12649283
REFERENCE   10 (bases 1 to 2388)
  AUTHORS   Macaulay,S.L., Grusovin,J., Stoichevska,V., Ryan,J.M.,
            Castelli,L.A. and Ward,C.W.
  TITLE     Cellular munc18c levels can modulate glucose transport rate and
            GLUT4 translocation in 3T3L1 cells
  JOURNAL   FEBS Lett 528 (1-3), 154-160 (2002)
   PUBMED   12297296
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB046544.1.
            
            On Aug 31, 2012 this sequence version replaced NM_053637.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046544.1, BC098660.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2388              AB046544.1         2-2389
FEATURES             Location/Qualifiers
     source          1..2388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2388
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /note="syntaxin binding protein 3"
                     /db_xref="GeneID:114095"
                     /db_xref="RGD:619968"
     exon            1..167
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1900
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /codon_start=1
                     /product="syntaxin-binding protein 3"
                     /protein_id="NP_446089.1"
                     /db_xref="GeneID:114095"
                     /db_xref="RGD:619968"
                     /translation="MAPPVTERGLKSVVWRKIKTTVFDDCRKEGEWKIMLLDDFTTRL
                     LSSCCKMTDLLEEGVTVIENIYKNREPVRQMKALYFISPTPKSVDCFLRDFGSKSEKK
                     YKAAYIYFTDFCPDSLFNKIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCY
                     SPDPSNAGRKEAVMEAMAEQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDY
                     YKIDENGLIKGKTQSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIEKDTYKYKTDGK
                     EKEAVLEEDDDLWVRVRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKM
                     PHFRKQISKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQRVKDSMLVLLP
                     VLLNKNHDNCDKIRAVLLYIFGVNGTTEENLDRLIHNVKIEDDSDMIRNWSHLGVPIV
                     PPSQQAKPPRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSRCPAVWNGS
                     GAVSARQKPRTNYLELDRKNGSRLIIFVIGGITYSEMRCAYEVSQAHKSCEVIIGSTH
                     ILTPRKLLDDIKMLNKSKDKVSFLKDE"
     exon            168..217
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            218..299
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            300..376
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            377..455
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            456..556
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            557..711
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            712..802
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            803..927
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1023
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1081
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1147
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1228
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1367
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1474
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1567
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1653
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1805
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..2388
                     /gene="Stxbp3"
                     /gene_synonym="Munc18-c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaggagc ctcccctccc ccgccgggag gggaagggcc gtccccctag tgctgctttc
       61 agggccaaag taggttgcga gtgggaggcg gtggctgcgg ctccacggct tggggaagat
      121 ggcgccgccg gtgacggaac gggggctgaa gagcgtcgtg tggcggaaaa taaaaacaac
      181 agtgtttgat gactgccgga aagaaggcga gtggaagatc atgctgttgg atgacttcac
      241 caccagactt ctgtcatcgt gctgcaaaat gacagacctt ctagaagagg gtgtgacagt
      301 tatagagaat atttataaga atcgtgaacc tgtcagacaa atgaaagctc tttattttat
      361 ctctccaaca ccaaaatctg tagattgttt cttgcgagat tttggaagta aatctgagaa
      421 aaagtacaaa gcagcatata tctacttcac tgacttttgt cccgacagtc tctttaacaa
      481 gattaaagca tcttgctcca aatcaataag aagatgtaag gaaataaata tttcctttat
      541 tccacatgaa tctcaggttt acactcttga tgtaccagac gcgttctatt actgttacag
      601 tccagaccct agcaatgccg gcagaaaaga agcagtcatg gaagcaatgg ctgagcagat
      661 tgtgaccgtg tgtgccactc tggatgagaa ccctggagtg aggtataaga gtaaacctct
      721 agataatgcc agtaagcttg cacagctggt tgaaaagaag cttgaagact actacaaaat
      781 tgatgagaac ggcctaataa agggtaaaac tcagtcccag ctcttaataa ttgaccgtgg
      841 ctttgaccct gtgtccactg tcctgcatga actgaccttt caggcaatgg catatgatct
      901 actaccaatt gagaaagata catacaaata taaaacagat gggaaagaga aggaggcagt
      961 tcttgaagaa gatgatgacc tgtgggtgcg ggttcggcac cggcacatcg cggttgtttt
     1021 ggaggaaatt ccaaagctta tgaaggaaat ttcatcaaca aagaaagcta cagaggggaa
     1081 gacctcactc agcgcgctta cccagctgat gaaaaagatg ccgcacttcc ggaaacagat
     1141 ctcgaagcaa gtcgtccatc ttaacctagc tgaagactgc atgaataagt ttaagctgaa
     1201 tattgagaag ctctgcaaaa ctgagcagga cctggcactt ggaacagatg cggaaggcca
     1261 gcgggtaaag gactccatgc tggtgctcct cccagtgctg ctcaacaaaa accacgacaa
     1321 ctgcgacaaa atacgggcag tcttgctcta catcttcggt gttaatggaa ccactgaaga
     1381 aaacctggac agactgatcc acaatgtaaa gatagaagat gacagtgata tgattcggaa
     1441 ctggagtcac ctcggtgttc ccattgttcc cccatcccaa caagccaaac caccaagaaa
     1501 agatcggtct gccgaagaga cttttcagct ttctcgatgg acacctttta tcaaagatat
     1561 catggaggat gccattgata atagattgga ttccaaagaa tggccatact gttcccggtg
     1621 cccagcggtg tggaatggct ctggagctgt aagtgctcgc cagaaaccca gaaccaacta
     1681 tttagagctg gaccggaaaa atggctcgag gctgattatt tttgtaattg gaggaattac
     1741 atactctgag atgcgttgtg cttatgaagt ttctcaggca cataaatcct gtgaagttat
     1801 tattggttcc acacatattt taacacccag aaagctgctg gatgacataa aaatgctgaa
     1861 taaatccaag gataaagttt cctttcttaa ggatgagtag cttttttatt gtggtttaga
     1921 ggttttgtta acatgcacag ctaaagcaga tgctgctgcg gtcactgaag cggtgtaaat
     1981 agtgtgtgga ggaacacggt cttcaggtgg acacctcgag gacgcttatg ttactggatt
     2041 tgccatttct aataatttaa gtactgttgc tgctttggtc aagacatgat gttaacgggc
     2101 cttgtaatca ggcagttttc accttggagc agaacctgtt ctgaggtgtg ggtgttttca
     2161 cagccagctg tatatgtgcc cactaattac tcactggata cttatgctga aattagtgcg
     2221 ggcaaaaacg actttgaatg aagagatcat aaacgtaaaa actgtaaatg tatgtatgat
     2281 agagttatta taatgcagtt tcttaagact gaaattcata atttttatgt ataaaataat
     2341 ttgttattaa tatgatgact tcactgtgta tattacctgc aagataat
//
