LOCUS       NM_013038               3500 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus syntaxin binding protein 1 (Stxbp1), mRNA.
ACCESSION   NM_013038
VERSION     NM_013038.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3500)
  AUTHORS   Bhaskar,B.R., Yadav,L., Sriram,M., Sanghrajka,K., Gupta,M., V,B.K.,
            Nellikka,R.K. and Das,D.
  TITLE     Differential SNARE chaperoning by Munc13-1 and Munc18-1 dictates
            fusion pore fate at the release site
  JOURNAL   Nat Commun 15 (1), 4132 (2024)
   PUBMED   38755165
  REMARK    GeneRIF: Differential SNARE chaperoning by Munc13-1 and Munc18-1
            dictates fusion pore fate at the release site.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3500)
  AUTHORS   Tang,F., Chen,L., Gao,H., Lei,Y., Pan,L., Xiao,D. and Li,X.
  TITLE     Munc18-1 Contributes to Hippocampal Injury in Septic Rats Through
            Regulation of Syntanxin1A and Synaptophysin and Glutamate Levels
  JOURNAL   Neurochem Res 48 (3), 791-803 (2023)
   PUBMED   36335177
  REMARK    GeneRIF: Munc18-1 Contributes to Hippocampal Injury in Septic Rats
            Through Regulation of Syntanxin1A and Synaptophysin and Glutamate
            Levels.
REFERENCE   3  (bases 1 to 3500)
  AUTHORS   Chirinskaite,A.V., Siniukova,V.A., Velizhanina,M.E., Sopova,J.V.,
            Belashova,T.A. and Zadorsky,S.P.
  TITLE     STXBP1 forms amyloid-like aggregates in rat brain and demonstrates
            amyloid properties in bacterial expression system
  JOURNAL   Prion 15 (1), 29-36 (2021)
   PUBMED   33590815
  REMARK    GeneRIF: STXBP1 forms amyloid-like aggregates in rat brain and
            demonstrates amyloid properties in bacterial expression system.
REFERENCE   4  (bases 1 to 3500)
  AUTHORS   Stepien,K.P. and Rizo,J.
  TITLE     Synaptotagmin-1-, Munc18-1-, and Munc13-1-dependent liposome fusion
            with a few neuronal SNAREs
  JOURNAL   Proc Natl Acad Sci U S A 118 (4) (2021)
   PUBMED   33468652
  REMARK    GeneRIF: Synaptotagmin-1-, Munc18-1-, and Munc13-1-dependent
            liposome fusion with a few neuronal SNAREs.
REFERENCE   5  (bases 1 to 3500)
  AUTHORS   Zhang,K., Wang,T., Liu,X., Yuan,Q., Xiao,T., Yuan,X., Zhang,Y.,
            Yuan,L. and Wang,Y.
  TITLE     CASK, APBA1, and STXBP1 collaborate during insulin secretion
  JOURNAL   Mol Cell Endocrinol 520, 111076 (2021)
   PUBMED   33159991
  REMARK    GeneRIF: CASK, APBA1, and STXBP1 collaborate during insulin
            secretion.
REFERENCE   6  (bases 1 to 3500)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (bases 1 to 3500)
  AUTHORS   Hata,Y. and Sudhof,T.C.
  TITLE     A novel ubiquitous form of Munc-18 interacts with multiple
            syntaxins. Use of the yeast two-hybrid system to study interactions
            between proteins involved in membrane traffic
  JOURNAL   J Biol Chem 270 (22), 13022-13028 (1995)
   PUBMED   7768895
REFERENCE   8  (bases 1 to 3500)
  AUTHORS   Shetty,K.T., Kaech,S., Link,W.T., Jaffe,H., Flores,C.M., Wray,S.,
            Pant,H.C. and Beushausen,S.
  TITLE     Molecular characterization of a neuronal-specific protein that
            stimulates the activity of Cdk5
  JOURNAL   J Neurochem 64 (5), 1988-1995 (1995)
   PUBMED   7536802
REFERENCE   9  (bases 1 to 3500)
  AUTHORS   Garcia,E.P., McPherson,P.S., Chilcote,T.J., Takei,K. and De
            Camilli,P.
  TITLE     rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the
            axon, but are not in a stable complex with syntaxin
  JOURNAL   J Cell Biol 129 (1), 105-120 (1995)
   PUBMED   7698978
REFERENCE   10 (bases 1 to 3500)
  AUTHORS   Katagiri,H., Terasaki,J., Murata,T., Ishihara,H., Ogihara,T.,
            Inukai,K., Fukushima,Y., Anai,M., Kikuchi,M., Miyazaki,J. et al.
  TITLE     A novel isoform of syntaxin-binding protein homologous to yeast
            Sec1 expressed ubiquitously in mammalian cells
  JOURNAL   J Biol Chem 270 (10), 4963-4966 (1995)
   PUBMED   7890599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 15, 2021 this sequence version replaced NM_013038.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088850.1, L26264.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000003.1  36535916-36536058   c
            144-193             JAXUCZ010000003.1  36511618-36511667   c
            194-275             JAXUCZ010000003.1  36509906-36509987   c
            276-352             JAXUCZ010000003.1  36507825-36507901   c
            353-431             JAXUCZ010000003.1  36506650-36506728   c
            432-535             JAXUCZ010000003.1  36504722-36504825   c
            536-684             JAXUCZ010000003.1  36501600-36501748   c
            685-769             JAXUCZ010000003.1  36497010-36497094   c
            770-900             JAXUCZ010000003.1  36496099-36496229   c
            901-1008            JAXUCZ010000003.1  36493545-36493652   c
            1009-1069           JAXUCZ010000003.1  36492449-36492509   c
            1070-1135           JAXUCZ010000003.1  36491417-36491482   c
            1136-1216           JAXUCZ010000003.1  36490811-36490891   c
            1217-1355           JAXUCZ010000003.1  36488031-36488169   c
            1356-1465           JAXUCZ010000003.1  36486987-36487096   c
            1466-1567           JAXUCZ010000003.1  36486414-36486515   c
            1568-1653           JAXUCZ010000003.1  36483838-36483923   c
            1654-1808           JAXUCZ010000003.1  36482187-36482341   c
            1809-3500           JAXUCZ010000003.1  36474428-36476119   c
FEATURES             Location/Qualifiers
     source          1..3500
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..3500
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /note="syntaxin binding protein 1"
                     /db_xref="GeneID:25558"
                     /db_xref="RGD:3785"
     exon            1..143
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1891
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /note="p67; unc-18A; unc-18-1; unc-18 homolog; protein
                     unc-18 homolog 1; protein unc-18 homolog A"
                     /codon_start=1
                     /product="syntaxin-binding protein 1"
                     /protein_id="NP_037170.1"
                     /db_xref="GeneID:25558"
                     /db_xref="RGD:3785"
                     /translation="MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSC
                     CKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAA
                     HVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPH
                     KAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPT
                     MGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARV
                     KEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKM
                     PQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVP
                     ILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPI
                     VTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSA
                     SFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVL
                     IGSTHILTPQKLLDTLKKLNKTDEEISS"
     exon            144..193
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..275
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..352
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..431
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..535
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..684
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..769
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..900
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1008
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1069
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1135
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1216
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1355
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1465
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1567
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1653
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1808
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..3500
                     /gene="Stxbp1"
                     /gene_synonym="ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A;
                     rbSec1; rbSec1A; rbSec1B; Sec1; Unc18-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagcgcgac tgcggggcgg cgggctgcag acagcggggc gcgcggcccg ggggaggcta
       61 cggtgtcgcg ggaggagcat cggagcccgg agactcgaag aacgccatgg cccccattgg
      121 cctcaaggcg gtggtcggag agaagatcat gcatgatgtt atcaagaagg tgaagaagaa
      181 gggcgagtgg aaggtgctgg tggtggacca gttaagcatg aggatgctgt cttcctgctg
      241 caagatgaca gacatcatga ccgaggggat cacaattgtg gaggatatca acaagcgccg
      301 agagccgctc cccagcctag aggccgtgta cctcatcacc ccgtctgaga agtctgtcca
      361 ctctctcatc agtgatttta aggacccgcc gactgctaaa tatcgggccg cacatgtgtt
      421 cttcacagac tcatgtccag atgccctgtt taacgagctg gtaaaatctc gagcagccaa
      481 agtcatcaag acgctgacgg aaatcaacat tgcgtttctc ccctatgagt cccaggtgta
      541 ttccctggac tccgctgact ctttccaaag tttctacagc cctcacaagg cacagatgaa
      601 gaatcccata ctggaacgcc tggcagagca aatcgccacc ctgtgtgcca ccctgaagga
      661 gtacccggct gtgcggtatc ggggggagta caaggacaat gccttgctgg ctcagctgat
      721 ccaggacaag ctggacgctt ataaagctga tgacccgaca atgggggagg gtcccgacaa
      781 ggcacggtcc cagctcctga tcctggatcg tggctttgac cccagctccc ctgtgcttca
      841 tgaactgacg tttcaggcta tgagttacga cctgctgcct attgaaaatg atgtttacaa
      901 gtatgagacc agcggcattg gagaggcgag ggtgaaggag gtgctcctgg atgaggacga
      961 tgacctgtgg attgcactgc gacacaagca catcgcagag gtgtcccagg aagtgacccg
     1021 gtctctgaag gacttttcct ctagcaagag gatgaatact ggagagaaga ccaccatgcg
     1081 ggacctgtcc cagatgctga agaaaatgcc ccagtaccag aaggagctca gcaagtattc
     1141 gactcacctg caccttgctg aagactgtat gaagcattac caaggcaccg tagacaaact
     1201 ctgccgcgtg gagcaggacc tggcgatggg cacagatgct gagggggaaa aaatcaagga
     1261 ccccatgaga gccattgtcc ccatcctgct ggatgcaaat gtcagcactt atgacaaaat
     1321 tcgcatcatc cttctctaca tcttcctgaa gaacggtatc actgaagaaa acctaaacaa
     1381 actcatccag cacgcccaga tccccccaga agacagtgag atcatcacca acatggctca
     1441 cctcggggtg cccatcgtca cggattccac actacgccgc agaagcaagc cggagcggaa
     1501 ggagcgcatc agtgagcaga cctaccagct ctcacgatgg accccgatca ttaaagacat
     1561 tatggaggac accattgaag acaaactgga tacaaagcac tacccataca tctctacccg
     1621 ctcttccgca tccttcagca ccactgctgt gagtgcccgc tatggacatt ggcacaagaa
     1681 taaggccccc ggggagtacc gcagcggccc ccgcctcatt attttcatcc ttgggggcgt
     1741 gagcctgaat gagatgcgct gtgcctacga agtgacgcag gccaacggca agtgggaagt
     1801 gctcatagga tccacgcaca ttctcacccc acagaaactg ctggacacgc tgaagaagct
     1861 gaataaaaca gacgaagaaa taagcagtta aaatcagctg ccctccaaaa ccctggctcc
     1921 cttcccacaa tgctctgcag ctccccagtg cgacacctcg gttactctgc tgcctcccca
     1981 gccctgcacg ccctggccac cctgttgccg cgctgagttc ttctcctgtg cgatgacacc
     2041 ccatcttgtc ctctgaaaag caagagagta atgtgttgtt ttttaaaaat gagtatcttc
     2101 tgtatgtatc ccacagtaag ttcacatgca agctccacac tgcagaagca tcagaactct
     2161 ggaccgagtg gactctccct tatttatgac cccgtgacct gtatatagcc ctgtaccacg
     2221 cgtgcacatt gcttggatat ggaaaggtag atgtgtgagt gtttctcaga gcttgtttgg
     2281 gctcatttct gttcttgttg gaatcataag gtctctgtcc ccaagatatg acatgctgag
     2341 gaagtgatgt ttttctctct agcccctgct caccccgttc tcatgcacag acactgagat
     2401 gaggtgagca gacacctctg gaggctggcg tggaatgagc ctcctctttg cagctgtggg
     2461 tggaggcttg gcatatccac aggaagccag tctgagtgct agccagtgtt gtctccagag
     2521 catgacactg cattccctga cctgtgtcca cagtgctgta acaagttaag tcctccaaac
     2581 taaatgagca tgcctagcag acttgggtcc tccagagtta ggtatgacca gcccagtcct
     2641 tcccgagcct tctcgtgagc atagccggga tagaggtcaa aggtcaggag tgaactggaa
     2701 gatgtgagtt tggcactctg gtcaaagcta ggcctgagga gggggccctg ctgctcagtc
     2761 agagtgtcct cagtttaaga tacttcatca atctttgtgt agtgtacagt catgtgtcat
     2821 tgtggttgta tgaaaacaat cattttttct ttgtattaaa gtcatcactg tataaaacat
     2881 agctagctat aaagcagaaa ttccagaagc agatgctgga aggatggtct ccatcctcag
     2941 gacgcagcag ctccctgagc atgccactca ccctgctgct gtagtcatga aacagacagt
     3001 ggaagtcaca aaaatgtccc cagcccagcc cctgcccctc cctccctccc gcagacttgt
     3061 atgtattact gtctcgtgct gtcttcacaa acgtggtgta cgcctgcctg ccgcagtgtc
     3121 cggtgccctc ctcccttcct gcctctagag ttctcctctc cttagttctc aggccccgcc
     3181 cctctccagt gaccctttcc ctaggatgaa ccttagcagc cctggttggt ttcttctgta
     3241 gcagcttctt ttgtcccttc tctctggtca agcaatgctc ttgcttcagg accttgtttg
     3301 tcgaacatgt ggggtttcct ttatgttatt tatataaata atttctcaaa tggatattta
     3361 aaaaaaaagc tagtctgtct tgaaacttgt taacttgaaa ctcttgaatc tcagtgttta
     3421 aagtatggaa gcacaaccgt gtaccgctct gtaccgtcct gtactgcagc atttgagtct
     3481 aataaagacg tcagctctca
//
