LOCUS       NM_031656                854 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus syntaxin 8 (Stx8), mRNA.
ACCESSION   NM_031656
VERSION     NM_031656.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 854)
  AUTHORS   Chen,B., Zhao,L., Li,X., Ji,Y.S., Li,N., Xu,X.F. and Chen,Z.Y.
  TITLE     Syntaxin 8 modulates the post-synthetic trafficking of the TrkA
            receptor and inflammatory pain transmission
  JOURNAL   J Biol Chem 289 (28), 19556-19569 (2014)
   PUBMED   24872407
  REMARK    GeneRIF: STX8 is a modulator of TrkA cell surface levels and
            biological functions.
REFERENCE   2  (bases 1 to 854)
  AUTHORS   Ikari,A., Tonegawa,C., Sanada,A., Kimura,T., Sakai,H., Hayashi,H.,
            Hasegawa,H., Yamaguchi,M., Yamazaki,Y., Endo,S., Matsunaga,T. and
            Sugatani,J.
  TITLE     Tight junctional localization of claudin-16 is regulated by
            syntaxin 8 in renal tubular epithelial cells
  JOURNAL   J Biol Chem 289 (19), 13112-13123 (2014)
   PUBMED   24659781
  REMARK    GeneRIF: These results suggest that STX8 mediates the recycling of
            CLDN16 and constitutes an important component of the CLDN16
            trafficking machinery in the kidney.
REFERENCE   3  (bases 1 to 854)
  AUTHORS   Zhang,L., Kang,L., Bond,W. and Zhang,N.
  TITLE     Interaction between syntaxin 8 and HECTd3, a HECT domain ligase
  JOURNAL   Cell Mol Neurobiol 29 (1), 115-121 (2009)
   PUBMED   18821010
REFERENCE   4  (bases 1 to 854)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   5  (bases 1 to 854)
  AUTHORS   Bilan,F., Nacfer,M., Fresquet,F., Norez,C., Melin,P.,
            Martin-Berge,A., Costa de Beauregard,M.A., Becq,F., Kitzis,A. and
            Thoreau,V.
  TITLE     Endosomal SNARE proteins regulate CFTR activity and trafficking in
            epithelial cells
  JOURNAL   Exp Cell Res 314 (11-12), 2199-2211 (2008)
   PUBMED   18570918
REFERENCE   6  (bases 1 to 854)
  AUTHORS   Pryor,P.R., Mullock,B.M., Bright,N.A., Lindsay,M.R., Gray,S.R.,
            Richardson,S.C., Stewart,A., James,D.E., Piper,R.C. and Luzio,J.P.
  TITLE     Combinatorial SNARE complexes with VAMP7 or VAMP8 define different
            late endocytic fusion events
  JOURNAL   EMBO Rep 5 (6), 590-595 (2004)
   PUBMED   15133481
REFERENCE   7  (bases 1 to 854)
  AUTHORS   Antonin,W., Fasshauer,D., Becker,S., Jahn,R. and Schneider,T.R.
  TITLE     Crystal structure of the endosomal SNARE complex reveals common
            structural principles of all SNAREs
  JOURNAL   Nat Struct Biol 9 (2), 107-111 (2002)
   PUBMED   11786915
  REMARK    GeneRIF: Crystal structure of the endosomal SNARE complex reveals
            common structural principles of all SNAREs
REFERENCE   8  (bases 1 to 854)
  AUTHORS   Antonin,W., Holroyd,C., Fasshauer,D., Pabst,S., Von Mollard,G.F.
            and Jahn,R.
  TITLE     A SNARE complex mediating fusion of late endosomes defines
            conserved properties of SNARE structure and function
  JOURNAL   EMBO J 19 (23), 6453-6464 (2000)
   PUBMED   11101518
REFERENCE   9  (bases 1 to 854)
  AUTHORS   Subramaniam,V.N., Loh,E., Horstmann,H., Habermann,A., Xu,Y.,
            Coe,J., Griffiths,G. and Hong,W.
  TITLE     Preferential association of syntaxin 8 with the early endosome
  JOURNAL   J Cell Sci 113 (Pt 6), 997-1008 (2000)
   PUBMED   10683148
REFERENCE   10 (bases 1 to 854)
  AUTHORS   Prekeris,R., Yang,B., Oorschot,V., Klumperman,J. and Scheller,R.H.
  TITLE     Differential roles of syntaxin 7 and syntaxin 8 in endosomal
            trafficking
  JOURNAL   Mol Biol Cell 10 (11), 3891-3908 (1999)
   PUBMED   10564279
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF033109.1.
            
            On Feb 21, 2013 this sequence version replaced NM_031656.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF033109.1, FM089053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-854               AF033109.1         6-859
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..854
                     /gene="Stx8"
                     /note="syntaxin 8"
                     /db_xref="GeneID:59074"
                     /db_xref="RGD:61917"
     exon            1..39
                     /gene="Stx8"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..733
                     /gene="Stx8"
                     /note="syntaxin-like protein 3I35"
                     /codon_start=1
                     /product="syntaxin-8"
                     /protein_id="NP_113844.1"
                     /db_xref="GeneID:59074"
                     /db_xref="RGD:61917"
                     /translation="MAPDPWFSTYDSTCQIAQEIAEKIQERNQCERRGEKTPKLTLTI
                     RTLLKNLKVKIDLLKDLLLRAVSTRQITQLEGDRRQNLLDDLVTRERLLLASFKNEGS
                     EPDLIRSSLMSEEAKRGTPNPWLCEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSS
                     IISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRTEARRVTLVDRKSASCGMIM
                     VILLLLVAIVVVAVWPTN"
     exon            40..139
                     /gene="Stx8"
                     /inference="alignment:Splign:2.1.0"
     exon            140..234
                     /gene="Stx8"
                     /inference="alignment:Splign:2.1.0"
     exon            235..345
                     /gene="Stx8"
                     /inference="alignment:Splign:2.1.0"
     exon            346..470
                     /gene="Stx8"
                     /inference="alignment:Splign:2.1.0"
     exon            471..563
                     /gene="Stx8"
                     /inference="alignment:Splign:2.1.0"
     exon            564..665
                     /gene="Stx8"
                     /inference="alignment:Splign:2.1.0"
     exon            666..839
                     /gene="Stx8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgcaggc ggagactgca ccatggcccc agacccctgg ttctccacgt acgattctac
       61 ttgtcagatt gcccaagaaa tcgctgagaa gattcaagaa cgaaatcagt gtgaaagaag
      121 aggtgagaag acacctaagc ttaccctgac aatcagaact ttgttgaaga atctgaaggt
      181 aaagatcgac ctcttgaagg acttacttct aagagctgtg tcgacgcgcc agataacaca
      241 actggagggg gatcgaagac agaaccttct ggatgatctt gtcacccgag agagactgct
      301 cctggcatcg tttaagaatg agggttccga gccggatttg atcaggtcca gcctgatgag
      361 tgaagaagca aagcgaggaa ctcccaaccc ttggctctgt gaggagccgg aggagaccag
      421 aggcttgggt ttcgatgaga tccggcaaca gcagcagaaa attattcaag aacaggacgc
      481 aggtcttgat gccctttcct ctatcataag tcgccaaaag caaatgggcc aggagattgg
      541 gaatgaactg gacgaacaga acgagatcat cgatgacctt gccaacctgg tggagaacac
      601 agatgagaag cttcgcactg aagccaggcg agtgaccctg gtggacagaa agtcagcttc
      661 ctgtgggatg ataatggtga tcttattgct gctcgtggct attgtggtgg ttgcagtgtg
      721 gccaaccaac tgatggcaat aaggggacca cccgcagtga cacagccaac aatgagtgaa
      781 agcccagcac ccttttggta cacaacacct cctctcaata aattctccac gctcccggca
      841 aaaaaaaaaa aaaa
//
