LOCUS       NM_031665               2515 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus syntaxin 6 (Stx6), mRNA.
ACCESSION   NM_031665
VERSION     NM_031665.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2515)
  AUTHORS   Koike,S. and Jahn,R.
  TITLE     SNAREs define targeting specificity of trafficking vesicles by
            combinatorial interaction with tethering factors
  JOURNAL   Nat Commun 10 (1), 1608 (2019)
   PUBMED   30962439
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2515)
  AUTHORS   Schindler,C., Chen,Y., Pu,J., Guo,X. and Bonifacino,J.S.
  TITLE     EARP is a multisubunit tethering complex involved in endocytic
            recycling
  JOURNAL   Nat Cell Biol 17 (5), 639-650 (2015)
   PUBMED   25799061
REFERENCE   3  (bases 1 to 2515)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   4  (bases 1 to 2515)
  AUTHORS   Shitara,A., Shibui,T., Okayama,M., Arakawa,T., Mizoguchi,I.,
            Sakakura,Y. and Takuma,T.
  TITLE     VAMP4 is required to maintain the ribbon structure of the Golgi
            apparatus
  JOURNAL   Mol Cell Biochem 380 (1-2), 11-21 (2013)
   PUBMED   23677696
  REMARK    Erratum:[Mol Cell Biochem. 2013 Aug;380(1-2):301. Shakakura,
            Yasunori [corrected to Sakakura, Yasunori]]
REFERENCE   5  (bases 1 to 2515)
  AUTHORS   Morawski,M., Nuytens,K., Juhasz,T., Zeitschel,U., Seeger,G.,
            Waelkens,E., Regal,L., Schulz,I., Arendt,T., Szeltner,Z.,
            Creemers,J. and Rossner,S.
  TITLE     Cellular and ultra structural evidence for cytoskeletal
            localization of prolyl endopeptidase-like protein in neurons
  JOURNAL   Neuroscience 242, 128-139 (2013)
   PUBMED   23485813
REFERENCE   6  (bases 1 to 2515)
  AUTHORS   Misura,K.M., Bock,J.B., Gonzalez,L.C. Jr., Scheller,R.H. and
            Weis,W.I.
  TITLE     Three-dimensional structure of the amino-terminal domain of
            syntaxin 6, a SNAP-25 C homolog
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9184-9189 (2002)
   PUBMED   12082176
REFERENCE   7  (bases 1 to 2515)
  AUTHORS   Charest,A., Lane,K., McMahon,K. and Housman,D.E.
  TITLE     Association of a novel PDZ domain-containing peripheral Golgi
            protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive
            fusion protein (NSF) attachment protein receptor) protein syntaxin
            6
  JOURNAL   J Biol Chem 276 (31), 29456-29465 (2001)
   PUBMED   11384996
REFERENCE   8  (bases 1 to 2515)
  AUTHORS   Simonsen,A., Gaullier,J.M., D'Arrigo,A. and Stenmark,H.
  TITLE     The Rab5 effector EEA1 interacts directly with syntaxin-6
  JOURNAL   J Biol Chem 274 (41), 28857-28860 (1999)
   PUBMED   10506127
REFERENCE   9  (bases 1 to 2515)
  AUTHORS   Bock,J.B., Klumperman,J., Davanger,S. and Scheller,R.H.
  TITLE     Syntaxin 6 functions in trans-Golgi network vesicle trafficking
  JOURNAL   Mol Biol Cell 8 (7), 1261-1271 (1997)
   PUBMED   9243506
REFERENCE   10 (bases 1 to 2515)
  AUTHORS   Bock,J.B., Lin,R.C. and Scheller,R.H.
  TITLE     A new syntaxin family member implicated in targeting of
            intracellular transport vesicles
  JOURNAL   J Biol Chem 271 (30), 17961-17965 (1996)
   PUBMED   8663448
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081769.1.
            
            On Sep 16, 2004 this sequence version replaced NM_031665.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081769.1, U56815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..2515
                     /gene="Stx6"
                     /note="syntaxin 6"
                     /db_xref="GeneID:60562"
                     /db_xref="RGD:61915"
     exon            1..205
                     /gene="Stx6"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..938
                     /gene="Stx6"
                     /note="Syn6"
                     /codon_start=1
                     /product="syntaxin-6"
                     /protein_id="NP_113853.1"
                     /db_xref="GeneID:60562"
                     /db_xref="RGD:61915"
                     /translation="MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQGPSAATREEID
                     WTTNELRNNLRSIEWDLEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQIVRDM
                     KDQMSASSVQALAERKNRQALLGDSSSQNWDAGVTDRYGRLDRELQLANSHFIEEQQA
                     QQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLDDFSHELESTQSRLDNV
                     MKKLAKVSHMTSDRRQWCAIAILFAVLLVVLTLFLVL"
     exon            206..375
                     /gene="Stx6"
                     /inference="alignment:Splign:2.1.0"
     exon            376..470
                     /gene="Stx6"
                     /inference="alignment:Splign:2.1.0"
     exon            471..533
                     /gene="Stx6"
                     /inference="alignment:Splign:2.1.0"
     exon            534..659
                     /gene="Stx6"
                     /inference="alignment:Splign:2.1.0"
     exon            660..766
                     /gene="Stx6"
                     /inference="alignment:Splign:2.1.0"
     exon            767..861
                     /gene="Stx6"
                     /inference="alignment:Splign:2.1.0"
     exon            862..2468
                     /gene="Stx6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctgtggg ggccggcttg gagtgggatt cgacccgcgg cgctgaccga gtgctggacc
       61 gacggctgtc gggcacccgg gcctgcgcgc actgctgctc cgggtcgccc cggccgaggc
      121 gctggccacg gtagacctca gggagggctc gggctgccgg gccgggcgcc atgtccatgg
      181 aggacccctt ctttgtagtg aaaggagagg tacagaaagc agtcaacact gcccagggat
      241 tgttccagag atggacggag cttctgcagg gcccctccgc agcaacgagg gaagagatcg
      301 actggaccac caacgagctg aggaacaatc tccgcagcat agagtgggat ctggaggacc
      361 tggatgaaac catcagcata gttgaagcaa atcctagaaa attcaacctg gatgcgactg
      421 aattgagcat aagaaaagcc ttcatcacaa gtactcggca aattgtcagg gacatgaagg
      481 atcagatgtc agcttcatct gtgcaagcgt tggcagaaag gaaaaacaga caggcgctac
      541 taggagatag cagcagccag aattgggatg ctggagtgac ggatcgatat gggcgccttg
      601 atcgggagct gcagctggcc aactcccatt tcatcgagga gcagcaggca cagcagcagt
      661 tgattgtgga acagcaggat gagcagttgg agctggtctc tggcagcatc ggggtgctga
      721 agaacatgtc ccagcgcatc ggaggggagc tggaggaaca ggcagtcatg ctggatgatt
      781 tctctcacga gttggagagc actcagtctc gactggacaa cgtgatgaag aaacttgcaa
      841 aagtgtctca catgaccagt gatcggcgcc agtggtgtgc catagccatc ctcttcgcgg
      901 tcctgctggt cgtgctgacc ctcttcctag tgctgtgatg gtggtcgcct tggcgcttct
      961 gcacgaggac ccagggaaga ggagcagcaa gcactcggcc acttacattc ctctcccaga
     1021 aacacacctc cgccctgctt cctctgtgac tccggcatcg ggacagcctt ctctcccagc
     1081 gttcaaaggg caggcttaga agaaggagga ggtgaccaca tgcccggctg gacagcagaa
     1141 gcccttggct gccccaggaa gctgaggaca gcaagcccct gctttgcctt actggacctc
     1201 gctccttgag gaaggaagga aggaaggaag gaaggaagga aggaaggaag gaaggaagga
     1261 aggaaggaag gaaggactcc gagtcatcag aagaactaac agccccactt actccgttgc
     1321 tcattctgct ggtctctggc agtctttctt tctactcaga ccctttccct gcttagatgg
     1381 gtgccactct cccttcagaa gaggcctggc aagaatgcgg gcgtctaggg tgtatgtttc
     1441 ccattgctgt ttgtttctta gcccgagagc tggctgctgc tgaggacaga aggctcagaa
     1501 tcacttcgtg acagaaatgc agtgtttcgt tttgctgggt aagagctgag attaaattgc
     1561 ttttccgggt gtctttgtgg cagggataag caataggaaa tagtgaaatc cctggggatt
     1621 ggggtgcaga tgacaaaagg ctttaaagga ctggggcagt tgagaacagc agcacctgcg
     1681 ttggtctagc ctattggaag ggctggtgat ctctctcaag gcctggacag agcaccaacc
     1741 tggtctgtcc cagggctctc tctccagagg tgcagcttgc atacgtagag ccctcataca
     1801 gtgtggagca gcatacacca ctcggccagg cgggcatggc ttcttctctg atgcgtattc
     1861 cgatggctct cagacgaggt cgaagggtca gcacagctac cacatctgtg cagaacccgt
     1921 tctgacacag aaagctgctt ctgggccagc ggtccttact ccatgagtaa taggatggag
     1981 gtaagagagc ttgtactccg ttctctaagg tgacaacttg acttcatcat ccattggaat
     2041 cactgaggga gtccaaattc actgacagat gcttcattgg gttgaagtag ctgaaactgc
     2101 tgacactcca cttggggctt tgggcctcag atgtgcagat gtatgtggga tttcttatac
     2161 tgtcccaaat gcatggcctg gtattgaagt agctgtcagg tccagagcca gcctttcaca
     2221 ctggggctgc cgctcagtct tctgtgcagg aagagcagcg tctggacagt ttgatctttg
     2281 acctctcttg ctttgccttt ctgtgcattc cttagcatgc caactttaaa aagagccctg
     2341 ggttgttcat atgccttggg atttcgactt ttgggccttt tttgtttgtt tattatttcc
     2401 aatgatgtgc ttgcccaggt aacttttaaa ttgcactttt aaataaatat ttgtaacaat
     2461 ttttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
