LOCUS       NM_031704               1807 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Rattus norvegicus syntaxin 5 (Stx5), mRNA.
ACCESSION   NM_031704
VERSION     NM_031704.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Hernandez-Zimbron,L.F. and Rivas-Arancibia,S.
  TITLE     Syntaxin 5 Overexpression and beta-Amyloid 1-42 Accumulation in
            Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by
            Ozone Exposure
  JOURNAL   Biomed Res Int 2016, 2125643 (2016)
   PUBMED   27366738
  REMARK    GeneRIF: O3 exposure (0.25 ppm) induced a significant increase of
            Syntaxin 5 and accumulation of betaA42 peptide in the reticulum in
            cells of the dentate gyrus
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Suga,K., Saito,A. and Akagawa,K.
  TITLE     ER stress response in NG108-15 cells involves upregulation of
            syntaxin 5 expression and reduced amyloid beta peptide secretion
  JOURNAL   Exp Cell Res 332 (1), 11-23 (2015)
   PUBMED   25596448
  REMARK    GeneRIF: Syx5 plays important roles in beta-amyloid precursor
            protein processing and in the endoplasmic reticulum stress
            response.
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Renna,M., Schaffner,C., Winslow,A.R., Menzies,F.M., Peden,A.A.,
            Floto,R.A. and Rubinsztein,D.C.
  TITLE     Autophagic substrate clearance requires activity of the syntaxin-5
            SNARE complex
  JOURNAL   J Cell Sci 124 (Pt 3), 469-482 (2011)
   PUBMED   21242315
REFERENCE   5  (bases 1 to 1807)
  AUTHORS   Laufman,O., Kedan,A., Hong,W. and Lev,S.
  TITLE     Direct interaction between the COG complex and the SM protein,
            Sly1, is required for Golgi SNARE pairing
  JOURNAL   EMBO J 28 (14), 2006-2017 (2009)
   PUBMED   19536132
REFERENCE   6  (bases 1 to 1807)
  AUTHORS   Rabouille,C., Kondo,H., Newman,R., Hui,N., Freemont,P. and
            Warren,G.
  TITLE     Syntaxin 5 is a common component of the NSF- and p97-mediated
            reassembly pathways of Golgi cisternae from mitotic Golgi fragments
            in vitro
  JOURNAL   Cell 92 (5), 603-610 (1998)
   PUBMED   9506515
REFERENCE   7  (bases 1 to 1807)
  AUTHORS   Tang,B.L., Low,D.Y., Lee,S.S., Tan,A.E. and Hong,W.
  TITLE     Molecular cloning and localization of human syntaxin 16, a member
            of the syntaxin family of SNARE proteins
  JOURNAL   Biochem Biophys Res Commun 242 (3), 673-679 (1998)
   PUBMED   9464276
REFERENCE   8  (bases 1 to 1807)
  AUTHORS   Okamoto,M. and Sudhof,T.C.
  TITLE     Mints, Munc18-interacting proteins in synaptic vesicle exocytosis
  JOURNAL   J Biol Chem 272 (50), 31459-31464 (1997)
   PUBMED   9395480
REFERENCE   9  (bases 1 to 1807)
  AUTHORS   Hui,N., Nakamura,N., Sonnichsen,B., Shima,D.T., Nilsson,T. and
            Warren,G.
  TITLE     An isoform of the Golgi t-SNARE, syntaxin 5, with an endoplasmic
            reticulum retrieval signal
  JOURNAL   Mol Biol Cell 8 (9), 1777-1787 (1997)
   PUBMED   9307973
REFERENCE   10 (bases 1 to 1807)
  AUTHORS   Bennett,M.K., Garcia-Arraras,J.E., Elferink,L.A., Peterson,K.,
            Fleming,A.M., Hazuka,C.D. and Scheller,R.H.
  TITLE     The syntaxin family of vesicular transport receptors
  JOURNAL   Cell 74 (5), 863-873 (1993)
   PUBMED   7690687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC127489.1.
            
            On Apr 9, 2013 this sequence version replaced NM_031704.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127489.1, SRR8487227.35556.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1807
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /note="syntaxin 5"
                     /db_xref="GeneID:65134"
                     /db_xref="RGD:68426"
     exon            1..118
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
     exon            119..362
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1205
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /note="syntaxin 5a"
                     /codon_start=1
                     /product="syntaxin-5"
                     /protein_id="NP_113892.2"
                     /db_xref="GeneID:65134"
                     /db_xref="RGD:68426"
                     /translation="MIPRKRYGSKNTDQGVYLGLSKTQVLSPATAINSSSDIAPLPTP
                     VALVPSPPDTMSCRDRTQEFLSACKSLQSRQNGIQTNKPALHATRQCSEFTLMARRIG
                     KDLSNTFAKLEKLTILAKRKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVRAK
                     GSQSGRHLQTHSNTIVVSLQSKLASMSNDFKSVLEVRTENLKQQRNRREQFSRAPVSA
                     LPLAPNNLGGGPIVLGGESRASRDVAIDMMDPRTSQQLQLIDEQDSYIQSRADTMQNI
                     ESTIVELGSIFQQLAHMVKEQEETIQRIDENVLGAQLDVEAAHSEILKYFQSVTSNRW
                     LMVKIFLILIVFFIIFVVFLA"
     exon            363..433
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
     exon            434..489
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
     exon            490..560
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
     exon            561..677
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
     exon            678..734
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
     exon            735..816
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
     exon            817..923
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1045
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1779
                     /gene="Stx5"
                     /gene_synonym="Stx5a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgtgtag gtgacgtggc ggctccagtt ctttggtccg gcttccactg cttacaagtc
       61 cggcgaggag gcggcaacga cctgaggaga gtagcggtgg cggtaggcaa cagaagagtc
      121 cgaggttatg cgactcgatg atcccgcgga aacgctacgg atctaagaac acggatcagg
      181 gtgtctacct gggtctctca aagacacagg ttctgtcccc tgcaactgct atcaatagca
      241 gcagtgacat cgctcctttg cccaccccgg tggccctggt cccctcccct cccgacacta
      301 tgtcctgccg ggatcggacc caggagttcc tgtctgcctg caagtcgctg cagagccgtc
      361 agaatggaat ccaaacaaat aaaccagctc tgcacgctac ccggcagtgc agcgagttta
      421 ccctcatggc caggcgcatt gggaaagatc tcagcaatac atttgccaag ctggagaagc
      481 taacaatcct ggcaaagcgc aagtccctct ttgatgataa agcagtagaa attgaggaac
      541 taacatacat catcaaacag gacatcaata gcctcaacaa acaaattgct cagcttcaag
      601 attttgtgag ggccaagggc agccagagtg gccggcatct gcagacccat tccaacacca
      661 ttgtagtttc attgcagtca aaactggctt ccatgtccaa tgacttcaag tctgttttgg
      721 aagtgaggac tgaaaatctg aaacagcaga ggaaccgtcg ggaacagttc tccagggcgc
      781 cagtgtcggc actgcctctg gcccccaaca accttggagg tggtcccata gttctgggag
      841 gagagtcccg agcctccagg gacgtggcca tcgacatgat ggaccctaga acaagccagc
      901 agcttcagct cattgatgag caggattcct acatccagag tcgggcagac accatgcaga
      961 acattgagtc tacaattgtt gagctgggct ccatttttca acaattggca cacatggtta
     1021 aagaacagga ggaaacaatt cagaggattg acgagaatgt gcttggagcc cagctggatg
     1081 ttgaggccgc ccattcagag atcctcaagt acttccagtc agtcacctcc aatcggtggc
     1141 tcatggtcaa aatcttcctc atcctcattg tcttcttcat catctttgtg gtcttccttg
     1201 cctgaaccct cctccctcat tctgagccac tccatggagg gcctggaacc cttctggaag
     1261 gacaggtggc cactattgcc actgagcctg tgcagggtag ttgggagaaa ggccatttcc
     1321 ttggaactgc taagaatggc cagtgtccct gattccccac ccttgtctct ggccactctg
     1381 tcctaccctc aggcccatga aacacactgg ttctggattt ggcctctgct gtgaagtggc
     1441 agggaacaga agccagctag ggccagtggg gaggttgtct ctaccatgag atttttataa
     1501 acccagacca gcctccccta aaggtaactg gcagcaagag gaaacaatgc ccttccttgc
     1561 cttctggaga gtgaggtgag gaagtaaaac tatcccaggg accaacttaa tcatctgggt
     1621 catctagaac ttgactgcca ccttctcctc accatgtgag gtgggggggg ctctgagccc
     1681 tacagttgca caaacctgac tttggctact ggtgactctc aatctgccaa acatgctgca
     1741 gcctgtttcc tcccaattac agcaagactg tcagcctcaa aaaaaaaaaa aaaaaaaaaa
     1801 aaaaaaa
//
