LOCUS       NM_031125                974 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus syntaxin 4 (Stx4), mRNA.
ACCESSION   NM_031125
VERSION     NM_031125.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 974)
  AUTHORS   Kuge,H., Miyamoto,I., Yagyu,K.I. and Honke,K.
  TITLE     PLRP2 selectively localizes synaptic membrane proteins via
            acyl-chain remodeling of phospholipids
  JOURNAL   J Lipid Res 61 (12), 1747-1763 (2020)
   PUBMED   32963038
REFERENCE   2  (bases 1 to 974)
  AUTHORS   Lin,M., Jiang,M., Ding,F. and Cao,Z.
  TITLE     Syntaxin-4 and SNAP23 act as exocytic SNAREs to release NGF from
            cultured Schwann cells
  JOURNAL   Neurosci Lett 653, 97-104 (2017)
   PUBMED   28119011
  REMARK    GeneRIF: Syntaxin-4 and SNAP23 act as exocytic soluble
            N-ethylmaleimide-sensitive factor attachment protein receptors
            (SNAREs) to release nerve growth factors from cultured Schwann
            cells.
REFERENCE   3  (bases 1 to 974)
  AUTHORS   Gu,Y. and Huganir,R.L.
  TITLE     Identification of the SNARE complex mediating the exocytosis of
            NMDA receptors
  JOURNAL   Proc Natl Acad Sci U S A 113 (43), 12280-12285 (2016)
   PUBMED   27791016
  REMARK    GeneRIF: Our study uncovers the postsynaptic function of the
            SNAP25-VAMP1-syntaxin4 complex in mediating the constitutive
            exocytosis of NMDA receptors, suggesting that this SNARE complex is
            involved in excitatory synaptic transmission
REFERENCE   4  (bases 1 to 974)
  AUTHORS   Soo Hoo,L., Banna,C.D., Radeke,C.M., Sharma,N., Albertolle,M.E.,
            Low,S.H., Weimbs,T. and Vandenberg,C.A.
  TITLE     The SNARE Protein Syntaxin 3 Confers Specificity for Polarized
            Axonal Trafficking in Neurons
  JOURNAL   PLoS One 11 (9), e0163671 (2016)
   PUBMED   27662481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 974)
  AUTHORS   Liu,S., Sahid,M.N., Takemasa,E., Kiyoi,T., Kuno,M., Oshima,Y. and
            Maeyama,K.
  TITLE     CRACM3 regulates the stability of non-excitable exocytotic vesicle
            fusion pores in a Ca(2+)-independent manner via molecular
            interaction with syntaxin4
  JOURNAL   Sci Rep 6, 28133 (2016)
   PUBMED   27301714
  REMARK    GeneRIF: Syntaxin-4 and CRACM3 interact in a non-excitable vesicle
            fusion.Extracellular loop 3 and the C-terminus of CRACM3 are
            critical for binding the N-peptide of syntaxin-4.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 974)
  AUTHORS   Pevsner,J., Hsu,S.C., Hyde,P.S. and Scheller,R.H.
  TITLE     Mammalian homologues of yeast vacuolar protein sorting (vps) genes
            implicated in Golgi-to-lysosome trafficking
  JOURNAL   Gene 183 (1-2), 7-14 (1996)
   PUBMED   8996080
REFERENCE   7  (bases 1 to 974)
  AUTHORS   Jagadish,M.N., Fernandez,C.S., Hewish,D.R., Macaulay,S.L.,
            Gough,K.H., Grusovin,J., Verkuylen,A., Cosgrove,L., Alafaci,A.,
            Frenkel,M.J. and Ward,C.W.
  TITLE     Insulin-responsive tissues contain the core complex protein SNAP-25
            (synaptosomal-associated protein 25) A and B isoforms in addition
            to syntaxin 4 and synaptobrevins 1 and 2
  JOURNAL   Biochem J 317 (Pt 3) (Pt 3), 945-954 (1996)
   PUBMED   8760387
REFERENCE   8  (bases 1 to 974)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
REFERENCE   9  (bases 1 to 974)
  AUTHORS   Hata,Y. and Sudhof,T.C.
  TITLE     A novel ubiquitous form of Munc-18 interacts with multiple
            syntaxins. Use of the yeast two-hybrid system to study interactions
            between proteins involved in membrane traffic
  JOURNAL   J Biol Chem 270 (22), 13022-13028 (1995)
   PUBMED   7768895
REFERENCE   10 (bases 1 to 974)
  AUTHORS   Bennett,M.K., Garcia-Arraras,J.E., Elferink,L.A., Peterson,K.,
            Fleming,A.M., Hazuka,C.D. and Scheller,R.H.
  TITLE     The syntaxin family of vesicular transport receptors
  JOURNAL   Cell 74 (5), 863-873 (1993)
   PUBMED   7690687
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031125.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20821.1, SRR26643298.5509.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000001.1  191882067-191882128
            63-164              JAXUCZ010000001.1  191882322-191882423
            165-264             JAXUCZ010000001.1  191882503-191882602
            265-339             JAXUCZ010000001.1  191882741-191882815
            340-410             JAXUCZ010000001.1  191883838-191883908
            411-519             JAXUCZ010000001.1  191886945-191887053
            520-596             JAXUCZ010000001.1  191887124-191887200
            597-734             JAXUCZ010000001.1  191887405-191887542
            735-845             JAXUCZ010000001.1  191888760-191888870
            846-944             JAXUCZ010000001.1  191888941-191889039
            945-974             JAXUCZ010000001.1  191889123-191889152
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..974
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /note="syntaxin 4"
                     /db_xref="GeneID:81803"
                     /db_xref="RGD:621019"
     exon            1..62
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..929
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /note="syntaxin 4A (placental)"
                     /codon_start=1
                     /product="syntaxin-4"
                     /protein_id="NP_112387.2"
                     /db_xref="GeneID:81803"
                     /db_xref="RGD:621019"
                     /translation="MRDRTHELRQGDNISDDEDEVRVALVVHSGAARLSSPDDEFFQK
                     VQTIRQTMAKLESKVRELEKQQVTILATPLPEESMKQGLQNLREEIKQLGREVRAQLK
                     AIEPQKEEADENYNSVNTRMKKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQL
                     KITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIR
                     ELHEIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKIALENQKKARKKKVMI
                     AICVSVTVLILAVIIGITITVG"
     exon            63..164
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
     exon            165..264
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
     exon            265..339
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
     exon            340..410
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
     exon            411..519
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
     exon            520..596
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
     exon            597..734
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
     exon            735..845
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
     exon            846..944
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
     exon            945..974
                     /gene="Stx4"
                     /gene_synonym="Stx4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgggctca ggtccagggc actccggcca ccatgcgcga caggacccat gagttgaggc
       61 agggggataa catctcagac gatgaagatg aggttcgagt cgcgttggtg gtgcactcag
      121 gtgccgcccg gctgagcagc ccggacgacg agttcttcca gaaggtgcag acaattcggc
      181 agactatggc caaactggag agtaaagtcc gggagttgga gaaacagcag gtcaccattc
      241 tggccacgcc tcttcccgag gagagcatga agcagggcct gcagaacctg cgagaggaga
      301 tcaaacagct ggggagagaa gtccgggcac agctaaaagc catagagccc cagaaggaag
      361 aagctgatga gaattataat tcagtcaaca caagaatgaa gaaaacccag catggggtcc
      421 tgtcccagca gtttgtggag ctcatcaaca agtgtaactc aatgcagtcc gagtaccgag
      481 agaagaacgt ggagcgcatt cggcggcagc tgaagatcac caatgctgga atggtgtctg
      541 acgaggaact ggagcagatg ctggacagtg ggcagagtga ggtgtttgtg tctaatatac
      601 tgaaggacac acaggtgacc cggcaggccc tgaatgagat ctctgcgcga cacagtgaga
      661 tccagcagtt ggagcgcagc atccgtgaac tccatgagat cttcactttt ctagctaccg
      721 aggtggagat gcagggagag atgatcaatc gtatcgaaaa gaacattctg agctcagcag
      781 actatgtgga acgtgggcaa gaacatgtca agatagcgct agagaatcag aagaaggcga
      841 ggaagaaaaa ggtcatgatt gccatctgtg tttctgtcac tgttctcatc ttggctgtca
      901 tcattggcat caccataacc gttggataat gtcacatgtt cttggcactg ggagaaacag
      961 agacccagca tttg
//
