LOCUS       NM_031124               1055 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus syntaxin 3 (Stx3), mRNA.
ACCESSION   NM_031124
VERSION     NM_031124.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1055)
  AUTHORS   Greitzer-Antes,D., Xie,L., Qin,T., Xie,H., Zhu,D., Dolai,S.,
            Liang,T., Kang,F., Hardy,A.B., He,Y., Kang,Y. and Gaisano,H.Y.
  TITLE     Kv2.1 clusters on beta-cell plasma membrane act as reservoirs that
            replenish pools of newcomer insulin granule through their
            interaction with syntaxin-3
  JOURNAL   J Biol Chem 293 (18), 6893-6904 (2018)
   PUBMED   29549124
  REMARK    GeneRIF: Kv2.1 forms reservoir clusters on the beta-cell plasma
            membrane and binds Syn-3 via its C-terminal C1b domain, which
            recruits newcomer insulin secretory granules into this large
            reservoir.
REFERENCE   2  (bases 1 to 1055)
  AUTHORS   Datta,P., Allamargot,C., Hudson,J.S., Andersen,E.K., Bhattarai,S.,
            Drack,A.V., Sheffield,V.C. and Seo,S.
  TITLE     Accumulation of non-outer segment proteins in the outer segment
            underlies photoreceptor degeneration in Bardet-Biedl syndrome
  JOURNAL   Proc Natl Acad Sci U S A 112 (32), E4400-E4409 (2015)
   PUBMED   26216965
REFERENCE   3  (bases 1 to 1055)
  AUTHORS   Liu,X., Heidelberger,R. and Janz,R.
  TITLE     Phosphorylation of syntaxin 3B by CaMKII regulates the formation of
            t-SNARE complexes
  JOURNAL   Mol Cell Neurosci 60, 53-62 (2014)
   PUBMED   24680688
REFERENCE   4  (bases 1 to 1055)
  AUTHORS   Brochetta,C., Suzuki,R., Vita,F., Soranzo,M.R., Claver,J.,
            Madjene,L.C., Attout,T., Vitte,J., Varin-Blank,N., Zabucchi,G.,
            Rivera,J. and Blank,U.
  TITLE     Munc18-2 and syntaxin 3 control distinct essential steps in mast
            cell degranulation
  JOURNAL   J Immunol 192 (1), 41-51 (2014)
   PUBMED   24323579
  REMARK    GeneRIF: Munc18-2 and STX3 perform distinct, but complementary,
            functions to support, respectively, SG translocation and membrane
            fusion in mast cells.
REFERENCE   5  (bases 1 to 1055)
  AUTHORS   Yatsu,A., Ohbayashi,N., Tamura,K. and Fukuda,M.
  TITLE     Syntaxin-3 is required for melanosomal localization of Tyrp1 in
            melanocytes
  JOURNAL   J Invest Dermatol 133 (9), 2237-2246 (2013)
   PUBMED   23549422
REFERENCE   6  (bases 1 to 1055)
  AUTHORS   Morgans,C.W., Brandstatter,J.H., Kellerman,J., Betz,H. and
            Wassle,H.
  TITLE     A SNARE complex containing syntaxin 3 is present in ribbon synapses
            of the retina
  JOURNAL   J Neurosci 16 (21), 6713-6721 (1996)
   PUBMED   8824312
REFERENCE   7  (bases 1 to 1055)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
REFERENCE   8  (bases 1 to 1055)
  AUTHORS   Hata,Y. and Sudhof,T.C.
  TITLE     A novel ubiquitous form of Munc-18 interacts with multiple
            syntaxins. Use of the yeast two-hybrid system to study interactions
            between proteins involved in membrane traffic
  JOURNAL   J Biol Chem 270 (22), 13022-13028 (1995)
   PUBMED   7768895
REFERENCE   9  (bases 1 to 1055)
  AUTHORS   Pevsner,J., Hsu,S.C. and Scheller,R.H.
  TITLE     n-Sec1: a neural-specific syntaxin-binding protein
  JOURNAL   Proc Natl Acad Sci U S A 91 (4), 1445-1449 (1994)
   PUBMED   8108429
REFERENCE   10 (bases 1 to 1055)
  AUTHORS   Bennett,M.K., Garcia-Arraras,J.E., Elferink,L.A., Peterson,K.,
            Fleming,A.M., Hazuka,C.D. and Scheller,R.H.
  TITLE     The syntaxin family of vesicular transport receptors
  JOURNAL   Cell 74 (5), 863-873 (1993)
   PUBMED   7690687
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000046.1.
            
            [WARNING] On Mar 28, 2024 this sequence was replaced by
            NM_031124.3.
            
            On Nov 26, 2020 this sequence version replaced NM_031124.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20820.1, BC168246.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JACYVU010000046.1  2512431-2512537     c
            108-191             JACYVU010000046.1  2493294-2493377     c
            192-291             JACYVU010000046.1  2480915-2481014     c
            292-366             JACYVU010000046.1  2479089-2479163     c
            367-434             JACYVU010000046.1  2477692-2477759     c
            435-543             JACYVU010000046.1  2476075-2476183     c
            544-617             JACYVU010000046.1  2475202-2475275     c
            618-752             JACYVU010000046.1  2474906-2475040     c
            753-863             JACYVU010000046.1  2472862-2472972     c
            864-977             JACYVU010000046.1  2471356-2471469     c
            978-1055            JACYVU010000046.1  2469651-2469728     c
FEATURES             Location/Qualifiers
     source          1..1055
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1055
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /note="syntaxin 3"
                     /db_xref="GeneID:81802"
                     /db_xref="RGD:621005"
     exon            1..107
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..947
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /codon_start=1
                     /product="syntaxin-3"
                     /protein_id="NP_112386.1"
                     /db_xref="GeneID:81802"
                     /db_xref="RGD:621005"
                     /translation="MKDRLEQLKAKQLTQDDDTDEVEIAIDNTAFMDEFFSEIEETRL
                     NIDKISEHVEEAKKLYSIILSAPIPEPKTKDDLEQLTTEIKKRANNVRNKLKSMEKHI
                     EEDEVRSSADLRIRKSQHSVLSRKFVEVMTKYNEAQVDFRERSKGRIQRQLEITGKKT
                     TDEELEEMLESGNPAIFTSGIIDSQISKQALSEIEGRHKDIVRLESSIKELHDMFMDI
                     AMLVENQGEMLDNIELNVMHTVDHVEKARDETKRAMKYQGQARKKLIIIIVIVVVLLG
                     ILALIIGLSVGLK"
     exon            108..191
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
     exon            192..291
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
     exon            292..366
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
     exon            367..434
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
     exon            435..543
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
     exon            544..617
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
     exon            618..752
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
     exon            753..863
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
     exon            864..977
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1055
                     /gene="Stx3"
                     /gene_synonym="Stx3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcagttg ctccaggccg ctcacttggg acgcgcttac ctgagacaag gcgcctgcca
       61 ccctcacctg gaccaggatg aaggaccgac tggagcagct gaaggccaag cagctgacgc
      121 aggatgatga cacggacgag gttgagattg ctattgataa tacagcgttc atggatgagt
      181 tcttttctga gattgaggaa acgaggctca acatcgacaa gatctcagag catgtggagg
      241 aagctaagaa actctacagt atcattctct ctgcaccgat tccagagcca aaaaccaaag
      301 acgaccttga acagctcaca actgagatca agaaaagggc caacaacgtc cggaacaaac
      361 tgaagagcat ggagaagcat attgaggaag acgaggtccg gtcatcagca gaccttcgga
      421 tacgaaagtc ccagcactcc gtcctctccc ggaagtttgt ggaggtgatg acaaagtaca
      481 atgaggcaca ggtggacttc cgtgaacgca gcaaagggcg catccaacgg cagcttgaaa
      541 ttactggcaa gaaaacaaca gatgaggagc tggaagaaat gttggagagt ggcaacccag
      601 ccatcttcac ttctgggatc attgactccc agatttccaa gcaagccctc agcgagattg
      661 agggtcggca caaggacatc gtgaggctgg agagcagcat caaggagctc catgacatgt
      721 ttatggacat cgccatgctg gtggagaatc agggtgagat gttagataac atagagttga
      781 atgtcatgca cacggtggac catgtggaga aggcacggga tgaaactaaa agagccatga
      841 agtatcaggg tcaggctcga aagaaattga taattatcat tgtgatagta gttgtgttgc
      901 tgggcatttt agcgttgatt attggattgt ccgttgggct gaaataagag tggcctaagg
      961 ggctgctgca ctgaaatctt ggcctgacca ctcttgtctc cagatgggaa caaagattaa
     1021 atggccttcc tgagaatgag gggtacctgt tcctt
//
