LOCUS       NM_012748               2623 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus syntaxin 2 (Stx2), transcript variant 1, mRNA.
ACCESSION   NM_012748 XM_006249249
VERSION     NM_012748.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Diao,X. and Sun,S.
  TITLE     PMicroRNA-124a regulates LPS-induced septic cardiac dysfunction by
            targeting STX2
  JOURNAL   Biotechnol Lett 39 (9), 1335-1342 (2017)
   PUBMED   28560580
  REMARK    GeneRIF: miR-124a aggravates lipopolysaccharide-induced cardiac
            dysfunction and the miR-124a/STX2 pathway might serve as the
            potential diagnostic and therapeutic targets for septic cardiac
            dysfunction.
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Akpinar,I., Korgun,D., Cetin,A., Yesilkaya,A., Karaguzel,G.,
            Boneval,C. and Melikoglu,M.
  TITLE     Epimorphin expression in a rat model of pulmonary hypoplasia
            associated with congenital diaphragmatic hernia
  JOURNAL   Pediatr Surg Int 30 (10), 1037-1043 (2014)
   PUBMED   25119302
  REMARK    GeneRIF: Epimorphin has morphogenetic effects on several epithelial
            tissues, including those of lung.
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Pritchett,J., Athwal,V.S., Harvey,E., Martin,K., Llewellyn,J.,
            Ireland,P., Nicolaides,A., Humphries,M.J., Bobola,N., Hanley,N.A.
            and Piper Hanley,K.
  TITLE     Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in
            activated hepatic stellate cells
  JOURNAL   PLoS One 9 (6), e100091 (2014)
   PUBMED   24971829
  REMARK    GeneRIF: These data provide evidence for EPIM and SOX9 functioning
            by mutual negative feedback to regulate attributes of the quiescent
            or activated state of HSCs.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Kadono,N., Miyazaki,T., Okugawa,Y., Nakajima,K. and Hirai,Y.
  TITLE     The impact of extracellular syntaxin4 on HaCaT keratinocyte
            behavior
  JOURNAL   Biochem Biophys Res Commun 417 (4), 1200-1205 (2012)
   PUBMED   22226963
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Jia,Y., Yao,H., Zhou,J., Chen,L., Zeng,Q., Yuan,H., Shi,L., Nan,X.,
            Wang,Y., Yue,W. and Pei,X.
  TITLE     Role of epimorphin in bile duct formation of rat liver epithelial
            stem-like cells: involvement of small G protein RhoA and C/EBPbeta
  JOURNAL   J Cell Physiol 226 (11), 2807-2816 (2011)
   PUBMED   21935930
  REMARK    GeneRIF: Epimorphin regulates bile duct formation of WB-F344 cells
            through effects on RhoA and C/EBPbeta, implicating a dual aspect of
            this morphoregulator in bile duct epithelial morphogenesis.
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Horikoshi,S., Yoshikawa,M., Shibata,T., Takahashi,K., Shirato,I.
            and Tomino,Y.
  TITLE     Protein localization and mRNA expression of epimorphin in mouse and
            human kidneys
  JOURNAL   Exp Nephrol 9 (6), 412-419 (2001)
   PUBMED   11702001
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Quinones,B., Riento,K., Olkkonen,V.M., Hardy,S. and Bennett,M.K.
  TITLE     Syntaxin 2 splice variants exhibit differential expression
            patterns, biochemical properties and subcellular localizations
  JOURNAL   J Cell Sci 112 (Pt 23), 4291-4304 (1999)
   PUBMED   10564647
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Thomas,D.M., Ferguson,G.D., Herschman,H.R. and Elferink,L.A.
  TITLE     Functional and biochemical analysis of the C2 domains of
            synaptotagmin IV
  JOURNAL   Mol Biol Cell 10 (7), 2285-2295 (1999)
   PUBMED   10397765
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Zha,H., Remmers,E.F., Szpirer,C., Szpirer,J., Zhang,H., Kozak,C.A.
            and Wilder,R.L.
  TITLE     The epimorphin gene is highly conserved among humans, mice, and
            rats and maps to human chromosome 7, mouse chromosome 5, and rat
            chromosome 12
  JOURNAL   Genomics 37 (3), 386-389 (1996)
   PUBMED   8938452
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Bennett,M.K., Garcia-Arraras,J.E., Elferink,L.A., Peterson,K.,
            Fleming,A.M., Hazuka,C.D. and Scheller,R.H.
  TITLE     The syntaxin family of vesicular transport receptors
  JOURNAL   Cell 74 (5), 863-873 (1993)
   PUBMED   7690687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Dec 28, 2022 this sequence version replaced
            XM_006249249.4, NM_012748.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.39802.1,
                                           SRR26360190.2232702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000012.1  33325869-33325989
            122-202             JAXUCZ010000012.1  33335384-33335464
            203-302             JAXUCZ010000012.1  33339134-33339233
            303-377             JAXUCZ010000012.1  33340574-33340648
            378-451             JAXUCZ010000012.1  33341726-33341799
            452-560             JAXUCZ010000012.1  33342993-33343101
            561-634             JAXUCZ010000012.1  33344025-33344098
            635-772             JAXUCZ010000012.1  33344200-33344337
            773-883             JAXUCZ010000012.1  33346442-33346552
            884-1008            JAXUCZ010000012.1  33347602-33347726
            1009-2623           JAXUCZ010000012.1  33349174-33350788
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     gene            1..2623
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /note="syntaxin 2"
                     /db_xref="GeneID:25130"
                     /db_xref="RGD:2558"
     exon            1..121
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..964
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /note="isoform 1 is encoded by transcript variant 1;
                     epimorphin"
                     /codon_start=1
                     /product="syntaxin-2 isoform 1"
                     /protein_id="NP_036880.2"
                     /db_xref="GeneID:25130"
                     /db_xref="RGD:2558"
                     /translation="MRDRLPDLTACRKSDDGDNAVIITVEKDHFMDAFFHQVEEIRSS
                     IARIAQHVEDVKKNHSIILSAPNPEGKIKEELEDLNKEIKKTANRIRGKLKAIEQSCD
                     QDENGNRTSVDLRIRRTQHSVLSRKFVDVMTEYNEAQILFRERSKGRIQRQLEITGRT
                     TTDEELEEMLESGKPSIFISDIISDSQITRQALNEIESRHKDIMKLETSIRELHEMFM
                     DMAMFVETQGEMVNNIERNVVNSVDYVEHAKEETKKAIKYQSKARRKKWIIAAVVVAV
                     IAVLALIIGLSVGK"
     exon            122..202
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
     exon            203..302
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
     exon            303..377
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
     exon            378..451
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
     exon            452..560
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
     exon            561..634
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
     exon            635..772
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
     exon            773..883
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1008
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..2623
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accccggcgg gcagaggcgg cgacgcggcc acccgagagt gtgcggcggg gcagctgagc
       61 ggcgggagct ccgccctgct ggctggtggg gatgcgggac cggctgccgg acctcacggc
      121 gtgtaggaaa agcgacgatg gagacaatgc tgtcatcatc acggtggaga aggaccactt
      181 catggatgcc ttcttccatc aggtggagga gattcgaagc agcatagcca ggattgctca
      241 gcacgtggag gatgtgaaga agaaccacag catcatcctc tctgccccaa acccagaagg
      301 aaaaataaaa gaagagctgg aggacctgaa caaagagatc aagaaaactg ctaacaggat
      361 ccggggcaag ctgaaggcta ttgagcagag ttgtgatcag gacgagaatg ggaaccgaac
      421 ttcagtggat ctgcggatac gaaggaccca gcactcagtg ctgtcacgga agtttgtgga
      481 cgtcatgaca gaatacaatg aagcacagat cctgtttcgg gagcgaagca aaggccgaat
      541 ccagcgccag ctagagatca ctgggaggac caccactgac gaggagctgg aggagatgct
      601 ggagagcggg aagccgtcca tcttcatctc ggacattata tcagattcac agattactag
      661 gcaagctctc aatgagatcg agtcacgcca caaagacatc atgaagctgg agaccagcat
      721 ccgagagctg cacgagatgt tcatggatat ggccatgttt gtcgagactc agggtgaaat
      781 ggtcaacaac attgagagaa acgtggtgaa ctccgtagat tacgtggagc acgccaagga
      841 agagactaag aaagccatca aataccagag caaggccaga cggaaaaagt ggataattgc
      901 tgctgtggtg gtggctgtca ttgctgtcct ggctctaatc attggcttgt cggttggcaa
      961 atgattgcgt agatggcgct gggtgcttgc ctctccctca gggtggcaaa ggtgatgttc
     1021 gtcctcatct gtgtagtcac tttgcttgtg atccttggaa ttattctagc aacagcattg
     1081 tcatagcaac cgcaccccaa gagctctttg tcctcagaga ctctgaccac acctgcagca
     1141 tggccggcgt gaacctcaga ccccagggct agcgcagagc gctgaggttt ttattggtga
     1201 tggagaataa agcgccacag aggtctcata ccatgaaaca ccgtgagccc cgtggatgcg
     1261 acatgccagc ccagagggcc tgggtctctc tgaaggacac caccgagatt tcacaatggt
     1321 ggccttgcct cagtggcttt gaaataggaa tgatcgagaa agtcttaact tttaaagatg
     1381 acgccagtgt taaaatgtac gttgtgttta attagggtgt gctctgtgct ctcggccgac
     1441 agtgctgacg aagagacttc gtgccaggcc tgatctctgt tcgtgtcttg tttgcagaat
     1501 catcacagaa ctgtgttttt gtaaggcacc tgtaatttta agtatctgta agttaagttc
     1561 cttaatatat taacatctaa actccctttt ctaagctaga cactgccttg tgaaggacaa
     1621 tgggccagcc ctaggcagcc atgtcgaggt tgctgttgtc cctgaaaaca tggcctcgca
     1681 gcccctcagg gcccttcttc agtgccttct ggtgaccctg actaggaagt gtaagggtct
     1741 gaagaggtga caagcggcca cacgctgcac tcgtgttgct cttccttgtt cactcatggt
     1801 aatggagtct cggcgacaaa gatggaggcg agacttggtg ctcactagac tctagggaac
     1861 cgtcccgggc acaaagccac tcccggacag catccgaagg accagatcct cagcccagcg
     1921 cccactagtg cccagagttc ctaggaagcc aggtgtaaag ctgtgcgctg cttcaccctt
     1981 gtgaataggt ggcccagtga ctgcatatct gttgagagct agtgtgtgaa ggacaccatg
     2041 cctagtgtgt gtgagggctc agtctgcccc agcctcactc ggtgggatct ggaacaccaa
     2101 gtgctacgaa ctatctagaa accacgatcc tctcagtggt gagtgtgcca cactgtcacc
     2161 gccttccacc tcccagcctg acaccccgtg tgccgagagc tactgcagca ggctgggcta
     2221 tgtgtcctgg tccagagcta gcctgcagtg cagacgctct ggctgatagc tcacccttcc
     2281 tgtctgcttc agtgccgtcg gatttagccg cagaggacac acataccaca taccacccag
     2341 gcttccacca cccacggcca ggtttccttc aagtccaacc tgagcccttg gcctgtgctc
     2401 acccagtgct caggaggcct ctcggccagg ccggcggctg catctggttt tccagtgaag
     2461 caggagtgtg tgggtgagtg agttagcact tcacatatgt ctctatgccg acttcatagc
     2521 ctacttaaaa atacatttac agagtccctt gttacttttt ccaagccttt cttcaaatat
     2581 tttgtgttta cattaaaaag ttctcagaga agcaaacaag aaa
//
