LOCUS       NP_036880                290 aa            linear   ROD 03-APR-2024
DEFINITION  syntaxin-2 isoform 1 [Rattus norvegicus].
ACCESSION   NP_036880 XP_006249311
VERSION     NP_036880.2
DBSOURCE    REFSEQ: accession NM_012748.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 290)
  AUTHORS   Diao,X. and Sun,S.
  TITLE     PMicroRNA-124a regulates LPS-induced septic cardiac dysfunction by
            targeting STX2
  JOURNAL   Biotechnol Lett 39 (9), 1335-1342 (2017)
   PUBMED   28560580
  REMARK    GeneRIF: miR-124a aggravates lipopolysaccharide-induced cardiac
            dysfunction and the miR-124a/STX2 pathway might serve as the
            potential diagnostic and therapeutic targets for septic cardiac
            dysfunction.
REFERENCE   2  (residues 1 to 290)
  AUTHORS   Akpinar,I., Korgun,D., Cetin,A., Yesilkaya,A., Karaguzel,G.,
            Boneval,C. and Melikoglu,M.
  TITLE     Epimorphin expression in a rat model of pulmonary hypoplasia
            associated with congenital diaphragmatic hernia
  JOURNAL   Pediatr Surg Int 30 (10), 1037-1043 (2014)
   PUBMED   25119302
  REMARK    GeneRIF: Epimorphin has morphogenetic effects on several epithelial
            tissues, including those of lung.
REFERENCE   3  (residues 1 to 290)
  AUTHORS   Pritchett,J., Athwal,V.S., Harvey,E., Martin,K., Llewellyn,J.,
            Ireland,P., Nicolaides,A., Humphries,M.J., Bobola,N., Hanley,N.A.
            and Piper Hanley,K.
  TITLE     Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in
            activated hepatic stellate cells
  JOURNAL   PLoS One 9 (6), e100091 (2014)
   PUBMED   24971829
  REMARK    GeneRIF: These data provide evidence for EPIM and SOX9 functioning
            by mutual negative feedback to regulate attributes of the quiescent
            or activated state of HSCs.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 290)
  AUTHORS   Kadono,N., Miyazaki,T., Okugawa,Y., Nakajima,K. and Hirai,Y.
  TITLE     The impact of extracellular syntaxin4 on HaCaT keratinocyte
            behavior
  JOURNAL   Biochem Biophys Res Commun 417 (4), 1200-1205 (2012)
   PUBMED   22226963
REFERENCE   5  (residues 1 to 290)
  AUTHORS   Jia,Y., Yao,H., Zhou,J., Chen,L., Zeng,Q., Yuan,H., Shi,L., Nan,X.,
            Wang,Y., Yue,W. and Pei,X.
  TITLE     Role of epimorphin in bile duct formation of rat liver epithelial
            stem-like cells: involvement of small G protein RhoA and C/EBPbeta
  JOURNAL   J Cell Physiol 226 (11), 2807-2816 (2011)
   PUBMED   21935930
  REMARK    GeneRIF: Epimorphin regulates bile duct formation of WB-F344 cells
            through effects on RhoA and C/EBPbeta, implicating a dual aspect of
            this morphoregulator in bile duct epithelial morphogenesis.
REFERENCE   6  (residues 1 to 290)
  AUTHORS   Horikoshi,S., Yoshikawa,M., Shibata,T., Takahashi,K., Shirato,I.
            and Tomino,Y.
  TITLE     Protein localization and mRNA expression of epimorphin in mouse and
            human kidneys
  JOURNAL   Exp Nephrol 9 (6), 412-419 (2001)
   PUBMED   11702001
REFERENCE   7  (residues 1 to 290)
  AUTHORS   Quinones,B., Riento,K., Olkkonen,V.M., Hardy,S. and Bennett,M.K.
  TITLE     Syntaxin 2 splice variants exhibit differential expression
            patterns, biochemical properties and subcellular localizations
  JOURNAL   J Cell Sci 112 (Pt 23), 4291-4304 (1999)
   PUBMED   10564647
REFERENCE   8  (residues 1 to 290)
  AUTHORS   Thomas,D.M., Ferguson,G.D., Herschman,H.R. and Elferink,L.A.
  TITLE     Functional and biochemical analysis of the C2 domains of
            synaptotagmin IV
  JOURNAL   Mol Biol Cell 10 (7), 2285-2295 (1999)
   PUBMED   10397765
REFERENCE   9  (residues 1 to 290)
  AUTHORS   Zha,H., Remmers,E.F., Szpirer,C., Szpirer,J., Zhang,H., Kozak,C.A.
            and Wilder,R.L.
  TITLE     The epimorphin gene is highly conserved among humans, mice, and
            rats and maps to human chromosome 7, mouse chromosome 5, and rat
            chromosome 12
  JOURNAL   Genomics 37 (3), 386-389 (1996)
   PUBMED   8938452
REFERENCE   10 (residues 1 to 290)
  AUTHORS   Bennett,M.K., Garcia-Arraras,J.E., Elferink,L.A., Peterson,K.,
            Fleming,A.M., Hazuka,C.D. and Scheller,R.H.
  TITLE     The syntaxin family of vesicular transport receptors
  JOURNAL   Cell 74 (5), 863-873 (1993)
   PUBMED   7690687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Dec 28, 2022 this sequence version replaced
            XP_006249311.1, NP_036880.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.39802.1,
                                           SRR26360190.2232702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     Protein         1..290
                     /product="syntaxin-2 isoform 1"
                     /note="epimorphin"
                     /calculated_mol_wt=33214
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P50279.2)"
     Region          33..228
                     /region_name="Syntaxin"
                     /note="pfam00804"
                     /db_xref="CDD:459942"
     Region          196..262
                     /region_name="SNARE"
                     /note="SNARE motif; cl22856"
                     /db_xref="CDD:473982"
     Site            order(224,231,234)
                     /site_type="other"
                     /note="flanking leucine-zipper layers"
                     /db_xref="CDD:277192"
     Site            227
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277192"
     Site            267..290
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P50279.2)"
     CDS             1..290
                     /gene="Stx2"
                     /gene_synonym="Epim"
                     /coded_by="NM_012748.2:92..964"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:25130"
                     /db_xref="RGD:2558"
ORIGIN      
        1 mrdrlpdlta crksddgdna viitvekdhf mdaffhqvee irssiariaq hvedvkknhs
       61 iilsapnpeg kikeeledln keikktanri rgklkaieqs cdqdengnrt svdlrirrtq
      121 hsvlsrkfvd vmteyneaqi lfrerskgri qrqleitgrt ttdeeleeml esgkpsifis
      181 diisdsqitr qalneiesrh kdimkletsi relhemfmdm amfvetqgem vnniernvvn
      241 svdyvehake etkkaikyqs karrkkwiia avvvaviavl aliiglsvgk
//
