LOCUS       NM_012700               1690 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus syntaxin 1B (Stx1b), mRNA.
ACCESSION   NM_012700 XM_346561
VERSION     NM_012700.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Vardar,G., Chang,S., Arancillo,M., Wu,Y.J., Trimbuch,T. and
            Rosenmund,C.
  TITLE     Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic
            Vesicle Docking, and Fusion in Mouse Neurons
  JOURNAL   J Neurosci 36 (30), 7911-7924 (2016)
   PUBMED   27466336
REFERENCE   2  (bases 1 to 1690)
  AUTHORS   Gu,Y., Chiu,S.L., Liu,B., Wu,P.H., Delannoy,M., Lin,D.T., Wirtz,D.
            and Huganir,R.L.
  TITLE     Differential vesicular sorting of AMPA and GABAA receptors
  JOURNAL   Proc Natl Acad Sci U S A 113 (7), E922-E931 (2016)
   PUBMED   26839408
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Murphy,S., Zweyer,M., Henry,M., Meleady,P., Mundegar,R.R.,
            Swandulla,D. and Ohlendieck,K.
  TITLE     Label-free mass spectrometric analysis reveals complex changes in
            the brain proteome from the mdx-4cv mouse model of Duchenne
            muscular dystrophy
  JOURNAL   Clin Proteomics 12, 27 (2015)
   PUBMED   26604869
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Mishima,T., Fujiwara,T., Sanada,M., Kofuji,T., Kanai-Azuma,M. and
            Akagawa,K.
  TITLE     Syntaxin 1B, but not syntaxin 1A, is necessary for the regulation
            of synaptic vesicle exocytosis and of the readily releasable pool
            at central synapses
  JOURNAL   PLoS One 9 (2), e90004 (2014)
   PUBMED   24587181
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Arancillo,M., Min,S.W., Gerber,S., Munster-Wandowski,A., Wu,Y.J.,
            Herman,M., Trimbuch,T., Rah,J.C., Ahnert-Hilger,G., Riedel,D.,
            Sudhof,T.C. and Rosenmund,C.
  TITLE     Titration of Syntaxin1 in mammalian synapses reveals multiple roles
            in vesicle docking, priming, and release probability
  JOURNAL   J Neurosci 33 (42), 16698-16714 (2013)
   PUBMED   24133272
REFERENCE   6  (bases 1 to 1690)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
REFERENCE   7  (bases 1 to 1690)
  AUTHORS   Hata,Y. and Sudhof,T.C.
  TITLE     A novel ubiquitous form of Munc-18 interacts with multiple
            syntaxins. Use of the yeast two-hybrid system to study interactions
            between proteins involved in membrane traffic
  JOURNAL   J Biol Chem 270 (22), 13022-13028 (1995)
   PUBMED   7768895
REFERENCE   8  (bases 1 to 1690)
  AUTHORS   Pevsner,J., Hsu,S.C. and Scheller,R.H.
  TITLE     n-Sec1: a neural-specific syntaxin-binding protein
  JOURNAL   Proc Natl Acad Sci U S A 91 (4), 1445-1449 (1994)
   PUBMED   8108429
REFERENCE   9  (bases 1 to 1690)
  AUTHORS   Bennett,M.K., Garcia-Arraras,J.E., Elferink,L.A., Peterson,K.,
            Fleming,A.M., Hazuka,C.D. and Scheller,R.H.
  TITLE     The syntaxin family of vesicular transport receptors
  JOURNAL   Cell 74 (5), 863-873 (1993)
   PUBMED   7690687
REFERENCE   10 (bases 1 to 1690)
  AUTHORS   Bennett,M.K., Calakos,N. and Scheller,R.H.
  TITLE     Syntaxin: a synaptic protein implicated in docking of synaptic
            vesicles at presynaptic active zones
  JOURNAL   Science 257 (5067), 255-259 (1992)
   PUBMED   1321498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and M95735.1.
            
            On Oct 23, 2007 this sequence version replaced NM_012700.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.5488.1, M95735.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                JAXUCZ010000001.1  191864594-191864635 c
            43-1288             M95735.1           202-1447
            1289-270519468      JAXUCZ010000001.1  1-270518180
            270519469-270519574 M95735.1           1448-1553
            270519575-270519869 M95735.1           1560-1854
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1690
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /note="syntaxin 1B"
                     /db_xref="GeneID:24923"
                     /db_xref="RGD:3784"
     exon            1..81
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..918
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /note="syntaxin 1B2; P35B; Syntaxin 2"
                     /codon_start=1
                     /product="syntaxin-1B"
                     /protein_id="NP_036832.1"
                     /db_xref="GeneID:24923"
                     /db_xref="RGD:3784"
                     /translation="MKDRTQELRSAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIE
                     KLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQSIEQE
                     EGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTT
                     NEELEDMLESGKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDM
                     AMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGV
                     VLASSIGGTLGL"
     exon            82..156
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /inference="alignment:Splign:2.1.0"
     exon            157..256
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /inference="alignment:Splign:2.1.0"
     exon            257..331
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..405
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /inference="alignment:Splign:2.1.0"
     exon            406..514
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..588
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /inference="alignment:Splign:2.1.0"
     exon            589..726
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..837
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1690
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcagcgg aggcgggagg acgaagaagg ggaggaggag cccgtcgcag gatgaaggat
       61 cggactcagg agctgcggag tgcaaaagac agtgacgatg aagaggaagt ggttcatgtg
      121 gatcgagacc actttatgga tgagttcttt gagcaggtgg aagagatccg aggctgcatc
      181 gagaaactgt ccgaggatgt ggagcaagtg aagaaacagc acagtgccat tcttgctgcc
      241 cccaaccccg atgagaagac taaacaggag ctggaggacc tcacggcaga catcaaaaag
      301 acggcaaaca aggtccggtc caagttgaaa gcgatcgagc agagcattga gcaggaagag
      361 gggttgaatc gttcttctgc agacctgcgt atccgtaaga cccagcactc cacactctca
      421 cggaagttcg tggaggtaat gaccgaatat aatgcaactc agtctaagta ccgggaccgc
      481 tgcaaggacc gtatccagag gcagctggag atcactggca ggactactac caacgaagag
      541 ctggaagaca tgttggaaag cgggaagctg gccatcttca cggacgacat caaaatggac
      601 tcgcagatga caaagcaagc cctgaatgag atagagacaa ggcacaatga gatcatcaaa
      661 ctggaaacca gcatccgaga gctgcacgac atgtttgtgg acatggccat gctcgtggag
      721 agccagggtg agatgatcga ccgaattgag tacaatgtgg aacattctgt ggactacgtg
      781 gagcgagccg tgtccgacac caagaaagct gtgaaatatc agagcaaggc caggaggaag
      841 aaaattatga tcatcatttg ctgtgtggtg ctgggggtgg tcttggcgtc atctattggg
      901 gggacactgg gcttgtaggc ccctaccctt ctcttcccca ggaccctccc cacacatcgg
      961 gagcaatacc cccaccaccc tttcactctt tcccctgctc caagctcact cccaaaacag
     1021 acccaggcag ttccagcctc tctcaccctc acgcagaccc tggagtccct ggctctcacc
     1081 ttgccatgga tccccctcca ccttgccgca catagatagc agcaggcgtg atcacacatg
     1141 cacaccaaca tgcatgccga gggcacatgc tcaagacgtg tggacacccc agcgtgtgtg
     1201 tacttgtgta gatgtatgta gatgccctga acctcttctt gctgccacct tcatcctgtg
     1261 tggtctgaac ttccctctct agccggttgc tgtgctgact gtagcagcct accatggccc
     1321 aacctgttct gtgtgaatag acatggtgtg tatgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1381 tgtgtgtgtg tgtgtagatc tgtgcccata caatgtatgt acatggagtt ttgtgaatgt
     1441 gaaaacccaa agcatttcct ccaccttctc tcctatctgt tacatttgga gtgggaggca
     1501 tatgtgagga taatttacat tctcagagga tccagggtgg cccggtgacc atgccacaca
     1561 tcttttgtga tgtagaacaa actttcctgg cttggttact gccaggggtc acatcatgtc
     1621 ctgaggattc tctctctcag cctctctctc tgtctctctg tccctcagtc tctgtctctg
     1681 tctctgtctc
//
