LOCUS       NM_145723               1680 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus syntaxin 17 (Stx17), mRNA.
ACCESSION   NM_145723
VERSION     NM_145723.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1680)
  AUTHORS   Zhang,D., Zhao,X., Zhang,D., Gao,S., Xue,X. and Fu,J.
  TITLE     Hyperoxia reduces STX17 expression and inhibits the autophagic flux
            in alveolar type II epithelial cells in newborn rats
  JOURNAL   Int J Mol Med 46 (2), 773-781 (2020)
   PUBMED   32467992
  REMARK    GeneRIF: Hyperoxia reduces STX17 expression and inhibits the
            autophagic flux in alveolar type II epithelial cells in newborn
            rats.
REFERENCE   2  (bases 1 to 1680)
  AUTHORS   Cheng,X., Ma,X., Ding,X., Li,L., Jiang,X., Shen,Z., Chen,S.,
            Liu,W., Gong,W. and Sun,Q.
  TITLE     Pacer Mediates the Function of Class III PI3K and HOPS Complexes in
            Autophagosome Maturation by Engaging Stx17
  JOURNAL   Mol Cell 65 (6), 1029-1043 (2017)
   PUBMED   28306502
REFERENCE   3  (bases 1 to 1680)
  AUTHORS   Hubert,V., Peschel,A., Langer,B., Groger,M., Rees,A. and Kain,R.
  TITLE     LAMP-2 is required for incorporating syntaxin-17 into
            autophagosomes and for their fusion with lysosomes
  JOURNAL   Biol Open 5 (10), 1516-1529 (2016)
   PUBMED   27628032
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1680)
  AUTHORS   Terawaki,S., Camosseto,V., Prete,F., Wenger,T., Papadopoulos,A.,
            Rondeau,C., Combes,A., Rodriguez Rodrigues,C., Vu Manh,T.P.,
            Fallet,M., English,L., Santamaria,R., Soares,A.R., Weil,T.,
            Hammad,H., Desjardins,M., Gorvel,J.P., Santos,M.A., Gatti,E. and
            Pierre,P.
  TITLE     RUN and FYVE domain-containing protein 4 enhances autophagy and
            lysosome tethering in response to Interleukin-4
  JOURNAL   J Cell Biol 210 (7), 1133-1152 (2015)
   PUBMED   26416964
REFERENCE   5  (bases 1 to 1680)
  AUTHORS   Diao,J., Liu,R., Rong,Y., Zhao,M., Zhang,J., Lai,Y., Zhou,Q.,
            Wilz,L.M., Li,J., Vivona,S., Pfuetzner,R.A., Brunger,A.T. and
            Zhong,Q.
  TITLE     ATG14 promotes membrane tethering and fusion of autophagosomes to
            endolysosomes
  JOURNAL   Nature 520 (7548), 563-566 (2015)
   PUBMED   25686604
REFERENCE   6  (bases 1 to 1680)
  AUTHORS   Itakura,E., Kishi-Itakura,C. and Mizushima,N.
  TITLE     The hairpin-type tail-anchored SNARE syntaxin 17 targets to
            autophagosomes for fusion with endosomes/lysosomes
  JOURNAL   Cell 151 (6), 1256-1269 (2012)
   PUBMED   23217709
REFERENCE   7  (bases 1 to 1680)
  AUTHORS   Muppirala,M., Gupta,V. and Swarup,G.
  TITLE     Tyrosine phosphorylation of a SNARE protein, syntaxin 17:
            implications for membrane trafficking in the early secretory
            pathway
  JOURNAL   Biochim Biophys Acta 1823 (12), 2109-2119 (2012)
   PUBMED   23006999
REFERENCE   8  (bases 1 to 1680)
  AUTHORS   Muppirala,M., Gupta,V. and Swarup,G.
  TITLE     Syntaxin 17 cycles between the ER and ERGIC and is required to
            maintain the architecture of ERGIC and Golgi
  JOURNAL   Biol Cell 103 (7), 333-350 (2011)
   PUBMED   21545355
REFERENCE   9  (bases 1 to 1680)
  AUTHORS   Steegmaier,M., Oorschot,V., Klumperman,J. and Scheller,R.H.
  TITLE     Syntaxin 17 is abundant in steroidogenic cells and implicated in
            smooth endoplasmic reticulum membrane dynamics
  JOURNAL   Mol Biol Cell 11 (8), 2719-2731 (2000)
   PUBMED   10930465
REFERENCE   10 (bases 1 to 1680)
  AUTHORS   Steegmaier,M., Yang,B., Yoo,J.S., Huang,B., Shen,M., Yu,S., Luo,Y.
            and Scheller,R.H.
  TITLE     Three novel proteins of the syntaxin/SNAP-25 family
  JOURNAL   J Biol Chem 273 (51), 34171-34179 (1998)
   PUBMED   9852078
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_145723.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF115435.1, FQ123984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                JAXUCZ010000005.1  67241743-67241766
            25-70               JAXUCZ010000005.1  67245831-67245876
            71-252              JAXUCZ010000005.1  67248108-67248289
            253-318             JAXUCZ010000005.1  67256544-67256609
            319-544             JAXUCZ010000005.1  67274543-67274768
            545-657             JAXUCZ010000005.1  67287941-67288053
            658-708             JAXUCZ010000005.1  67288202-67288252
            709-795             JAXUCZ010000005.1  67296391-67296477
            796-1680            JAXUCZ010000005.1  67297225-67298109
FEATURES             Location/Qualifiers
     source          1..1680
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1680
                     /gene="Stx17"
                     /note="syntaxin 17"
                     /db_xref="GeneID:252853"
                     /db_xref="RGD:708499"
     exon            1..24
                     /gene="Stx17"
                     /inference="alignment:Splign:2.1.0"
     exon            25..70
                     /gene="Stx17"
                     /inference="alignment:Splign:2.1.0"
     exon            71..252
                     /gene="Stx17"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1035
                     /gene="Stx17"
                     /codon_start=1
                     /product="syntaxin-17"
                     /protein_id="NP_663775.1"
                     /db_xref="GeneID:252853"
                     /db_xref="RGD:708499"
                     /translation="MSEDEEKVKLRRLEPAIQKFTKIVIPTDLERLKKHQINIEKYQR
                     CRIWDKLHEEHINAGRTVQQLRSNIREMEKLCLKVHKDDLILLKRMIDPMKEAAAAAT
                     AEFLQLHLESVEELKKQVKNEEALLQPSLTRSTTIDGVHTGEAEAASQSLTQIYALPE
                     IPRDQNAAESWETLEADLIELSHLVTDMSLLVNSQQEKIDSIADHVNSAAVNVEEGTK
                     NLQKAAKYKLAALPVAGAVIGGVVGGPIGLLAGFKVAGIAAALGGGVLGFTGGKLIQR
                     RKQKMMEKLTSSCPDLPSQSDKKCS"
     exon            253..318
                     /gene="Stx17"
                     /inference="alignment:Splign:2.1.0"
     exon            319..544
                     /gene="Stx17"
                     /inference="alignment:Splign:2.1.0"
     exon            545..657
                     /gene="Stx17"
                     /inference="alignment:Splign:2.1.0"
     exon            658..708
                     /gene="Stx17"
                     /inference="alignment:Splign:2.1.0"
     exon            709..795
                     /gene="Stx17"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1680
                     /gene="Stx17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcctcgag cgcctaggcg ggagacttca tcttgtcatc gtccgcattc tgagccctct
       61 ctccagctag gtgtttctgt attagaggag agagctgctg tacgagctag cagctcgcca
      121 ggctgcagga tgtccgaaga tgaggaaaag gtgaagctac gcaggcttga accagccatc
      181 cagaaattca ccaagatcgt gatcccaaca gacctggaga ggctaaagaa gcaccagata
      241 aacatcgaga agtatcaacg gtgcagaatc tgggacaagt tgcatgaaga gcacatcaat
      301 gccgggcgca ctgttcagca actgcgctcc aatatccgag aaatggagaa gctttgctta
      361 aaagtgcaca aagatgatct gatccttttg aagcgaatga tagatcctat gaaggaagca
      421 gcagcagccg ccacagccga gtttctccag ctccacttgg aatctgtgga agaactcaag
      481 aaacaagtca agaatgaaga agctttacta cagccttctc tgaccagatc cacaaccatt
      541 gatggagtcc acactggaga ggctgaagct gcttcccaga gtctgactca gatatatgcc
      601 ttgcctgaaa ttcctcgaga ccaaaatgct gctgagtcct gggaaacctt agaagcggac
      661 ttaattgagc ttagccatct ggtcaccgat atgtccctcc tagtaaattc tcagcaggag
      721 aagattgaca gcattgcaga ccatgtcaac agtgctgctg tgaatgttga agagggaacc
      781 aaaaacttgc agaaggctgc aaaatacaag ctggcagccc tgcctgtggc aggtgcagtc
      841 atcggaggag tggtgggggg tcccatcggc ctcctcgcag gcttcaaagt ggcaggaatt
      901 gcagctgcac ttggtggtgg ggtgttaggc ttcacaggtg gaaaattgat acaaagaagg
      961 aaacagaaaa tgatggagaa gctcacttcc agctgtccag atctccctag ccaaagtgac
     1021 aaaaaatgca gttaaagccc agcttccagc tggtactgtg cacccgacct aaggagcaac
     1081 ttgctggtgt tggaacagtg ttaagaagtg gctccccctg tccatgcagc cttgagccac
     1141 cataagtgga cgtgtttgtt tgctgggtgt taatggagat tttagaggtg gaggagcctg
     1201 ggcagagggt ccgtcaggtc aagtttaaag actgccaaag agcaaaggtt cagcctagca
     1261 atgtgaaaac tggatctgta actctaagga tctaagatgt gtaggaatat attggatgcc
     1321 tgagggtcag tgtgtttgta gaatgtttct tcctataggg aggaacagag tgtgagtcag
     1381 gagtctttct gtcaggtagg gatgtgctca gcagggggca caggtgaact tcttgtagac
     1441 ttgagaactg ttgtacttgg atccatctaa attttctggg gaaggaaatt aatactccaa
     1501 aatagaaaga gaagcccatt ttctctttat agtgtcttca ctgtggcacg ggtgttttcc
     1561 tggtctttcc tgtctccagg tgaggagtac agaacctccc caccccacat gctaggcctg
     1621 ctgaccaccc gtcaagccca tttcctgctg ccaagtctga agactatccg cttccagggt
//
