LOCUS       NM_022939               2313 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus syntaxin 12 (Stx12), mRNA.
ACCESSION   NM_022939
VERSION     NM_022939.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2313)
  AUTHORS   Shin,H.A., Park,M., Lee,H.J., Duong,V.A., Kim,H.M., Hwang,D.Y.,
            Lee,H. and Lew,H.
  TITLE     Unveiling Neuroprotection and Regeneration Mechanisms in Optic
            Nerve Injury: Insight from Neural Progenitor Cell Therapy with
            Focus on Vps35 and Syntaxin12
  JOURNAL   Cells 12 (19), 2412 (2023)
   PUBMED   37830626
  REMARK    GeneRIF: Unveiling Neuroprotection and Regeneration Mechanisms in
            Optic Nerve Injury: Insight from Neural Progenitor Cell Therapy
            with Focus on Vps35 and Syntaxin12.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2313)
  AUTHORS   Koike,S. and Jahn,R.
  TITLE     SNAREs define targeting specificity of trafficking vesicles by
            combinatorial interaction with tethering factors
  JOURNAL   Nat Commun 10 (1), 1608 (2019)
   PUBMED   30962439
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2313)
  AUTHORS   Wang,H., Jiang,Y., Lu,M., Sun,B., Qiao,X., Xue,D. and Zhang,W.
  TITLE     STX12 lncRNA/miR-148a/SMAD5 participate in the regulation of
            pancreatic stellate cell activation through a mechanism involving
            competing endogenous RNA
  JOURNAL   Pancreatology 17 (2), 237-246 (2017)
   PUBMED   28202235
  REMARK    GeneRIF: The activation and regulation of STX12, miR-148a and SMAD5
            in pancreatic stellate cells may serve as a new gene therapy
            strategy for the treatment of chronic pancreatitis and reversal of
            pancreatic fibrosis.
REFERENCE   4  (bases 1 to 2313)
  AUTHORS   Lu,Y., Zhang,Z., Sun,D., Sweeney,S.T. and Gao,F.B.
  TITLE     Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal
            dementia, is required for autophagosome maturation
  JOURNAL   Mol Cell 52 (2), 264-271 (2013)
   PUBMED   24095276
REFERENCE   5  (bases 1 to 2313)
  AUTHORS   Hoogenraad,C.C., Popa,I., Futai,K., Martinez-Sanchez,E., Wulf,P.S.,
            van Vlijmen,T., Dortland,B.R., Oorschot,V., Govers,R., Monti,M.,
            Heck,A.J., Sheng,M., Klumperman,J., Rehmann,H., Jaarsma,D.,
            Kapitein,L.C. and van der Sluijs,P.
  TITLE     Neuron specific Rab4 effector GRASP-1 coordinates membrane
            specialization and maturation of recycling endosomes
  JOURNAL   PLoS Biol 8 (1), e1000283 (2010)
   PUBMED   20098723
  REMARK    Erratum:[PLoS Biol. 2010;8(9)
            doi:10.1371/annotation/b17dfb99-8809-4c5a-86c2-c2a0f7ca7f5e..
            Sanchez-Martinez, Emma [corrected to Martinez-Sanchez, Emma]]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2313)
  AUTHORS   Park,M., Penick,E.C., Edwards,J.G., Kauer,J.A. and Ehlers,M.D.
  TITLE     Recycling endosomes supply AMPA receptors for LTP
  JOURNAL   Science 305 (5692), 1972-1975 (2004)
   PUBMED   15448273
REFERENCE   7  (bases 1 to 2313)
  AUTHORS   Richardson,S.C., Winistorfer,S.C., Poupon,V., Luzio,J.P. and
            Piper,R.C.
  TITLE     Mammalian late vacuole protein sorting orthologues participate in
            early endosomal fusion and interact with the cytoskeleton
  JOURNAL   Mol Biol Cell 15 (3), 1197-1210 (2004)
   PUBMED   14668490
REFERENCE   8  (bases 1 to 2313)
  AUTHORS   Steiner,P., Sarria,J.C., Glauser,L., Magnin,S., Catsicas,S. and
            Hirling,H.
  TITLE     Modulation of receptor cycling by neuron-enriched endosomal protein
            of 21 kD
  JOURNAL   J Cell Biol 157 (7), 1197-1209 (2002)
   PUBMED   12070131
REFERENCE   9  (bases 1 to 2313)
  AUTHORS   Advani,R.J., Bae,H.R., Bock,J.B., Chao,D.S., Doung,Y.C.,
            Prekeris,R., Yoo,J.S. and Scheller,R.H.
  TITLE     Seven novel mammalian SNARE proteins localize to distinct membrane
            compartments
  JOURNAL   J Biol Chem 273 (17), 10317-10324 (1998)
   PUBMED   9553086
REFERENCE   10 (bases 1 to 2313)
  AUTHORS   Tang,B.L., Tan,A.E., Lim,L.K., Lee,S.S., Low,D.Y. and Hong,W.
  TITLE     Syntaxin 12, a member of the syntaxin family localized to the
            endosome
  JOURNAL   J Biol Chem 273 (12), 6944-6950 (1998)
   PUBMED   9507000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK602227.1, CB581551.1, AF044581.1 and JAXUCZ010000005.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_022939.3.
            
            On Oct 14, 2005 this sequence version replaced NM_022939.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2525732.1,
                                           SRR22399489.1943403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CK602227.1         1-11
            12-131              CB581551.1         1-120
            132-1087            AF044581.1         782-1737
            1088-2313           JAXUCZ010000005.1  150348105-150349330 c
FEATURES             Location/Qualifiers
     source          1..2313
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2313
                     /gene="Stx12"
                     /note="syntaxin 12"
                     /db_xref="GeneID:65033"
                     /db_xref="RGD:620977"
     exon            1..196
                     /gene="Stx12"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..903
                     /gene="Stx12"
                     /note="Syn13; syntaxin-13"
                     /codon_start=1
                     /product="syntaxin-12"
                     /protein_id="NP_075228.2"
                     /db_xref="GeneID:65033"
                     /db_xref="RGD:620977"
                     /translation="MSYGPLDMYRNPGPSGPQPRDFNSIIQTCSGNIQRISQATAQIK
                     NLMSQLGTKQDSSKLQENLQQFQHSTNQLAKETNELLKELGSLPLPLSASEQRQQKLQ
                     KERLMNDFSSALNNFQVVQRKVSEKEKESIARARAGSRLSAEDRQREEQLVSFDSHEE
                     WNQMQSQEEEAAITEQDLELIKERETAIQQLEADILDVNQIFKDLAMMIHDQGDLIDS
                     IEANVESSEVHVERASDQLQRAAYYQKKSRKKMCILVLVLSVIVTVLVVVIWVASK"
     exon            197..266
                     /gene="Stx12"
                     /inference="alignment:Splign:2.1.0"
     exon            267..366
                     /gene="Stx12"
                     /inference="alignment:Splign:2.1.0"
     exon            367..504
                     /gene="Stx12"
                     /inference="alignment:Splign:2.1.0"
     exon            505..548
                     /gene="Stx12"
                     /inference="alignment:Splign:2.1.0"
     exon            549..654
                     /gene="Stx12"
                     /inference="alignment:Splign:2.1.0"
     exon            655..727
                     /gene="Stx12"
                     /inference="alignment:Splign:2.1.0"
     exon            728..810
                     /gene="Stx12"
                     /inference="alignment:Splign:2.1.0"
     exon            811..2313
                     /gene="Stx12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctcagctac tgggcccggt cagtggcagc ttccggtagg agcgccgtga agcgcgaccc
       61 cggtctctgc tccgtgtcat gtcctacggt cccttagaca tgtatcggaa tcccgggccg
      121 tcggggcctc agccccgtga cttcaacagc atcatccaga catgcagtgg caacatccag
      181 cggatcagcc aagccactgc tcagataaag aatttgatga gccaacttgg aactaagcag
      241 gactcaagca aactccagga aaatttgcaa cagttccagc actccacaaa tcagcttgcc
      301 aaggagacaa atgagttgct gaaggagtta gggtccttgc ccctaccctt gtctgcatca
      361 gagcagcgcc aacagaagct tcagaaggag cggctcatga atgacttctc gtcggccttg
      421 aacaatttcc aggttgtgca gagaaaggta tctgagaagg agaaagaaag catcgcgaga
      481 gcgagggctg gatcccgtct ttctgcagaa gacaggcaaa gagaagagca gctcgtctca
      541 tttgacagcc atgaggagtg gaaccagatg cagagccagg aggaagaggc ggccatcact
      601 gagcaagacc tggaacttat taaagagagg gaaacggcga ttcagcagct ggaggctgac
      661 attttggatg tcaatcagat ctttaaagac ttagctatga tgatccacga ccaaggtgat
      721 ctgattgata gcatagaagc caatgtggaa agctcagagg tgcatgtgga aagagcctct
      781 gatcagctac agagagctgc ttactatcag aaaaaatctc gcaagaagat gtgtatcctc
      841 gtgcttgtcc tctcagtgat tgttacagtc ttggtagttg ttatctgggt tgcttctaag
      901 tgaagtgtgg ttgcctcaga gccttctcct gctgagttgt tttcgagggc aagtgtttga
      961 tggagtcttg ccagaacaaa ctgaccacag aagagagtgt gtaccacagt gtcctgtgat
     1021 aatttagcta gaaactaact actaactagt ccttggaatt agtgaccatg gaggcagtat
     1081 ttatcaattt atgcatatat tctcttcatt tctcaaagaa cgaattaact tatgtgtatt
     1141 ttcctttctc ttgtattttg attgcccttt attgcaagtg tttattgaca gtcccactgt
     1201 ggatattctt tgtgacaggt gacactacat catagtactg tctttttgta tatacacaaa
     1261 ctataccttt ttatgcatat ctgagataaa tttccttctg gagccagcct atcagagtct
     1321 gagaagctgt acaatatgcc agcaattttt attatttaac gttttgcttt gagtttctga
     1381 ggggtctgtt ctctgttttg caaggttttg gcactataaa taactgggga gtaagaacac
     1441 tgcacccatg acttcagagg aaatgagaaa aacttgtcag agtgggcccg ctgccagggt
     1501 ttgtgggaaa gtctgggttt gggttaaact gaccttattg tctgcgggtg ttgtttacgg
     1561 agtccatcct cgcacactaa gccatcccgc tcctggttta gagaggatca gttcattacc
     1621 attgttctaa tcaatcaggt ctctctccca cctgtctgca tagaaggggg attcgctcag
     1681 cccagcatga ctttggagag cagatgagga ctgtttggaa tgattgagtc cctctcgtcc
     1741 acgtgtggct ttcattctga tgaatgataa acgctgctgt caaaggctga tccaggccct
     1801 tggaagggtt gcctggcttt gatggcaaga ttttgaaatt tagactgaag tgcggtttaa
     1861 aactcggtct gtgaacctat tgataaagca aagcaaaggt tcactttgta aataacactg
     1921 gtttagtgat gtcagaatta gcctaattta tgaacaagag atcaaactct gtgtagtttt
     1981 agataaaaac agttttaata aaaggtttct gtcttgtata taaatgttgt ctactgccct
     2041 ttttcacaga cctagaacag tcagagagcg tgtaattggt ttgggctctc agataaatgt
     2101 ggattgaggc cggaaatgtc agcagcacat ccttggctga cgtagaggat ctggctgctg
     2161 tggcaatatc tgtgtttgtt ccttctatcc ctcatgctgt cacttactgc tgtcccacac
     2221 taatgtgacc agtggagaag caagggccca aatgcatagg tttctccgca ctgttgcacc
     2281 atccctactc aacacaataa acgtttaaaa gct
//
