LOCUS       NM_001025625            1283 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus STIP1 homology and U-box containing protein 1
            (Stub1), mRNA.
ACCESSION   NM_001025625 XM_213270
VERSION     NM_001025625.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1283)
  AUTHORS   Barik,P., Kuo,W.W., Kuo,C.H., Hsieh,D.J., Day,C.H., Daddam,J.,
            Chen,M.Y., Padma,V.V., Shibu,M.A. and Huang,C.Y.
  TITLE     Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by
            co-chaperone carboxyl-terminus of Hsp70 interacting protein in
            adipose-derived stem cells provide augmented cardioprotection in
            aging-hypertensive rats
  JOURNAL   Aging (Albany NY) 15 (23), 14019-14038 (2023)
   PUBMED   38085649
  REMARK    GeneRIF: Rewiring of IGF1 secretion and enhanced IGF1R signaling
            induced by co-chaperone carboxyl-terminus of Hsp70 interacting
            protein in adipose-derived stem cells provide augmented
            cardioprotection in aging-hypertensive rats.
REFERENCE   2  (bases 1 to 1283)
  AUTHORS   Cao,N., Wang,D., Liu,B., Wang,Y., Han,W., Tian,J., Xiang,L. and
            Wang,Z.
  TITLE     Silencing of STUB1 relieves osteoarthritis via inducing
            NRF2-mediated M2 macrophage polarization
  JOURNAL   Mol Immunol 164, 112-122 (2023)
   PUBMED   37992540
  REMARK    GeneRIF: Silencing of STUB1 relieves osteoarthritis via inducing
            NRF2-mediated M2 macrophage polarization.
REFERENCE   3  (bases 1 to 1283)
  AUTHORS   Chao,C.N., Lai,C.H., Badrealam,K.F., Lo,J.F., Shen,C.Y., Chen,C.H.,
            Chen,R.J., Viswanadha,V.P., Kuo,W.W. and Huang,C.Y.
  TITLE     CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and
            apoptosis by promoting NFATc3 proteasomal degradation
  JOURNAL   J Cell Physiol 234 (11), 20128-20138 (2019)
   PUBMED   30980393
  REMARK    GeneRIF: CHIP attenuates LPS-induced cardiac hypertrophy.
REFERENCE   4  (bases 1 to 1283)
  AUTHORS   Shi,C.H., Rubel,C., Soss,S.E., Sanchez-Hodge,R., Zhang,S.,
            Madrigal,S.C., Ravi,S., McDonough,H., Page,R.C., Chazin,W.J.,
            Patterson,C., Mao,C.Y., Willis,M.S., Luo,H.Y., Li,Y.S.,
            Stevens,D.A., Tang,M.B., Du,P., Wang,Y.H., Hu,Z.W., Xu,Y.M. and
            Schisler,J.C.
  TITLE     Disrupted structure and aberrant function of CHIP mediates the loss
            of motor and cognitive function in preclinical models of SCAR16
  JOURNAL   PLoS Genet 14 (9), e1007664 (2018)
   PUBMED   30222779
  REMARK    GeneRIF: Study using two rodent models demonstrated that T246M
            mutation (described in autosomal recessive spinocerebellar
            ataxia-16 patients) results in structural disorganization and
            misfolding of the CHIP U-box domain, promoting oligomerization, and
            increased proteasome-dependent turnover. CHIP-T246M has no ligase
            activity but maintains interactions with chaperones and
            chaperone-related functions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1283)
  AUTHORS   Lizama,B.N., Palubinsky,A.M., Raveendran,V.A., Moore,A.M.,
            Federspiel,J.D., Codreanu,S.G., Liebler,D.C. and McLaughlin,B.
  TITLE     Neuronal Preconditioning Requires the Mitophagic Activity of
            C-terminus of HSC70-Interacting Protein
  JOURNAL   J Neurosci 38 (31), 6825-6840 (2018)
   PUBMED   29934347
  REMARK    GeneRIF: In forebrain neuron cultures, C terminus of
            HSC70-Interacting Protein (CHIP) is critical for neuronal responses
            to stress. CHIP upregulation and localization to mitochondria is
            required for mitochondrial autophagy (mitophagy).
REFERENCE   6  (bases 1 to 1283)
  AUTHORS   Nikolay,R., Wiederkehr,T., Rist,W., Kramer,G., Mayer,M.P. and
            Bukau,B.
  TITLE     Dimerization of the human E3 ligase CHIP via a coiled-coil domain
            is essential for its activity
  JOURNAL   J Biol Chem 279 (4), 2673-2678 (2004)
   PUBMED   14610072
REFERENCE   7  (bases 1 to 1283)
  AUTHORS   Imai,Y., Soda,M., Hatakeyama,S., Akagi,T., Hashikawa,T.,
            Nakayama,K.I. and Takahashi,R.
  TITLE     CHIP is associated with Parkin, a gene responsible for familial
            Parkinson's disease, and enhances its ubiquitin ligase activity
  JOURNAL   Mol Cell 10 (1), 55-67 (2002)
   PUBMED   12150907
REFERENCE   8  (bases 1 to 1283)
  AUTHORS   Hatakeyama,S., Yada,M., Matsumoto,M., Ishida,N. and Nakayama,K.I.
  TITLE     U box proteins as a new family of ubiquitin-protein ligases
  JOURNAL   J Biol Chem 276 (35), 33111-33120 (2001)
   PUBMED   11435423
REFERENCE   9  (bases 1 to 1283)
  AUTHORS   Connell,P., Ballinger,C.A., Jiang,J., Wu,Y., Thompson,L.J.,
            Hohfeld,J. and Patterson,C.
  TITLE     The co-chaperone CHIP regulates protein triage decisions mediated
            by heat-shock proteins
  JOURNAL   Nat Cell Biol 3 (1), 93-96 (2001)
   PUBMED   11146632
REFERENCE   10 (bases 1 to 1283)
  AUTHORS   Ballinger,C.A., Connell,P., Wu,Y., Hu,Z., Thompson,L.J., Yin,L.Y.
            and Patterson,C.
  TITLE     Identification of CHIP, a novel tetratricopeptide repeat-containing
            protein that interacts with heat shock proteins and negatively
            regulates chaperone functions
  JOURNAL   Mol Cell Biol 19 (6), 4535-4545 (1999)
   PUBMED   10330192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB568781.1, CB326459.1 and JAXUCZ010000010.1.
            
            On Oct 10, 2007 this sequence version replaced NM_001025625.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2210348.1,
                                           SRR26643294.38610.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               CB568781.1         2-605
            605-739             CB326459.1         545-679             c
            740-107714547       JAXUCZ010000010.1  1-107713808
            107714548-107715090 CB326459.1         1-543               c
FEATURES             Location/Qualifiers
     source          1..1283
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1283
                     /gene="Stub1"
                     /gene_synonym="Chip"
                     /note="STIP1 homology and U-box containing protein 1"
                     /db_xref="GeneID:287155"
                     /db_xref="RGD:1306167"
     exon            1..265
                     /gene="Stub1"
                     /gene_synonym="Chip"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1018
                     /gene="Stub1"
                     /gene_synonym="Chip"
                     /EC_number="2.3.2.27"
                     /note="carboxy terminus of Hsp70-interacting protein;
                     STIP1 homology and U-box containing protein 1, E3
                     ubiquitin protein ligase; RING-type E3 ubiquitin
                     transferase CHIP"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CHIP"
                     /protein_id="NP_001020796.2"
                     /db_xref="GeneID:287155"
                     /db_xref="RGD:1306167"
                     /translation="MKGKEEKEGGARLGTGGGGSPDKSPSAQELKEQGNRLFVGRKYP
                     EAAACYGRAITRNPLVAVYYTNRALCYLKMQQPEQALADCRRALELDGQSVKAHFFLG
                     QCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQES
                     ELHSYLTRLIAAERERELEECQRNHEGDEDDGHIRAQQACIEAKHDKYMADMNELFSQ
                     VDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPL
                     TQEQLIPNLAMKEVIDAFISENGWVEDY"
     exon            266..464
                     /gene="Stub1"
                     /gene_synonym="Chip"
                     /inference="alignment:Splign:2.1.0"
     exon            465..630
                     /gene="Stub1"
                     /gene_synonym="Chip"
                     /inference="alignment:Splign:2.1.0"
     exon            631..718
                     /gene="Stub1"
                     /gene_synonym="Chip"
                     /inference="alignment:Splign:2.1.0"
     exon            719..775
                     /gene="Stub1"
                     /gene_synonym="Chip"
                     /inference="alignment:Splign:2.1.0"
     exon            776..892
                     /gene="Stub1"
                     /gene_synonym="Chip"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1266
                     /gene="Stub1"
                     /gene_synonym="Chip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagttccg gtggcggatc gccgaccggg cggagctgat agctgcgcgg gctgcgagat
       61 ctaggtggcc gggcgcggag cccaagccgt gccgcgcggc gccatgaagg gcaaggagga
      121 aaaggagggc ggcgcgcggc tgggcactgg tggcggcggc agccctgata agagcccgag
      181 tgcgcaagag ctcaaggagc agggaaaccg gctcttcgtg ggccgcaagt acccggaggc
      241 ggcggcctgc tacggccgcg ccatcacccg gaacccactt gtggcagtgt actacaccaa
      301 ccgggccctg tgctatctga agatgcagca gcctgaacag gcacttgctg actgccggag
      361 agccctggag ctggatgggc agtctgtgaa ggcgcacttc ttcctggggc agtgccagct
      421 agagatggag agttatgatg aggccattgc caatctgcag cgagcctata gtttggccaa
      481 ggagcagcga ctcaactttg gggatgatat tcctagtgcc cttcgcattg ctaagaagaa
      541 gcgctggaac agtatcgagg aacggcgcat ccaccaggag agtgagctgc actcctatct
      601 caccaggctc attgctgctg agcgagagag ggaactggaa gagtgtcagc ggaaccacga
      661 gggtgatgag gatgatggcc acatcagggc ccagcaggcc tgcattgagg ccaagcacga
      721 taaatacatg gcggacatga atgagctctt ctctcaggtg gatgagaaaa gaaagaagcg
      781 agatatccct gactacttgt gtggcaagat cagctttgag ctgatgcggg aaccctgcat
      841 tacacccagt ggcatcacct atgaccgcaa ggacattgag gagcacctgc agcgcgtggg
      901 ccatttcgat cctgtgaccc ggagccctct gacccaggaa cagctcatcc ccaacttagc
      961 catgaaggaa gtcattgatg ctttcatctc tgagaatggc tgggtagagg actactgata
     1021 ccccatgtcc tgcctggcac cctggcccag gagggtctgg aggcagaagc tccagtccct
     1081 gtatatagtt tgtgtccctg ggcctgcccc catcggtcct gatgatgggt tctgaactgc
     1141 tccccttctc agcatatccc ttgctgggcc atgagcctcc cttgtctccc ttctgggctg
     1201 gagagctggt gagggtgggt tgctgctgct gctgccactg tcctgtaata aagtctgtga
     1261 gcactaaaaa aaaaaaaaaa aaa
//
