LOCUS       NM_012661               2536 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus steroid sulfatase (Sts), mRNA.
ACCESSION   NM_012661 XM_006256960
VERSION     NM_012661.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2536)
  AUTHORS   Purohit,A., Woo,L.W. and Potter,B.V.
  TITLE     Steroid sulfatase: a pivotal player in estrogen synthesis and
            metabolism
  JOURNAL   Mol Cell Endocrinol 340 (2), 154-160 (2011)
   PUBMED   21693170
  REMARK    Review article
REFERENCE   2  (bases 1 to 2536)
  AUTHORS   Ishida,H., Nakata,T., Suzuki,M., Shiotsu,Y., Tanaka,H., Sato,N.,
            Terasaki,Y., Takebayashi,M., Anazawa,H., Murakata,C., Li,P.K.,
            Kuwabara,T. and Akinaga,S.
  TITLE     A novel steroidal selective steroid sulfatase inhibitor KW-2581
            inhibits sulfated-estrogen dependent growth of breast cancer cells
            in vitro and in animal models
  JOURNAL   Breast Cancer Res Treat 106 (2), 215-227 (2007)
   PUBMED   17268815
REFERENCE   3  (bases 1 to 2536)
  AUTHORS   Zito,E., Fraldi,A., Pepe,S., Annunziata,I., Kobinger,G., Di
            Natale,P., Ballabio,A. and Cosma,M.P.
  TITLE     Sulphatase activities are regulated by the interaction of
            sulphatase-modifying factor 1 with SUMF2
  JOURNAL   EMBO Rep 6 (7), 655-660 (2005)
   PUBMED   15962010
  REMARK    Erratum:[EMBO Rep. 2016 Dec;17(12):1901. doi:
            10.15252/embr.201570010.. PMID: 27909074]
REFERENCE   4  (bases 1 to 2536)
  AUTHORS   Malini,B., Purohit,A., Ganeshapillai,D., Woo,L.W., Potter,B.V. and
            Reed,M.J.
  TITLE     Inhibition of steroid sulphatase activity by tricyclic coumarin
            sulphamates
  JOURNAL   J Steroid Biochem Mol Biol 75 (4-5), 253-258 (2000)
   PUBMED   11282279
REFERENCE   5  (bases 1 to 2536)
  AUTHORS   Johnson,D.A., Wu,T., Li,P. and Maher,T.J.
  TITLE     The effect of steroid sulfatase inhibition on learning and spatial
            memory
  JOURNAL   Brain Res 865 (2), 286-290 (2000)
   PUBMED   10821934
REFERENCE   6  (bases 1 to 2536)
  AUTHORS   Eriksson,L., Nilsson,B., Carlstrom,K., Oscarsson,J., Eden,S. and
            von Schoultz,B.
  TITLE     Secretory pattern of growth hormone regulates steroid sulfatase
            activity in rat liver
  JOURNAL   J Steroid Biochem 33 (3), 413-416 (1989)
   PUBMED   2779233
REFERENCE   7  (bases 1 to 2536)
  AUTHORS   Kawano,J., Kotani,T., Ohtaki,S., Minamino,N., Matsuo,H., Oinuma,T.
            and Aikawa,E.
  TITLE     Characterization of rat and human steroid sulfatases
  JOURNAL   Biochim Biophys Acta 997 (3), 199-205 (1989)
   PUBMED   2765556
REFERENCE   8  (bases 1 to 2536)
  AUTHORS   Kawano,J., Kotani,T., Umeki,K., Oinuma,T., Ohtaki,S. and Aikawa,E.
  TITLE     A monoclonal antibody to rat liver arylsulfatase C and its
            application in immunohistochemistry
  JOURNAL   J Histochem Cytochem 37 (5), 683-690 (1989)
   PUBMED   2703703
REFERENCE   9  (bases 1 to 2536)
  AUTHORS   Mouhadjer,N., Pointis,G., Malassine,A. and Bedin,M.
  TITLE     Testicular steroid sulfatase in a cryptorchid rat strain
  JOURNAL   J Steroid Biochem 34 (1-6), 555-558 (1989)
   PUBMED   2576297
REFERENCE   10 (bases 1 to 2536)
  AUTHORS   Nilsson,B., Carlstrom,K. and von Schoultz,B.
  TITLE     Effects of estrogen and growth hormone on steroid sulfatase
            activity and estrogen binding in rat liver
  JOURNAL   J Steroid Biochem 29 (3), 293-295 (1988)
   PUBMED   2965775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Nov 30, 2020 this sequence version replaced
            XM_006256960.3, NM_012661.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.893991.1,
                                           SRR26360172.159880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-586               JAXUCZ010000021.1  46102760-46103345
            587-752             JAXUCZ010000021.1  46103657-46103822
            753-874             JAXUCZ010000021.1  46104480-46104601
            875-997             JAXUCZ010000021.1  46104968-46105090
            998-1421            JAXUCZ010000021.1  46105944-46106367
            1422-1558           JAXUCZ010000021.1  46106706-46106842
            1559-1696           JAXUCZ010000021.1  46107136-46107273
            1697-1856           JAXUCZ010000021.1  46108257-46108416
            1857-1978           JAXUCZ010000021.1  46108941-46109062
            1979-2536           JAXUCZ010000021.1  46110311-46110868
FEATURES             Location/Qualifiers
     source          1..2536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..2536
                     /gene="Sts"
                     /note="steroid sulfatase"
                     /db_xref="GeneID:24800"
                     /db_xref="RGD:3783"
     exon            1..586
                     /gene="Sts"
                     /inference="alignment:Splign:2.1.0"
     exon            587..752
                     /gene="Sts"
                     /inference="alignment:Splign:2.1.0"
     CDS             604..2337
                     /gene="Sts"
                     /EC_number="3.1.6.2"
                     /note="steryl-sulfatase; ASC; arylsulfatase C;
                     steryl-sulfate sulfohydrolase; steroid sulfatase
                     (microsomal), isozyme S"
                     /codon_start=1
                     /product="steryl-sulfatase precursor"
                     /protein_id="NP_036793.2"
                     /db_xref="GeneID:24800"
                     /db_xref="RGD:3783"
                     /translation="MLWPCLLALLLSQLNFLCAARPGPGPNFLLIMADDLGIGDLGCY
                     GNRTLRTPHIDRLALEGVKLTQHLAAAPLCTPSRAAFLTGRYPVRSGMASHGRLGVFL
                     FSASSGGLPPNEVTFAKLLKGQGYTTGLVGKWHLGLSCQAASDFCHHPGRHGFDRFLG
                     TPTTNLRDCKPGGGTVFGSAQQVFVVLPMNILGAVLLAMALARWAGLARPPGWVFGVT
                     VAAMAAVGGAYVAFLYHFRPANCFLMADFTITQQPTDYKGLTQRLASEAGDFLRRNRD
                     TPFLLFLSFMHVHTAHFANPEFAGQSLHGAYGDAVEEMDWAVGQVLATLDKLGLANNT
                     LVYFTSDHGAHVEELGPNGERHGGSNGIYRGGKANTWEGGIRVPGLVRWPGVIVPGQE
                     VEEPTSNMDVFPTVARLAGAELPTDRVIDGRDLMPLLLGHVQHSEHEFLFHYCNAYLS
                     AVRWRPHNSSSVWKAFYFTPNFDPPGSNGCFSTHVCMCHGHHVTHHDPPLLFDIARDP
                     RERHPLTPETEPRHGEILRNMDAAARAHVATLEEAPNQLSMSNVAWKPWLQLCCASKP
                     HPLACRCAGDG"
     exon            753..874
                     /gene="Sts"
                     /inference="alignment:Splign:2.1.0"
     exon            875..997
                     /gene="Sts"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1421
                     /gene="Sts"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1558
                     /gene="Sts"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1696
                     /gene="Sts"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1856
                     /gene="Sts"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1978
                     /gene="Sts"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2536
                     /gene="Sts"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtgacccgc gggtataaac agccccgggc agggaaggtg ctgggagaga acctgacaga
       61 gccggtctaa ccgaggcggc aacaccgcga cctctgaacc cgtgcctcag agacaacacc
      121 gcgaccctct ggcgacctct gaccctgtga ccctgtgggt gtgacctcac gaccctggcg
      181 ccctcagcgg tgacctttga ccccgcagcg accccgagac cccaggaccc ctgcacttat
      241 ccacaactct gggacctcta accccgcgac cccagcagcg acctctgacc ctggtgaaag
      301 caggagaacc cgggacacca gtgaccctgc aacttctgac cccactaagg gcaacaactc
      361 tgagactgtg cggtgacctc tgacctctga ccctgggctg ttcccccgag ataacagtga
      421 ccccaggaac tccaactcag ctacaacctg gtgacaacca aggtaaccca gggacaacct
      481 ctgacccctt gaatccacga cttttcaccc agtgctgacc actgcagtgt ggggcagtct
      541 gagagagtgc gtgacctttg atctctgacc tctgaccccg acccaggcct tgcccacagg
      601 acgatgctct ggccctgtct ccttgccctg ctcctctccc agctcaactt tctctgtgct
      661 gcccgtcctg gccctggacc taacttcctg ctcatcatgg ctgatgacct tggcattggg
      721 gacctaggct gctatggcaa ccgcacactc aggacgccac acatcgaccg cctggccctt
      781 gagggggtga agttgactca gcacctggcg gctgcgcccc tgtgcacccc gagccgcgct
      841 gccttcctta ccgggcgcta ccctgtgcgg tcagggatgg catcacatgg ccgcctgggt
      901 gtattcctgt tctcggcatc atctgggggg ctcccgccca atgaagtcac ctttgcaaag
      961 ttgctcaagg gtcaaggcta caccaccggg cttgtaggga agtggcatct ggggctgagc
     1021 tgccaagcag cctctgactt ctgccaccac cctgggcgcc atggctttga ccgcttcctg
     1081 ggcacgccca ccaccaacct gagggactgc aagccagggg gcgggaccgt gtttggctct
     1141 gcccaacaag tattcgtggt cctgcccatg aatattctgg gggcagtgct gctggccatg
     1201 gcacttgcgc ggtgggcagg gctggcccgg cccccagggt gggtgttcgg ggtgacagtg
     1261 gctgccatgg cggcggtggg cggggcctat gtggccttcc tctaccactt ccgcccagcc
     1321 aactgcttcc tcatggccga cttcaccatc acccaacagc ccacggacta caaggggctc
     1381 acacagcgcc tggcaagcga ggctggggac ttcctgcgca ggaacaggga cacgcccttc
     1441 ctgctattcc tgtctttcat gcatgtgcac acggcacact tcgccaaccc tgagtttgcc
     1501 gggcagagcc tgcatggggc ctatggagat gctgtggagg agatggactg ggccgtaggc
     1561 caggtccttg ccacactgga caagctgggc ctcgccaaca acacactcgt gtacttcacg
     1621 tccgaccatg gcgcacacgt ggaggagctt ggccccaacg gtgaacggca tggcgggagc
     1681 aacggaattt acaggggcgg gaaggccaac acgtgggagg gtggcatccg tgtgcctgga
     1741 cttgtgcgct ggcccggcgt gattgtgccc ggccaggagg tcgaggagcc cacgagcaac
     1801 atggacgtct tccccactgt ggccaggctt gcaggggcag agctgccgac tgacagggtg
     1861 attgacgggc gtgacttgat gcccctgctg ctgggccatg tacaacactc tgagcatgaa
     1921 ttcctgttcc actactgcaa tgcctacctc agcgctgtgc gatggcggcc ccacaacagc
     1981 tcgtccgtgt ggaaggcgtt ttacttcaca ccgaacttcg accccccagg ctctaatggc
     2041 tgcttctcca cacacgtgtg catgtgccac ggccaccatg tcacgcacca tgatccgccc
     2101 ctgctcttcg acattgcccg tgaccccagg gagcgccacc cgctcacgcc tgaaacagag
     2161 ccgcgccatg gtgagatcct gcgcaacatg gatgctgcgg cccgtgcaca cgttgctacc
     2221 ctagaggagg cgcccaatca gctttccatg tcaaatgtcg catggaagcc atggctgcag
     2281 ctctgctgcg cttccaagcc ccacccactc gcatgccgct gtgctggcga cgggtgagtt
     2341 gggcatgcca aacacacagg tatgcaagca tgggacactg tggcctggtg atttcacctc
     2401 ctgaactgat acctgacaca atcttgctga catgtatgaa aacatatgaa catgtatgaa
     2461 catgtgtatg ctgagtacaa aacacaggaa gagcccctca gcatgaccct gtatgaataa
     2521 atgatgtgga cacgga
//
