LOCUS       NM_001107480            3517 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus striatin 4 (Strn4), transcript variant 1, mRNA.
ACCESSION   NM_001107480 XM_001074709 XM_218432
VERSION     NM_001107480.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3517)
  AUTHORS   Lin,L., Lo,L.H., Lyu,Q. and Lai,K.O.
  TITLE     Determination of dendritic spine morphology by the striatin
            scaffold protein STRN4 through interaction with the phosphatase
            PP2A
  JOURNAL   J Biol Chem 292 (23), 9451-9464 (2017)
   PUBMED   28442576
  REMARK    GeneRIF: STRN4 is preferentially expressed in mushroom spines, and
            STRN4 specifically maintains mushroom spines but not thin spines
            and filopodia through interaction with the phosphatase PP2A
REFERENCE   2  (bases 1 to 3517)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   3  (bases 1 to 3517)
  AUTHORS   Breitman,M., Zilberberg,A., Caspi,M. and Rosin-Arbesfeld,R.
  TITLE     The armadillo repeat domain of the APC tumor suppressor protein
            interacts with Striatin family members
  JOURNAL   Biochim Biophys Acta 1783 (10), 1792-1802 (2008)
   PUBMED   18502210
REFERENCE   4  (bases 1 to 3517)
  AUTHORS   Benoist,M., Baude,A., Tasmadjian,A., Dargent,B., Kessler,J.P. and
            Castets,F.
  TITLE     Distribution of zinedin in the rat brain
  JOURNAL   J Neurochem 106 (2), 969-977 (2008)
   PUBMED   18466332
REFERENCE   5  (bases 1 to 3517)
  AUTHORS   Gaillard,S., Bailly,Y., Benoist,M., Rakitina,T., Kessler,J.P.,
            Fronzaroli-Molinieres,L., Dargent,B. and Castets,F.
  TITLE     Targeting of proteins of the striatin family to dendritic spines:
            role of the coiled-coil domain
  JOURNAL   Traffic 7 (1), 74-84 (2006)
   PUBMED   16445688
REFERENCE   6  (bases 1 to 3517)
  AUTHORS   Baillat,G., Moqrich,A., Castets,F., Baude,A., Bailly,Y.,
            Benmerah,A. and Monneron,A.
  TITLE     Molecular cloning and characterization of phocein, a protein found
            from the Golgi complex to dendritic spines
  JOURNAL   Mol Biol Cell 12 (3), 663-673 (2001)
   PUBMED   11251078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and BQ198897.1.
            
            On Jun 18, 2009 this sequence version replaced NM_001107480.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.1184.1,
                                           SRR26643299.1335.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 18466332
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-733               JAXUCZ010000001.1  86614193-86614925
            734-837             JAXUCZ010000001.1  86620308-86620411
            838-911             JAXUCZ010000001.1  86620809-86620882
            912-990             JAXUCZ010000001.1  86622023-86622101
            991-1188            JAXUCZ010000001.1  86624162-86624359
            1189-1330           JAXUCZ010000001.1  86626221-86626362
            1331-1490           JAXUCZ010000001.1  86629475-86629634
            1491-1604           JAXUCZ010000001.1  86630157-86630270
            1605-1720           JAXUCZ010000001.1  86630597-86630712
            1721-1896           JAXUCZ010000001.1  86632150-86632325
            1897-1944           JAXUCZ010000001.1  86632401-86632448
            1945-2066           JAXUCZ010000001.1  86633104-86633225
            2067-2237           JAXUCZ010000001.1  86636659-86636829
            2238-2378           JAXUCZ010000001.1  86636958-86637098
            2379-2477           JAXUCZ010000001.1  86637377-86637475
            2478-2564           JAXUCZ010000001.1  86637651-86637737
            2565-2796           JAXUCZ010000001.1  86638808-86639039
            2797-3499           JAXUCZ010000001.1  86639256-86639958
            3500-3517           BQ198897.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3517
                     /gene="Strn4"
                     /note="striatin 4"
                     /db_xref="GeneID:308392"
                     /db_xref="RGD:1307030"
     exon            1..733
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..2734
                     /gene="Strn4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     zinedin; striatin, calmodulin binding protein 4"
                     /codon_start=1
                     /product="striatin-4 isoform 1"
                     /protein_id="NP_001100950.2"
                     /db_xref="GeneID:308392"
                     /db_xref="RGD:1307030"
                     /translation="MMEERAAAAVASAASCRPLGSGTAPNPTAAAPASSPAPGPGPVG
                     KGGGGGGSPGPTAGPEPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGE
                     RKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTDLNQGEKKADLSEQVSNGPVES
                     VTLDNSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVRSLLGRSLELNGAGEPVEGA
                     PRASPGPGGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGSVLEQIPFLQNCEDEDSD
                     EDDELDSVQHKKQRVRLPSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGSPDPR
                     RCASEGNPHELESRRVKLQGILADLRDVDGLPPKVTVPPPGTPQPRPHEGSFGFSSDV
                     FIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDSKDAFKKTWNPKFTLRSHYDGIRSL
                     AFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVTMGSN
                     SEYCYSGGADARIHSWKIPDLNMDPYDGYDPSVLSCVLEGHGDAVWGLAFSPTSQRLA
                     SCSADGTIRIWDPSSSGSSCLCTFPMAGEHGIPTSVAFTSTEPAHVVASFRSGDTVLY
                     DLEAGGALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKSVHSMV
                     AHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACH
                     PSKALIASAGADALAKVFV"
     exon            734..837
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            838..911
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            912..990
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1188
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1330
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1490
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1604
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1720
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1896
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1944
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2066
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2237
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2378
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2477
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2564
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2796
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..3500
                     /gene="Strn4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggataggg ttactatgac aaccgacttc ctcgggacag agcccactcc ccacaccagg
       61 tcgtctgttt tctttttttc tttttccttt tagtaagtga aagacacggg ggtgtatttg
      121 catctggagg ggatattact ctgacattgg ggagaaggca gaaaaagtcc tgtctggtct
      181 cactcccgca aaggagacaa ttgcgaggga ccctgggtcc tttgccttcg ttgaggcagc
      241 ccctctccct ccctgtcagc aaccttgcgg tgcgcaccac ccgggacgac cccggtgggc
      301 gaggctcgcg cccagccccg tgctcgtctc cgctcccctc gcccgcccag tgcgcgcgcg
      361 cgcgcacacg aggcgggggt gtgtaagtgt gaatctgcgc gtccgcgcag gcgcgcgagg
      421 cagagcgggc gcgcgggccg gcccgggggc ctccatgatg gaggagcgag cggccgccgc
      481 ggtcgcatcg gccgcctcct gccgccctct gggctcgggc acggctccca acccaacagc
      541 cgcggcccca gcctccagcc ctgctcctgg gccaggcccg gtaggtaaag gaggtggcgg
      601 cggaggcagc ccgggcccca cggcgggccc ggagcccctc agcctgcctg gcatcctgca
      661 ctttatccaa cacgagtggg cacgcttcga agccgagaag gcccgctggg aggccgagcg
      721 cgccgagctg caggctcagg tggctttcct ccagggcgag aggaaaggcc aagagaatct
      781 aaagacggac ctggtgcggc ggatcaagat gctggagtat gcactgaagc aagagagggc
      841 caaatatcat aaactgaagt ttggtacaga cctgaatcag ggggagaaga aggcagatct
      901 gtcagaacaa gtctccaatg gccctgtaga gtctgtcaca ctggacaaca gcccattggt
      961 gtggaaggag gggcgacagc ttctgcggca gtacctggaa gaggtgggct acacagatac
     1021 catcctggac atgcggtcca agcgtgtgcg ttcccttctg ggccgttctc tggaactcaa
     1081 tggggctggt gagcctgtcg agggggcccc cagggcttca ccaggccctg ggggacttag
     1141 cggtggcgag tctctactgg tgaaacagat cgaggaacag atcaagagga acgcagctgg
     1201 caaagatggc aaggagcgcc tgggcggctc ggtgctggag cagataccct tcttgcagaa
     1261 ctgcgaggat gaagacagcg atgaggatga cgaactggac agtgtgcaac ataagaagca
     1321 acgtgtgagg ctcccatcca aggccctagt tcctgaaatg gaggacgagg atgaagaaga
     1381 tgactcagaa gatgccatca atgagtttga tttcctgggc tcaggagagg acggagaggg
     1441 gtctccagac cctcgacgct gtgcttcaga ggggaacccc catgagctgg aaagccgtcg
     1501 ggtcaaactc cagggaattc ttgctgacct ccgggatgtg gatgggctgc ccccaaaagt
     1561 gactgtcccg cctcctggca caccccagcc ccggcctcat gaaggttcct ttggcttctc
     1621 ctcagacgtc ttcatcatgg acactatcgg gggcggggag gtgagcctgg gggacttggc
     1681 agatctcacc gtcaccaatg acaacgacct cagctgtgat ctgtctgaca gcaaagacgc
     1741 tttcaagaag acatggaacc ccaagtttac tctccgctca cactacgatg gcatccgttc
     1801 cctggccttc caccacagcc agtcagcact gcttactgcc tctgaggatg gcacactcaa
     1861 actgtggaac ctgcagaagg cagttacagc caagaaaaat gctgcactgg atgtggagcc
     1921 aatccatgct ttccgggctc acaggggccc tgtgctggcc gtcaccatgg gcagcaacag
     1981 cgagtactgt tacagtggtg gggctgatgc cagaatccac agctggaaga ttcctgacct
     2041 caacatggac ccatatgatg gttatgaccc aagtgtgctg agctgtgtcc tggaaggcca
     2101 tggggatgcc gtgtggggtc tggccttcag ccccacctcc cagcgcctag catcctgctc
     2161 tgccgatggc accatccgca tctgggatcc cagcagcagt ggttcaagct gcctctgtac
     2221 cttccccatg gctggagaac acgggattcc cacctcagtg gccttcacca gcacggaacc
     2281 tgcccacgtc gtggcctcct ttcgttctgg tgatactgtt ctttatgact tggaagctgg
     2341 tggcgccctg ctcacattgg agtcccgagg gagcagtggc ccaacacaga tcaaccaggt
     2401 ggtgagtcac ccaaaccagc ctctcaccat cactgcgcac gacgacaggg gcatccggtt
     2461 cctggacaat cggacaggta aatccgtgca ttccatggtg gcccacctgg acgcagtcac
     2521 ctgcctagct gtggacccaa atggcgtgtt cttgatgtca ggaagccatg actgttctct
     2581 gcgtttgtgg agcctagaca ataagacatg tgtgcaggag atcacggccc accggaagaa
     2641 gcacgaagag gccatccatg cggtggcctg ccatcccagc aaggcactca ttgccagtgc
     2701 tggtgctgat gccctagcca aggtcttcgt atgatcccac ctggcctcgc cctggctgca
     2761 cagtggcagg gagcggggcc aggcagtggg gctgagcagc ccccagcctc cctttagagg
     2821 ctctgagtct tggcctcctt catcttcctg gagcctggtg gtgctaatgg ccctttcccc
     2881 aggaatcacc cctcaaggat ggcctctggg gtttctgctc atgccccatt cccaactcct
     2941 gacatagctg tcatcctgag gttgacacag ccccagctgg gtgtcctttg ggatctcatt
     3001 ttgtccaaga tgaaagaagg caccaggctc caccctagag agccacccat cgggggaagg
     3061 gctgtctgag aggggtctcc tagggccctc ctatgtgggc cccagattgt ccttttggac
     3121 ctcagtccct tcttgctttc caacactaat caagcctctg gggccaggcc ttcctgggga
     3181 gggcctccac tcctccaggg cattgtccta gccacaggcc ctcctcgaga tgtggagggt
     3241 ggagggggcg ctgtgcccct agctcagtgt atatgtgtgt aaaggaatgg gattttaatg
     3301 gcgcctaccc cacgttatca ctgtgtgata gtctgtcagt ctccttgctc cacactttgg
     3361 cctctattta tttcactctt tatttgggtc ccaccttatg cccttggttc ccctttcagg
     3421 ttcctgttta taagcccctt cctttttgtc ccaacttgta tgtgaaaaaa aactgtctca
     3481 ataaaccctt tggagtaaga aaaaaaaaaa aaaaaaa
//
