LOCUS       NM_019148               2981 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus striatin (Strn), mRNA.
ACCESSION   NM_019148 XM_346757
VERSION     NM_019148.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2981)
  AUTHORS   Inthachart,K., Manotham,K., Eiam-Ong,S. and Eiam-Ong,S.
  TITLE     Aldosterone Rapidly Enhances Levels of the Striatin and Caveolin-1
            Proteins in Rat Kidney: The Role of the Mineralocorticoid Receptor
  JOURNAL   Endocrinol Metab (Seoul) 34 (3), 291-301 (2019)
   PUBMED   31565882
  REMARK    GeneRIF: Study demonstrating that aldosterone rapidly enhances
            renal levels of striatin and caveolin-1 (cav-1). Aldosterone
            increases striatin levels via an mineralocorticoid receptor
            (MR)-independent pathway, whereas cav-1 is partially regulated
            through MR.
REFERENCE   2  (bases 1 to 2981)
  AUTHORS   Li,D., Musante,V., Zhou,W., Picciotto,M.R. and Nairn,A.C.
  TITLE     Striatin-1 is a B subunit of protein phosphatase PP2A that
            regulates dendritic arborization and spine development in striatal
            neurons
  JOURNAL   J Biol Chem 293 (28), 11179-11194 (2018)
   PUBMED   29802198
REFERENCE   3  (bases 1 to 2981)
  AUTHORS   Nader,M., Alotaibi,S., Alsolme,E., Khalil,B., Abu-Zaid,A.,
            Alsomali,R., Bakheet,D. and Dzimiri,N.
  TITLE     Cardiac striatin interacts with caveolin-3 and calmodulin in a
            calcium sensitive manner and regulates cardiomyocyte spontaneous
            contraction rate
  JOURNAL   Can J Physiol Pharmacol 95 (10), 1306-1312 (2017)
   PUBMED   28825318
  REMARK    GeneRIF: Suggest a novel role for striatin in regulating
            cardiomyocyte spontaneous contraction rate and the dynamics of the
            STRN/caveolin-3/calmodulin complex.
REFERENCE   4  (bases 1 to 2981)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   5  (bases 1 to 2981)
  AUTHORS   Breitman,M., Zilberberg,A., Caspi,M. and Rosin-Arbesfeld,R.
  TITLE     The armadillo repeat domain of the APC tumor suppressor protein
            interacts with Striatin family members
  JOURNAL   Biochim Biophys Acta 1783 (10), 1792-1802 (2008)
   PUBMED   18502210
REFERENCE   6  (bases 1 to 2981)
  AUTHORS   Gaillard,S., Bartoli,M., Castets,F. and Monneron,A.
  TITLE     Striatin, a calmodulin-dependent scaffolding protein, directly
            binds caveolin-1
  JOURNAL   FEBS Lett 508 (1), 49-52 (2001)
   PUBMED   11707266
REFERENCE   7  (bases 1 to 2981)
  AUTHORS   Baillat,G., Moqrich,A., Castets,F., Baude,A., Bailly,Y.,
            Benmerah,A. and Monneron,A.
  TITLE     Molecular cloning and characterization of phocein, a protein found
            from the Golgi complex to dendritic spines
  JOURNAL   Mol Biol Cell 12 (3), 663-673 (2001)
   PUBMED   11251078
REFERENCE   8  (bases 1 to 2981)
  AUTHORS   Bartoli,M., Ternaux,J.P., Forni,C., Portalier,P., Salin,P.,
            Amalric,M. and Monneron,A.
  TITLE     Down-regulation of striatin, a neuronal calmodulin-binding protein,
            impairs rat locomotor activity
  JOURNAL   J Neurobiol 40 (2), 234-243 (1999)
   PUBMED   10413453
REFERENCE   9  (bases 1 to 2981)
  AUTHORS   Kachidian,P., Vuillet,J., Bartoli,M., Castets,F., Nieoullon,A. and
            Kerkerian-Le Goff,L.
  TITLE     Relationships between striatin-containing neurons and cortical or
            thalamic afferent fibres in the rat striatum. An ultrastructural
            study by dual labelling
  JOURNAL   Neuroscience 85 (1), 111-122 (1998)
   PUBMED   9607707
REFERENCE   10 (bases 1 to 2981)
  AUTHORS   Castets,F., Bartoli,M., Barnier,J.V., Baillat,G., Salin,P.,
            Moqrich,A., Bourgeois,J.P., Denizot,F., Rougon,G., Calothy,G. and
            Monneron,A.
  TITLE     A novel calmodulin-binding protein, belonging to the WD-repeat
            family, is localized in dendrites of a subset of CNS neurons
  JOURNAL   J Cell Biol 134 (4), 1051-1062 (1996)
   PUBMED   8769426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019148.2.
            
            Sequence Note: The sequence X99326.1 is from a chimeric clone. Only
            the striatin, calmodulin binding protein sequence region was
            propagated into this RefSeq record.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1550493.1,
                                           SRR26360186.1632382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               JAXUCZ010000006.1  22087509-22087786
            279-382             JAXUCZ010000006.1  22122800-22122903
            383-456             JAXUCZ010000006.1  22131044-22131117
            457-535             JAXUCZ010000006.1  22135812-22135890
            536-703             JAXUCZ010000006.1  22139331-22139498
            704-839             JAXUCZ010000006.1  22140916-22141051
            840-975             JAXUCZ010000006.1  22147266-22147401
            976-1086            JAXUCZ010000006.1  22151602-22151712
            1087-1230           JAXUCZ010000006.1  22154449-22154592
            1231-1367           JAXUCZ010000006.1  22157622-22157758
            1368-1543           JAXUCZ010000006.1  22160039-22160214
            1544-1591           JAXUCZ010000006.1  22161863-22161910
            1592-1713           JAXUCZ010000006.1  22163066-22163187
            1714-1881           JAXUCZ010000006.1  22164419-22164586
            1882-2022           JAXUCZ010000006.1  22166087-22166227
            2023-2130           JAXUCZ010000006.1  22167167-22167274
            2131-2217           JAXUCZ010000006.1  22168268-22168354
            2218-2981           JAXUCZ010000006.1  22168443-22169206
FEATURES             Location/Qualifiers
     source          1..2981
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..2981
                     /gene="Strn"
                     /note="striatin"
                     /db_xref="GeneID:29149"
                     /db_xref="RGD:3782"
     exon            1..278
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2387
                     /gene="Strn"
                     /note="striatin, calmodulin binding protein"
                     /codon_start=1
                     /product="striatin"
                     /protein_id="NP_062021.2"
                     /db_xref="GeneID:29149"
                     /db_xref="RGD:3782"
                     /translation="MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAAR
                     AQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRI
                     KMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQFMWKQGRQ
                     LLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVINGTEAEVKETAM
                     IGKSELTDSASVLDNFKFLENAAADFSDEDEDEDIDGREKSVIDTSTIVRKKPLPDTS
                     EDRDTKEALKEFDFLVASEEGDNESRSAGDGTDWEKEDQCLTPEAWNVDQGVITRLKE
                     QYKKERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEQDISR
                     ADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLAYDIANNKDALR
                     KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEP
                     IYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQSWSTTNPNVDPYDSYDPSVLRGPLL
                     GHTDAVWGLAYSAAHQRLLSCSADGTLRLWTTTEVAPALTVFNDNQELGIPASVDLVS
                     SDPSHMVASFSKGYTSIFNMETQQRILTLESNVDSTASSSCQINRVISHPTLPISITA
                     HEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTC
                     IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV"
     exon            279..382
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            383..456
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            457..535
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            536..703
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            704..839
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            840..975
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1086
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1230
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1367
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1543
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1591
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1713
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1881
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2022
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2130
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2217
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2981
                     /gene="Strn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctgggcgc ctaggcagag ctccccgggg ttcgtgcggc cgccatggac gagcaggcgg
       61 ggcccggcgt cttcttcagc aacaaccatc cgggagctgg cggtgctaag gggctcgggc
      121 ctctggcgga ggctgcagcg gcgggagacg gagcggctgc ggcgggggcg gcccgagctc
      181 agtacagcct cccggggatc ttgcacttcc tgcagcacga atgggcccgc ttcgaggtgg
      241 agagagccca gtgggaggtg gagcgggcgg agttgcaggc tcagattgct ttccttcagg
      301 gggagaggaa aggccaagaa aacttgaaga aagatcttgt gaggaggatc aaaatgttgg
      361 aatatgctct gaagcaggaa agagccaaat accacaagtt gaaatatggg acagaactga
      421 atcagggaga catgaagcct ccaagctatg attctgatga aggcaatgaa acggaggtgc
      481 agccacagca gaacagccag ttcatgtgga agcaaggccg gcagctcctc agacagtatc
      541 tccaggaggt cggctacaca gatactattc tagatgtgaa gtccaagcgt gtgcgggcat
      601 tgttgggctt ttcaagtgat gtcactgaca gggaggatga caaaaaccag gactcggtga
      661 taaatggcac agaggctgaa gttaaagaga cagcaatgat tggaaaatct gagttaacgg
      721 attctgcctc cgtgctggac aatttcaaat tccttgaaaa tgcagctgca gatttcagtg
      781 atgaagacga ggatgaggac attgatggaa gagagaaaag tgtcattgat acttcaacca
      841 ttgttaggaa aaaaccatta cctgatacca gtgaagatcg agacacaaaa gaagctctga
      901 aggagtttga cttccttgtc gcctcagagg aaggagacaa cgagtccaga agtgcaggcg
      961 acggaacgga ctgggaaaag gaagatcagt gtctgacgcc ggaggcctgg aatgtggacc
     1021 agggagtgat caccagactg aaggagcagt acaaaaagga gaggaagggg aagaaagggg
     1081 tgaagaggcc caataggtca aaactacaag atatgcttgc taatttgaga gacgttgatg
     1141 aacttccctc cttgcagcca tctgttggct ccccttccag acccagcagc tccaggcttc
     1201 ctgagcagga catcagtagg gcagatgaag tggaagcatt gacgttcccg ccttcttcag
     1261 ggaagtcatt tatcatggga gcagatgaag cccttgaaag cgagctgggg cttggagaat
     1321 tagcaggcct tacagtggcc aatgaagcag actcattagc ttatgatata gcgaataaca
     1381 aagacgcctt gaggaagacg tggaacccta agtttacatt aaggagtcac tttgatggca
     1441 tccgagccct tgctttccac cccatcgagc ctgtgttaat aaccgcgtca gaggaccaca
     1501 cgctgaaaat gtggaatctg cagaaaacag ccccagctaa aaagagtact tctttagatg
     1561 tggagcctat ctacaccttc agggctcaca aaggtccggt gctgtgtgtg gtcatgagta
     1621 gcaatggtga gcagtgctac agcggcggca ctgatggcct catccagagc tggagcacca
     1681 ccaatcccaa cgtcgacccc tacgattctt atgatccttc ggttctaaga ggccctctgt
     1741 tgggccacac ggatgcggtg tgggggctgg cctacagcgc ggcccaccag cgcttgttgt
     1801 cctgttcagc agacggcact cttcgtctat ggaccaccac tgaggttgct ccagcgctga
     1861 ctgtatttaa tgataaccaa gaactgggaa tccctgcttc tgtggatctg gtgagcagtg
     1921 acccgagcca tatggtagca tcgttcagca agggatatac aagcatcttc aacatggaaa
     1981 cacagcagcg aattctcacg ttagaatcca atgtcgattc aacggccagt tcttcctgcc
     2041 aaataaacag agtcatcagt caccccaccc tcccgatcag catcactgct cacgaggaca
     2101 ggcacatcaa gttctacgat aacaacacag gcaaactgat ccactcgatg gtggcccacc
     2161 tggaagccgt tacaagtttg gcggttgatc ccaacggcct gtacctgatg tctggcagtc
     2221 atgactgttc aatacgcttg tggaatttag aaagtaagac gtgtatccag gagttcacag
     2281 ctcatcggaa aaagtttgaa gagtcgatcc atgatgtagc attccaccct tctaaatgct
     2341 atatagccag cgctggagcc gacgccctgg ctaaggtctt tgtatgatgg ggtacttcag
     2401 cttcaccctg cagctcttac aagtcaaccg cacacaggaa acggaagacc agggcgggag
     2461 ccagctcgcc ctgccctttt gtttggctga gggagcacag agacctctgt taaagtacag
     2521 ttttgcagtt cctatacagt tttctaaaat taaggtttgt tcaggttgct gcaagctcag
     2581 ctgaacctgt gagcccgaaa ctttcagatc cccccaaaga ggcactttta tttctgaggt
     2641 tgttctcact cgctaggcgg gcccgagcgt tcgttctccc ttttgagtaa gcagggcatg
     2701 ctgtaatgga taattagagg tgaatgccgg gaatgagtag aatggaaact taactatcct
     2761 tccaccccga gacatctgct accacactag gtagtcagct ctgcggctgt gtgtgctcta
     2821 ctaaccccac tgtgtagaag gagacagtgt gtgtcagtgt tcacatgagg tcctcccgct
     2881 gctgtcctct cagccgttct catgaagcac agggaagagt gttccttcca cctgttagga
     2941 ggaagagatg caataatatg ttaattatat gatattcaga a
//
