LOCUS       NM_053416               3065 bp    mRNA    linear   ROD 04-FEB-2024
DEFINITION  Rattus norvegicus spermatid perinuclear RNA binding protein
            (Strbp), mRNA.
ACCESSION   NM_053416
VERSION     NM_053416.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3065)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 3065)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 3065)
  AUTHORS   Pires-daSilva,A., Nayernia,K., Engel,W., Torres,M., Stoykova,A.,
            Chowdhury,K. and Gruss,P.
  TITLE     Mice deficient for spermatid perinuclear RNA-binding protein show
            neurologic, spermatogenic, and sperm morphological abnormalities
  JOURNAL   Dev Biol 233 (2), 319-328 (2001)
   PUBMED   11336498
REFERENCE   4  (bases 1 to 3065)
  AUTHORS   Coolidge,C.J. and Patton,J.G.
  TITLE     A new double-stranded RNA-binding protein that interacts with PKR
  JOURNAL   Nucleic Acids Res 28 (6), 1407-1417 (2000)
   PUBMED   10684936
REFERENCE   5  (bases 1 to 3065)
  AUTHORS   Schumacher,J.M., Artzt,K. and Braun,R.E.
  TITLE     Spermatid perinuclear ribonucleic acid-binding protein binds
            microtubules in vitro and associates with abnormal manchettes in
            vivo in mice
  JOURNAL   Biol Reprod 59 (1), 69-76 (1998)
   PUBMED   9674995
REFERENCE   6  (bases 1 to 3065)
  AUTHORS   Schumacher,J.M., Lee,K., Edelhoff,S. and Braun,R.E.
  TITLE     Spnr, a murine RNA-binding protein that is localized to cytoplasmic
            microtubules
  JOURNAL   J Cell Biol 129 (4), 1023-1032 (1995)
   PUBMED   7744952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO564209.1, CA512540.1, DY547419.1, DY320620.1, BU759091.1 and
            CK839498.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_053416.3.
            
            On Mar 15, 2007 this sequence version replaced NM_053416.1.
            
            Sequence Note: This RefSeq record was created from transcript
            sequence data from multiple strains because no single transcript
            from the same strain was available for the full length of the gene.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               CO564209.1         78-648
            572-581             CA512540.1         1-10
            582-589             CO564209.1         659-666
            590-1213            CA512540.1         19-642
            1214-1832           DY547419.1         82-700
            1833-2414           DY320620.1         147-728
            2415-2559           BU759091.1         17-161              c
            2560-3065           CK839498.1         19-524              c
FEATURES             Location/Qualifiers
     source          1..3065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q11"
     gene            1..3065
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /note="spermatid perinuclear RNA binding protein"
                     /db_xref="GeneID:84476"
                     /db_xref="RGD:620673"
     exon            1..171
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2187
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /note="p74; 74 kDa double-stranded RNA-binding protein;
                     double-stranded RNA-binding protein p74"
                     /codon_start=1
                     /product="spermatid perinuclear RNA-binding protein"
                     /protein_id="NP_445868.2"
                     /db_xref="GeneID:84476"
                     /db_xref="RGD:620673"
                     /translation="MRSIRSFANDDRHVMVKHSTIYPSPEELEAVQNMVSTVECALKH
                     VSDWLDETNKGTKPEGETEVKKDDAVENYSKDQGGRTLCGVMRIGLVAKGLLIKDDMD
                     LELVLMCKDKPTETLLNTVKDNLPIQIQKLTEEKYQVEQCINEASIIIRNTKEPTLTL
                     KVILTSPLIRDELEKKDGENVMMKDPPDLLDRQKCLNALASLRHAKWFQARANGLKSC
                     VIVLRILRDLCNRVPTWAPLKGWPLELICEKSIGTCNRPLGAGEALRRVMECLASGIL
                     LPGGPGLHDPCERDPTDALSYMTTQQKEDITHSAQHALRLSAFGQIYKVLEMDPLPSS
                     KPFQKYSWSVTDKEGAGSSALKRPFEDGLGDDKDPNKKMKRNLRKILDSKAIDLMNAL
                     MRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASGPSKKTAKLHVAVKVLQA
                     MGYPTGFDADIECMSSDEKSDNESKNDTVSSNSSNNTGNCTTETSSTLEVRTQGPILT
                     ASGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNKKVAKASA
                     ALAALEKLFSGPNAANNKKKKIIPQAKGVVNTAVSAAVQAVRGRGRGTLTRGAFVGAT
                     AAPGYIAPGYGTPYGYSTAAPAYGLPKRMVLLPVMKFPTYPVPHYSFF"
     exon            172..392
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            393..558
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            559..703
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            704..795
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            796..891
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1003
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1101
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1213
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1306
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1506
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1665
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1800
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1941
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2065
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2110
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..3065
                     /gene="Strbp"
                     /gene_synonym="Spnr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2540..2545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Strbp"
                     /gene_synonym="Spnr"
     polyA_site      2565
                     /gene="Strbp"
                     /gene_synonym="Spnr"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Strbp"
                     /gene_synonym="Spnr"
     polyA_site      3065
                     /gene="Strbp"
                     /gene_synonym="Spnr"
ORIGIN      
        1 ggtgctttcc agagagcaat tttcaaacat ctttgcttat atttgacatt gagcagtcag
       61 gggattcagg catatgagga ggtactgtta cccaaaacag tgtctagtga agacgacaag
      121 aaagagagaa aaggatcgta aaaagaagct aaaataccat aggaaaccat gagatctatt
      181 agatcttttg ccaatgatga tcgccatgtt atggtgaaac attcaacaat ctatccttct
      241 ccagaggaac ttgaagctgt gcaaaatatg gtgtctactg ttgaatgtgc tcttaaacat
      301 gtctcagatt ggctggacga aacaaacaaa ggcacaaaac ctgaggggga gacagaagta
      361 aagaaagatg acgctgtgga aaactattcc aaggatcaag gtggccggac attgtgtggt
      421 gtaatgagga ttggcttggt tgcaaaaggc ttgctgatta aagatgacat ggacctggag
      481 ctggtcttaa tgtgtaaaga caaacccaca gaaactctgc taaatacagt gaaagataac
      541 cttcctattc aaattcagaa actaacagaa gagaaatacc aagtggaaca atgtataaat
      601 gaagcgtcca ttataattcg gaacacgaaa gagccaacac tgactttgaa ggtgatactt
      661 acttcccctc taattaggga cgaattggag aagaaggatg gagaaaatgt tatgatgaaa
      721 gaccctccgg acttattgga caggcagaaa tgcctgaatg ccttggcttc tcttcgacat
      781 gccaaatggt ttcaggcaag ggcaaatgga ttaaaatcat gtgtaattgt cctccgcatt
      841 ctgcgtgatt tgtgcaacag agtacccaca tgggcaccat tgaaaggatg gccactagag
      901 cttatatgtg aaaagtctat aggtacttgt aatagacctt tgggcgctgg ggaggccttg
      961 agacgagtaa tggagtgttt ggcatctgga atactacttc ctggtggtcc tggtcttcat
     1021 gatccttgtg agcgagaccc aaccgatgct ctaagctaca tgaccactca gcaaaaagaa
     1081 gatatcaccc atagtgcaca gcatgcactt agactatcag cctttggcca gatttataaa
     1141 gtactggaga tggaccctct tccatctagt aagccttttc agaagtattc ctggtcagtt
     1201 actgataaag aaggtgccgg gtcttcagct ctaaagaggc catttgaaga tggattaggg
     1261 gatgataaag atcccaacaa gaagatgaaa cgaaacttaa ggaaaattct ggatagtaaa
     1321 gcaatagacc ttatgaatgc actaatgaga ttaaatcaga tcaggcctgg gcttcagtat
     1381 aagcttttgt cgcagtctgg cccggtccat gccccagtct tcacaatgtc ggtagatgtg
     1441 gacggcacaa catacgaagc ctcaggacca tccaagaaaa cagcaaagct tcatgtggca
     1501 gtgaaggttt tacaggcaat gggataccca acaggttttg atgcagatat tgaatgtatg
     1561 agttccgatg aaaaatcaga taatgaaagc aaaaatgata cagtatcttc aaactcaagc
     1621 aataatactg gaaattgtac aactgagacc tccagtacct tagaggtaag aactcagggt
     1681 cctatcctca cagcaagtgg caaaaatcct gtgatggagc tcaatgaaaa aagaagaggt
     1741 ctcaagtatg aactcatctc agaaactggt ggaagccatg acaagcgctt tgtaatggag
     1801 gtagaagtag atggacagaa attcagaggt gcaggtccaa acaagaaagt ggccaaggca
     1861 agtgcagcgc tagctgccct ggaaaagctg ttttctggac ccaatgcagc aaataataag
     1921 aaaaagaaga tcattcctca ggcaaagggt gttgtgaata cggcagtatc tgcagcagtc
     1981 caggcagttc gaggcagagg aagaggaact ctgacaaggg gagcgttcgt gggagctaca
     2041 gcagctcctg gatatatagc tccaggttat ggaactccat atggttacag cacagctgcc
     2101 cctgcatatg gtttgcccaa gagaatggtt ctgttacccg ttatgaaatt cccaacatat
     2161 cctgttcccc actactcatt cttttagcaa atgacagaag ctcattccta ttgaacaaca
     2221 atacagtaca atgcagaatg ttagagaaaa aagccttttt atcctgcttt ctttgaacac
     2281 atacttactt gatcaaaatt atttgtaaag aacatctttc ctactttttg attttaacaa
     2341 atgcaaatcc agttctctaa aacttgaaaa caaacaaaag aaaccagttc tgtgaaacgg
     2401 tacctcattc ctggaaataa tttataccag ccccttcgtt gtagggaagt ctagcagctc
     2461 aaagttgacg ttttaagaga gtatcagatt atgtaaagtt aaatttgtga aggatgtata
     2521 gagtctcaac actgatcaca ataaactgct ttgttgtaac acagagtact gcctggttcc
     2581 tgatgcagtc actgattggt atctgagtga tatgtgcttg ctccagggca ctggaatttg
     2641 ggctgtagtt attttttttt tttaaataaa gtagaaactt ttcatttaaa cctttacttt
     2701 gtaaataacg aagtgtgtaa ttaaagccaa taaaatatgg gtttgaatat tgttttagct
     2761 tattattttt gatttgtttt gttatcaaat ttcaaggaat tgaaaactag taataacttg
     2821 gccctagaaa cccatttatt tgtaagcaag ccgctaaaac aaagcaaaga tgatttctca
     2881 atctattcat tttgtaagct ctatgtactc cagttgtaca agggcatccc ctgataaggt
     2941 tacattctgt tatcccagca ttgcttatta aaatgatggc accatccaaa gatggggaag
     3001 gaggattgtg attatcttag tttacgaatt tccaagttta aaaaaaaata aattaatcaa
     3061 tcacc
//
