LOCUS       NM_001011969            1755 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus serine/threonine kinase receptor associated
            protein (Strap), mRNA.
ACCESSION   NM_001011969 XM_216287
VERSION     NM_001011969.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Huang,L., Kuang,F., Xie,Q.Y. and Jing,R.
  TITLE     STRAP reduces endoplasmic reticulum stress and apoptosis in
            cardiomyocytes and attenuates myocardial ischemia-reperfusion
            injury by activating PI3K/PDK1/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (8), 4430-4439 (2020)
   PUBMED   32373981
  REMARK    GeneRIF: STRAP reduces endoplasmic reticulum stress and apoptosis
            in cardiomyocytes and attenuates myocardial ischemia-reperfusion
            injury by activating PI3K/PDK1/Akt signaling pathway.
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Liu,W., Shi,R., Yang,W., Zhao,N., Du,Y., Zou,Y. and Yu,W.
  TITLE     Synchronous alteration pattern between serine-threonine kinase
            receptor-associated protein and Smad7 in pilocarpine-induced rats
            of epilepsy
  JOURNAL   Synapse 68 (6), 275-282 (2014)
   PUBMED   24577865
  REMARK    GeneRIF: Study found that STRAP and Smad7 are significantly
            decreased in the pilocarpine-induced epileptic rats compared with
            the normal rats
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Li,D.M., Zhang,J., Li,W.M., Cui,J.T., Pan,Y.M., Liu,S.Q., Xing,R.
            and Lu,Y.Y.
  TITLE     MAWBP and MAWD inhibit proliferation and invasion in gastric cancer
  JOURNAL   World J Gastroenterol 19 (18), 2781-2792 (2013)
   PUBMED   23687415
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1755)
  AUTHORS   Chari,A., Golas,M.M., Klingenhager,M., Neuenkirchen,N., Sander,B.,
            Englbrecht,C., Sickmann,A., Stark,H. and Fischer,U.
  TITLE     An assembly chaperone collaborates with the SMN complex to generate
            spliceosomal SnRNPs
  JOURNAL   Cell 135 (3), 497-509 (2008)
   PUBMED   18984161
REFERENCE   7  (bases 1 to 1755)
  AUTHORS   Zhang,J., Kang,B., Tan,X., Bai,Z., Liang,Y., Xing,R., Shao,J.,
            Xu,N., Wang,R., Liu,S. and Lu,Y.
  TITLE     Comparative analysis of the protein profiles from primary gastric
            tumors and their adjacent regions: MAWBP could be a new protein
            candidate involved in gastric cancer
  JOURNAL   J Proteome Res 6 (11), 4423-4432 (2007)
   PUBMED   17929853
REFERENCE   8  (bases 1 to 1755)
  AUTHORS   Lisinski,I., Matsumoto,H., Yver,D.R., Schurmann,A., Cushman,S.W.
            and Al-Hasani,H.
  TITLE     Identification and characterization of p49/STRAP as a novel
            GLUT4-binding protein
  JOURNAL   Biochem Biophys Res Commun 344 (4), 1179-1185 (2006)
   PUBMED   16647043
REFERENCE   9  (bases 1 to 1755)
  AUTHORS   Halder,S.K., Anumanthan,G., Maddula,R., Mann,J., Chytil,A.,
            Gonzalez,A.L., Washington,M.K., Moses,H.L., Beauchamp,R.D. and
            Datta,P.K.
  TITLE     Oncogenic function of a novel WD-domain protein, STRAP, in human
            carcinogenesis
  JOURNAL   Cancer Res 66 (12), 6156-6166 (2006)
   PUBMED   16778189
REFERENCE   10 (bases 1 to 1755)
  AUTHORS   Datta,P.K., Chytil,A., Gorska,A.E. and Moses,H.L.
  TITLE     Identification of STRAP, a novel WD domain protein in transforming
            growth factor-beta signaling
  JOURNAL   J Biol Chem 273 (52), 34671-34674 (1998)
   PUBMED   9856985
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083714.1.
            
            On Feb 11, 2005 this sequence version replaced XM_216287.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083714.1, SRR8487227.307468.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..1755
                     /gene="Strap"
                     /note="serine/threonine kinase receptor associated
                     protein"
                     /db_xref="GeneID:297699"
                     /db_xref="RGD:1311114"
     exon            1..317
                     /gene="Strap"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1258
                     /gene="Strap"
                     /note="UNR-interacting protein; serine-threonine kinase
                     receptor-associated protein-like"
                     /codon_start=1
                     /product="serine-threonine kinase receptor-associated
                     protein"
                     /protein_id="NP_001011969.1"
                     /db_xref="GeneID:297699"
                     /db_xref="RGD:1311114"
                     /translation="MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLR
                     QGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHI
                     VKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILS
                     ADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLEPIK
                     SFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPD
                     GELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETAEEELEEIA
                     SENSDSIYSSTPEVKA"
     exon            318..453
                     /gene="Strap"
                     /inference="alignment:Splign:2.1.0"
     exon            454..535
                     /gene="Strap"
                     /inference="alignment:Splign:2.1.0"
     exon            536..608
                     /gene="Strap"
                     /inference="alignment:Splign:2.1.0"
     exon            609..705
                     /gene="Strap"
                     /inference="alignment:Splign:2.1.0"
     exon            706..843
                     /gene="Strap"
                     /inference="alignment:Splign:2.1.0"
     exon            844..980
                     /gene="Strap"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1130
                     /gene="Strap"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1196
                     /gene="Strap"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1732
                     /gene="Strap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagtggcgg cgggccggtt ttccggcgct cccctcccct tctccctccc tccctgtccc
       61 tcccttggcg accgcgcgtc gcggggattc ccgacccggc ctcggcgtga gtgcgggggc
      121 cttaagcagc tgaggcgccg cggcagagaa ggaagaggac cgcgaccctc ggtccccgct
      181 ccgcgtcacc gcgctcgccg ccgccatggc catgaggcag acgccgctca cttgctcggg
      241 ccacacgcgg cccgtggtgg atttggcctt cagcggcatc acgccttacg gctactttct
      301 gatcagcgct tgcaaagatg gcaaacctat gctccgccag ggagatacag gagactggat
      361 cggaacattt ttgggtcata aaggtgctgt ttggggtgca acattgaata aggacgccac
      421 caaagctgcc acagcagctg cagacttcac agccaaagtg tgggacgctg tctctggaga
      481 tgaactgatg accctggctc acaagcacat cgtcaagacc gtggatttca cacaggatag
      541 caattacctg ttgactggag gacaggacaa actgctgcgc atatacgact tgaacaaacc
      601 tgaagcagaa cccaaggaaa ttagtggtca cacgtccggt attaaaaagg ctctgtggtg
      661 cagtgaggat aaacagatcc tttcagctga tgataaaact gttcggctct gggatcatgc
      721 cacaatgaca gaagtaaaat ctctaaattt taatatgtct gttagcagca tggaatatat
      781 tcctgaggga gagatcttgg tcattactta tgggcgatcc attgcttttc atagtgcagt
      841 aagtctggag ccaattaaat cctttgaagc tcctgcaacc atcaattctg catctcttca
      901 tcctgagaag gaatttcttg ttgctggtgg agaagacttt aaactgtata agtatgatta
      961 taatagtgga gaggaattag aatcctacaa aggtcacttt ggccccattc actgtgtgag
     1021 attcagtccc gatggtgaac tctatgccag tggttctgaa gatgggacac tgagattgtg
     1081 gcaaactgtg gttggaaaga cctacggcct gtggaaatgc gtgcttcctg aggaagatag
     1141 cggggaactg gcaaagccaa agatcggatt tccagaaaca gcagaagaag agctggaaga
     1201 gattgcttca gagaattcag attccatcta ttcgtcaact cctgaagtga aggcctgagc
     1261 agcgtcagac gtgtgccgca gatgccatgc agttgatgga ctgaacaagc agagaccggc
     1321 atcggccttc agttactctg cctgtggcaa aggggacaga ctgttggggc atggattgct
     1381 ccagtgcacg aaccactaca gtgttgcctg tgagggaact ggctgagcgt gcggtgcagg
     1441 caggaggagt ctgttcacct agtgcctgcc aaagcctgct gccgtgatga aaagccaact
     1501 tagtgtccac tttaccccag atctcctgta gctgtttctg tcatggagaa gaaaaatata
     1561 ttggcctatt tttctgacat ttcccttgaa gaatgccttt ttttctctgc ttagttgtga
     1621 agaagaggaa atacatgata aagtaactgg tttgatctct ttcattgtac actgacggct
     1681 tctggacatc taatttttta gttatctaaa taaaatgcct ctaaaacaat aaaaaaaaaa
     1741 aaaaaaaaaa aaaaa
//
