LOCUS       NM_001029924            2904 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus signaling receptor and transporter of retinol
            STRA6 (Stra6), mRNA.
ACCESSION   NM_001029924 XM_343400
VERSION     NM_001029924.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2904)
  AUTHORS   Berner,D., Hoja,U., Zenkel,M., Ross,J.J., Uebe,S., Paoli,D.,
            Frezzotti,P., Rautenbach,R.M., Ziskind,A., Williams,S.E.,
            Carmichael,T.R., Ramsay,M., Topouzis,F., Chatzikyriakidou,A.,
            Lambropoulos,A., Sundaresan,P., Ayub,H., Akhtar,F., Qamar,R.,
            Zenteno,J.C., Cruz-Aguilar,M., Astakhov,Y.S., Dubina,M., Wiggs,J.,
            Ozaki,M., Kruse,F.E., Aung,T., Reis,A., Khor,C.C., Pasutto,F. and
            Schlotzer-Schrehardt,U.
  TITLE     The protective variant rs7173049 at LOXL1 locus impacts on retinoic
            acid signaling pathway in pseudoexfoliation syndrome
  JOURNAL   Hum Mol Genet 28 (15), 2531-2548 (2019)
   PUBMED   30986821
REFERENCE   2  (bases 1 to 2904)
  AUTHORS   Kang,M.K., Lee,E.J., Kim,Y.H., Kim,D.Y., Oh,H., Kim,S.I. and
            Kang,Y.H.
  TITLE     Chrysin Ameliorates Malfunction of Retinoid Visual Cycle through
            Blocking Activation of AGE-RAGE-ER Stress in Glucose-Stimulated
            Retinal Pigment Epithelial Cells and Diabetic Eyes
  JOURNAL   Nutrients 10 (8), 1046 (2018)
   PUBMED   30096827
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2904)
  AUTHORS   Pasutto,F., Flinter,F., Rauch,A. and Reis,A.
  TITLE     Novel STRA6 null mutations in the original family described with
            Matthew-Wood syndrome
  JOURNAL   Am J Med Genet A 176 (1), 134-138 (2018)
   PUBMED   29168296
  REMARK    Review article
REFERENCE   4  (bases 1 to 2904)
  AUTHORS   Malechka,V.V., Moiseyev,G., Takahashi,Y., Shin,Y. and Ma,J.X.
  TITLE     Impaired Rhodopsin Generation in the Rat Model of Diabetic
            Retinopathy
  JOURNAL   Am J Pathol 187 (10), 2222-2231 (2017)
   PUBMED   28734946
REFERENCE   5  (bases 1 to 2904)
  AUTHORS   Berry,D.C., Jacobs,H., Marwarha,G., Gely-Pernot,A., O'Byrne,S.M.,
            DeSantis,D., Klopfenstein,M., Feret,B., Dennefeld,C., Blaner,W.S.,
            Croniger,C.M., Mark,M., Noy,N. and Ghyselinck,N.B.
  TITLE     The STRA6 receptor is essential for retinol-binding protein-induced
            insulin resistance but not for maintaining vitamin A homeostasis in
            tissues other than the eye
  JOURNAL   J Biol Chem 288 (34), 24528-24539 (2013)
   PUBMED   23839944
REFERENCE   6  (bases 1 to 2904)
  AUTHORS   Wu,L. and Ross,A.C.
  TITLE     Acidic retinoids synergize with vitamin A to enhance retinol uptake
            and STRA6, LRAT, and CYP26B1 expression in neonatal lung
  JOURNAL   J Lipid Res 51 (2), 378-387 (2010)
   PUBMED   19700416
REFERENCE   7  (bases 1 to 2904)
  AUTHORS   Stankiewicz,P., Sen,P., Bhatt,S.S., Storer,M., Xia,Z.,
            Bejjani,B.A., Ou,Z., Wiszniewska,J., Driscoll,D.J.,
            Maisenbacher,M.K., Bolivar,J., Bauer,M., Zackai,E.H.,
            McDonald-McGinn,D., Nowaczyk,M.M., Murray,M., Hustead,V.,
            Mascotti,K., Schultz,R., Hallam,L., McRae,D., Nicholson,A.G.,
            Newbury,R., Durham-O'Donnell,J., Knight,G., Kini,U., Shaikh,T.H.,
            Martin,V., Tyreman,M., Simonic,I., Willatt,L., Paterson,J.,
            Mehta,S., Rajan,D., Fitzgerald,T., Gribble,S., Prigmore,E.,
            Patel,A., Shaffer,L.G., Carter,N.P., Cheung,S.W., Langston,C. and
            Shaw-Smith,C.
  TITLE     Genomic and genic deletions of the FOX gene cluster on 16q24.1 and
            inactivating mutations of FOXF1 cause alveolar capillary dysplasia
            and other malformations
  JOURNAL   Am J Hum Genet 84 (6), 780-791 (2009)
   PUBMED   19500772
  REMARK    Erratum:[Am J Hum Genet. 2009 Oct;85(4):537. multiple author names
            added]
REFERENCE   8  (bases 1 to 2904)
  AUTHORS   Chassaing,N., Golzio,C., Odent,S., Lequeux,L., Vigouroux,A.,
            Martinovic-Bouriel,J., Tiziano,F.D., Masini,L., Piro,F.,
            Maragliano,G., Delezoide,A.L., Attie-Bitach,T., Manouvrier-Hanu,S.,
            Etchevers,H.C. and Calvas,P.
  TITLE     Phenotypic spectrum of STRA6 mutations: from Matthew-Wood syndrome
            to non-lethal anophthalmia
  JOURNAL   Hum Mutat 30 (5), E673-E681 (2009)
   PUBMED   19309693
REFERENCE   9  (bases 1 to 2904)
  AUTHORS   Pasutto,F., Sticht,H., Hammersen,G., Gillessen-Kaesbach,G.,
            Fitzpatrick,D.R., Nurnberg,G., Brasch,F., Schirmer-Zimmermann,H.,
            Tolmie,J.L., Chitayat,D., Houge,G., Fernandez-Martinez,L.,
            Keating,S., Mortier,G., Hennekam,R.C., von der Wense,A.,
            Slavotinek,A., Meinecke,P., Bitoun,P., Becker,C., Nurnberg,P.,
            Reis,A. and Rauch,A.
  TITLE     Mutations in STRA6 cause a broad spectrum of malformations
            including anophthalmia, congenital heart defects, diaphragmatic
            hernia, alveolar capillary dysplasia, lung hypoplasia, and mental
            retardation
  JOURNAL   Am J Hum Genet 80 (3), 550-560 (2007)
   PUBMED   17273977
REFERENCE   10 (bases 1 to 2904)
  AUTHORS   Szeto,W., Jiang,W., Tice,D.A., Rubinfeld,B., Hollingshead,P.G.,
            Fong,S.E., Dugger,D.L., Pham,T., Yansura,D.G., Wong,T.A.,
            Grimaldi,J.C., Corpuz,R.T., Singh,J.S., Frantz,G.D., Devaux,B.,
            Crowley,C.W., Schwall,R.H., Eberhard,D.A., Rastelli,L., Polakis,P.
            and Pennica,D.
  TITLE     Overexpression of the retinoic acid-responsive gene Stra6 in human
            cancers and its synergistic induction by Wnt-1 and retinoic acid
  JOURNAL   Cancer Res 61 (10), 4197-4205 (2001)
   PUBMED   11358845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 4, 2021 this sequence version replaced NM_001029924.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3329220.1,
                                           SRR26643295.31893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000008.1  67444757-67444981
            226-354             JAXUCZ010000008.1  67445597-67445725
            355-421             JAXUCZ010000008.1  67449439-67449505
            422-507             JAXUCZ010000008.1  67449834-67449919
            508-647             JAXUCZ010000008.1  67450951-67451090
            648-671             JAXUCZ010000008.1  67451398-67451421
            672-838             JAXUCZ010000008.1  67451597-67451763
            839-961             JAXUCZ010000008.1  67453349-67453471
            962-1029            JAXUCZ010000008.1  67455870-67455937
            1030-1109           JAXUCZ010000008.1  67456121-67456200
            1110-1171           JAXUCZ010000008.1  67456400-67456461
            1172-1334           JAXUCZ010000008.1  67457883-67458045
            1335-1410           JAXUCZ010000008.1  67459585-67459660
            1411-1544           JAXUCZ010000008.1  67460507-67460640
            1545-1662           JAXUCZ010000008.1  67461599-67461716
            1663-1764           JAXUCZ010000008.1  67461801-67461902
            1765-1928           JAXUCZ010000008.1  67462610-67462773
            1929-2084           JAXUCZ010000008.1  67463205-67463360
            2085-2904           JAXUCZ010000008.1  67463900-67464719
FEATURES             Location/Qualifiers
     source          1..2904
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2904
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /note="signaling receptor and transporter of retinol
                     STRA6"
                     /db_xref="GeneID:363071"
                     /db_xref="RGD:1307551"
     exon            1..225
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            226..354
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2254
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /note="stimulated by retinoic acid gene 6 protein homolog;
                     stimulated by retinoic acid gene 6 homolog;
                     retinol-binding protein receptor STRA6; stimulated by
                     retinoic acid 6"
                     /codon_start=1
                     /product="receptor for retinol uptake STRA6"
                     /protein_id="NP_001025095.1"
                     /db_xref="GeneID:363071"
                     /db_xref="RGD:1307551"
                     /translation="MESQASENGSQTSSGVTDDYSSWYIEEPLGAEEVQPEGVNPLCQ
                     PTVPPALHHACLASLSLLALLLLALLVRRRRLWPHCAHCRPGLPSPVDFLAGNRSWTV
                     PTAVFVALFSNLCLLLPDENPLPFLNRTAASSPDGEPETSRGPWKLLALLYYPALYYP
                     LAACATAGHRAAYLLGTVLSWVHVSVQVWQRAECPQDPKIYKHYSLLASLPLLLSLGF
                     LSLWYPVQVVQSIRHRTGAGSQGLQTSYSEKYLRALLCPKKLDSCSHPASKRSLLSRA
                     WAFSQHSIYTPEPGFCLPLKLVISATLTGTATYQVALLLLVSVVPTVQKVRAGITTDV
                     SYLLAGFGIVLSEDRQEVVELVKHHLWAVEACYISALVLSCSLTFLLLIRSLRTHRAN
                     LKALHRGAALDLGPPLQSTHPSRQAIVCWMSFSAYQTAFSCLGLLVQQVIFFLGTTIL
                     AFLVFVPLLHGRNLLLLRSLESTWPFWLTLVLAVILQNIAANWVFLESHHGYPELTNR
                     RMLCVATFLLFPINMLVGAIMAIWRVLLSSLYNTVHLGQMDLSLLPQRAASLDPGYHT
                     YRNFLRIEASQSHPGVIAFCALLLHVPSPQPQPPLAPQDSLRPAAEEEGMQLLQTKDL
                     MAKGAGPKGSRSRARWGLAYTLLHNPSLQAFRKAALTSAKANGTQP"
     exon            355..421
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            422..507
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            508..647
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            648..671
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            672..838
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            839..961
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1029
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1109
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1171
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1334
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1410
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1544
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1662
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1764
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1928
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2084
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2904
                     /gene="Stra6"
                     /gene_synonym="RGD1307551"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tatatactca ggagaccatg tggataggtt ccctccctgt ctccgtggcc agccccagta
       61 gggtgttgcc ttaagatgcc acgatgctgg gttctgaaga ggggctatgc ctaggcagag
      121 agcttggggc aggtgctgga ggtagacttg cgcacggtca gcagccattc gtcttcgggg
      181 tctcatcaag agttatggtg tgttcccagc actgaggctg aaaaggaaga agagctggag
      241 catggaatcc caggcctctg agaatggaag ccagacctcc tccggggtga cagatgacta
      301 cagcagctgg tacatcgagg aacctctagg agctgaggag gtgcagccag agggggtgaa
      361 tcccctttgc cagcccactg taccgcctgc cctgcaccat gcctgcttgg cctcactgtc
      421 gctcctggct ctgctgctgc tggccttact ggtgagacgt cgcaggcttt ggccacactg
      481 tgctcattgc agacctggac tgcccagccc tgtggatttc ttggctggga accgatcctg
      541 gacagttcct actgctgtct ttgtggccct cttcagcaat ctgtgcctgt tgctccctga
      601 tgagaaccca ctgcctttcc tgaaccgcac tgcagcatcc agtccagatg gagagccgga
      661 gacatcaaga gggccctgga agctcctggc tctgctctac tacccagccc tctactaccc
      721 tctggctgcc tgtgctacgg cagggcaccg agctgcatac ttactgggta ctgtgctatc
      781 ttgggttcac gtcagtgttc aggtctggca gagagcagag tgtcctcagg accccaagat
      841 ctacaagcac tactccttgc tggcctccct gcctctgctt ctgagtcttg gattcctgag
      901 cctttggtat ccagtacaag tggtgcagag tatccgtcat cggacaggag caggctccca
      961 ggggctacag accagctact ccgagaagta tctgagagcc ctcctctgtc caaagaagct
     1021 ggacagctgc tcccatcccg cctccaagcg tagccttctg tctcgggctt gggccttttc
     1081 ccagcattcc atctacactc cagagccagg attctgcctg cccttgaagc tggtgatctc
     1141 ggccaccctg acaggaacag ccacttacca ggtggccctg ctgttgctgg tgagcgtggt
     1201 gcctactgtg cagaaggtga gggcagggat caccacagat gtctcctacc tgctggcggg
     1261 ctttgggatt gtgctctctg aagacaggca ggaggtggta gagctggtga agcatcacct
     1321 atgggccgtg gaagcatgtt atatctcagc tctggtcttg tcctgctcat taaccttcct
     1381 gcttctgatc cgctccctga ggactcacag ggccaatctt aaagcactgc accgaggggc
     1441 tgccctggat ctgggtcccc ctcttcagag tactcacccc tctcgccaag ccatagtctg
     1501 ctggatgagc ttcagtgcct accagacggc cttcagctgc cttgggctcc tggtgcagca
     1561 ggtcatcttc ttcctgggga ccacaatcct ggccttccta gtgtttgtgc ctttactcca
     1621 tggtaggaac ctcttgctcc tccggtccct ggaatccaca tggcccttct ggctgactct
     1681 ggtcttggct gtaatcctgc agaacatagc agccaattgg gtcttcctag agtctcacca
     1741 cggatacccg gagctgacca accggcgcat gctctgcgta gccacttttc ttctcttccc
     1801 catcaacatg ctggtgggag ccataatggc tatttggcgg gtgctcctct cttctctcta
     1861 caacactgtt cacctcggcc agatggacct cagcctgctg ccgcagagag ctgcctccct
     1921 ggatccaggc tatcacacat accgaaactt cctgaggatt gaggccagcc agtcacaccc
     1981 aggagtcata gccttctgtg ccctgctcct tcatgtgcca agtccacagc cccagccccc
     2041 actggccccc caggacagcc tcagaccagc agcagaagaa gaaggtatgc aattgctaca
     2101 gaccaaggac ctgatggcca agggagcagg acccaaaggc agccggagca gggcccggtg
     2161 gggtctggcc tacacattgc tccacaaccc aagtctgcag gcctttcgga aggcagccct
     2221 tactagtgcc aaggccaatg gcacccagcc ctgagggtga agaaaaccac accaccctgc
     2281 ttttatgtgc taaggcacat tcttgtctac atcctccctc tcattcatgt cagcaagccc
     2341 ctcccccagc agcaactctg ccaaccaggg gatcagggga ctggagtcac tgtgtctaca
     2401 ccaccagctt ccagaggact ttggtctgtg cttgtccaca agactaccag ctagggctct
     2461 agaggaaaca gctagtgggt tctttgtcct ggaacagtca gggaaagggt gggcacattt
     2521 aggcctctcc tccgcacact ggctctgcca tcagcttgct gggcctcagt gaggcccctc
     2581 ttactccctg ttggtaatga aaatccagaa tatctcctat cccagctcgc cccacctcag
     2641 cctcccacca taaaggtgga gcctgtgtgg gtttcctctc tgccccagct ctctgcttcc
     2701 tctctcttcc actcccgccc cttcttgtgc agccaagtca gactccaaga ggccccacgg
     2761 aactgccctc tccaaaaacc agattttttt ttgtagtttt aatgctgtta gttgtcatga
     2821 aagaagttag tgtgctctct gtaataaatg tgcctctgag gaacactcct cctcactgga
     2881 ggagggctct caggggaacc acta
//
