LOCUS       NM_001135874            3185 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus stonin 2 (Ston2), mRNA.
ACCESSION   NM_001135874 XM_234454
VERSION     NM_001135874.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3185)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 3185)
  AUTHORS   Willox,A.K. and Royle,S.J.
  TITLE     Stonin 2 is a major adaptor protein for clathrin-mediated synaptic
            vesicle retrieval
  JOURNAL   Curr Biol 22 (15), 1435-1439 (2012)
   PUBMED   22727701
  REMARK    GeneRIF: major adaptor for vesicle retrieval at hippocampal
            synapses
REFERENCE   3  (bases 1 to 3185)
  AUTHORS   Granata,A., Koo,S.J., Haucke,V., Schiavo,G. and Warner,T.T.
  TITLE     CSN complex controls the stability of selected synaptic proteins
            via a torsinA-dependent process
  JOURNAL   EMBO J 30 (1), 181-193 (2011)
   PUBMED   21102408
REFERENCE   4  (bases 1 to 3185)
  AUTHORS   Rumpf,J., Simon,B., Jung,N., Maritzen,T., Haucke,V., Sattler,M. and
            Groemping,Y.
  TITLE     Structure of the Eps15-stonin2 complex provides a molecular
            explanation for EH-domain ligand specificity
  JOURNAL   EMBO J 27 (3), 558-569 (2008)
   PUBMED   18200045
  REMARK    GeneRIF: High-affinity ligand for the second EH domain (EH2) of the
            clathrin accessory protein Eps15.
REFERENCE   5  (bases 1 to 3185)
  AUTHORS   Diril,M.K., Wienisch,M., Jung,N., Klingauf,J. and Haucke,V.
  TITLE     Stonin 2 is an AP-2-dependent endocytic sorting adaptor for
            synaptotagmin internalization and recycling
  JOURNAL   Dev Cell 10 (2), 233-244 (2006)
   PUBMED   16459302
REFERENCE   6  (bases 1 to 3185)
  AUTHORS   Walther,K., Diril,M.K., Jung,N. and Haucke,V.
  TITLE     Functional dissection of the interactions of stonin 2 with the
            adaptor complex AP-2 and synaptotagmin
  JOURNAL   Proc Natl Acad Sci U S A 101 (4), 964-969 (2004)
   PUBMED   14726597
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 16, 2008 this sequence version replaced XM_234454.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.36693.1,
                                           SRR26643292.26890.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000006.1  116406882-116407092 c
            212-487             JAXUCZ010000006.1  116403163-116403438 c
            488-685             JAXUCZ010000006.1  116368265-116368462 c
            686-2524            JAXUCZ010000006.1  116306899-116308737 c
            2525-2727           JAXUCZ010000006.1  116300253-116300455 c
            2728-3185           JAXUCZ010000006.1  116298198-116298655 c
FEATURES             Location/Qualifiers
     source          1..3185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..3185
                     /gene="Ston2"
                     /gene_synonym="RGD1311502"
                     /note="stonin 2"
                     /db_xref="GeneID:314349"
                     /db_xref="RGD:1311502"
     exon            1..211
                     /gene="Ston2"
                     /gene_synonym="RGD1311502"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2811
                     /gene="Ston2"
                     /gene_synonym="RGD1311502"
                     /note="homolog of stoned B"
                     /codon_start=1
                     /product="stonin-2"
                     /protein_id="NP_001129346.1"
                     /db_xref="GeneID:314349"
                     /db_xref="RGD:1311502"
                     /translation="MTTLDHVIATHQSEWVSFSEEPLFPTPLEGGTEEHFPGLSSSSD
                     RSESSSGENHAVDEGSQDLSHSEQDDSSEKMGLISEAASPPGSPVQPTPDLASAISNW
                     VQFEDDTPWSNTSAPHKETALTLTVPCWTCPSLDSLRRCPLASESSWTTHSEDTSSPS
                     VAPSYTDLQLINAEEQASGRASGTDSTDNSSSLQEDEEVEMETISWWAGSPAMNGHPA
                     VPQVTTARFPSWVTFEDNEVGCPSPTVPSPKKPNAPSAATAGPDVPFNSTGSFKRDRP
                     KSTLMNLSKVQKLDISSLNRPPSVTEAPPWRATNPFLNESLQDIQPSPINPFSAFFEE
                     QERRSQNSSISGTSGKSQRDSLIVIYQDAISFDDSGKSQSHPDAIEKLKQLQIDDPDP
                     VGNAALPDDDPTASVEPDAPSPTSALSQPRDGWPMMLRIPEKKNIMSSRHWGPIYIKL
                     TDSGYLQLYYEQGLEKPFREFKLEICHEVSEPRLQNYDENGRIHSLRIDRVTYKEKKK
                     YQPKPAVAHAAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVQSMDLSTVGLNYLEE
                     EITVDIRDEFSGTVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILIKGNEIVS
                     RQDIMPTTTTKWIKLHECRFHGCVDEDVFNSSRVILFNPLDACRFELMRFRTVFAEKT
                     LPFTLRTAASINGAEVEVQSWLRMSPGFSSNRDPLTQVPCENVMVRYPVPSEWVKNFR
                     RESVLGEKSLKAKVNRGASFGSAGASGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDK
                     NSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKAAVRSISVEDKPDVR
                     KWVNYSAHYSYKVEIEQKKSLKPDFEGEDLENPKECGVQ"
     exon            212..487
                     /gene="Ston2"
                     /gene_synonym="RGD1311502"
                     /inference="alignment:Splign:2.1.0"
     exon            488..685
                     /gene="Ston2"
                     /gene_synonym="RGD1311502"
                     /inference="alignment:Splign:2.1.0"
     exon            686..2524
                     /gene="Ston2"
                     /gene_synonym="RGD1311502"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2727
                     /gene="Ston2"
                     /gene_synonym="RGD1311502"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..3185
                     /gene="Ston2"
                     /gene_synonym="RGD1311502"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccattcacaa gacatctgtg gcatactgta gcccgagccc cctgtgctgc cctgtttacc
       61 ccagacatct ttctggggtc cacttgaggt cagcagcgtg aagatgaaca gaaccctctt
      121 agcatgacga ccttggacca tgtcattgcc acccaccagt cagagtgggt ctccttcagt
      181 gaagagccat tgttccccac ccctttagag gggggcactg aagagcactt cccaggattg
      241 tcatcttcct cagaccggtc tgagagctcc tctggggaga atcatgcagt ggacgaaggc
      301 tcgcaggacc tttcacactc tgagcaggat gactcctctg aaaagatggg cctcatctct
      361 gaagcagcct cccctccggg gagccctgtg cagcccacac ctgatctggc ctcagccatc
      421 agcaactggg tccagtttga agatgacaca ccctggagca acacctcagc accgcacaag
      481 gagacagccc tcacattgac cgtgccctgc tggacatgcc cttccttgga ctctttgaga
      541 agatgccctt tggcgtccga gagcagttgg accacccatt ctgaggacac cagcagccct
      601 agtgttgctc catcatatac agacctgcag ctcatcaacg ctgaggaaca ggcaagcggc
      661 agggcttctg ggaccgactc caccgacaat tcctcctccc tccaggaaga tgaagaagta
      721 gaaatggaga ccatcagttg gtgggcaggc agtccagcca tgaacgggca tcctgccgtc
      781 ccacaggtga ccactgctcg tttccccagc tgggtcacct ttgaagacaa tgaagtcggc
      841 tgcccttcgc caacagtccc ctctccaaag aagccaaatg ctccatctgc tgcaactgct
      901 ggcccagacg tacctttcaa ctcaactggg tcatttaaga gggaccgtcc caagagcaca
      961 ctgatgaact tatccaaagt tcagaagctg gacatatcct ccttaaaccg tccaccttct
     1021 gtcacggagg ccccaccctg gagggccacc aatcctttcc tgaatgagtc gctccaggac
     1081 atacagccct cccccatcaa cccgttcagt gctttcttcg aagagcagga acggcgctcc
     1141 caaaacagtt ccatttccgg tacctcgggc aaaagccaaa gagattctct gattgtcatc
     1201 taccaggatg ccatcagctt tgatgattca ggcaaaagcc agtcccaccc cgacgctatt
     1261 gaaaagctca agcaactcca aattgatgat cccgatcccg ttggcaatgc agccctgccc
     1321 gatgacgacc ccacagcctc ggttgaaccc gatgcgccct cacccacctc agcgctatct
     1381 cagcccaggg atggatggcc aatgatgctg agaatccccg agaagaaaaa catcatgtcc
     1441 tccaggcact ggggaccaat ctacatcaaa ctgactgaca gtggttacct gcagctgtat
     1501 tacgagcaag gcctagaaaa accattccgg gaattcaagc tggagatctg ccacgaggtg
     1561 tcggaacccc ggctccaaaa ctatgatgag aatgggagga tccacagctt gaggatagac
     1621 cgggtcactt acaaggagaa gaagaaatac cagcccaagc ctgctgtggc ccatgcagcc
     1681 gaaagggaac aggtaattaa actgggcacc accaactacg acgacttcct gagcttcatc
     1741 cacgcggttc aggaccgcct catggattta ccagtgcagt cgatggactt gagcacagtt
     1801 ggcttaaact acctcgaaga ggagattaca gtggacatcc gagatgagtt ctctggcaca
     1861 gtaagcaaag gagacaacca gatcctacag caccacgtct tgacacggat ccacatactg
     1921 agtttcctct ctgggctcgc cgagtgccgc ttgggcctca acgacatcct catcaaaggg
     1981 aacgaaatcg tctcccggca ggacatcatg cccaccacca ccaccaagtg gatcaagctc
     2041 cacgagtgcc gtttccacgg gtgcgtggac gaggacgtgt ttaacagttc ccgggtcatt
     2101 ctgttcaacc ctctggatgc ctgccggttc gagctaatga ggttcaggac cgtgtttgcc
     2161 gagaagacct tgcccttcac cctcaggaca gcagcgagca ttaacggggc ggaagtggag
     2221 gtgcagagct ggctgaggat gtctcccggc ttctcttcta accgtgaccc tctcactcag
     2281 gttccctgtg agaacgtaat ggttcgctac ccagtaccca gtgagtgggt gaaaaacttc
     2341 cgcagggaaa gtgttctagg ggaaaagtct ttgaaagcca aagtgaaccg gggggcaagt
     2401 tttggctccg ctggcgcctc tggctcggag cccgtcatga gagtaactct gggaacagcc
     2461 aagtacgagc acgccttcaa ctccattgtg tggaggataa accggctgcc agacaagaac
     2521 tcagcttctg gccacccaca ctgtttcttt tgccaccttg aacttggctc tgaccgggaa
     2581 gtgccttcca gatttgccaa tcatgtaaac gtcgagttca gcatgcccac gacgtctgcc
     2641 tccaaagcag ctgtgagatc catctctgtg gaagacaagc ccgatgtcag gaagtgggtc
     2701 aattattccg cacactacag ctacaaggtg gaaattgaac aaaaaaagag tttgaagcca
     2761 gactttgagg gagaggactt ggaaaaccca aaggaatgtg gggtacagtg acagtgaccc
     2821 acctcaagga actgaggacc gctgactcgc aaccgggtgt cttccccgaa taactcaagt
     2881 ttaagtcgac acctgctgcg gctgctccac attgggggct gcctacctcc gtttcctgtg
     2941 tgcacctacc tgtgggtcac aggaaatcct gaggggggct gccttcagta ggccccttga
     3001 cactgagcat gcccgaagta cgtggcacac ctggcttctg gagtttacca agtattgagc
     3061 ctccttgtct cttttctgct tgtatcatgg cactggtatg tggtttgtgg tgactattag
     3121 aaacccagaa agaaccgcca gcatcagtgt tggcacaatt tgcccccagt actcacatgt
     3181 cactt
//
