LOCUS       NM_001011943            1555 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus STN1 subunit of CST complex (Stn1), mRNA.
ACCESSION   NM_001011943 XM_215273
VERSION     NM_001011943.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Iles,M.M., Bishop,D.T., Taylor,J.C., Hayward,N.K., Brossard,M.,
            Cust,A.E., Dunning,A.M., Lee,J.E., Moses,E.K., Akslen,L.A.,
            Andresen,P.A., Avril,M.F., Azizi,E., Scarra,G.B., Brown,K.M.,
            Debniak,T., Elder,D.E., Friedman,E., Ghiorzo,P., Gillanders,E.M.,
            Goldstein,A.M., Gruis,N.A., Hansson,J., Harland,M., Helsing,P.,
            Hocevar,M., Hoiom,V., Ingvar,C., Kanetsky,P.A., Landi,M.T.,
            Lang,J., Lathrop,G.M., Lubinski,J., Mackie,R.M., Martin,N.G.,
            Molven,A., Montgomery,G.W., Novakovic,S., Olsson,H., Puig,S.,
            Puig-Butille,J.A., Radford-Smith,G.L., Randerson-Moor,J., van der
            Stoep,N., van Doorn,R., Whiteman,D.C., MacGregor,S., Pooley,K.A.,
            Ward,S.V., Mann,G.J., Amos,C.I., Pharoah,P.D., Demenais,F.,
            Law,M.H., Newton Bishop,J.A. and Barrett,J.H.
  CONSRTM   AMFS Investigators; IBD investigators; QMEGA and QTWIN
            Investigators; SDH Study Group; GenoMEL Consortium
  TITLE     The effect on melanoma risk of genes previously associated with
            telomere length
  JOURNAL   J Natl Cancer Inst 106 (10) (2014)
   PUBMED   25231748
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Chen,L.Y., Redon,S. and Lingner,J.
  TITLE     The human CST complex is a terminator of telomerase activity
  JOURNAL   Nature 488 (7412), 540-544 (2012)
   PUBMED   22763445
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Wan,M., Qin,J., Songyang,Z. and Liu,D.
  TITLE     OB fold-containing protein 1 (OBFC1), a human homolog of yeast
            Stn1, associates with TPP1 and is implicated in telomere length
            regulation
  JOURNAL   J Biol Chem 284 (39), 26725-26731 (2009)
   PUBMED   19648609
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Casteel,D.E., Zhuang,S., Zeng,Y., Perrino,F.W., Boss,G.R.,
            Goulian,M. and Pilz,R.B.
  TITLE     A DNA polymerase-{alpha}{middle dot}primase cofactor with homology
            to replication protein A-32 regulates DNA replication in mammalian
            cells
  JOURNAL   J Biol Chem 284 (9), 5807-5818 (2009)
   PUBMED   19119139
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079096.1.
            
            On Feb 11, 2005 this sequence version replaced XM_215273.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079096.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1555
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="STN1 subunit of CST complex"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
     exon            1..175
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            176..351
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1424
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="oligonucleotide/oligosaccharide-binding
                     fold-containing protein 1; suppressor of cdc thirteen
                     homolog; oligonucleotide/oligosaccharide-binding fold
                     containing 1; STN1, CST complex subunit"
                     /codon_start=1
                     /product="CST complex subunit STN1"
                     /protein_id="NP_001011943.1"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
                     /translation="MPEPCLLMQCESSPKEEEIPSLFWGLDPVFLAFAKLYIKDILEM
                     KESQQVPGMYFYNGHPIRRVDIMGAVISVKERETFYSYGVDDATGVINCVCWKRPSNA
                     ESSSDPAILSTSRELSMTSQLKKLQETIEQKTKIGIGDIIRVRGYVRMFREEREICAT
                     IYYKVDDPVWNMQIARMLELPELYKKVYDQPFRNPALKEEEALNSKDTLDLAGLTALL
                     SEKVKEFLQEKKVQSFYQKELEMVEPLQSLASQPVTHSTCSDQVELKNDAASDIHSVF
                     KNALHLLQEKGFVFQRDGGSDKLYYVTSKDKDLHQKIYQIIKEDCQKPNLWCMLPQEA
                     WRGTEEGLAVVVTLSVCLPLPVDVEKGCHLMHVLNCVLLNLRWDLNKAVLQQVLELLE
                     DQSDIVSTGDHYYTAF"
     exon            352..447
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..516
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..684
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..808
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..980
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1100
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1173
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1530
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcctgctc cgggagaggc tgtaaaccgc tctgattctg cctccttttc ctttcctccg
       61 ctcttcccag aaggtgaaat gtcgaagagt ggatagacac acctccaggg cccaaagtcc
      121 acggccacag gggcgccatt cactctccgg actcattcgt taaaactcct ttgggagtct
      181 tggctcaggg ttagcagatg ccagaacctt gccttttgat gcagtgcgaa tccagtccaa
      241 aagaagagga gatcccgtcc ctcttttggg gtctggatcc cgtgtttcta gcctttgcaa
      301 aactctacat caaggacatc ctggagatga aggagtccca acaagtgcca ggcatgtatt
      361 tttacaatgg acatccaata agacgggtgg atatcatggg agctgtcatc agtgtgaaag
      421 agagagagac tttctacagc tatggagtgg atgacgccac aggggttata aactgtgtgt
      481 gctggaaaag gccaagcaat gccgagtctt catcagaccc agctattctg agcacttcga
      541 gagaactcag catgacctca cagcttaaga aactgcagga gaccattgag cagaaaacca
      601 agatcgggat tggggatatc atccgagtcc gaggctacgt gcgtatgttc cgagaagagc
      661 gagagatctg tgccaccatt tattataagg tggacgatcc agtgtggaac atgcaaattg
      721 caaggatgct tgagctgcca gagctctaca agaaggtgta tgaccagccc ttccggaacc
      781 cagccctaaa ggaggaagag gcactaaaca gtaaagacac tttggatctc gctggcctca
      841 cggctttgtt gagtgagaaa gttaaagaat ttctccagga gaagaaagtg caaagcttct
      901 accagaagga gctggaaatg gtggagccct tgcagtctct ggccagtcag cccgtgaccc
      961 acagcacgtg ctcggaccaa gtggagttaa agaacgacgc cgcttctgac atacacagtg
     1021 tgtttaagaa tgctctgcac ctgcttcagg aaaaggggtt cgtgttccag agagacggtg
     1081 gctccgataa gctgtactat gttaccagta aggacaaaga cctgcaccag aagatctacc
     1141 agatcattaa ggaagactgt cagaaaccaa atctgtggtg catgctgcct caggaggcct
     1201 ggagagggac tgaggaaggc ctggccgtcg tggtcacact tagtgtctgc ctgcccttgc
     1261 ccgtagatgt ggagaagggc tgccacttga tgcacgtcct gaactgcgtg ctcctcaacc
     1321 tccgctggga cctgaacaag gctgtgctgc agcaggtgct ggagctcctg gaggaccaga
     1381 gcgacattgt gagtactgga gaccactact acacggcctt ctgagcagag ccacggagag
     1441 gcagcaggca gctttacccc aggttctgct cccaggcgtt gtagagactt atttgtgtat
     1501 aatcctctaa taaagtctga tacagccaca aaaaaaaaaa aaaaaaaaaa aaaaa
//
