LOCUS       NM_001270856            1280 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus stathmin 4 (Stmn4), transcript variant 3, mRNA.
ACCESSION   NM_001270856
VERSION     NM_001270856.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1280)
  AUTHORS   Nakazawa,T., Morii,H., Tamai,M. and Mori,N.
  TITLE     Selective upregulation of RB3/stathmin4 by ciliary neurotrophic
            factor following optic nerve axotomy
  JOURNAL   Brain Res 1061 (2), 97-106 (2005)
   PUBMED   16256088
  REMARK    GeneRIF: RB3 is the unique response protein in the stathmin-related
            proteins following optic nerve axotomy and the induced RB3 may play
            a critical role in the CNTF-induced response on the axotomized
            retinal ganglion cells
REFERENCE   2  (bases 1 to 1280)
  AUTHORS   Nakao,C., Itoh,T.J., Hotani,H. and Mori,N.
  TITLE     Modulation of the stathmin-like microtubule destabilizing activity
            of RB3, a neuron-specific member of the SCG10 family, by its
            N-terminal domain
  JOURNAL   J Biol Chem 279 (22), 23014-23021 (2004)
   PUBMED   15039434
  REMARK    GeneRIF: regulatory role of the unique N-terminal domain of RB3 in
            microtubule dynamics would contribute to the physiological
            regulation of neuronal morphogenesis
REFERENCE   3  (bases 1 to 1280)
  AUTHORS   Ozon,S., El Mestikawy,S. and Sobel,A.
  TITLE     Differential, regional, and cellular expression of the stathmin
            family transcripts in the adult rat brain
  JOURNAL   J Neurosci Res 56 (5), 553-564 (1999)
   PUBMED   10369222
REFERENCE   4  (bases 1 to 1280)
  AUTHORS   Gavet,O., Ozon,S., Manceau,V., Lawler,S., Curmi,P. and Sobel,A.
  TITLE     The stathmin phosphoprotein family: intracellular localization and
            effects on the microtubule network
  JOURNAL   J Cell Sci 111 (Pt 22), 3333-3346 (1998)
   PUBMED   9788875
REFERENCE   5  (bases 1 to 1280)
  AUTHORS   Ozon,S., Byk,T. and Sobel,A.
  TITLE     SCLIP: a novel SCG10-like protein of the stathmin family expressed
            in the nervous system
  JOURNAL   J Neurochem 70 (6), 2386-2396 (1998)
   PUBMED   9603203
REFERENCE   6  (bases 1 to 1280)
  AUTHORS   Ozon,S., Maucuer,A. and Sobel,A.
  TITLE     The stathmin family -- molecular and biological characterization of
            novel mammalian proteins expressed in the nervous system
  JOURNAL   Eur J Biochem 248 (3), 794-806 (1997)
   PUBMED   9342231
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1 and BC092646.1.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (c) has the same
            N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213134.1, FQ212976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000015.1  44716880-44716942
            64-288              BC092646.1         1-225
            289-689             BC092646.1         307-707
            690-1280            BC092646.1         761-1351
FEATURES             Location/Qualifiers
     source          1..1280
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1280
                     /gene="Stmn4"
                     /gene_synonym="Lagl; Rb3"
                     /note="stathmin 4"
                     /db_xref="GeneID:79423"
                     /db_xref="RGD:69349"
     exon            1..101
                     /gene="Stmn4"
                     /gene_synonym="Lagl; Rb3"
                     /inference="alignment:Splign:2.1.0"
     exon            102..192
                     /gene="Stmn4"
                     /gene_synonym="Lagl; Rb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..749
                     /gene="Stmn4"
                     /gene_synonym="Lagl; Rb3"
                     /note="isoform c is encoded by transcript variant 3;
                     stathmin-like protein B3; stathmin-like-protein RB3;
                     stathmin-like 4"
                     /codon_start=1
                     /product="stathmin-4 isoform c"
                     /protein_id="NP_001257785.1"
                     /db_xref="GeneID:79423"
                     /db_xref="RGD:69349"
                     /translation="MTLAAYKEKMKELPLVSLFCSCFLSDPLNKSSYKYEADTVDLNW
                     CVISDMEVIELNKCTSGQSFEVILKPPSFDGVPEFNASLPRRRDPSLEEIQKKLEAAE
                     ERRKYQEAELLKHLAEKREHEREVIQKAIEENNNFIKMAKEKLAQKMESNKENREAHL
                     AAMLERLQEKDKHAEEVRKNKELKEEASR"
     exon            193..288
                     /gene="Stmn4"
                     /gene_synonym="Lagl; Rb3"
                     /inference="alignment:Splign:2.1.0"
     exon            289..497
                     /gene="Stmn4"
                     /gene_synonym="Lagl; Rb3"
                     /inference="alignment:Splign:2.1.0"
     exon            498..689
                     /gene="Stmn4"
                     /gene_synonym="Lagl; Rb3"
                     /inference="alignment:Splign:2.1.0"
     exon            690..1279
                     /gene="Stmn4"
                     /gene_synonym="Lagl; Rb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcgagagc ccagcagtgg tgctgatgtt gagagaagct cagggtacca ctaattgaag
       61 gagtgagaag agaacagctc gctttggaaa ccggactgca ggattgtgat ccagttctga
      121 gctggtgata aacactcctt gtgacttttg gtcaattcag ctaccagatt ccagccaaca
      181 tgaccctcgc agcctataag gagaagatga aggaactccc actagtgtct ctgttctgct
      241 cctgttttct gtctgatccc ctgaataaat catcctacaa atatgaagca gatacggtag
      301 acctgaactg gtgtgtcatc tctgatatgg aagtcatcga gctgaataag tgtacctcgg
      361 gccagtcctt tgaagtcatc ctgaagccac cttcctttga cggggtgcct gagtttaatg
      421 cctccctccc aagacgtcga gacccatcgc tagaagagat acagaagaag ctagaagcag
      481 cagaggagcg aaggaagtac caggaagctg agctcctaaa acaccttgca gagaaacgag
      541 agcatgagcg tgaggtaatc cagaaagcta tcgaggaaaa caacaacttc atcaagatgg
      601 cgaaagagaa gctggcccag aagatggagt ccaataagga aaaccgggag gcccatctgg
      661 ctgccatgtt ggagcggctg caagagaagg acaagcacgc agaggaggtg cggaaaaaca
      721 aggagctgaa ggaagaggcc tccaggtaaa gcccagaggc caaggaagtt tccaggacag
      781 ccggacagct cccgcagcaa cctggttcca gcagcatcgg ccgctggctg ctctcccagc
      841 actggggttc ggggggaggg gggtggccaa aggggcgttt cctctgcttt tggtgtttgt
      901 acatgtaaaa gattgaccag tgaagccatc ctatttgttt ctggggaaca atgatggggt
      961 gggagagggg acagagagtg tgtggaaaag gaggtgaaga tgagcccgag gactttgtga
     1021 cactgtccac tgactgcaga cttgggccaa ggcccccgct tttcacggct ctgcctggac
     1081 attcggcctc caggttccta gtggagagaa gatgtgacag aagttcagag tgaagggccg
     1141 agtcctggtg gggtggtgtg cagggccagc aggacgagcc cgtctggatg gagtgaaacc
     1201 taccctgagc gggtgggata aggtctgtgt gcgtctgttc attgtcatct tttgatcatc
     1261 atgaccaacg aaacatttaa
//
