LOCUS       NM_053440               1870 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus stathmin 2 (Stmn2), mRNA.
ACCESSION   NM_053440
VERSION     NM_053440.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Levy,A.D., Devignot,V., Fukata,Y., Fukata,M., Sobel,A. and
            Chauvin,S.
  TITLE     Subcellular Golgi localization of stathmin family proteins is
            promoted by a specific set of DHHC palmitoyl transferases
  JOURNAL   Mol Biol Cell 22 (11), 1930-1942 (2011)
   PUBMED   21471001
  REMARK    GeneRIF: palmitoylation of stathmins 2 and 3 likely occurs at the
            Golgi and is crucial for their specific subcellular localization
            and trafficking
REFERENCE   2  (bases 1 to 1870)
  AUTHORS   Sobczak,A., Debowska,K., Blazejczyk,M., Kreutz,M.R., Kuznicki,J.
            and Wojda,U.
  TITLE     Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite
            outgrowth
  JOURNAL   Biochim Biophys Acta 1813 (5), 1025-1037 (2011)
   PUBMED   21215777
  REMARK    GeneRIF: CaMy1 via SCG10 couples Ca(2+) signals with the dynamics
            of microtubules during neuronal outgrowth in the developing brain.
REFERENCE   3  (bases 1 to 1870)
  AUTHORS   Paradis,V., Dargere,D., Bieche,Y., Asselah,T., Marcellin,P.,
            Vidaud,M. and Bedossa,P.
  TITLE     SCG10 expression on activation of hepatic stellate cells promotes
            cell motility through interference with microtubules
  JOURNAL   Am J Pathol 177 (4), 1791-1797 (2010)
   PUBMED   20802173
  REMARK    GeneRIF: Overexpression of SCG10 is associated with Liver Fibrosis.
REFERENCE   4  (bases 1 to 1870)
  AUTHORS   Alves,M.M., Burzynski,G., Delalande,J.M., Osinga,J., van der
            Goot,A., Dolga,A.M., de Graaff,E., Brooks,A.S., Metzger,M.,
            Eisel,U.L., Shepherd,I., Eggen,B.J. and Hofstra,R.M.
  TITLE     KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to
            microtubule dynamics and neuronal differentiation
  JOURNAL   Hum Mol Genet 19 (18), 3642-3651 (2010)
   PUBMED   20621975
  REMARK    GeneRIF: KBP-depleted PC12 cells were defective in nerve growth
            factor-induced differentiation and neurite outgrowth, suggesting
            that KBP is required for cell differentiation and neurite
            development.
REFERENCE   5  (bases 1 to 1870)
  AUTHORS   Cartwright,M.J., Schlauch,K., Lenburg,M.E., Tchkonia,T.,
            Pirtskhalava,T., Cartwright,A., Thomou,T. and Kirkland,J.L.
  TITLE     Aging, depot origin, and preadipocyte gene expression
  JOURNAL   J Gerontol A Biol Sci Med Sci 65 (3), 242-251 (2010)
   PUBMED   20106964
  REMARK    GeneRIF: age-related changes in preadipocyte gene expression differ
            among depots, potentially contributing to fat redistribution and
            dysfunction.
REFERENCE   6  (bases 1 to 1870)
  AUTHORS   Greka,A., Navarro,B., Oancea,E., Duggan,A. and Clapham,D.E.
  TITLE     TRPC5 is a regulator of hippocampal neurite length and growth cone
            morphology
  JOURNAL   Nat Neurosci 6 (8), 837-845 (2003)
   PUBMED   12858178
REFERENCE   7  (bases 1 to 1870)
  AUTHORS   Nixon,A.B., Grenningloh,G. and Casey,P.J.
  TITLE     The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10
            to promote microtubule disassembly
  JOURNAL   J Biol Chem 277 (20), 18127-18133 (2002)
   PUBMED   11882662
  REMARK    GeneRIF: The microtubule-destabilizing protein SCG10 (superior
            cervical ganglia, neural specific 10) was found to directly
            interact with RGSZ1 in the yeast system, and this interaction was
            further verified using direct binding assays.
REFERENCE   8  (bases 1 to 1870)
  AUTHORS   Ozon,S., El Mestikawy,S. and Sobel,A.
  TITLE     Differential, regional, and cellular expression of the stathmin
            family transcripts in the adult rat brain
  JOURNAL   J Neurosci Res 56 (5), 553-564 (1999)
   PUBMED   10369222
REFERENCE   9  (bases 1 to 1870)
  AUTHORS   Gavet,O., Ozon,S., Manceau,V., Lawler,S., Curmi,P. and Sobel,A.
  TITLE     The stathmin phosphoprotein family: intracellular localization and
            effects on the microtubule network
  JOURNAL   J Cell Sci 111 (Pt 22), 3333-3346 (1998)
   PUBMED   9788875
REFERENCE   10 (bases 1 to 1870)
  AUTHORS   Stein,R., Mori,N., Matthews,K., Lo,L.C. and Anderson,D.J.
  TITLE     The NGF-inducible SCG10 mRNA encodes a novel membrane-bound protein
            present in growth cones and abundant in developing neurons
  JOURNAL   Neuron 1 (6), 463-476 (1988)
   PUBMED   3272176
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087660.1.
            
            On Dec 26, 2004 this sequence version replaced NM_053440.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087660.1, AF306458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..1870
                     /gene="Stmn2"
                     /gene_synonym="Scg10; Scgn10"
                     /note="stathmin 2"
                     /db_xref="GeneID:84510"
                     /db_xref="RGD:68947"
     exon            1..45
                     /gene="Stmn2"
                     /gene_synonym="Scg10; Scgn10"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..566
                     /gene="Stmn2"
                     /gene_synonym="Scg10; Scgn10"
                     /note="superiorcervical ganglia, neural specific 10;
                     superior cervical ganglion-10 protein; stathmin-like 2"
                     /codon_start=1
                     /product="stathmin-2"
                     /protein_id="NP_445892.1"
                     /db_xref="GeneID:84510"
                     /db_xref="RGD:68947"
                     /translation="MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQ
                     INKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEGRRKSQEAQV
                     LKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEK
                     ERHAAEVRRNKELQVELSG"
     exon            46..141
                     /gene="Stmn2"
                     /gene_synonym="Scg10; Scgn10"
                     /inference="alignment:Splign:2.1.0"
     exon            142..314
                     /gene="Stmn2"
                     /gene_synonym="Scg10; Scgn10"
                     /inference="alignment:Splign:2.1.0"
     exon            315..506
                     /gene="Stmn2"
                     /gene_synonym="Scg10; Scgn10"
                     /inference="alignment:Splign:2.1.0"
     exon            507..1848
                     /gene="Stmn2"
                     /gene_synonym="Scg10; Scgn10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctccgag cgtgcacatc cctacaatgg ctaaaacagc aatggcctac aaggaaaaaa
       61 tgaaggagct gtctatgctg tcactgatct gctcctgctt ctacccggag cctcgcaaca
      121 tcaacatcta cacctacgat gacatggagg tgaagcagat caacaagcgt gcttccggcc
      181 aggctttcga gctgatctta aagcccccgt ctcccatctc ggaagctcca cgaactctag
      241 cttctccaaa gaagaaagac ctgtctctgg aggagatcca gaaaaagctg gaggctgcag
      301 aggggcgaag gaagtctcag gaggcccagg tgctgaagca gttggcagag aagagggagc
      361 acgagcgaga agtcctccag aaggctttgg aggagaataa caacttcagc aagatggcgg
      421 aggagaagct gatcctgaaa atggaacaaa ttaaggaaaa ccgtgaggct aatctagctg
      481 ctatcattga acgtctgcag gaaaaggaga ggcatgctgc cgaggtgcgc aggaacaagg
      541 aactgcaggt tgaactgtct ggctgaagca atggcgggta tggcacgccc ctcccatagt
      601 aaatccccct gcctatatta taatggatca tgcgatatca gtatgggaaa atgtatgaca
      661 tggtttaaaa agaactcatt atgaaaaaaa aacagaatca aaaataaaat aaatcaatgc
      721 ggtctctttg cagaatgttt tgcttgatgt ttaaaaaagt accttggatc ttattttgta
      781 aatatttaca tttttgttaa aaaatacaag tattgcatta tgcaagttat ttcataatct
      841 tacatgtcct gtaacaggca ttcgatgttg tgtcttccca ctcaaatgaa tttgctagct
      901 ctattctttt ggaagctccc ccatgttgaa ctcagtccct gcccttttca ttccacccaa
      961 aaatgaggtc agtagacagt ctatggtgct agaaacccac cattgcctag tgacctagat
     1021 gactccatac tctccgagct tggccaagac cacacctaga tcgtggggac cgtgtgccca
     1081 tgtgaacctc cacatttctc tgctcataat ctgcttcctg cctagaaacc acaaagccag
     1141 gctaaggaaa tccaccagtc ctagcactga cctctgcttc tcgtggagtg tgtgcttcac
     1201 tcgtgtttgg gttttagaaa gagatgaatg ggaagacaga gctgtgctca atgagggtag
     1261 aagggcgagg ctgaaccttc taatgggccg aacacaaaca caaagctaga gggttcgagc
     1321 ggccatgacg ttgttcttca tgaagtgggc tttcttctct tgtttcggtt attttgatgg
     1381 aatgacttaa tcaacatgtc gatggcttat ctgtgggtgc catgggtgac gatgttcgtt
     1441 ttaagctttt gcctgtagta caagcacatg atgctactaa atatttttcc acttggagac
     1501 tgtgagctgg ttgttgcatt aaacacacaa acgaaatcac aaacactgtg gacttttact
     1561 caagctggtc tttcattccc agtgtagggc aatcctgcct ataaacaaga ccaaatcact
     1621 ccatctgtga cgctgccgca gttaaggggg ctaggcaggg catttgtgcc actgtaagaa
     1681 tcagcagaga cccagcatac gtaccttttg cagttttgaa gttgtctttc cccaactccc
     1741 aactcctgaa ggttgctgcc tgcatactta cttctcgtca gtgctatctt cttgtatgtc
     1801 attgtgagca aactgtgatg aataaagaat tggagttctg tgaactaaaa aaaaaaaaaa
     1861 aaaaaaaaaa
//
